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Nathan Goodyear

Microalbuminuria: causes and implications - 0 views

www.ncbi.nlm.nih.gov/...PMC3178015

microalbumin disease CVD cardiovascular disease

shared by Nathan Goodyear on 14 Mar 17 - No Cached
  • Nathan Goodyear on 14 Mar 17
     
    good review of microalbumin
Nathan Goodyear

Hormone Replacement Therapy Associated with Lower Mortality - American College of Cardi... - 0 views

www.acc.org/...ssociated-with-lower-mortality

HRT hormone replacement therapy hormones menopause atherosclerosis cardiovascular disease hormone therapy

shared by Nathan Goodyear on 22 Mar 17 - No Cached
  • Nathan Goodyear on 22 Mar 17
     
    Just a press release of yet to be published study that finds women on HRT have lower atherosclerosis, calcium score, and death than younger women not on HRT.
Nathan Goodyear

Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipopr... - 0 views

www.ncbi.nlm.nih.gov/...24075767

Mediterranean diet nuts nutrition waist circumference LDL particle number lipoproteins cardiovascular disease

shared by Nathan Goodyear on 29 Aug 17 - No Cached
  • Nathan Goodyear on 29 Aug 17
     
    Mediterranean diet with added mixed nuts reduced atherogenic lipoprotein profile: decreased LDL particle number, increased LDL particle size...Even reduced waist circumference.
Nathan Goodyear

Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet - 0 views

www.ncbi.nlm.nih.gov/...PMC3005482

cardiovascular disease Mediterranean diet diabetes nutrition insulin resistance inflammation

shared by Nathan Goodyear on 29 Aug 17 - No Cached
  • Nathan Goodyear on 29 Aug 17
     
    Mediterranean diet + EVOO or + nuts reduced diabetes risk those in high risk by 52%.  This was a 4 year f/u study.  A reduction of circulating inflammatory biomarkers was also noted.  Insulin resistance was noted to be improved as early as 3 months, but weight was not changed statistically throughout this study
Nathan Goodyear

Vegetarian Diets and Blood Pressure: Meta-analysis | Cardiology | JAMA Internal Medicin... - 0 views

jamanetwork.com/...1832195

vegetarian blood pressure hypertension CVD cardiovascular disease diet

shared by Nathan Goodyear on 14 Aug 17 - No Cached
  • Nathan Goodyear on 14 Aug 17
     
    vegetarian diet lowers blood pressure by 4.8 mmHg to 6.9 mmHg in meta-analysis.
Nathan Goodyear

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde... - 0 views

www.hindawi.com/...360438

MDA malondialdehyde peroxidation oxidative stress free radicals

shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Hydroxyl radicals cause oxidative damage to cells because they unspecifically attack biomolecules [22] located less than a few nanometres from its site of generation and are involved in cellular disorders such as neurodegeneration [23, 24], cardiovascular disease [25], and cancer [26, 27].
  • It is generally assumed that in biological systems is formed through redox cycling by Fenton reaction, where free iron (Fe2+) reacts with hydrogen peroxide (H2O2) and the Haber-Weiss reaction that results in the production of Fe2+ when superoxide reacts with ferric iron (Fe3+)
  • other transition-metal including Cu, Ni, Co, and V can be responsible for formation in living cells
  • ...20 more annotations...
  • The hydroperoxyl radical () plays an important role in the chemistry of lipid peroxidation
  • The is a much stronger oxidant than superoxide anion-radical
  • Lipid peroxidation can be described generally as a process under which oxidants such as free radicals or nonradical species attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs) that involve hydrogen abstraction from a carbon, with oxygen insertion resulting in lipid peroxyl radicals and hydroperoxides as described previously
  • under medium or high lipid peroxidation rates (toxic conditions) the extent of oxidative damage overwhelms repair capacity, and the cells induce apoptosis or necrosis programmed cell death
  • The overall process of lipid peroxidation consists of three steps: initiation, propagation, and termination
  • Once lipid peroxidation is initiated, a propagation of chain reactions will take place until termination products are produced.
  • The main primary products of lipid peroxidation are lipid hydroperoxides (LOOH)
  • Among the many different aldehydes which can be formed as secondary products during lipid peroxidation, malondialdehyde (MDA), propanal, hexanal, and 4-hydroxynonenal (4-HNE) have been extensively studied
  • MDA has been widely used for many years as a convenient biomarker for lipid peroxidation of omega-3 and omega-6 fatty acids because of its facile reaction with thiobarbituric acid (TBA)
  • MDA is one of the most popular and reliable markers that determine oxidative stress in clinical situations [53], and due to MDA’s high reactivity and toxicity underlying the fact that this molecule is very relevant to biomedical research community
  • 4-HNE is considered as “second toxic messengers of free radicals,” and also as “one of the most physiologically active lipid peroxides,” “one of major generators of oxidative stress,” “a chemotactic aldehydic end-product of lipid peroxidation,” and a “major lipid peroxidation product”
  • MDA is an end-product generated by decomposition of arachidonic acid and larger PUFAs
  • Identifying in vivo MDA production and its role in biology is important as indicated by the extensive literature on the compound (over 15 800 articles in the PubMed database using the keyword “malondialdehyde lipid peroxidation” in December 2013)
  • MDA reactivity is pH-dependent
  • When pH decreases MDA exists as beta-hydroxyacrolein and its reactivity increases
  • MAA adducts are shown to be highly immunogenic [177–181]. MDA adducts are biologically important because they can participate in secondary deleterious reactions (e.g., crosslinking) by promoting intramolecular or intermolecular protein/DNA crosslinking that may induce profound alteration in the biochemical properties of biomolecules and accumulate during aging and in chronic diseases
  • MDA is an important contributor to DNA damage and mutation
  • This MDA-induced DNA alteration may contribute significantly to cancer and other genetic diseases.
  • Dietary intake of certain antioxidants such as vitamins was associated with reduced levels of markers of DNA oxidation (M1dG and 8-oxodG) measured in peripheral white blood cells of healthy subjects, which could contribute to the protective role of vitamins on cancer risk
  • 4-HNE is an extraordinarily reactive compound
  • Nathan Goodyear on 05 Dec 17
     
    Great review of lipid peroxidation
Nathan Goodyear

ApoB but not LDL-cholesterol is reduced by exercise training in overweight healthy men.... - 0 views

www.ncbi.nlm.nih.gov/...17645591

apo B Apolipoprotein B exercise cardiovascular death

shared by Nathan Goodyear on 13 Dec 17 - No Cached
  • Nathan Goodyear on 13 Dec 17
     
    exercise in overweight, otherwise healthy men reduced ApoB.
Nathan Goodyear

Nutrigenomics of extra-virgin olive oil: A review - Piroddi - 2016 - BioFactors - Wiley... - 0 views

onlinelibrary.wiley.com/...full

olive oil nutrigenomics epigenetics nutrition CVD cardiovascular disease

shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Nathan Goodyear on 05 Dec 17
     
    Great review on the nutrigenomics of Olive oil.
Nathan Goodyear

Hypercholesterolemia and apolipoprotein B expression: Regulation by selenium status | L... - 0 views

lipidworld.biomedcentral.com/...1476-511X-4-28

selenium Apolipoprotein B apo B cardiovascular disease

shared by Nathan Goodyear on 18 Dec 17 - No Cached
  • Nathan Goodyear on 18 Dec 17
     
    study finds selenium and apoB inversely related.
Nathan Goodyear

Ascorbic Acid-Induced Modulation of Venous Tone in Humans | Hypertension - 0 views

hyper.ahajournals.org/...949

vitamin C IV vitamin C hypertension blood pressure cardiovascular disease CVD

shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Nathan Goodyear on 20 Dec 17
     
    Acute vasodilation with IV vitamin C found to be independent of NO.
Nathan Goodyear

Endothelium and control of vascular function. State of the Art lecture. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2661425

vitamin C NO nitric oxide blood pressure CV cardiovascular disease hypertension endothelium

shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Nathan Goodyear on 20 Dec 17
     
    vitamin C, absorbed via the endothelium, increases NO.  This will have a positive effect in lowering the blood pressure.
Nathan Goodyear

The acute effect of high-dose intravenous vitamin C and other nutrients on blood pressu... - 0 views

www.ncbi.nlm.nih.gov/...PMC4864764

vitamin C IV vitamin C hypertension vitamin B12 blood pressure cardiovascular disease CVD

shared by Nathan Goodyear on 14 Aug 17 - No Cached
  • the reduction in BP within the first 10–20 min may be primarily attributed to a direct vasodilatory physiological effect, described as venodilation
  • BP reduction observed after 70–90 min is likely attributable to pharmacokinetically plausible vitamin C absorption and vasodilation because of nitric oxide release
  • Pharmacokinetic studies of IVC administration observed peak plasma levels within the first 90 min, with plasma levels reaching 13350 μmol/l for 50 g of IVC
  • ...6 more annotations...
  • Essential hypertension, associated with endothelial dysfunction because of an impaired nitric oxide/l-arginine pathway and impaired vasodilation can be restored by vitamin C
  • marked increase in BP response when IVB12 is administered
  • The mean BP increased significantly up to 12–16 mmHg systolic and diastolic independent of the dosage of vitamin B12
  • The production of norepinephrine, which can stimulate angiotensin-II production, which in turn influences BP, has been suggested as a possible mechanism for the increase in BP with IVB12
  • excess norephinephrine levels stimulate the sympathetic nervous system, leading to increased cortisol production, which has also been linked to increases in BP
  • Animal studies have found higher serum levels of norepinephrine (noradrenaline) in the adrenal medulla of rats receiving methylcobalamin (methyl-vitamin B12)
  • Nathan Goodyear on 14 Aug 17
     
    IV vitamin C in mostly normotensive patients (> 30 grams) reduced blood pressure.  Some of the patients were pre-hypertensive. Vitamin B12 increase the blood pressure.
Nathan Goodyear

Statins use and coronary artery plaque composition: Results from the International Mult... - 0 views

www.ncbi.nlm.nih.gov/...PMC4277888

statin statins plaque CAD coronary artery disease coronary artery calcium cardiovascular disease

shared by Nathan Goodyear on 17 Oct 17 - No Cached
  • Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium
  • As compared with individuals not taking statins, those taking statins possessed a significantly higher prevalence of obstructive CAD, as well as higher numbers of vessels with obstructive CAD
  • non-calcified plaques (NCP)
  • ...11 more annotations...
  • non-calcified (NCP), mixed (MP), or calcified (CP) plaque
  • statin use was each associated with a significantly higher prevalence of NCP, MP and CP
  • statin use was associated with increased presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27–1.68, p < 0.001] and CP (OR 1.54, 95% CI 1.36–1.74, p < 0.001], but not NCP
  • statin use was associated with increasing numbers of coronary segments possessing MP and CP but not associated with increasing numbers of coronary segments possessing NCP
  • North America, Europe and Asia
  • A total of 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) comprised the study population
  • we identified a strong association of statin use to coronary artery plaque features
  • statin use was associated with a differentially increased prevalence and extent of MP and CP
  • one potential unifying hypothesis is that rather than regression of coronary plaque, statins may contribute to the conversion of coronary plaque constituents, perhaps by conversion of NCP to plaque possessing calcium
  • Coronary computed tomographic angiography (CCTA)
  • Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive CAD
  • Nathan Goodyear on 17 Oct 17
     
    Study finds statin therapy associated with increased coronary plaque with calcium.
golibeetscardio

Goli Nutrition Beets Cardio Gummies- Goli Beets Cardio Gummies, Reviews! - 1 views

https://goli-beets-cardio-gummies.company.site/ Goli Nutrition Beets Cardio Gummies Goli Beets Cardio Gummies Goli Beets Cardio Gummies Reviews ➢Direct purchase ➠Click here ➢ Product name ➠Go...

started by golibeetscardio on 05 Aug 23 no follow-up yet
Nathan Goodyear

Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic pat... - 0 views

bmccardiovascdisord.biomedcentral.com/...s12872-017-0560-z

cancer red yeast rice simvastatin

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • Nathan Goodyear on 01 Sep 23
     
    Less side effects with red yeast rice.
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