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Nathan Goodyear

Salivary Cortisol Measurement: A Practical Approach to Assess Pituitary-Adrenal Function - 0 views

  • We conclude that salivary cortisol measurements are an excellent index of plasma free cortisol concentrations
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    this study showed salivary cortisol to be an "excellent" means to evaluate both those with adrenal disease and adrenal dysfunction.  Salivary test is a good tool to evaluate the free active cortisol.
Nathan Goodyear

Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Cl... - 0 views

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    androgen deficiency and guidelines for Testosterone therapy.  Nice review of statistics and symptoms.  Many symptoms of low T go unrecognized.
Nathan Goodyear

Hormone Replacement Therapy in the Geriatric Patient: Current State of the Evidence and... - 0 views

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    TSH is not a reliable reproducible reflection of tissue T3 levels. In fact, in many ways TSH is merely just a screening tool. Research has shown that inflammation decreases TSH levels.
Nathan Goodyear

Practicalities of glutathione supplementation in nutritional... : Current Opinion in Cl... - 0 views

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    high dose IV glutathione proven to be safe
Nathan Goodyear

Salivary Hormone Measurement Using LC/MS/MS: Specific and Patient- Friendly Tool for As... - 0 views

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    Great review on the literature of LC-MS/MS and now the new ESI-MS/MS method in saliva hormone testing. This technique is highly sensitive and specific. This article goes through the literature support for each hormone. It also discusses how/why saliva testing is valid. Conclusion: "the author believes that the saliva-based hormone test will be integrated into clinical practice in the near future".
Nathan Goodyear

Nature Clinical Practice Endocrinology & Metabolism | Testosterone and ill-health in ag... - 0 views

  • Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
  • as were total testosterone and SHBG in men aged 65–96 years
  • and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
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  • In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
  • Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
  • Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
  • men with T2DM commonly have low total or free testosterone levels
  • Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
  • total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
  • low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
  • the recognized association between low SHBG level and insulin resistance
  • Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
  • Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
  • Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
  • In men aged 73–94 years, total testosterone was inversely correlated with CIMT
  • a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
  • A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
  • a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
  • the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
  • previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
  • Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
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    Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
Nathan Goodyear

Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views

  • The vast majority (88%) did not screen cardiac patients for TDS.
  • Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
  • Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
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  • Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
  • Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
  • Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
  • ower levels of testosterone and SHBG predict a higher incidence of metabolic syndrome.
  • Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
  • testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
  • The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
  • Andropausal men (age 58 ± 7 years) have a higher maximal carotid artery intima-media thickness
  • There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
  • Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
  • TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
  • Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
  • ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
  • ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
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    Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
Nathan Goodyear

Testosterone for the aging male; current evidence and recommended practice - 0 views

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    review of central and peripheral contribution to low T and metabolic dysfunction.
Nathan Goodyear

Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic... - 0 views

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    Testosterone therapy followed over 5 years in hypogonadal men found physiologic replacement of Testosterone decreased Total cholesterol, decreased LDL, increased HDL, decreased blood pressure, decreased blood glucose, decreased HgbA1c, decreased CRP, ALT, and AST. All men with metabolic syndrome  should have appropriate hormone evaluation done.
Nathan Goodyear

The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic ... - 0 views

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    CDC recommendations on lyme treatment
Nathan Goodyear

A practical guide to male hypogonadism in the primary care setting - 0 views

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    Good, but limited study to the incidence of low T in men.  
Nathan Goodyear

Episiotomy pain relief: Use of Lavender oil essence in primiparous Iranian women - Comp... - 0 views

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    Lavender effective in healing episiotomy pain and discomfort compared to traditional therapies.
wheelchairindia9

Commode Wheelchair - 0 views

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    This lightweight portable shower chair commode with casters is packed with features to ensure a pleasant and comfortable bathing experience. One of the greatest benefits is the ultra comfort padded seat featuring an open front design making personal hygiene easy and convenient. When the shower chair is not in use the back and 12 qt. commode bucket can be removed without tools making cleaning and storage simple. The frame is manufactured with lightweight rust resistant anodized aluminum able to withstand a 300 lb. weight capacity. Easy to operate, shower chair. Commode comes equipped with 3" non-skid casters, making transfer to and from any bathroom safe and secure. Commode/shower chair soft seat features strong and practical armrests designed to withstand a lot of load, including the sideways forces that are exerted during sideways transfers.The armrests offer comfortable support for the forearms while sitting and they are long enough to provide sustained support when standing up and sitting down. The armrests can be folded up individually, e.g. to facilitate a sideways transfers. When folded down, the armrest rests behind the backrest thereby preventing fingers, skin or hair from getting caught. Commode Wheelchair Rainbow 6: Karma commode wheelchair rainbow 6 comes with lot of exiting features for elderly or physically challenged person who want commode in wheelchair. Karma Rainbow 6 has single seat with center cut commode having cushion cover on top and removable pan or plastic commode seat with pot. Commode Wheelchair Rainbow 6 Features: Frame Material : M.S.Chrome Plated Single Seat with center cut commode Both Option Available In Single Seat Plastic Commode Seat With Pot. Cushioned Top Cover Square Pan Commode Pan Removable Pan Commode Wheelchair Rainbow 6 Measurements: Frame Style : Foldable Open Position Wheel To Wheel Width In : 26" (Inches) Seat Width : 18" (Inches) Total Width in Closing Position : 11" (Inches) Rear Whe
Nathan Goodyear

[The Prostate Cancer Prevention Trial (PCPT). Relevance for clinical practice]. - 0 views

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    Finasteride does not increase prostate cancer.
Nathan Goodyear

Salivary testosterone measurements: reliability ac... [Physiol Behav. 1990] - PubMed re... - 0 views

  • Salivary assays offer a practical way of measuring testosterone in free-ranging subjects outside the laboratory.
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    saliva testing validated for male hormones
Nathan Goodyear

Clinical controversies in screening women for thyr... [J Midwifery Womens Health. 2006 ... - 0 views

  • In November 2002, the American Association of Clinical Endocrinologists (AACE) released new guidelines for clinical practice for the diagnosis and treatment of hyperthyroidism and hypothyroidism, which includes a new thyroid-stimulating hormone (TSH) reference range of 0.3 to 3.0 mIU/
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    TSH "screening" needs to be between 0.3 and 3 according to American Association of Clinical Endocrinologists
Nathan Goodyear

Antidepressants, Metabolic Syndrome May Be Tied : Family Practice News - 0 views

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    antidepressants correlated with metabolic syndrome
Nathan Goodyear

Understanding the Relation Between Obesity and Depression: Causal Mechanisms and Implic... - 0 views

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    obesity and depression linked
Nathan Goodyear

Guidelines have done more harm than good. [Blood Purif. 2008] - PubMed result - 0 views

  • Guidelines certainly do not encourage clinicians to consider and treat each patient as an individual
  • This all but guarantees many guidelines are obsolete by the time they are published
  • unlikely to stimulate original research
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  • reated by a process that is artificial, laborious and cumbersome
  • uidelines are produced with industry support and recommendations often have a major impact on sales of industry products
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    Medical guidelines likely do more harm than good
Nathan Goodyear

Nighttime salivary cortisol: a useful test for the... [J Clin Endocrinol Metab. 2002] -... - 0 views

  • Salivary cortisol measurements worked as well as plasma measurements and better than urine glucocorticoid excretion. We concluded that bedtime salivary cortisol measurement is a practical and accurate screening test for the diagnosis of Cushing's syndrome.
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    Cortisol Salivary testing shown to be test of choice for diagnosis of Cushing's syndrome
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