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Nathan Goodyear

Magnesium sulphate for women at r... [Cochrane Database Syst Rev. 2009] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...19160238

IV IV magnesium magnesium cerebral palsy CP nutritional therapy

shared by Nathan Goodyear on 07 Feb 13 - No Cached
  • Nathan Goodyear on 07 Feb 13
     
    Cochrane database finds IV magnesium helps to prevent cerebral palsy.
Nathan Goodyear

Indications, Contraindications, and Complications of Mesh in Surgical Treatment of Pelv... - 0 views

www.ncbi.nlm.nih.gov/...PMC3644007

erosion mesh POP complication

shared by Nathan Goodyear on 07 Aug 16 - No Cached
  • Nathan Goodyear on 07 Aug 16
     
    Maude database has erosions as the highest reported complication.
Nathan Goodyear

http://journals.sagepub.com/doi/pdf/10.1177/1534735410369673 - 0 views

journals.sagepub.com/...1534735410369673

mistletoe cancer

shared by Nathan Goodyear on 21 Jun 18 - No Cached
  • Nathan Goodyear on 21 Jun 18
     
    Mistletoe improves QOL in database review.
Nathan Goodyear

Huperzine A for Alzheimer's disease. [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18425924

alzheimer disease Alzheimer's disease Alzheimer's Huperzine-A memory cognition

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    Review of 6 trials on 454 patients found Huperzine A improved cognition and executive function with no serious adverse events in patients with Alzheimer's disease.  Yet, their conclusion is, "...inadequate evidence to make any recommendation..."   Does it improve executive cognitive function?   Yes.  Does in have serious side effects?  No.  And we are waiting on...?
Nathan Goodyear

Vitamin B for treating peripheral... [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18646107

B vitamins peripheral neuropathy neuropathy Vitamin B vitamins B

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Cochrane review did show that B vitamins improve peripheral neuropathy; though less than alpha lipoic acid.  And B vitamins are well tolerated.
Nathan Goodyear

Vaccines for preventing influenza... [Cochrane Database Syst Rev. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16437500

flu influenza vaccine vaccination children pediatrics

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    Review of studies involving over 260,000 children finds that flu vaccine provides no benefit to children under the age of 2.
Nathan Goodyear

Vaccines for preventing influenza... [Cochrane Database Syst Rev. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20614424

influenza vaccines flu adults prevention

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    Flu vaccines only found to have modest effect in adults.  Conclusion: "there is no evidence that they affect complications, such as pneumonia, or transmission".
Nathan Goodyear

Vaccines for preventing influenza... [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18425905

flu influenza children pediatrics vaccine vaccination vaccines prevention

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    2008 cochrane review again finds no benefit of flu vaccine for children under the age of 2.  Addtionally, the study finds only 1 "inactivated" vaccine in the review of 51 studies.  The other vaccines then are obviously not "inacivated".  All this when this review and a 2006 review found no benefit in children under the age of 2.  Are we really helping our children with this?
Nathan Goodyear

Vitamin D supplementation for pre... [Cochrane Database Syst Rev. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21735411

Vitamin-D D3 D2 mortality vitamin

shared by Nathan Goodyear on 30 Nov 11 - No Cached
  • Nathan Goodyear on 30 Nov 11
     
    6% relative risk reduction in mortality with vitamin D3 vs. 2% relative risk increase with vitamin D2.
Nathan Goodyear

Progesterone for acute traumatic ... [Cochrane Database Syst Rev. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21249708

progesterone BHRT bioidentical TBI hormone hormones brain injury natural

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • Nathan Goodyear on 18 Jan 12
     
    significant improvement found in 3 studies that looked at progesterone in people with acute traumatic brain injuries. 
Nathan Goodyear

METHYLISOTHIAZOLINONE || Skin Deep® Cosmetics Database | Environmental Workin... - 0 views

www.ewg.org/...METHYLISOTHIAZOLINONE

methylisothiazolinone MI

shared by Nathan Goodyear on 15 Jul 13 - No Cached
  • Nathan Goodyear on 15 Jul 13
     
    good data review on methylisothiazolinone. Also known as MI for short.
Nathan Goodyear

European Journal of Clinical Nutrition - Table 1 for article: Identification of the 100... - 0 views

www.nature.com/...ejcn2010221t1.html

polyphenols nutrition antioxidants

shared by Nathan Goodyear on 29 Sep 15 - No Cached
  • Nathan Goodyear on 29 Sep 15
     
    top food sources for polyphenols
Nathan Goodyear

ATSDR Home - 0 views

www.atsdr.cdc.gov

ATSDR environmental toxins database health Environment toxic reference

shared by Nathan Goodyear on 26 Feb 11 - Cached
  • Nathan Goodyear on 26 Feb 11
     
    great resource for environmental toxins
Nathan Goodyear

Nutrients | Free Full-Text | Vitamin C Status Correlates with Markers of Metabolic and ... - 0 views

www.mdpi.com/...htm

vitamin C health cognition

shared by Nathan Goodyear on 28 Feb 18 - No Cached
  • vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
  • Hypovitaminosis C (defined as a plasma concentration ≤23 µmol/L)
  • The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
  • ...17 more annotations...
  • The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
  • inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
  • adequate plasma levels (i.e., >50 µmol/L)
  • Higher plasma vitamin C status was associated with lower weight, BMI and waist circumference
  • plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
  • No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
  • 2.4% of 50-year-olds were deficient in vitamin C (i.e., <11 µmol/L)
  • hypovitaminosis C (i.e., <23 µmol/L)
  • A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
  • The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
  • higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
  • A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
  • In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
  • The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
  • Vitamin C is present at very high concentrations in the brain
  • animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
  • A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
  • Nathan Goodyear on 28 Feb 18
     
    New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue.  Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.
Nathan Goodyear

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde... - 0 views

www.hindawi.com/...360438

MDA malondialdehyde peroxidation oxidative stress free radicals

shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Hydroxyl radicals cause oxidative damage to cells because they unspecifically attack biomolecules [22] located less than a few nanometres from its site of generation and are involved in cellular disorders such as neurodegeneration [23, 24], cardiovascular disease [25], and cancer [26, 27].
  • It is generally assumed that in biological systems is formed through redox cycling by Fenton reaction, where free iron (Fe2+) reacts with hydrogen peroxide (H2O2) and the Haber-Weiss reaction that results in the production of Fe2+ when superoxide reacts with ferric iron (Fe3+)
  • other transition-metal including Cu, Ni, Co, and V can be responsible for formation in living cells
  • ...20 more annotations...
  • The hydroperoxyl radical () plays an important role in the chemistry of lipid peroxidation
  • The is a much stronger oxidant than superoxide anion-radical
  • Lipid peroxidation can be described generally as a process under which oxidants such as free radicals or nonradical species attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs) that involve hydrogen abstraction from a carbon, with oxygen insertion resulting in lipid peroxyl radicals and hydroperoxides as described previously
  • under medium or high lipid peroxidation rates (toxic conditions) the extent of oxidative damage overwhelms repair capacity, and the cells induce apoptosis or necrosis programmed cell death
  • The overall process of lipid peroxidation consists of three steps: initiation, propagation, and termination
  • Once lipid peroxidation is initiated, a propagation of chain reactions will take place until termination products are produced.
  • The main primary products of lipid peroxidation are lipid hydroperoxides (LOOH)
  • Among the many different aldehydes which can be formed as secondary products during lipid peroxidation, malondialdehyde (MDA), propanal, hexanal, and 4-hydroxynonenal (4-HNE) have been extensively studied
  • MDA has been widely used for many years as a convenient biomarker for lipid peroxidation of omega-3 and omega-6 fatty acids because of its facile reaction with thiobarbituric acid (TBA)
  • MDA is one of the most popular and reliable markers that determine oxidative stress in clinical situations [53], and due to MDA’s high reactivity and toxicity underlying the fact that this molecule is very relevant to biomedical research community
  • 4-HNE is considered as “second toxic messengers of free radicals,” and also as “one of the most physiologically active lipid peroxides,” “one of major generators of oxidative stress,” “a chemotactic aldehydic end-product of lipid peroxidation,” and a “major lipid peroxidation product”
  • MDA is an end-product generated by decomposition of arachidonic acid and larger PUFAs
  • Identifying in vivo MDA production and its role in biology is important as indicated by the extensive literature on the compound (over 15 800 articles in the PubMed database using the keyword “malondialdehyde lipid peroxidation” in December 2013)
  • MDA reactivity is pH-dependent
  • When pH decreases MDA exists as beta-hydroxyacrolein and its reactivity increases
  • MAA adducts are shown to be highly immunogenic [177–181]. MDA adducts are biologically important because they can participate in secondary deleterious reactions (e.g., crosslinking) by promoting intramolecular or intermolecular protein/DNA crosslinking that may induce profound alteration in the biochemical properties of biomolecules and accumulate during aging and in chronic diseases
  • MDA is an important contributor to DNA damage and mutation
  • This MDA-induced DNA alteration may contribute significantly to cancer and other genetic diseases.
  • Dietary intake of certain antioxidants such as vitamins was associated with reduced levels of markers of DNA oxidation (M1dG and 8-oxodG) measured in peripheral white blood cells of healthy subjects, which could contribute to the protective role of vitamins on cancer risk
  • 4-HNE is an extraordinarily reactive compound
  • Nathan Goodyear on 05 Dec 17
     
    Great review of lipid peroxidation
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