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Nathan Goodyear

The Incretins: GLP-1 Agonists and DPP-4 Inhibitors | Diabetesnet.com - 0 views

www.diabetesnet.com/...incretins

GLP-1 incretins insulin glucose diabetes obesity overweight

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Nathan Goodyear on 06 Apr 11
     
    GLP-1 agonists improve insulin/glucose control
Nathan Goodyear

Glucagon-like peptide 1 improves the ability of th... [Diabetes. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9703326

glucagon-like peptid-1 insulin glucose control diabetes resistance

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • We concluded that low dosage GLP-1 improves the ability of the beta-cell to secrete insulin in both IGT and NIDDM subjects, but that the ability to sense and respond to subtle changes in plasma glucose is improved in IGT subjects, with only a variable response in NIDDM subjects. Beta-cell dysfunction was improved by GLP-1 infusion, suggesting that early GLP-1 therapy may preserve beta-cell function in subjects with IGT or mild NIDDM.
  • Nathan Goodyear on 06 Apr 11
     
    glucagon-like peptide-1 improves insulin/glucose regulation
Nathan Goodyear

Incretin-based therapies: can we achieve glycemic control and cardioprotection? - 0 views

joe.endocrinology-journals.org/...T17.full

incretin incretins GLP-1 glucagon-like peptide 1) glucose homeostasis

shared by Nathan Goodyear on 24 Mar 14 - No Cached
  • Nathan Goodyear on 24 Mar 14
     
    Good discussion on the incretin: (Glucagon-like peptide 1 (GLP-1).
Nathan Goodyear

http://www.diabetologia-journal.org/files/Narendran.pdf - 0 views

www.diabetologia-journal.org/...Narendran.pdf

exercise inflammation growth hormone GH IGF-1 TNF-alpha IL-6 IL-1beta IL-1Ra interferon-gamma diabetes islet cells

shared by Nathan Goodyear on 28 Oct 14 - No Cached
  • Nathan Goodyear on 28 Oct 14
     
    Exercise is not just for calories out.  Exercise increases growth hormone, IGF-1, glucagon-like peptide 1, IL-6, and IL-1ra.  The effect is to GH increases beta islet cell mass and protects beta cell lines against IL-1beta, Interferon-gamma and TNF-alhpa induced apoptosis.  IL-6 increased production increases GLP-1 and IL-1ra which counters IL-1beta.  Interleukin-1beta induces islet cell apoptosis and thus IL-1ra counters this pro-inflammatory signal.
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