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Nathan Goodyear

http://www.eje-online.org/content/146/5/673.full.pdf - 0 views

www.eje-online.org/...673.full.pdf

Testosterone pharmacodynamics pharmacokinetics therapy treatment men male hormone hormones hypogonadism

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    discussion of the pharmacodynamics and pharmacokinetics of Testosterone topical therapy.  Hard to draw conclusions from this study as the dosing was 100 mg + daily.
Nathan Goodyear

Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 dia... - 0 views

www.ajhp.org/...173.short

exenatide byetta diabetes overweight obesity pharmacodynamics pharmacokinetics

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • exenatide dose-dependently reduced postprandial plasma glucose excursion by insulinotropism
  • suppression of plasma glucagon, and slowing of gastric emptying.
  • Nathan Goodyear on 06 Apr 11
     
    exenatide improves insulin/glucose regulation
Nathan Goodyear

The Effects of High Concentrations of Vitamin C on Cancer Cells - 0 views

www.ncbi.nlm.nih.gov/...PMC3798917

cancer leukemia vitamin C IV vitamin C

shared by Nathan Goodyear on 23 Oct 17 - No Cached
  • Nathan Goodyear on 23 Oct 17
     
    Great review of the pharmacological/pharmacodynamic effects of vitamin C in cancer, particularly leukemias.
Nathan Goodyear

Pharmacokinetics vs pharmacodynamics - 0 views

pharmacokinetics pharmacodynamics

shared by Nathan Goodyear on 04 Aug 19 - No Cached
  • Nathan Goodyear on 04 Aug 19
     
    Good review
Nathan Goodyear

Pharmacokinetics and pharmacodynamic... [J Clin Endocrinol Metab. 1990] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2115044

SHBG pellets therapy pellet hormon hormones

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • Nathan Goodyear on 12 Jun 13
     
    This study finds not change in SHBG as a result from pellet hormones.
Nathan Goodyear

L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic rela... - 0 views

www.ncbi.nlm.nih.gov/...PMC1873701

L-Arginine NO

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • Nathan Goodyear on 30 Apr 13
     
    l-Arginine
Nathan Goodyear

1210_article_14 - 0 views

jpp.krakow.pl/...14_article.html

neurotoxic thimerosal vaccinations

shared by Nathan Goodyear on 03 Apr 11 - No Cached
  • These modulatory effects - which most likely involve binding with functional thiol residues - are interwoven with neurotoxic actions of both mercurials.
  • THIM is metabolized in the body to ethyl mercury (EtHg) and subsequently to inorganic mercury forms, which accumulate in tissues of vital organs, including the brain (22). Information about neurochemical and neurotoxic effects of THIM is still limited, but the existing data indicate that in pharmacodynamics and toxicity THIM/EtHg does not differ significantly from methyl mercury (MeHg), which has been studied more extensively, although these compounds differ somewhat in pharmacokinetics (8).
  • Several studies documented that the neurotoxic effects of mercurials involve glutamate-mediated excitotoxicty, due to their ability to inhibit uptake of glutamate in astrocytes, resulting in an increase of the extracellular level of this excitatory amino acid
  • Nathan Goodyear on 03 Apr 11
     
    neurotoxic effects of thimerosal
Nathan Goodyear

Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in... - 0 views

onlinelibrary.wiley.com/...full

ginger ginkgo biloba blood thinners coumadin plavix

shared by Nathan Goodyear on 13 Oct 11 - No Cached
  • Nathan Goodyear on 13 Oct 11
     
    ginkgo biloba and ginger shown to be safe when given to patients on coumadin; when given at recommended doses
Nathan Goodyear

Clinical Pharmacodynamic Effects of the Growth Hormone Receptor Antagonist Pegvisomant:... - 0 views

clincancerres.aacrjournals.org/...1000

cancer GH growth hormone

shared by Nathan Goodyear on 12 Aug 19 - No Cached
  • Nathan Goodyear on 12 Aug 19
     
    Pegvisomant shown to provide more GH, IGF-1 suppression compared to octreotide. The doses used were 40, 60, and 80 mg SQ. The higher dose resulted in the greatest suppression.
Nathan Goodyear

Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria t... - 0 views

www.ncbi.nlm.nih.gov/...PMC3489518

malaira artesunate pharmacokinetics dihydroartimisinin

shared by Nathan Goodyear on 02 May 20 - No Cached
  • Nathan Goodyear on 02 May 20
     
    to be read
Nathan Goodyear

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A... - 0 views

www.ncbi.nlm.nih.gov/...PMC9925039

COVID-19 SARS-CoV-2 COVID WBC ascorbic acid vitamin C

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • vitamins A, B, C, E, B6, B12, folate, zinc, iron, copper, and selenium
  • White blood cells, including neutrophils and monocytes, accumulate concentrations of vitamin C up to 100 times greater than that of plasma
  • Vitamin C is a crucial component of both the innate (nonspecific) and adaptive (specific) portions of the immune system
  • ...52 more annotations...
  • play a role during the initial chemotactic response of neutrophils shortly after infection
  • following vitamin C supplementation, a 20% increase in neutrophil chemotactic activity was observed
  • also contributes to the phagocytosis and killing of microbes by neutrophils
  • low levels of vitamin C occurring in high-stress situations
  • maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
  • Vitamin C has been shown to directly affect the number of Igs released from B cells
  • vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
  • effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
  • when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
  • vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
  • vitamin C also acts as an important antioxidant to the cells of the immune system.
  • human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
  • Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
  • vitamin C can decrease the activation of NF-kB
  • can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic 
  • subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
  • subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
  • hydroxylating proline and lysine
  • mature and stabilize the tissue of a healing wound
  • healing
  • oral surgery
  • improved soft tissue regeneration
  • vitamin C increases the mRNA levels of type I and type III collagen in the human dermis
  • Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
  • viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
  • prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
  • combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
  • high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
  • improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
  • 8 g doses of oral vitamin C
  • there is a negative correlation between age and serum levels of vitamin C
  • Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
  • Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
  • high doses of 1-2 g/day of oral vitamin C could prevent other upper respiratory infections
  • It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Flawed statement. What is normal? Vitamin D. Many variables effect levels and dose, including the two compartment kinetics and absorption.
  • Hiedra et al. were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin
  • some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
  • oral vitamin C in combination with zinc provided the largest amount of antibody titers 42 days
  • linear relationship between days of vitamin C therapy and survival duration
  • other studies were unable to find any definitive improvement concerning therapy with vitamin C
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Either these studies are designed to fail or the authors are lacking some basic understanding of pharmacokinetics and pharmacodynamics with vitamin C.
  • Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      At what dose, duration, frequency???
  • in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      They are kind of make the point from my earlier note.
  • continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Again, designed to fail or ignorance designed the study which failed
  • Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
  • High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • reduced overall mortality
  • reduced overall mortality
  • propose the use for high-dose vitamin C to aid in the treatment of septic shock-induced hypotension
  • treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      High dose here is laughable. Again, duration and frequency also.
  • Maintaining a daily intake of 75 and 100 mg for men and women, respectively, as recommended by the U.S. Institute of Medicine
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      This recommendation is FRANK IGNORANCE
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