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Nathan Goodyear

Exposure to pesticides or solvents and risk of Parkinson disease - 0 views

www.neurology.org/...2035.abstract

pesticides disease Parkinson's Parkinson's disease solvents environmental toxins toxins paraquat

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    meta-analysis finds that exposure to pesticide and solvents increase Parkinson's disease by 80%.  One potentially problematic pesticide was paraquat.
Nathan Goodyear

Endocrine disruptors: can biological... [Regul Toxicol Pharmacol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12383724

xenoestrogens endocrine disruptors hormones environmental toxins environment toxins

shared by Nathan Goodyear on 15 Dec 12 - No Cached
  • Nathan Goodyear on 15 Dec 12
     
    Xenoestrogens disrupt hormones, despite being very weak compared to estradiol.
Nathan Goodyear

Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisp... - 0 views

endo.endojournals.org/...s56.full

BPA bisphenol A pregnant children hormone receptors environment environmental toxins

shared by Nathan Goodyear on 15 Dec 12 - No Cached
  • Nathan Goodyear on 15 Dec 12
     
    Very low levels of BPA shown to be present in pregnant and unborn children.  These levels exceed the levels at which documented receptor change occurs as the result of BPA.
Nathan Goodyear

Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist - 0 views

jcem.endojournals.org/...5185.abstract

BPA Bisphenol A T3 thyroid hormone thyroid hormone environmental toxins

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction.  This study even showed that BPA inhibited thyroid receptor transcription.
Nathan Goodyear

Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pes... - 0 views

pediatrics.aappublications.org/...e1270.long

ADHD pediatrics children organophosphates environmental toxins pesticides

shared by Nathan Goodyear on 21 Feb 13 - No Cached
  • Nathan Goodyear on 21 Feb 13
     
    No longer a hypothesis, study shows that organophosphate exposure in children contributes to ADHD incidence.
Nathan Goodyear

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphe... - 0 views

press.endocrine.org/...en.2015-1937

BPA toxins environmental toxins xenoextrogens bisphenol A hormones

shared by Nathan Goodyear on 18 May 16 - No Cached
  • Nathan Goodyear on 18 May 16
     
    low dose of BPA in rat model finds delayed sexual maturation.
Nathan Goodyear

Telomerase at the intersection of cancer and aging - 0 views

www.ncbi.nlm.nih.gov/...PMC3896987

telomere telomeres telomerase telomerase activator aging disease cancer

shared by Nathan Goodyear on 18 May 16 - No Cached
  • The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
  • Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
  • increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
  • ...15 more annotations...
  • mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
  • In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
  • Although recent findings strongly support the idea that short telomeres drive several age-related diseases 38 we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
  • the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
  • telomerase activation can be an early event in cancer, it is not necessary for cancer initiation
  • telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
  • Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
  • recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
  • Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
  • telomerase activation is a potential therapeutic strategy for the treatment of age-related diseases
  • telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
  • These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
  • humans almost completely lose telomerase activity from somatic tissues in the adulthood
  • a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
  • Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
  • Nathan Goodyear on 18 May 16
     
    Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
Nathan Goodyear

http://ehp.niehs.nih.gov/wp-content/uploads/advpub/2016/5/EHP205.acco.pdf - 0 views

ehp.niehs.nih.gov/...EHP205.acco.pdf

obesity bisphenol A BPA EDC toxins environmental toxins endocrine disrupting chemicals

shared by Nathan Goodyear on 08 Jun 16 - No Cached
  • Nathan Goodyear on 08 Jun 16
     
    mothers with BPA exposure and thus prenatal exposure, increases risk of obesity risk in child.
Nathan Goodyear

Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoest... - 0 views

carcin.oxfordjournals.org/...1567.short

xenoestrogens cancer environmental toxins estrogen

shared by Nathan Goodyear on 18 Mar 12 - No Cached
  • Nathan Goodyear on 18 Mar 12
     
    article discusses the increased estrogenic effect of the xenoestrogens found in chemical toxins.  This has serious implications in cancer that is estrogenic.
Nathan Goodyear

JSTOR: Epidemiology, Vol. 13, No. 4 (Jul., 2002), pp. 454-458 - 0 views

www.jstor.org/...3703770

DDE environmental toxins low T testosterone men endocrine disruptors

shared by Nathan Goodyear on 21 May 12 - No Cached
  • Nathan Goodyear on 21 May 12
     
    High DDE levels in African American men associated with a 23% lower Testosteone levels
Nathan Goodyear

Sugar in Children's Cereals | Environmental Working Group - 0 views

breakingnews.ewg.org/...sugar_in_childrens_cereals

breakfast cereal healthy sugar children

shared by Nathan Goodyear on 08 Dec 11 - No Cached
  • Nathan Goodyear on 08 Dec 11
     
    great resource to make healthy breakfast cereal choices for your family.  You would never think to feed your family twinkies for breakfast, but the sugar content of many cereals is doing just that.
Nathan Goodyear

Urinary Bisphenol A Concentrations in Relation to Serum Thyroid and Reproductive Hormon... - 0 views

pubs.acs.org/...es9028292

BPA Bisphenol-A bisphenol infertility men's health men E2:T free androgen index hypothyroidism TSH low T testosterone

shared by Nathan Goodyear on 12 Dec 11 - No Cached
  • Nathan Goodyear on 12 Dec 11
     
    Granted, these are in men seen in an infertility clinic, but Bisphenol A (BPA) found to disrupt thyroid, increase the E2:T ratio, and a decrease in the free androgen index.  Interestingly, 89% of the men seen in this study tested positive for BPA in the urine.
Nathan Goodyear

Parabens in male infertility-Is there a mitochondrial connection? 10.1016/j.reprotox.20... - 0 views

www.sciencedirect.com/...S0890623808002682

male infertility parabens mitochondrial mitochondria xenobiotics environmental toxins

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • Nathan Goodyear on 02 Feb 12
     
    parabens effect through mitochondrial disruption in testes?
Nathan Goodyear

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity - Gash - 2007... - 0 views

onlinelibrary.wiley.com/...abstract

TCE environmental toxins mitochondria Parkinson's Disease PD

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    TCE shown to mitochondrial toxic and risk factor for Parkinson's disease
Nathan Goodyear

CDC Fourth Report - 0 views

www.altmedrev.com/...101.pdf

CDC environmental toxin toxins PCB's PCBs organophosphates pesticides herbicides BPA heavy metals

shared by Nathan Goodyear on 27 Feb 12 - No Cached
  • Nathan Goodyear on 27 Feb 12
     
    CDC's report on the toxic load of Americans.
Nathan Goodyear

EWGs shopper's guide to Pesticides in produce - 0 views

www.ewg.org/summary

pesticides fruits vegetables veggies EWG environmental working group

shared by Nathan Goodyear on 07 Mar 12 - No Cached
  • Nathan Goodyear on 07 Mar 12
     
    Know your fruits and veggies better. Those items that should provide you with health may actually be robbing you of it.
Nathan Goodyear

SpringerLink - Environmental Health and Preventive Medicine, Volume 7, Number 4 - 0 views

www.springerlink.com/...35l447247110p261

green tea folate health

shared by Nathan Goodyear on 25 Nov 11 - No Cached
  • Nathan Goodyear on 25 Nov 11
     
    green tea is a good source of folate in japanese diets
Nathan Goodyear

Epidemiology of Systemic Sclerosis - 0 views

www.medscape.com/...758480

scleroderma silica environmental toxins toxin autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    silica exposure plays a role in the development of scleroderma
Nathan Goodyear

Neurobehavioural effects of developmental toxicity : The Lancet Neurology - 0 views

www.thelancet.com/...abstract

flourine toxins environmental brain neurology ADD ADHD autism ASD pediatrics children

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    new study out of the Lancet labels Flouride as neurotoxicant, along with lead, methyl mercury, PCBs, arsenic, toluene and others.   This is not a political issue and needs to be reviewed scientifically.  These toxicants impair neurodevelopment and may be one reason for the rapidly rising conditions associated: i.e. ADD, ADHD, autism...
Nathan Goodyear

Pesticides in Mississippi air and rain:... [Environ Toxicol Chem. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24549493

pesticides farming glyphosate AMPA xenoestrogens environmental toxins

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    Scary stat--75% of samples from air and rainfall taken in delta contaminated with glyphosate and its metabolite AMPA.  These levels were not measured in 1995 so % increase is unable to be determined.  We do know that roundup use has increased dramatically over that time frame.  
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