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Nathan Goodyear

Dehydroepiandrosterone in the treatment of erectile... [Urol Res. 2001] - PubMed - NCBI - 0 views

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    DHEA may be beneficial in those with ED + hypertension and those with organic ED cause.  "Organic" causes like diabetes and neurological problems DHEA provided no benefit.
Nathan Goodyear

Dehydroepiandrosterone in the treatment of erectile ... [Urology. 1999] - PubMed - NCBI - 0 views

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    small study finds 50 mg of DHEA improves symptoms of ED.  Small study, so hard to take a lot from this, but DHEA is an androgen, so logically it makes sense.  
Nathan Goodyear

Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to ... - 0 views

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    TNF-alpha inhibited activation of DHEA in RA.
Nathan Goodyear

Web of Knowledge [v.5.3] - Web of Science - 0 views

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    animal model: showed that DHEA treatment resulted in increased adiponectin secretion from fat cells. This occurred with an associated increase in PPAR-gamma receptors.  The suggestion is that DHEA through PPAR-gamma increased fat cell production and secretion of adiponectin.
Nathan Goodyear

Dehydroepiandrosterone and Analogs Inhibit DNA Binding of AP-1 and Airway Smooth Muscle... - 0 views

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    DHEA beneficial at the biochemistry level in asthma.  DHEA inhibits the activation of transcription factor activator protein-1.
Nathan Goodyear

Effect of dehydroepiandrosterone derivatives... [Bioorg Med Chem. 2014] - PubMed - NCBI - 0 views

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    Interesting abstract of study of DHEA metabolites.  In vivo study finds some DHEA metabolites inhibit 5-alpha-reductase activity.  The opening sentence implies that 5alpha-reductase and conversion of T to DHT promotes androgen dependent disease.  The inference here is cancer, however, what they fail to mention is that this activity is via the estrogen receptors.
Nathan Goodyear

http://www.biomedcentral.com/content/pdf/1756-0500-3-204.pdf - 0 views

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    salivary DHEA-S ranges from 4-10 ng/dl in men versus 1-5 in women with no variance between drool or cotton technique.
Nathan Goodyear

Salivary Cortisol and DHEA Levels in the Korean Population: Age-Related Differences, Di... - 0 views

  • As the cortisol and DHEA levels in saliva reflected those in serum, the measurement of steroid levels in saliva provide a useful and practical tool to evaluate adrenal functions, which are essential for clinical diagnosis.
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    cortisol and DHEA in saliva correlates well with that in serum; said to be "practical  and useful tool" for clinical diagnosis
Nathan Goodyear

Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection m... - 0 views

  • Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva:
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    assessing cortisol and DHEA in saliva
Nathan Goodyear

Salivary cortisol and DHEA levels in the Korean po... [Yonsei Med J. 2007] - PubMed result - 0 views

  • As the cortisol and DHEA levels in saliva reflected those in serum, the measurement of steroid levels in saliva provide a useful and practical tool to evaluate adrenal functions, which are essential for clinical diagnosis.
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    salivary cortisol and DHEA validated.  
Nathan Goodyear

Dehydroepiandrosterone for women in the peri- or postmenopausal phase. - PubMed - NCBI - 0 views

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    Supporting evidence for DHEA improvement for women is mixed and minimal.  Full article is not available so the question as whether a need was indicated based on testing is not available.  Side effects were seen with DHEA--primarily acne.  
Nathan Goodyear

ENDOGENOUS SEX HORMONES, BLOOD PRESSURE CHANGE, AND RISK OF HYPERTENSION IN POSTMENOPAU... - 0 views

  • Among postmenopausal women, serum T was elevated in hypertensive participants [9, 11, 12], and total T, free T, and DHEA were positively correlated with SBP
  • T and DHEA were attenuated by adjustment for BMI, reflecting either a confounding or a mediating effect of obesity
  • SHBG concentration was inversely associated with risk of hypertension and longitudinal rise of BP over time
  • ...8 more annotations...
  • SHBG has been postulated as a marker for insulin resistance
  • In vitro studies showed that insulin inhibits SHBG production from hepatoma cells
  • In intervention studies, successful weight loss and weight maintenance increased SHBG in men with obesity
  • E2 may also induce insulin resistance and thereafter tend to raise BP.
  • strong association between E2 and measures of insulin resistance in postmenopausal women, independent of adiposity
  • In postmenopausal women that received hormone replacement therapy, estrogen therapy increased mononuclear cell secretion of tumor necrosis factor alpha (TNF-α)
  • estrone levels were positively associated with inflammatory markers in postmenopausal women
  • higher baseline concentrations of endogenous E2, total and bioavailable T, and DHEA and lower concentration of SHBG were associated with a higher incidence of hypertension and a greater increase in BP during follow-up
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    Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-2934 - 0 views

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    Again, what is the evidence on androgens in women.  The majority of data is points to negative metabolic effects.  This study looked at men and women and found inverse relationships between Testosterone and DHEA in the sexes.  In women, higher bioavailable Testosterone and DHEA was associated with visceral and subcutaneous fat in women, where as the opposite is true in men.  In both men and women, higher SHBG was associated with lower fat.
Nathan Goodyear

Effect of Dehydroepiandrosterone Replacement on Insulin Sensitivity and Lipids in Hypoa... - 0 views

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    Study finds 50 mg of DHEA improves insulin sensitivity in Hypoadrenal women.  The authors also found and increase in DHEAS, bioavailable T, androstenedione, and a reduced SHBG, insulin, and glucagon.
Nathan Goodyear

Hyperandrogenism induces a proinflam... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

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    Very insightful study.  Study looked at hyperadrogenism and inflammation in women on the orders of PCOS.  The study subjects did not have PCOS, but hyperandrogenism via 130 mg DHEA was associated with an increase in TNF-alpha in these lean o/w healthy women.  We know this is due to hyperandrogenism as elevated Testosterone, DHEA, and androstenedione were documented with treatment. Take home:  androgens promote inflammation in women.  I believe this has serious negative implications about the massive Testosterone doping that is occurring in women today.
Nathan Goodyear

Prevention of diabetes, hepatic injury, and colon cancer with dehyd... - PubMed - NCBI - 0 views

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    This article focus' more on the liver and insulin effect of DHEA, but highlights the 2002 study of DHEA and decreased aberrant crypt foci in potential cancer prevention.
Nathan Goodyear

Effect of DHEA on recovery of muscle atro... [J Korean Acad Nurs. 2011] - PubMed - NCBI - 0 views

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    DHEA improves muscle atrophy in Parkinson's disease.
Nathan Goodyear

Associated hormonal declines in aging: D... [J Endocrinol Invest. 2005] - PubMed - NCBI - 0 views

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    DHEAS declines with aging.
Nathan Goodyear

Dehydroepiandrosterone (DHEA)--a precursor steroid... [J Sex Med. 2011] - PubMed - NCBI - 0 views

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    DHEA reduces inflammation, improves insulin function, and provides improved cognitive function.
Nathan Goodyear

Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammator... - 0 views

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    DHEA is reduced in chronic inflammatory conditions.
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