this study showed salivary cortisol to be an "excellent" means to evaluate both those with adrenal disease and adrenal dysfunction. Salivary test is a good tool to evaluate the free active cortisol.
TSH is not a reliable reproducible reflection of tissue T3 levels. In fact, in many ways TSH is merely just a screening tool. Research has shown that inflammation decreases TSH levels.
Great review on the literature of LC-MS/MS and now the new ESI-MS/MS method in saliva hormone testing. This technique is highly sensitive and specific. This article goes through the literature support for each hormone. It also discusses how/why saliva testing is valid. Conclusion: "the author believes that the saliva-based hormone test will be integrated into clinical practice in the near future".
Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
as were total testosterone and SHBG in men aged 65–96 years
and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
men with T2DM commonly have low total or free testosterone levels
Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
the recognized association between low SHBG level and insulin resistance
Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
In men aged 73–94 years, total testosterone was inversely correlated with CIMT
a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
Declining Testosterone or low Testosterone is clearly associated with poor health in men.
Very nice review of the association between low Testosterone and metabolic dysfunction. Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
The vast majority (88%) did not screen cardiac patients for TDS.
Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
ower levels of testosterone and SHBG predict a higher incidence of metabolic syndrome.
Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
Andropausal men (age 58 ± 7 years) have a higher maximal carotid artery intima-media thickness
There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada. Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone. A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance.
The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies. This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
Testosterone therapy followed over 5 years in hypogonadal men found physiologic replacement of Testosterone decreased Total cholesterol, decreased LDL, increased HDL, decreased blood pressure, decreased blood glucose, decreased HgbA1c, decreased CRP, ALT, and AST.
All men with metabolic syndrome should have appropriate hormone evaluation done.
This lightweight portable shower chair commode with casters is packed with features to ensure a pleasant and comfortable bathing experience. One of the greatest benefits is the ultra comfort padded seat featuring an open front design making personal hygiene easy and convenient. When the shower chair is not in use the back and 12 qt. commode bucket can be removed without tools making cleaning and storage simple. The frame is manufactured with lightweight rust resistant anodized aluminum able to withstand a 300 lb. weight capacity. Easy to operate, shower chair. Commode comes equipped with 3" non-skid casters, making transfer to and from any bathroom safe and secure.
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Commode Wheelchair Rainbow 6:
Karma commode wheelchair rainbow 6 comes with lot of exiting features for elderly or physically challenged person who want commode in wheelchair. Karma Rainbow 6 has single seat with center cut commode having cushion cover on top and removable pan or plastic commode seat with pot.
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Single Seat with center cut commode
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Rear Whe
In November 2002, the American Association of Clinical Endocrinologists (AACE) released new guidelines for clinical practice for the diagnosis and treatment of hyperthyroidism and hypothyroidism, which includes a new thyroid-stimulating hormone (TSH) reference range of 0.3 to 3.0 mIU/
Salivary cortisol measurements worked as well as plasma measurements and better than urine glucocorticoid excretion. We concluded that bedtime salivary cortisol measurement is a practical and accurate screening test for the diagnosis of Cushing's syndrome.