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Nathan Goodyear

Effects of thyroxine as compared with thyroxine pl... [N Engl J Med. 1999] - PubMed result - 0 views

  • n patients with hypothyroidism, partial substitution of triiodothyronine for thyroxine may improve mood and neuropsychological function;
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    Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.
Nathan Goodyear

Effects of thyroid hormones on hu... [J Steroid Biochem Mol Biol. 2008] - PubMed - NCBI - 0 views

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    T3 may promote cancer cell proliferation says study.  Triiodothyronine was found to enhance the MCF-7 and T47-D breast cancer cell lines.  The conclusion of the abstract discusses a role of T3 in breast cancer development and progression.  This likely has more to do with progression than development through increased metabolism of the cell lines.
Nathan Goodyear

Free triiodothyronine: a novel predictor of postoperative atrial fibrillation -- Cerillo et al. 24 (4): 487 -- European Journal of Cardio-Thoracic Surgery - 0 views

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    Conclusions: Low basal fT3 concentration can reliably predict the occurrence of postoperative Atrial Fibrillation in Coronary-bypass patients
Nathan Goodyear

Low Serum Triiodothyronine (T3) and Hypothyroidism in Anorexia Nervosa -- CROXSON and IBBERTSON 44 (1): 167 -- Journal of Clinical Endocrinology & Metabolism - 0 views

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    low t3 conversion implicated in Anorexia Nervosa
Nathan Goodyear

Free T4, Free T3, and Reverse T3 in Critically III, Thermall... : The Journal of Trauma - 0 views

  • Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen
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    low free T3: elevated reverse T3 in critically ill patients
Nathan Goodyear

Reciprocal Changes in Serum Concentrations of 3,3',5'-Triiodothyronine (Reverse T3) and 3,3'5-Triiodothyronine (T3) in Systemic Illnesses -- CHOPRA et al. 41 (6): 1043 -- Journal of Clinical Endocrinology & Metabolism - 0 views

  • The mechanism or the biological significance of such a diversion of T4, from the normally occurring conversion to highly potent T3, to the generation of poorly calorigenic rT3 in systemic illness
  • such a change in the metabolism of T4 can be reversible.
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    effects of systemic illness on thyroid function: elevated Reverse T3 and low free T3
Nathan Goodyear

Extrathyroidal Conversion of Thyroxine to 3,3',5'-Triiodothyronine (Reverse-T3)and to 3,5,3 '-Triiodothyronine -- GAVIN et al. 44 (4): 733 -- Journal of Clinical Endocrinology & Metabolism - 0 views

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    reverse T3 comes from peripheral conversion from free T4
Nathan Goodyear

Triiodothyronine and breast cancer. [World J Clin Oncol. 2014] - PubMed - NCBI - 0 views

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    T3 may have effects similar to Estradiol in breast cell proliferation.  This may be, but what about the effects on increased metabolism and resultant fat loss which leads to reduce inflammation...I believe this is all about context of the environment in the individual and the importance of customizing therapy.
Nathan Goodyear

Implication from thyroid function decreasing during chemotherapy in breast cancer patients: chemosensitization role of triiodothyronine - 0 views

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    Article points to potential chemosensitizing effect of T3 in cancer treatment.  Chemotherapy with increased metabolic demand with T3 may improve cancer kill rate.
Nathan Goodyear

Arquivos Brasileiros de Endocrinologia & Metabologia - Influence of estradiol and triiodothyronine on breast cancer cell lines proliferation and expression of estrogen and thyroid hormone receptors - 0 views

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    Study finds T3 effects on ER-alpha is likely a non-genomic pathway.  This study found a down regulation of ER-alpha in tumor cell lines by T3.
Nathan Goodyear

Specific 3,3′,5′-Triiodothyronine (Reverse T3) Binding Sites on Rat Liver Plasma Membranes: Comparison with Thyroxine (T4) Binding Sites, Journal of Receptors and Signal Transduction, Informa Healthcare - 0 views

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    rat model finds T4 and rT3 receptors at plasma membrane.  T3 was found to bind with lower affinity than rT3 and T4 at the same receptor binding site.
Nathan Goodyear

Adverse effects of reverse triiodothyronine on cellular metabolism as assessed by 1H and 31P NMR spectroscopy. - ResearchGate - 0 views

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    Only abstract available here.  In vitro study finds that rT3 decreased the metabolic effect of T3.  This gives the impression that rT3 has an antagonist effect to T3 on the receptor.
Nathan Goodyear

Sex Hormone-Binding Globulin in the Diagnosis of Peripheral Tissue Resistance to Thyroid Hormone: The Value of Changes after Short Term Triiodothyronine Administration - 0 views

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    T3, and T4 for that matter, increases SHBG.  This would be a novel method to determine thyroid hormone receptor insensitivity or resistance.
Nathan Goodyear

TSH and free triiodothyronine concentrations are associated with weight loss in a lifestyle intervention and weight regain afterwards in obese children - 0 views

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    weight loss in obese children with low TSH and free T3 indicates high risk or regain of weight.  The important value here is the free T3.
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Heart Failure and Low-T3 Syndrome: A Randomized, Placebo-Controlled Study - 0 views

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    IV T3 was given to patients with chronic heart failure.  What the study found may surprise you: improved heart function (ventricular), improved BNP, decrease heart rate, no side effects.  T3 has been shown to be more predictive of cardiac death in those with cardiac disease, than elevated lipids or decreased ejection fraction.
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Heart Failure and Low-T3 Syndrome: A Randomized, Placebo-Controlled Study - 0 views

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    T3 replacement in people with low T3 and cardiac dysfunction found to improve cardiac performance.
Nathan Goodyear

Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive Heart Failure - 0 views

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    Patients with CHF often have low T3 levels.  In this study, IV T3 was shown to be safe and well tolerated
Nathan Goodyear

Low-T3 Syndrome - 0 views

  • More than 80% of the biologically active hormone triiodothyronine (T3) derives from peripheral conversion of prohormone thyroxine (T4) secreted by the thyroid gland
  • Low thyroid hormone concentrations, in particular low serum T3 concentrations, are a common finding in patients with nonthyroidal illnesses, including cardiac disorders
  • a direct relationship between low circulating levels of T3 and adverse prognosis of cardiac patients
  • ...4 more annotations...
  • The present study clearly shows the existence of a strong association between the reduction of biologically active T3 and mortality in a large population of cardiac hospitalized patients
  • highly significant increase in the incidence of cardiac and cumulative deaths in patients with low T3 compared with patients with normal T3 levels
  • the relevance of the low T3 state as a strong, independent predictor of mortality in cardiac patients
  • low T3 concentrations are a strong independent predictive marker of poor prognosis in cardiac patients
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    low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.
Nathan Goodyear

Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism - NEJM - 0 views

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    Armour Thyroid (T4 and T3 combined) provides better symptom control when compared to synthroid alone (T4)
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