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FMS Dental Hospital

Best Cosmetic Dental Clinic in India - 0 views

FMS DENTAL is one of the top dental clinics in Hyderabad, India and 5th best dental center in the world (GCR Rating), with multi-specialty practice, in-patient facility and 24 hr. emergency dental ...

Best Cosmetic Dental Clinic in India Dentist

started by FMS Dental Hospital on 27 Mar 18 no follow-up yet
Nathan Goodyear

Platelet Transfusion: A Clinical Practice Guideline From the AABB | Annals of Internal ... - 0 views

annals.org/...l-practice-guideline-from-aabb

platelets

shared by Nathan Goodyear on 10 Jan 19 - No Cached
  • Nathan Goodyear on 10 Jan 19
     
    Platelets and "recommended" indications for transfusion.
Nathan Goodyear

Levothyroxine Monotherapy Cannot Guarantee Euthyroidism in All Athyreotic Patients - 0 views

www.ncbi.nlm.nih.gov/...PMC3148220

Thyroid hypothyroidism levothyroxine

shared by Nathan Goodyear on 16 Aug 17 - No Cached
  • Nathan Goodyear on 16 Aug 17
     
    retrospective study finds that levothyroxine, T4 only therapy, is ineffective in adequately supporting peripheral T3 production in up to 20%, I would gather much higher based on my 11 years of practice.
healthtips2233

Benefits Of Yoga - Health And Fitness - 0 views

bit.ly/2RsJ6uO

#yoga ##healthylifestyle #health #fitness #workout

shared by healthtips2233 on 21 Feb 20 - No Cached
  • healthtips2233 on 21 Feb 20
     
    Most of the people in the entire world think that yoga is only for stretching and flexibility of the body, but there is a lot more about yoga. Yoga also gives the health benefits of daily practice of asanas and exercises.
healthwiseindian

Diet tips for healthy weight loss - 0 views

www.slideshare.net/HealthWiseIndian

Weight loss motivation healthy weight loss tips Diet for weight loss diet plan for weight loss diet chart for weight loss how to lose weight weight loss tips weight loss healthy eating how to reduce weight healthy diet healthy food diet plans eating healt

shared by healthwiseindian on 02 Nov 17 - No Cached
  • healthwiseindian on 02 Nov 17
     
    Weight loss is an important topic of worry. Not all kinds of dieting practices are helpful in achieving a healthy weight loss. Follow the advice of Dr. Binita who has compiled a comprehensive study about weight loss. At Healthwise Indian, we help in giving health guidance to people in order to improve their lifestyle.
spineneuro

Dr Paresh Doshi Helps Creating Guidelines for Neurodegenerative Disorders - 0 views

www.briefingwire.com/...or-neurodegenerative-disorders

Dr. Paresh Doshi Best Deep Brain Stimulation Neurosurgeon in India Top 10 Neurosurgeons for DBS in India Top Neurosurgeon at Jaslok Hospital Mumbai Dr Paresh Doshi Jaslok Mumbai

shared by spineneuro on 17 Aug 21 - No Cached
  • spineneuro on 17 Aug 21
     
    Dr. Paresh Doshi top neurosurgeon at Jaslok Hospital Mumbai outlines best practices in the control of these difficult-to-treat disorders.
pharmacybiz

NHS New Campaign To Promote Better Care For Mental Health - 0 views

www.pharmacy.biz/-better-care-for-mental-health

NHS-Better-Health-campaign pharmacy-business NHS-Better-Health-app NHS-healthy-eating NHS-Better-Health-lose-weight NHS-Better-health-every-Mind-matters

shared by pharmacybiz on 18 Jan 22 - No Cached
  • pharmacybiz on 18 Jan 22
     
    The NHS is going to launch a new campaign using the iconic Beatles song 'Help!" to encourage people to take better care of their mental health. The campaign, being launched today (January 17), is backed by some of the UK's biggest artists, urging people to seek support for their mental wellbeing. Since the beginning of the pandemic around 2.3 million people have come forward for NHS talking therapies, with over 50 per cent being concerned about their mental health last year. The NHS is encouraging anybody experiencing anxiety, depression, or other common mental health concerns to experience how talking therapies can help them. NHS mental health talking therapies are a confidential service run by fully trainedexperts that can be accessed through self-referral or GP practice.
umar111

Computer Science: Computer hardware - 0 views

computersciencetopper.blogspot.com/...computer-hardware.html

Best computer computer computer Science it blog

shared by umar111 on 26 Apr 23 - No Cached
  • umar111 on 26 Apr 23
     
    Computer Science Tuesday, April 25, 2023 Computer hardware Computer hardware is the physical components that make up a computer system. It includes everything from the central processing unit (CPU) to the monitor, keyboard, and mouse. Understanding the different types of hardware and how they work together is essential for anyone who works with computers. In this article, we will explore the various components of computer hardware, including internal and external components, and the peripherals that connect to them. We will also discuss the importance of hardware maintenance, the latest advancements in computer technology, and factors to consider when choosing the right hardware for your needs. Whether you are a computer technician, a gamer, or simply someone who uses a computer for everyday tasks, this article will help you better understand the world of computer hardware. Introduction to Computer Hardware Computer hardware refers to the physical components that make up a computer system. It includes everything from the processor and memory to input/output devices such as the keyboard and monitor. In this article, we will explore the different types of computer hardware and their functions. What is Computer Hardware Computer hardware refers to the physical components of a computer system. It includes all the components that can be touched, seen, and used to interact with a computer, such as the monitor, keyboard, and mouse. Hardware is different from computer software, which refers to the programs and applications that run on a computer system. History of Computer Hardware The history of computer hardware dates back to the 1820s when Charles Babbage, an English mathematician, and inventor, designed the first analytical engine, which was considered to be the first mechanical computer. With time, more complex electronic computers were developed, including the first Intel microprocessor in 1971. Since then, computer hardware has continued to evolve, becoming
harshitatyagi

Dr. Sweta Gupta- Best IVF doctor in Noida - 0 views

top-ivf-clinic-in-india.blogspot.com/...-best-ivf-doctor-in-noida.html

IVF Doctor in Noida IVF Specialists in Noida Dr. Sweta Gupta Infertility Specialists in Noida Fertility Expert in Noida

shared by harshitatyagi on 26 Aug 22 - No Cached
  • harshitatyagi on 26 Aug 22
     
    Being one of the top fertility specialists in Noida, Dr. Sweta Gupta is the medical director of Crysta IVF and has been practicing for more than 25+ years. With her immense knowledge and compassion, she has treated thousands of couples and helped her in their journey to becoming proud parents.
spineneuro

Unveiling Excellence in Spine Care: Dr. Mihir Bapat, Mumbai's Leading Minimally Invasiv... - 0 views

www.briefingwire.com/...ing-minimally-invasive-surgeon

Dr. Mihir Bapat Minimally Invasive Surgeon Spine Surgeon in Nanavati Mumbai

shared by spineneuro on 24 Jun 23 - No Cached
  • spineneuro on 24 Jun 23
     
    Spine issues bring hundreds of people to their doctors every year. Dr. Mihir Bapat is a highly renowned spine surgeon in Mumbai, India strives to provide the most advanced medical spinal treatments possible based on practices by utilizing the latest in surgical technology.
Nathan Goodyear

Doctors and Medical Science - 2 views

www.ncbi.nlm.nih.gov/...PMC3442191

fraud medical research

shared by Nathan Goodyear on 29 Jun 22 - No Cached
frankbkelly liked it
  • Nathan Goodyear on 29 Jun 22
     
    Most medical research is intended for profit, much is retracted, is not read by physicians, takes at least 17+ years to reach clinical practice, and is not useful for patient care.
spineneuro

The Very Best in Spine Care in India Begins With Dr. Vidyadhara S - 0 views

bestsurgeonsandsurgeryinindia.blogspot.com/...gins-with-dr-vidyadhara-s.html

Dr. Vidyadhara S Top spine specialist at Manipal Hospital Bangalore spine specialist at Manipal Hospital Best Spine Surgeon in India

shared by spineneuro on 12 May 22 - No Cached
  • spineneuro on 12 May 22
     
    Dr. Vidyadhara S offers a multi-disciplinary approach to care that permits him to provide you, the patient, with best practice. Top spine specialist at Manipal Hospital Bangalore performs more outpatient, minimally invasive spine surgeries each month than any other spine surgeon in the world.
spineneuro

Dr. Sandeep Vaishya India Offering Outstanding Care in Neurosurgery Expertise - 0 views

www.briefingwire.com/...care-in-neurosurgery-expertise

Dr. Sandeep Vaishya Best neurologists best neurosurgeon at Fortis Hospital Delhi neurosurgeon

shared by spineneuro on 04 Jun 22 - No Cached
  • spineneuro on 04 Jun 22
     
    The mission of Dr. Sandeep Vaishya India's practice is to provide the best surgical treatment of disorders that impair the spine and brain. He utilizes proven standard techniques and new, minimally invasive techniques for surgical intervention whenever possible. Best neurologists and neurosurgeons in India combine their experience, training, and clinical expertise in providing an environment where surgical intervention is performed to optimize a patient's outcome.
Nathan Goodyear

Advances in the Diagnosis, Classification, Risk Stratification, and Management of Monoc... - 1 views

www.ncbi.nlm.nih.gov/...PMC2947967

MGUS multiple myeloma cancer disease monoclonal gammopathy of undetermined significance

shared by Nathan Goodyear on 25 Sep 17 - No Cached
  • Nathan Goodyear on 25 Sep 17
     
    Monoclonal gammopathy of undetermined significance (MGUS) is a precursor to multiple myeloma.  I have seen numerous cases in my practice.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

A practical model of low-volume high-intensity interval training induces mitochondrial ... - 0 views

jp.physoc.org/...1011.long

HIT high-intensity interval training exercise muscle mitochondria training

shared by Nathan Goodyear on 13 Jan 13 - No Cached
  • Nathan Goodyear on 13 Jan 13
     
    High-intensity interval training increase mitochondrial performance.
Nathan Goodyear

Endocrinology of the Aging Male - 0 views

www.ncbi.nlm.nih.gov/...PMC3073592

aging male hormone hormones

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • All steps beyond the formation of pregnenolone take place in the smooth endoplasmic reticulum
  • Cytochrome P450 enzyme, CYP11A is located on the inner mitochondrial membrane and catalyses the rate limiting step of pregnenolone synthesis
  • Estrogen and related steroids, thyroid hormone and insulin increase SHBG levels.
  • ...21 more annotations...
  • SHBG decreases in response to androgens, and in the presence of hypothyroidism, and insulin resistance.
  • Plasma SHBG levels tend to increase with increasing age
  • The apparent metabolic clearance rate of testosterone is decreased in elderly as compared to younger men
  • Testosterone circulates predominantly bound to the plasma proteins SHBG and albumin, with high and low affinity respectively
  • Testosterone is secreted in a pulsatile fashion
  • Current clinical guidelines suggest at least two measurements
  • In adult men, there is a well-documented diurnal variation (particularly in younger subjects) in testosterone levels, which are highest in the early morning and progressively decline throughout the day to a nadir in the evening
  • In older men, the diurnal variation is blunted
  • it is standard practice for samples to be obtained between 0800 and 1100 h.
  • Testosterone and DHEA decline, whereas LH, FSH, and SHBG rise
  • DHT remains constant despite the decline of its precursor testosterone
  • Longitudinal studies show an average annual decline of 1–2% total testosterone levels, with decline in free testosterone more rapid because of increases in SHBG with aging
  • Massachusetts Male Aging Study (MMAS) data show DHEA, DHEAS, and Ae declining at 2–3% per year
  • DHT showed no cross-sectional age trend
  • Androstanediol glucuronide (AAG) declined cross-sectionally with age in the MMAS sample, at 0.6% per year
  • The EMAS data show that, consistent with the longitudinal findings of MMAS (Figure 1), the core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total testosterone and progressively blunted free testosterone associated with higher LH
    • Nathan Goodyear
      Nathan Goodyear on 01 May 13
       
      This author proves the point in the review of these two studies, that TT may remain constant in aging men, however, FT drops.
  • obesity impairs hypothalamic/pituitary function
  • Androgen deprivation in men with prostate cancer has been associated with increased insulin resistance, worse glycemic control, and a significant increase in risk of incident diabetes
  • Low serum testosterone is associated with the development of metabolic syndrome 116, 117 and type 2 diabetes. 118 SHBG has been inversely correlated with type 2 diabetes
  • Improvement in insulin sensitivity with testosterone treatment has been reported in healthy 121 and diabetic 122 adult men
  • In studies conducted in men with central adiposity, testosterone has been shown to inhibit lipoprotein lipase activity in abdominal adipose tissue leading to decreased triglyceride uptake in central fat depots. 123
  • Nathan Goodyear on 30 Apr 13
     
    great review of hormone changes associated with aging in men.
Nathan Goodyear

SOGC Clinical Practice Guideline. Magn... [J Obstet Gynaecol Can. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21639972

IV magnesium nutritional therapy cerebral palsy CP neuroprotection IV magnesium

shared by Nathan Goodyear on 07 Feb 13 - No Cached
  • Nathan Goodyear on 07 Feb 13
     
    IV magnesium shown to be neuroprotective in those at risk for cerebral palsy.  How?  NMDA inhibition.
wheelchairindia9

Karma KM 2500 Wheelchair - 0 views

www.wheelchaircostindia.com/...KM-2500-Small-Wheel-Wheelchair

Comfortable KM 2500 Small Wheel Wheelchair KM 2500 Wheelchair uncomplicated and stress free Karma KM 2500 Wheelchair overall lighter equipment Karma KM 2500 full sized battery for easy transportation

shared by wheelchairindia9 on 17 Oct 15 - No Cached
  • wheelchairindia9 on 17 Oct 15
     
    Karma KM 2500 Small Wheel Wheelchair: Karma KM 2500 Small Wheel Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 14" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 9.2 k.g. Karma KM 2500 Small Wheel Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 Small Wheel Wheelchair Extended Armrest: By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (9.2 kg) with a compact design for either attendant assisted or self propelling users. The use of aircraft-grade aluminium alloy and double cross brace provide this model with outstanding strength and durability. Karma Healthcare KM-2500 Premium Wheelchair is amazingly light and compact transit wheelchair which is ideal for outings and travelers. It folds down to take up virtually no space in the boot of a car and weighs just over 9.2 kg making it easy for anyone to lift into a vehicle. Backrest folds-down for easy transportation. Maximum user weight: 100 K.g. Aluminium frame. Fixed armrest/fixed footrest. Foldable frame via double cross bars. Comfortable & durable upholstery. Swing-away foot plates. Puncture proof tyres. Attendant cable brake. 14" flat-free rear wheels. Detachable and washable cushion. One Year Warranty. It folds down to take up virtually no space in the boot of a car. This amazingly light and compact transit wheelchair is ideal for outings and travelling. It comes with detachable and washable cushion. The wheel chair has attendant cable brake. It is made from aircraft-grade aluminium alloy fra
Nathan Goodyear

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Re... - 0 views

www.sciencedirect.com/...S1931312816305170

gut gut bacteria gut flora gut health gut microbiome gut microbiota diet nutrition

shared by Nathan Goodyear on 02 Jan 17 - No Cached
  • Long-term DPs play a large role in determining the selective environment that the gut microbiota faces, ultimately influencing the composition and diversity of taxa maintained within the gut microbial community
  • Americans consuming unrestricted diets maintained less diverse fecal microbiota than those of individuals adhering to a plant-rich diet with restricted caloric intake
  • Experiments in mice have shown that multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” can lead to extirpation of specific bacterial lineages
  • Nathan Goodyear on 02 Jan 17
     
    Diet is the key to gut microbe diversity.  Gut microbes are key to maintaining optimal cellular metabolism.  Nutrition can be a prescription for improving and reprogramming gut bacteria.
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