Skip to main content

Home/ Dr. Goodyear/ Group items tagged genes

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Molecular mechanism links stress with predisposition for depression - 0 views

www.sciencedaily.com/...110126121452.htm

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    How you respond to stress is a reflection of your genetics and environment.  The bodies ability to express genes, such as the glial cell
Nathan Goodyear

Neuron - Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility an... - 0 views

www.cell.com/...S0896627310010718

stress depression methylation glial cell-derived neurotrophic factor Gdnf

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    How you respond to stress is a reflection of your genetics and environment.  The bodies ability to express genes, such as the glial cell-derived neurotrophic factor, impacts an individual's expression in the face of stress.  You have a genetic predisposition, but with poor methylation you end up with more depression in the presence of stress
Nathan Goodyear

Divergence of gut permeability and mucosal immune gene expression in two glut... - 0 views

fulltextreports.com/...disease-and-gluten-sensitivity

Gluten sensitivity

shared by Nathan Goodyear on 03 May 11 - No Cached
  • GS as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.
  • Nathan Goodyear on 03 May 11
     
    Gluten sensitivity a result of the innate immunity
Nathan Goodyear

Effects of estrogen on gene expression profiles in mouse hypothalamus and whi... - 0 views

joe.endocrinology-journals.org/...547.short

obesity overweight glutathione stress oxidative weight loss detoxification

shared by Nathan Goodyear on 02 Nov 11 - No Cached
  • Nathan Goodyear on 02 Nov 11
     
    obesity causes oxidative stress, which depletes glutathione.  Lower weight and increase glutathione
Nathan Goodyear

Paradoxical effects of antioxidants on cancer. [Rejuvenation Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24828241

cancer antioxidants vitamin C

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    Just the abstract available here.  Cancer is proving to be very complex--no surprise here.  Antioxidant therapy can actually promote cancer progression as can tumor suppressor genes.  The issue is context of the environment and the tumor in that environment.   Vitamin C is antioxidant in serum, but pro oxidant in the cancer cell.  The result is a production of H2O2 and lysis of the cell.
Nathan Goodyear

Testicular synthesis and vitamin D a... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24937537

vitamin D Testosterone male men hormone hormones

shared by Nathan Goodyear on 29 Jul 14 - No Cached
  • Nathan Goodyear on 29 Jul 14
     
    Vitamin D regulates genes involved in Testosterone production in men.  Another reason, why evaluating Testosterone alone in men is unacceptable.
Nathan Goodyear

The role of MicroRNAs in human cancer | Signal Transduction and Targeted Therap - 0 views

www.nature.com/...sigtrans20154

MicroRNA miRNA cancer epigenetics

shared by Nathan Goodyear on 16 Dec 18 - No Cached
  • Nathan Goodyear on 16 Dec 18
     
    Great review of the relationship between miRNA and cancer. MicroRNA are regulators, post-translationally, in gene expression.
Nathan Goodyear

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on g... - 0 views

www.ncbi.nlm.nih.gov/...PMC4741919

adenoid cystic carcinoma

shared by Nathan Goodyear on 03 Oct 18 - No Cached
  • Cisplatin and 5-FU or CAP (cisplatin, doxorubicin, and cyclophosphamide) regimens can be used for combination chemotherapy
  • patients with advanced salivary gland malignancy treated with the CAP regimen achieved partial response (PR) or stable disease (SD) rates of 67% (8 out of 12 patients)
  • Agents commonly given as monotherapy for treating ACC are cisplatin, mitoxantrone, epirubicin, vinorelbine, paclitaxel, and gemcitabine. However, few of these agents have shown efficacy
  • ...23 more annotations...
  • single agent mitoxantrone or vinorelbine were recommended as reasonable choices
  • ACC is subdivided into 3 histological groups based on solid components of the tumor including cribriform, tubular, and solid
  • Cribriform and tubular ACCs usually exhibit a more indolent course, whereas the solid subtype is associated with worse prognosis
  • ACC consists of two different cell types: inner luminal epithelial cells and outer myoepithelial cells
  • epithelial cells express c-kit, cox-2 and Bcl-2
  • myoepithelial cells express EGFR and MYB
  • a balanced translocation of the v-myb avian myeloblastosis viral oncogene homolog-nuclear factor I/B (MYB-NFIB) is considered to be a signature molecular event of ACC oncogenesis
  • As a transcription factor, MYB is known to modulate multiple genetic downstream targets involved in oncogenesis, such as cox-2, c-kit, Bcl-2 and BclX
  • Various signaling cascades are essential for cancer cells to survive and grow. The PI3K/Akt/mTOR pathway is one of them
  • This pathway regulates cell survival and growth and is upregulated in many cancers
  • Mutations in genes associated with DNA repair are frequently found in familial cancer syndromes, such as hereditary breast-ovarian cancer syndrome (HBOC), hereditary non-polyposis colorectal cancer (HNPCC, also called Lynch syndrome) and Li-Fraumeni syndrome [30, 31]. These mutations were also reported in non-hereditary cancers
  • 70% of ACC samples (58 of 84) were found to have genetic alterations in the MYB/MYC pathway, indicating that changes in this pathway are crucial in ACC pathogenesis
  • The second most frequently mutated pathway was involved in chromatin remodeling (epigenetic modification), a pathway that includes multiple histone related proteins, and was altered in 44% of samples
  • C-kit
  • VEGF, iNOS and NF-κB were noted to be highly expressed in ACC cells as compared to normal salivary gland cells
  • members of the SOX family, such as SOX 4 and SOX10, are overexpressed in ACC
  • FABP7 (Fatty acid binding protein 7) and AQP1 (Aquaporin 1) tend to be overexpressed in ACC cell lines
  • considerable variability in HER2 overexpression ranging from 0–58% in patients with ACC
  • the study with cetuximab and concurrent chemoradiation or chemotherapy showed the highest ORR (total 43%, 9.5% CR and 33% PR), but this regimen was only given to the EGFR positive patients
  • Cancer immunotherapy can be classified into 3 major groups. Active immunization using anti-tumor vaccines to induce and recruit T cells, passive immunization based on monoclonal antibodies, and adoptive cell transfer to expand tumor-reactive autologous T cells ex vivo and then reintroduce these cells into the same individual
  • LAK cells showed cytotoxicity against ACC cells
  • cytokine-induced cell apoptosis and the cytotoxic effect of the LAK cells contributed to tumor regression
  • molecular finding of the MYB-NFIB fusion gene has the greatest potential to target what appears to be a fundamental event in disease pathogenesis
  • Nathan Goodyear on 03 Oct 18
     
    good review of adenoid cystic carcinoma
Nathan Goodyear

Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights ... - 0 views

cancerci.biomedcentral.com/...s12935-015-0241-x

curcumin tumeric cancer colorectal cancer colon cancer

shared by Nathan Goodyear on 11 Sep 17 - No Cached
  • Nathan Goodyear on 11 Sep 17
     
    curcumin effective in inhibition of cancer and cancer stem cell activity through increasing apoptotic genes, affecting cellular signaling, altering growth factor receptors, microRNAs, tumor spheroid formation, and epithelial-mesenchymal transition; and found to be helpful in increasing chemo sensitivity to chemo and radiotherapy.
Nathan Goodyear

Omega-3 Fatty Acids and Inflammatory Processes - 0 views

www.ncbi.nlm.nih.gov/...PMC3257651

fats nutrition diet omega 3 inflammation NF-kappaB TNF-alpha omega-3 fish oil DHA EPA docosahexaenoic acid eicosapentaenoic acid

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • marine n-3 PUFAs have also been shown to alter the production of inflammatory proteins including chemokines, cytokines, growth factors and matrix proteases
  • Two transcription factors that are likely to play a role in inflammation are nuclear factor κ B (NFκB) and PPAR-γ
  • NFκB is the principal transcription factor involved in upregulation of inflammatory cytokine, adhesion molecule and cyclooxygenase-2 genes
  • ...3 more annotations...
  • PPAR-γ, is believed to act in an anti-inflammatory manner
  • PPAR-γ directly regulates inflammatory gene expression, it also interferes with the activation of NFκB creating an intriguing interaction between these two transcription factors
  • Both NFκB and PPAR-γ may be regulated by n-3 PUFAs.
  • Nathan Goodyear on 15 Sep 17
     
    great review of the anti-inflammatory effects of omega 3 DHA and EPA.  EPA inhibits COX and 5-LOX and their downstream prostaglandin and leukotrienes.  EPA/DHA inhibited endotoxin-stimulated IL-6, IL-8,TNF-alpha, and NFkappaB.
Nathan Goodyear

Mendelian randomization suggests non-causal associations of testosterone with cardiomet... - 0 views

www.ncbi.nlm.nih.gov/...23258625

Testosterone SNPs epigenetics

shared by Nathan Goodyear on 20 Sep 17 - No Cached
  • Nathan Goodyear on 20 Sep 17
     
    Study questions causal associations of testosterone and cardiometabolic risk.  In this analysis they used to SNPs, one on the SHBG gene rs12150660 and the other on the X chromosome rs59344505.
Nathan Goodyear

Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary ... - 0 views

www.nature.com/...srep22883

epigenetics PCOS polycystic ovarian syndrome

shared by Nathan Goodyear on 20 Sep 17 - No Cached
  • Nathan Goodyear on 20 Sep 17
     
    Study finds statistically increased methylation of many genes in women with PCOS: it is called epigenetics.
Nathan Goodyear

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent... - 0 views

www.ncbi.nlm.nih.gov/...PMC3595363

CSC cancer stem cells leukemia oxidative phosphorylation cancer

shared by Nathan Goodyear on 28 Nov 18 - No Cached
  • Nathan Goodyear on 28 Nov 18
     
    Leukemia stem cells use oxidative phosphorylation metabolism via upregulation of bcl-2 gene.
fnfdoc

Stroke Genetics And Risk Factors | Your Health Our Priority - 0 views

www.fnfdoc.com/...stroke-genetics-risk-factors

Genetics Ischemic Stroke

shared by fnfdoc on 03 May 18 - No Cached
  • fnfdoc on 03 May 18
     
    Stroke is a cerebrovascular syndrome that involves the blockage and bursting of blood vessels in the brain. It shows a multifactorial pattern of inheritance. High cholesterol levels, high blood pressure, hypertension and obesity are the key causes of stroke besides inherited genes.
Nathan Goodyear

Cancer stem cells in the development of liver cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3635728

cancer liver cancer CSC cancer stem cells liver

shared by Nathan Goodyear on 01 Feb 18 - No Cached
  • the finding of a stem cell–like gene expression signature is of great interest because it reflects the malignant nature of a tumor with poor survival outcome
  • poor prognosis of HCC in patients with stemness-associated gene expression traits is assumed to reflect the abundance of liver CSCs with highly tumorigenic and/or metastatic features
  • CSCs have a highly invasive and metastatic capacity
  • ...1 more annotation...
  • The discovery and exploration of liver CSCs has expanded our knowledge of the mechanisms by which liver cancers obtain tumorigenic, metastatic, and chemotherapy- and radiation-resistant capacities
  • Nathan Goodyear on 01 Feb 18
     
    Good review and discussion of liver cancer Cancer Stem cells.
Nathan Goodyear

The role of nutrition related genes and nutrigenetics in understanding the pathogenesis... - 0 views

www.sciencedirect.com/...S2213879X16000183

nutrition diet epigenetics nutrigenomics cancer genes DNA

shared by Nathan Goodyear on 07 Feb 18 - No Cached
mamdouh_hfz liked it
  • Nathan Goodyear on 07 Feb 18
     
    good review article on nutrition, epigenetics, and cancer
Nathan Goodyear

Demystified . . . Human endogenous retroviruses - 0 views

www.ncbi.nlm.nih.gov/...PMC1187282

HERV retroviruses human endogenous retroviruses

shared by Nathan Goodyear on 14 May 18 - No Cached
  • HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits
  • However, several HERVs have been implicated in certain cancers and autoimmune diseases
  • HERVs constitute about 1% of the human genome
  • ...16 more annotations...
  • Human endogenous retroviruses (HERVs) represent footprints of previous retroviral infection and have been termed “fossil viruses”
  • HERVs possess a similar genomic organisation to present day exogenous retroviruses such as human immunodeficiency virus (HIV) and human T cell leukaemia virus (HTLV)
  • Retroviruses in effect are retrograde, because the flow of genetic information is reversed compared with the normal pathway of molecular biosynthesis—DNA → RNA → protein. Indeed, all retroviruses necessitate the conversion of viral RNA into a cDNA intermediary, which is catalysed by the enzyme reverse transcriptase
  • Overall, human endogenous retroviruses constitute about 1% of the human genome”
  • some HERVs have been implicated in certain autoimmune diseases and cancers
  • A unit of sugar, phosphate, and base is strictly termed a nucleotide
  • human genes are composed of exons, which are transcribed and translated into amino acids
  • introns, which are interspersed between exons and represent non-translated regions that contribute to the large size of some genes
  • convincing argument for the possible involvement of HERVs in malignancy
  • HERVs may be involved in carcinogenesis by virtue of the expression of HERV mRNA,26 functional proteins,27 or retroviral-like particles
  • They may also be associated with the generation of new promoters29 or the activation of proto-oncogenes
  • inhibition of an effective immune response,
  • encode immunosuppressive proteins
  • “It has been suggested that HERV-K may be important in the progression of testicular germ cell tumours through inhibition of an effective immune response”
  • HERV-K might be important in the pathogenesis of human breast cancer
  • activation of proto-oncogenes of the ras family is common in many tumour types, and some studies have suggested a potential role for HERVs in ras activation
  • Nathan Goodyear on 14 May 18
     
    good review of HERVs.
Nathan Goodyear

Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation - ScienceDi... - 0 views

www.sciencedirect.com/...S1934590919302759

cancer radiation cat scan imaging CT

shared by Nathan Goodyear on 19 Jul 19 - No Cached
  • Nathan Goodyear on 19 Jul 19
     
    Low dose radiation from CT found to contribute to altered genetic expression of p53 tumor suppressor gene to give competitive advantage to potential cancer cells over health cells.
Nathan Goodyear

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to ... - 0 views

academic.oup.com/...JC.2015-2284

sleep epigenetics BMAL1 CLOCK CRY1 PER1 sleep deprivation

shared by Nathan Goodyear on 30 Aug 17 - No Cached
  • Nathan Goodyear on 30 Aug 17
     
    Sleep deprivation, defined as 1 night of no sleep, changed epigenetic expression of BMAL via increased methylation. Other findings: decreased cortisol, increased glucose...
Nathan Goodyear

Short term vitamin D exposure alters methylation status of term placental villi - Placenta - 0 views

www.placentajournal.org/...pdf

epigenetics vitamin d pregnancy placenta methylation

shared by Nathan Goodyear on 10 Nov 17 - No Cached
  • Nathan Goodyear on 10 Nov 17
     
    Vitamin D alters genetic expression of the placenta during pregnancy through methylation of CpG islands to effect transcription and increased expression and decreased expression of genes.
« First ‹ Previous 41 - 60 of 178 Next › Last »
Showing 20▼ items per page