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Nathan Goodyear

PLoS ONE: Influence of Milk-Feeding Type and Genetic Risk of Developing Coeliac Disease... - 0 views

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    fascinating article on how the environment and genetics play a role in the development of celiac disease.  In this study, the PROFICEL study, the intestinal microbiota was influenced by breast milk.  Those children breast fed had a favorable microbiota that decreased the incidence of celiac disease.
Nathan Goodyear

JAMA Network | JAMA | The Familial Risk of Autism - 0 views

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    New study finds autism is mix of genetic and environmental factors.
Nathan Goodyear

How environmental and genetic factors combine to c... [Neurotoxicology. 2008] - PubMed ... - 0 views

  • Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects.
  • a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.
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    proposed hypothesis of autism
Nathan Goodyear

Genetic Determinants of Serum Testosterone Concentrations in Men - 0 views

  • mean serum testosterone concentrations were found to be lower in men with GG than in those with TT genotype for rs12150660
  • men with the CT genotype for rs6258 had lower serum testosterone concentrations than those with CC genotype.
  • The two autosomal SNPs identified by GWAS had a significant influence on the risk of having low serum testosterone (serum testosterone <300 ng/dl) in both the discovery and the replication cohorts with a combined odds ratio (OR) per minor allele of 0.72 (95% CI, 0.65 – 0.79) and 2.7 (95% CI, 2.1 – 3.5) for rs12150660 and rs6258, respectively
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  • The risk of having low serum testosterone concentrations increased by the number of risk alleles with an OR of 1.62 (95% CI, 1.41 – 1.86) for each risk allele (Figure S4). Low serum testosterone concentrations were 6.5-times more prevalent in men with ≥3 risk alleles (30.1% prevalence of low serum testosterone) compared to men without any risk allele (4.6% prevalence of low serum testosterone;
  • SNP rs5934505 was associated with serum testosterone without SHBG-adjustment (combined p-value of 1.7×10−9) and with free testosterone (combined p-value of 6.7×10−15), but not with SHBG
  • The mean serum testosterone and calculated free testosterone but not SHBG concentrations were lower in men with T genotype than in those with C genotype for rs5934505
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    Genetic SNP rs5934505 associated with lower total Testosterone and lower calculated free Testosterone.  No effects on SHBG.
fnfdoc

Stroke Genetics And Risk Factors | Your Health Our Priority - 0 views

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    Stroke is a cerebrovascular syndrome that involves the blockage and bursting of blood vessels in the brain. It shows a multifactorial pattern of inheritance. High cholesterol levels, high blood pressure, hypertension and obesity are the key causes of stroke besides inherited genes.
Nathan Goodyear

microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Co... - 0 views

  • dysregulated miRNA could be involved in tumor cell proliferation and growth as well as cell cycle progression
  • under-expression of miR-497, 376c and 1271 in Lebanese breast cancer tissues
  • The upregulated miR-183 in our samples was predicted to be responsible for the decrease in expression of the BTG1 mRNA whose protein is involved in cell cycle arrest and apoptosis in breast cancer cells18.
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  • nother molecule related to cell proliferation that was over-expressed in our data and suggested as a target of downregulated miR-376c is AURKA
  • the over-expression of miR-183 and miR-21 in Lebanese breast cancer tissues is consistent with downregulation of two important tumor suppressor predicted targets: AKAP12 whose protein regulates cellular adhesion dynamics by controlling cytoskeletal architecture, cell migration, and mitogenic signaling20; and LATS2 whose protein causes cell cycle arrest
  • dysregulation in cancer particularly in breast cancer highlights their importance in tumor development
  • mRNA-miRNA integration analysis of early breast cancer revealed a potential role of miRNA in increasing cellular proliferation and progression, and decreasing invasion and migration
  • most of the miRNA dysregulated in Lebanese breast cancer patients are similar to those dysregulated in American patients, differences in miRNA expression exist and could be attributed either to the patients’ age at diagnosis or to ethnic variation in miRNA epigenetic regulation and sequence variation of pre-miRNA
  • the number one cancer killer of women worldwide
  • microRNA (miRNA) are small non-coding 18–25 nucleotide RNA molecules currently being studied as potential diagnostic, prognostic and therapeutic biomarkers for cancer and other diseases
  • Extensive research on these post-transcriptional modulators has proven that they are deregulated in breast cancerous tissues and even in biological fluids from breast cancer patients
  • five candidate miRNAs (miR-10b, miR-148b, miR-221, miR-21, and miR-155)
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    Epigenetics plays a role, via disregulated miRNA, in increased cell growth, progression, and invasion in Lebanese women with breast cancer.  It is not just genetics that play a role, but epigenetics.
Nathan Goodyear

Eczema in early life: Genetics, the skin barrier, and lessons learned from birth cohort... - 0 views

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    LPS implicated, through CD14, in eczema.  This was linked to those with high genetic prediposition.  This review article also discusses the heterogeneous disease eczema is.
Nathan Goodyear

A Review on Impacts of Genetically Modified Food on Human Health | Sanjay Mishra - Acad... - 0 views

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    Good review of GMOs impact on the health.
Nathan Goodyear

ScienceDirect.com - Food and Chemical Toxicology - Long term toxicity of a Roundup herb... - 0 views

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    First long-term study on GMO effects on rats. The majority of studies on GMO have been on animals with the end point at < 90 days.  This study followed the rats for 2 years.  Increased mammary tumors were found.  Is this definitive?  Of course not, but this is the first study to look at long term effects.
Nathan Goodyear

High-protein and high-carbohydrate breakfasts differentially change the transcriptome o... - 0 views

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    Diet effects genetic expression, which effects the metabolic rate and satiety.
Nathan Goodyear

Oxidative response gene polymorphisms and risk of adult brain tumors - 0 views

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    Good study shows that genetic polymorphisms play role in brain tumor risk with oxidative damage.  This study found an increased risk with SOD 2/3, and with CAT polymorphisms.  
Nathan Goodyear

Cancer as a metabolic disease - 0 views

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    Dr. Seyfried provides a different perspective on cancer as a metabolic disease and not as a "genetic" disease as is the current dogma. Dr. Seyfried is well published on this topic and presents valid points to show that a ketogenic diet with intermittent fasting is anti-cancer.
wheelchairindia

Pediatric Wheelchair - 0 views

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    The body size differences are paralleled by maturational changes. The smaller body of an infant or neonate is substantially different physiologically from that of an adult. Congenital defects, genetic variance, and developmental issues are of greater concern to pediatricians than they often are to adult physicians. A major difference between pediatrics and adult medicine is that children are minors and, in most jurisdictions, cannot make decisions for themselves. The issues of guardianship, privacy, legal responsibility and informed consent must always be considered in every pediatric procedure. In a sense, pediatricians often have to treat the parents and sometimes, the family, rather than just the child. Adolescents are in their own legal class, having rights to their own health care decisions in certain circumstances. In basic terms, pediatricians take care of all of the children's needs from emotional support to medical support. Wheelchair india as Pediatric Wheelchair Manufacturers and Pediatric Wheelchair supplier sale at low cost - price, We Sale online Pediatric Powered Wheelchair and Pediatric Electric Wheelchair at wholesale prices...
Nathan Goodyear

Lifestyle and nutritional imbalances associated with Western diseases: causes and conse... - 0 views

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    This study finds most "western" diseases are the result of environment and only <5% genetic. Evidence is growing that the environment is the largest contributor to disease.  The greatest environment contributor is diet. This is great, because we can change diet...if one wants too. This article also shows are current understanding on how dietary inflammation results in insulin/glucose disruption.
Nathan Goodyear

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tis... - 0 views

  • SCFAs play a dual role both as substrates for metabolism and as signaling molecules
  • SCFAs can be either directly converted (acetate) or oxidized (propionate and butyrate) to acetyl-Co
  • Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner
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  • complex functional interactions between diet, gut microbiota, and host health.
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    diet changes gut microbiota, which changes genetic expression--it is called epigenetics.  This is an animal study.
Nathan Goodyear

Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in ... - 0 views

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    probiotics found to reduce body fat in diet-induced obesity study in rats.  Both L. curvets and planetarum found to be the most effective in decreasing dietary fat induction.  Also of not, genetic transcription of inflammatory cytokines was found to be reduced.  The different strains may be of importance here as well.
Nathan Goodyear

Benzyl butyl phthalate induces epigenetic stress to enhance adipogenesis in mesenchymal... - 0 views

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    Phthalates effect genetic expression of fat prior to birth.  This is science, not politics.
Nathan Goodyear

Chronic Traumatic Encephalopathy: Chronic Degenerative Disease - 0 views

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    Good discussion on chronic traumatic encephalopathy. CTE is a condition found in the military and sports related head trauma. This is usually the result of low, repetitive impact injuries to the brain. Though, genetic susceptibility is discussed as well.
Nathan Goodyear

Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different ... - 0 views

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    DHEA-S shown to increase genetic expression of adiponectin in human adipose tissue.  This has enormous implications on the link between DHEA and insulin resistance induce obesity. This is a peripheral tissue problem, not a central problem.
Nathan Goodyear

Access : The neurobiology of appetite: hunger as addiction : International Journal of O... - 0 views

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    complex interplay between behavior, genetics, and CNS play role in over-eating.  Add in environment as well.
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