Fructose decreases physical activity and increases body fat without affecting hippocamp... - 0 views
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the fructose animals gained significantly more weight than the glucose animals
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The average liver mass of mice in the fructose treatment group was 20% heavier than for mice in the glucose group
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The fat pads of mice consuming the fructose diet were 69% heavier than the fat pads of animals consuming the glucose diet
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there are many studies showing that consumption of fructose in comparison to other monosaccharides results in increased de novo lipogenesis, dyslipidemia, insulin resistance, BW6, 7 and, most recently, impaired cognitive function
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in the present study, the intake of fructose by mice was more similar to that of typical human consumption in comparison to previous studies
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studies in humans confirm that fructose, but not glucose (when provided as 25% of energy requirements), in the context of an energy-balanced diet increases de novo lipogenesis and visceral adiposity along with dyslipidemia, decreases insulin sensitivity10, 12 and decreases in fat oxidation
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significant reduction (~20%) in physical activity in the fructose-fed animals in comparison to glucose
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a recent study reported that ingestion of fructose (25% energy intake, 10 weeks) in human volunteers also resulted in reduced energy expenditure in relation to a diet with the same glucose dose
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There is certainly evidence to suggest that, for example, exercise is able to prevent dyslipidemia in healthy subjects fed a weight-maintenance high-fructose diet (30%)54, which strongly suggests a protective role of physical activity in metabolic regulation.
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the potential negative effects of fructose in brain and cognitive function have been investigated, with a series of studies showing cognitive deficits in spatial memory and learning in adolescent and adult animals following access to a high fructose diet
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access to both fructose and sucrose, but not glucose, results in a 40% reduction in hippocampal neurogenesis
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Collectively these studies seem to suggest that fructose consumption can have a considerable impact on hippocampal function and learning, which is in direct contrast with what we observed.
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the impact of fructose is apparent only in BW, liver mass and body fat, but not in cognitive measures or rates of neurogenesis