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This study found that lower TT and E1 associated with more "poor health" as defined by questionnaire.  The conclusion might lead one to think that Estrogen therapy is need in men.  Eightly percent of estrogen production in men occurs from Testosterone.  If Testosterone declines, then estrogen production will likewise decline.  A simple fact that the authors did not comment on.  Also, E1 binds with high affinity to ER alpha, which is pro-inflammatory and pro-proliferative: neither of which is a positive health benefit.   This appears to point more to a broad HPA suppression as an association to the "poor health".

low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.

exhaustive review of the flu vaccine data reveals VERY poor matching of vaccine, poor prevention of flu symptoms, and only modest effect on reduction in hospital admission or complication rates.   Final conclusion: "There is no evidence that they affect complications, such as pneumonia, or TRANSMISSION.

Low Total testosterone associated with poor exercise capacity, increased obesity, poor glucose control including diabetes, increased cardiac hypertrophy in those with CAD.  Simply put, low T in men is associated with metabolic dysregulation.

poor grip strength test equals poor health in men. especially cardiovascular health

low T is found in 20-70% of men with HIV.  What is interesting about this article is that Total Testosterone was found to be a poor assessment of biological active Testosterone.  Free Testosterone assessed in the am was shown to be a better functional assessment in these men.  Serum is a poor choice though.  The process of equilibrium dialysis to calculate free Testosterone is filled with variables that will effect reliability.  Increases SHBG was found associated.

Vitamin D has key impact in performance of soldiers.  low vitamin D has been shown to be associated with increased risk for muscle/bone injury, weakness, and poor healing.  Low vitamin D has been associated with low Testosterone.  Low vitamin D has also been associated with poor cognition, depression and less than optimal recovery after TBI.  This follows recent publication that normalization of vitamin D levels increases Testosterone levels.  

More and more, low Testosterone is clearly a marker of poor health in men.  This study finds that low T at the time of renal transplant is associated with increase graft rejection/loss and patient death.  It appears to me that Testosterone levels should be a part of assessment for any man in poor health and/or headed for surgery.

A large body of evidence exists to associate low vitamin D with cardiovascular disease.  However, this review finds no causal relationship.  Is vitamin D an indicator of poor health?  Or is it the cause of poor health.  Yet to be determined.  Is vitamin D safe? Yes.

Poor thyroid function = poor cholesterol control

Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.

Testosterone reduced the vascular benefits of Estrogen (conjugated equine Estrogen) in female rat model.  Testosterone is seeing widespread use in women with very little positive data.  In fact, the majority of data points to poor metabolic effects and poor outcomes.

Lower Testosterone levels are found in men with more advanced HIV.  This relationship is bidirectional.  This decreased biomarker is likely more a biomarker of poor health than one of a direct relationship.  As in the fT3 is lower in hypogonadal men versus eugonadal men.  This points to the significant problems in the way Testosterone is thought of and used in therapy for men today.  For many men, low T is the effect and not the cause.

Thymidine kinase 1 useful as a prognostic biomarker and to monitor therapy efficacy. TK-1 levels were very low in those without cancer. Higher TK-1 levels pretreatment were associated with poor prognosis and poor survival. TK-1 "increases with progress of the disease, decreases during successful therapy, and finally increases during relapse.

anemia is a poor prognostic biomarker in cancer.  But is it simply a biomarker of more advanced disease and thus merely the result of poor health?

low vitamin D associated with poor outcomes in hematologic cancers. This chapter reviews several studies that highlight the link with low vitamin D and poor outcomes in AML patients.

Elevated RDW associated with poor outcomes and poor prognosis in patients with cancer.

Testosterone is inversely associated with inflammatory cytokines and thus low T can be used as a marker of poor health in men.  This study found a specific association with TNF-alpha and MIP1-alpha.  

Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...

low Testosterone in men at the time a diagnosis of prostate is found to be associated with a poor prognosis in the Prostate cancer.