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annebronte

Environmental Issues in Pakistan : News 313 | Pakistan Latest News | - 1 views

news313.pk/...vironmental-issues-in-pakistan

envirnoment issues

shared by annebronte on 09 Aug 18 - No Cached
  • annebronte on 09 Aug 18
     
    Usually and mostly we know about three types of pollutions; air pollution, water pollution, and noise pollution. These changes to the planet have already caused much of the disastrous conditions for the future. So, in this article, we will discuss Environmental Issues in Pakistan.
babajemofficial

How To Your Bleached Hair At Home - BabaJem - 0 views

www.babajem.com/eal-your-bleached-hair-at-home

Bleached Heal

shared by babajemofficial on 11 Feb 23 - No Cached
  • babajemofficial on 11 Feb 23
     
    You might require more than simple lifestyle changes and DIY remedies to improve your hair if it has been seriously damaged by bleach or any other environmental factors.
  • babajemofficial on 11 Feb 23
     
    You might require more than simple lifestyle changes and DIY remedies to improve your hair if it has been seriously damaged by bleach or any other environmental factors.
Nathan Goodyear

Environmental Chemicals in Pregnant Women in the United States: NHANES 2003-2004 - 0 views

www.ncbi.nlm.nih.gov/...PMC3114826

environmental chemicals toxins pregnant women pregnant women

shared by Nathan Goodyear on 04 Dec 12 - No Cached
  • Nathan Goodyear on 04 Dec 12
     
    2011 study finds that 43 toxic chemicals of 163 evaluated found in "virtually all" 268 pregnant women in small study.  Many of these chemical have not been commercially available for 30 years.
Nathan Goodyear

Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease... - 0 views

ebm.rsmjournals.com/...1136.full

low vitamin D vitamin D deficiency vitamin D autoimmune disease autoimmune disease environmental factor

shared by Nathan Goodyear on 15 May 13 - No Cached
  • Nathan Goodyear on 15 May 13
     
    low vitamin D associated with increase prevalence of autoimmune disease.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

Combining xenoestrogens at levels below individual no-observed-effect concentrations dr... - 0 views

www.ncbi.nlm.nih.gov/...ehp0110-000917.pdf

xenoestrogens xenoestrogen environmental toxins estrogen hormones hormone

shared by Nathan Goodyear on 15 Dec 12 - No Cached
  • Nathan Goodyear on 15 Dec 12
     
    low levels of environmental toxins add to the effective hormone levels in the body. These are in very low levels of exposure.
Nathan Goodyear

ScienceDirect.com - The Journal of Steroid Biochemistry and Molecular Biology - Estroge... - 0 views

www.sciencedirect.com/...S0960076011001518

xenoestrogen xenoestrogens prostate male hormone estrogen receptor estrogen receptor alpha ER alpha estrogen receptor receptors environmental chemicals drugs

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    low dose xenoestrogen exposure increases prostate growth and future disease through fetal exposure and increased ER alpha expression.
Nathan Goodyear

Exposure of Newborn Male and Female Rats to Environmental Estrogens: Delayed and Sustai... - 0 views

endo.endojournals.org/...4512.long

xenoestrogen xenoestrogens ER alpha ER-beta estrogen receptor estrogen receptor alpha estrogen receptor beta estrogen receptor receptors hormone hormones pituitary environmental

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    xenoestrogen exposure has been shown to increase ER alpha and ER beta in the pituitary.
Nathan Goodyear

ScienceDirect.com - Environmental Research - Adipose tissue concentrations of persisten... - 0 views

www.sciencedirect.com/...S0013935112003210

diabetes type II DM type II diabetes environmental toxins PCB's organochlorine pesticides polychlorinated biphenyls

shared by Nathan Goodyear on 08 Feb 13 - No Cached
  • Nathan Goodyear on 08 Feb 13
     
    PCBs and organochlorine pesticides associated with increased risk of type II diabetes
Nathan Goodyear

Greater Lifetime Pesticide Use Causes Telomere Shortening - 0 views

www.greenmedinfo.com/...e-causes-telomere-shortening-0

pesticide toxins toxicants pesticides Telomere

shared by Nathan Goodyear on 02 Jul 13 - No Cached
  • Nathan Goodyear on 02 Jul 13
     
    Hard to show causation here, but volume of environmental toxicants associated with shortening of Telomeres.  Mechanism?  Increased free radical induced mitochondrial disruption resulting in relocation of the Telomerase enzyme from the mitochondria to the nuclei.   This has been shown to occur in cancer pathogenesis.
Nathan Goodyear

Bisphenol A at Low Nanomolar Doses Confers Chemoresistance in Estrogen Recept... - 0 views

www.ncbi.nlm.nih.gov/...PMC2649216

ER-alpha estrogen receptor Bisphenol A toxins cancer breast

shared by Nathan Goodyear on 18 Oct 12 - No Cached
  • Nathan Goodyear on 18 Oct 12
     
    How do environmental chemicals interfere?  This study shows how Bisphenol A actually interferes at the site of the estrogen receptor alpha.  Bisphenol A decreased the efficacy of chemotherapy in ER +/- breast cancer.  Again, the focus is on the interaction with ER alpha.
Nathan Goodyear

Male Reproductive Health and Environmental Xenoestrogens - 0 views

www.ncbi.nlm.nih.gov/...envhper00347-0052.pdf

xenoestrogens endocrine disruptors men male low Testosterone T environmental toxins

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    Good review of xenoestrogens and the impact these endocrine disruptors are having on men.
Nathan Goodyear

Reproductive Hormone Levels in Men Exposed to Persistent Organohalogen Pollutants: A St... - 0 views

www.ncbi.nlm.nih.gov/...PMC1570059

POP organochlorides endocrine disruptors persistent organohalogen men pollutants DDE DDT low T testosterone hormone male hormones

shared by Nathan Goodyear on 21 May 12 - No Cached
  • Nathan Goodyear on 21 May 12
     
    Review finds endocrine disruption from Organocholrides, also called persistent organohalogen pollutants. Common POP, would be DDE, DDT... This is a review of several cohorts, but this follows the rest of the literature that these environmental toxicants are endocrine disruptors.
Nathan Goodyear

Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower grow... - 0 views

oem.bmj.com/5.full

DDE persistent organohalogen pollutants male hormones hormone low T testosterone men mexican environmental

shared by Nathan Goodyear on 21 May 12 - No Cached
  • Nathan Goodyear on 21 May 12
     
    DDE in hispanic farm workers found to be inversely associated with testosterone.  Again, DDE and other persistent organohalogen pollutants, work to lower testosterone in men.
Nathan Goodyear

Environmental Health | Full text | Arsenic in drinking water and cerebrovascular diseas... - 0 views

www.ehjournal.net/4

arsenic diabetes environmental health disease mortality drinking

shared by Nathan Goodyear on 07 Dec 11 - No Cached
  • Nathan Goodyear on 07 Dec 11
     
    low levels of Arsenic in drinking water in Michigan shown to increase diabetes and other diseases
Nathan Goodyear

Access : Urinary DEHP metabolites and fasting time in NHANES : Journal of Exposure Scie... - 0 views

www.nature.com/...jes201128a.html

urinary DEHP metabolites environmental intake exposure

shared by Nathan Goodyear on 12 Dec 11 - No Cached
  • Nathan Goodyear on 12 Dec 11
     
    urinary DEHP metabolites shown to be good test to evaluate recent dietary intake or exposure
Nathan Goodyear

ScienceDirect - Environmental Research : Inorganic arsenic exposure and type 2 diabetes... - 0 views

www.sciencedirect.com/...S0013935107000746

Arsenic diabetes inorganic environmental exposure

shared by Nathan Goodyear on 06 Dec 11 - No Cached
  • Nathan Goodyear on 06 Dec 11
     
    Arsenic exposure, inorganic, shown to be diabetogenic.
Nathan Goodyear

PHTHALATES AND HUMAN HEALTH -- Hauser and Calafat 62 (11): 806 -- Occupational and Envi... - 0 views

oem.bmj.com/...806.full

health occupational environmental Phthalate Phthalates toxins

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • Nathan Goodyear on 02 Feb 12
     
    Phthalates and health effects.
Nathan Goodyear

Environmental Health Perspectives: Polychlorinated Biphenyls, Lead, and Mercury Are Ass... - 0 views

ehsehplp03.niehs.nih.gov/...ehp.1002720

elevated enzymes ALT lead mercury PCBs heavy metals liver disease environmental health

shared by Nathan Goodyear on 05 Mar 12 - No Cached
  • Nathan Goodyear on 05 Mar 12
     
    Lead, Mercury, and PCBs shown to be a associated with elevations of liver enzymes, especially ALT.
Nathan Goodyear

Estrogens in Men: Clinical Implications for Sexual Function and the Treatment of Testos... - 0 views

onlinelibrary.wiley.com/...abstract

men male testosterone estrogen estrone estradiol low T low testosterone testosterone deficiency

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    Several flaws with this study. First, the majority of testing done in the meta-analysis was serum--unreliable.  Second, this study flies in the face of many other studies that have shown elevated estrogens contribute to low testosterone in men.  Third, this flies in the face of observation.  I see over and over again, by lowering a male's estrogen level, he in turn will start producing more Testosterone.  And finally, the environmental xenoestrogens have helped to contribute to a all time low of testosterone/infertility rate in men today.
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