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Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.

T3 may promote cancer cell proliferation says study.  Triiodothyronine was found to enhance the MCF-7 and T47-D breast cancer cell lines.  The conclusion of the abstract discusses a role of T3 in breast cancer development and progression.  This likely has more to do with progression than development through increased metabolism of the cell lines.

Conclusions: Low basal fT3 concentration can reliably predict the occurrence of postoperative Atrial Fibrillation in Coronary-bypass patients

low t3 conversion implicated in Anorexia Nervosa

low free T3: elevated reverse T3 in critically ill patients

effects of systemic illness on thyroid function: elevated Reverse T3 and low free T3

reverse T3 comes from peripheral conversion from free T4

T3 may have effects similar to Estradiol in breast cell proliferation.  This may be, but what about the effects on increased metabolism and resultant fat loss which leads to reduce inflammation...I believe this is all about context of the environment in the individual and the importance of customizing therapy.

Article points to potential chemosensitizing effect of T3 in cancer treatment.  Chemotherapy with increased metabolic demand with T3 may improve cancer kill rate.

Study finds T3 effects on ER-alpha is likely a non-genomic pathway.  This study found a down regulation of ER-alpha in tumor cell lines by T3.

rat model finds T4 and rT3 receptors at plasma membrane.  T3 was found to bind with lower affinity than rT3 and T4 at the same receptor binding site.

Only abstract available here.  In vitro study finds that rT3 decreased the metabolic effect of T3.  This gives the impression that rT3 has an antagonist effect to T3 on the receptor.

Elevated rT3 as a part of non-thyroid all illness syndrome

T3, and T4 for that matter, increases SHBG.  This would be a novel method to determine thyroid hormone receptor insensitivity or resistance.

weight loss in obese children with low TSH and free T3 indicates high risk or regain of weight.  The important value here is the free T3.

IV T3 was given to patients with chronic heart failure.  What the study found may surprise you: improved heart function (ventricular), improved BNP, decrease heart rate, no side effects.  T3 has been shown to be more predictive of cardiac death in those with cardiac disease, than elevated lipids or decreased ejection fraction.

T3 replacement in people with low T3 and cardiac dysfunction found to improve cardiac performance.

Patients with CHF often have low T3 levels.  In this study, IV T3 was shown to be safe and well tolerated

low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.

Armour Thyroid (T4 and T3 combined) provides better symptom control when compared to synthroid alone (T4)