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nice review of the relationship between obesity and Testosterone in men.

obesity and type II diabetes found to be associated with low adiponectin and elevated insulin as found in insulin resistance.  This study revealed the inverse relationship of adiponectin and insulin resistance.  The interesting thing is that inflammation causes insulin resistance.  Here you can see the inflammation-insulin resistance-low adiponectin-obesity-diabetes link.

Increase in visceral fat reduces glucose "disposal".  Translated: as visceral adiposity increases, associated insulin resistance increases glucose levels and all associated metabolic dysfunction.

great read on the relationship of adiponectin and insulin resistance, metabolic syndrome, diabetes,  and obesity.

inflammation associated with metabolic syndrome.  Whether a cause or effect, a clear relationship does exist.

some relationship is suggested to exist between Aluminum and autism. So much attention is given to thermerosol, yet aluminum in its own right has been shown to be neurotoxic.  Aluminum is a common component of the flu vaccine 

low vitamin D associated with obesity.  Exact relationship is yet to be determined.

Androgen deprivation therapy in men has been shown to worsen insulin resistance and precipitate type II Diabetes as well as stimulate weight gain.  This suggests a cause effect relationship between Testosterone and insulin sensitivity.  Other studies have pointed to a reciprocal decline in Testosterone due to hyperglycemia--both acute and chronic.   Androgen deprivation has a significant long list of cardiovascular risks and this should be discussed with the patient.

Review finds that low SHBG and higher Testosterone levels are associated with increased CVD risk in post menopausal women.  Exact relationship is undetermined.

Study finds that Testosterone regulates glucose metabolism, in part, through adiponectin production.  Early state of low T will slow the use of fats as a source of fuel and this results in an increased energy balance and results in the increased adiponectin production to increase metabolism.  Testosterone and adiponectin exist in an inverse relationship. This study does not mimic normal physiology.  Men with low T are unhealthy with significant metabolic dysfunction.  These young, "healthy" men were induced to a low T state--that is not a clear picture as the physiology of a "young healthy" man is quite different than that of one with low T.   Testosterone conversion to DHT increases GLUT4 and thus glucose uptake--another mechanism of Testosterone's effect on glucose metabolism.

Women with the lower estradiol levels have an associated increased risk of Alzheimer's disease.  Inverse relationship found in women.

Elevated cortisol associated with syncope in case study. Cause and effect relationship not known.

Great confusion exists in the medical profession about Testosterone and PSA and the health of the prostate. The conversion of Estrogen, whether E2 or E1, and other variables are responsible for increases in PSA while on Testosterone therapy. This study points out that Estradiol in men stimulates cell line growth of prostate cancer. In contrast, Epitestosterone, an androgen metabolite, has antiandrogen, inhibits this estrogen activity. Epitestosterone exists in an inverse relationship to Estradiol and IGF-1.

good discussion of the relationship between obesity, hormones and cancer. This article also contrasts the difference between men and women.

This study finds no relationship between ER and PR expression and tumor activity.

Study of 500 men with CHF and reduced LVEF found that estradiol has a "U" shaped relationship to prognosis.  A low and high estradiol levels are associated with increased poor prognosis.  Other biomarkers in these 2 groups were different, suggesting different physiologic mechanisms.

Good review of the data looking at the relationship between MetS and cancer.

Study of 890 men finds that Total testosterone and free testosterone decline with age.  The question is the relationship.  Is it the chicken or the egg.

A large body of evidence exists to associate low vitamin D with cardiovascular disease.  However, this review finds no causal relationship.  Is vitamin D an indicator of poor health?  Or is it the cause of poor health.  Yet to be determined.  Is vitamin D safe? Yes.

Viagra associated with a 84% increased risk of melanoma.  The key word here is associated.  No cause and effect relationship is seen.  Anytime use was also associated with increased risk.  This study did not look at the other phopsphodiesterase 5 inhibitors, though the logic is there risk may be higher as they are longer acting.