Longitudinal and cross-sectional rel... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views
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Nathan Goodyear on 24 Feb 14This study found that lower TT and E1 associated with more "poor health" as defined by questionnaire. The conclusion might lead one to think that Estrogen therapy is need in men. Eightly percent of estrogen production in men occurs from Testosterone. If Testosterone declines, then estrogen production will likewise decline. A simple fact that the authors did not comment on. Also, E1 binds with high affinity to ER alpha, which is pro-inflammatory and pro-proliferative: neither of which is a positive health benefit. This appears to point more to a broad HPA suppression as an association to the "poor health".