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Nathan Goodyear

Effects of Simvastatin and Oral Contraceptive Agent on Polycystic Ovary Syndrome: Prosp... - 0 views

jcem.endojournals.org/...456.full

simvastatin low T testosterone PCOS hyerplipidemia statins statin therapy

shared by Nathan Goodyear on 28 Oct 11 - No Cached
  • Nathan Goodyear on 28 Oct 11
     
    simvastatin, a cholesterol lowering drug, shown to decrease testosterone by 38% in women with PCOS. This supports what has been seen in men on statin therapy.
Nathan Goodyear

Resveratrol Plus Simvastatin Are Effective in Decreasing IgM Secretion in Asymptomatic ... - 0 views

www.bloodjournal.org/...4401

Waldenstrom lymphoma "waldenstrom's macroglobulinemia" Cancer resveratrol simvastatin

shared by Nathan Goodyear on 30 Oct 18 - No Cached
  • Nathan Goodyear on 30 Oct 18
     
    Resveratrol and Simvastatin found to be helpful in lowering IgM levels in Asymptomatic patients with Waldenstrom's lymphoma
Nathan Goodyear

Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic pat... - 0 views

bmccardiovascdisord.biomedcentral.com/...s12872-017-0560-z

cancer red yeast rice simvastatin

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • Nathan Goodyear on 01 Sep 23
     
    Less side effects with red yeast rice.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

content.onlinejacc.org/article.aspx

statin therapy statins CoQ10 mitochondria

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    Small study, but well designed study shows that statins inhibit CoQ10 mediated oxidative phosphorylation through decrease in CoQ10.  This points directly at a decrease in mitochondrial function as a result of statin therapy.
Nathan Goodyear

The Effect of Simvastatin on Plasma Steroid Hormone Levels in Metformin-Treated Women w... - 0 views

www.ncbi.nlm.nih.gov/...26824284

statins statin therapy Testosterone androgens DHEA hormones women CAH

shared by Nathan Goodyear on 02 Feb 16 - No Cached
  • Nathan Goodyear on 02 Feb 16
     
    Statins are known to reduce Testosterone in men; new study finds statins reduce all androgens in women.
Nathan Goodyear

Statin use and risk of diabetes mellitus - 0 views

www.ncbi.nlm.nih.gov/...PMC4360430

statin statin therapy diabetes insulin resistance GLUT4 HgbA1c

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • An increase in new onset diabetes, i.e., 3% in statin arm and 2.4% in placebo arm was reported. This was accompanied by increase in median value of glycated haemoglobin and was one of the earlier studies to report the increase in new onset diabetes in patients on statins
  • Even after adjustment for potential confounders, statin therapy was associated with an increased risk of new-onset diabetes mellitus
  • Authors suggest that statin-induced diabetes mellitus is a medication class effect
  • ...10 more annotations...
  • Another study also reported that as compared to placebo, statin group showed a higher risk of physician reported incident diabetes and it was also observed that risk was higher in women as compared to men
  • Meta-analysis of randomized controlled trials by Sattar et al[25] involving 91140 non-diabetic patients showed that statin therapy was associated with 9% increased risk of incident diabetes
  • A number of studies showed dose dependent association between statin administration and incident diabetes
  • intensive dose of statins was associated with high incidence of new - onset diabetes
  • Treatment with atorvastatin and simvastatin may be associated with an increased risk of new onset diabetes as compared to pravastatin
  • Increased incidence of diabetes was seen with atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial
  • Increased insulin resistance secondary to statins was demonstrated in a prospective non randomised study in patients with coronary bypass surgery
  • downregulation of GLUT4
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Nathan Goodyear on 04 Oct 17
     
    Great review article of the increased risk of worsening insulin resistance, glycated hemoglobin, and diabetes risk.  Atorvastatin appears to be the worst culprit.  Mechanism partially through a decrease in GLUT4.
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