measurement of salivary steroids, by reflecting their free hormone concentration in plasma, may be useful in evaluating endocrine function in both health and disease
salivary testing of testosterone and androstenedione reflects free hormone concentration in plasma, proving to be very useful in evaluating endocrine function and disease
non-SHBG bound serum estradiol, testosterone and DHEA reveal increase breast cancer risk; other studies show saliva testing equal to serum non-bound SHBG hormones
quercetin and resveratrol shown to inhibit estrogen sulfonyltransferase activity. important implications in estrogen dependent cancers, like breast cancer
As the cortisol and DHEA levels in saliva reflected those in serum, the measurement of steroid levels in saliva provide a useful and practical tool to evaluate adrenal functions, which are essential for clinical diagnosis.
Pregnancy has a positive effect on MS patients, especially during the 3rd trimester. Rebound of MS increases in the postpartum period. Estriol is the dominant pregnancy estrogen. Progesterone is also produced at high levels. The withdrawal of these hormones in the postpartum period are likely to lead to this rebound in MS.
From a broad perspective, this paradigm can be seen as an example of how hormones are activated or inactivated in a controlled fashion in specific extraglandular tissues, in an analogous role to 5α-reductase and P450 aromatase in sex steroid metabolism and to 11β-hydroxysteroid dehydrogenase in glucocorticoid metabolism.
The DHT metabolite 3beta-androstanediol found to increase proliferation of endometrial tissue in women with PCOS. In contrast, Testosterone repressed proliferation.
It is always important to work out the biochemical mechanism of action. Study finds Siberian Rhubarbs mechanism of action is through activation ER-beta receptors. No activity/affinity for ER-alpha found in this study. This is important as the ER-beta provides an anti-inflammatory, antigrowth signal.
Licorice root extract, also known as glycyrrhizic acid, found to quickly reduce endogenous Testosterone production in women. The proposed mechanism is via inhibition of 17-hydroxysteroid dehydrogenase and 17-20 Lyase. This is a good adjuvant in the treatment of PCOS.
Statin and combined Ezetimibe-statin therapy reduce Testosterone levels in men--though combination therapy reduced LH and Testosterone levels less than high dose statin therapy, but it still did reduce Testosterone. This is so counterproductive and reveals much of the thought behind cholesterol. Low T in men is associated with all CVD.