HERB n' CLAY provides you with 100 percent all natural Calcium Bentonite Clay. Bentonite clay has microscopic layers through which it absorbs the toxins in our bowels.
It contains silica with high traces of Calcium. In addition there are more than 50 trace elements in Calcium Bentonite Clay.
Physiologic levels of testosterone shown to induce Calcium channel blockade. This induces the beneficial cardiovascular vasodilation. It is known that testosterone binds to the same receptor as the common calcium channel blocker nifedipine.
Estradiol stimulates hypothalamic progesterone synthesis in astrocytes in rat model. This occurs through activation of calcium channels and influx of calcium. ER alpha appears to be the prominent ER involved.
Hypercalcemia of malignancy occurs as the result of direct bone metastasis and via humoral mechanisms such as parathyroid hormone-related protein (PTHrP) or 1,25-dihydroxyvitamin D mediated pathways
ectopic secretion of parathyroid hormone (PTH) has been implicated
Hypercalcemia due to osteolytic bone lesions is common in multiple myeloma, leukemia, and breast cancer
Humoral hypercalcemia is predominant in squamous cell, renal cell and ovarian cancers, and lymphomas are associated with 1,25-dihydroxyvitamin D mediated hypercalcemia
20% of cases of hypercalcemia of malignancy and is frequently encountered in multiple myeloma, metastatic breast cancer, and to a lesser extent in leukemia and lymphoma
Physiologic bone turnover requires the complementary activity of osteoblasts – mesenchymal stem cell-derived bone-forming cells – and bone-resorbing cells of monocyte and macrophage lineage known as osteoclasts
In local osteolytic hypercalcemia, the RANKL/RANK interaction results in excessive osteoclast activation leading to enhanced bone resorption and thus hypercalcemia
In addition, osteoclast activation is also mediated by malignancy secreted cytokines, including interleukin-1, initially termed “osteoclast stimulating factor”
Macrophage inflammation protein 1-alpha (MIP 1-alpha)
hypercalcemia is through extra-renal 1,25-dihydroxyvitamin D (calcitriol) production
1% of cases
increased production of 1,25-dihydroxyvitamin D occurs nearly exclusively in Hodgkin and non-Hodgkin lymphoma with case reports of the same in ovarian dysgerminoma
1-α-hydroxylase in the kidney, a process regulated by PTH
in 1,25-dihydroxyvitamin D induced hypercalcemia, malignant cells likely recruit and induce adjacent macrophages to express 1-α-hydroxylase, converting endogenous calcidiol into calcitriol.31 Calcitriol then binds to receptors in the intestine leading to heightened enteric calcium reabsorption with resultant hypercalcemia
this mechanism of disease is best conceptualized as an absorptive form of hypercalcemia
Ectopic production of PTH by malignant cells has been described in a handful of cases involving cancer of the ovary and lung, as well as neuroendocrine tumors and sarcoma
primary hyperparathyroidism and malignancy comprising nearly 90% of cases of hypercalcemia
an initial panel consisting of PTH, PTHrP, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D should be obtained
Lymphoma, a hypercalcemia due to 1,25-dihydroxyvitamin D mediated pathways, is implied by elevations in 1,25-dihydroxyvitamin D without concomitant elevations in 25-hydroxyvitamin D. In such cases, PTH is low and PTHrP undetectable
Treatment of hypercalcemia of malignancy is aimed at lowering the serum calcium concentration by targeting the underlying disease, specifically by inhibiting bone resorption, increasing urinary calcium excretion, and to a lesser extent by decreasing intestinal calcium absorption
mildly symptomatic disease
marked symptoms
hydration with isotonic fluid (if admitted), avoidance of thiazide diuretics, and a low-calcium diet
denosumab
Denosumab is an RANKL antibody that inhibits osteoclast maturation, activation, and function
Bentonite clay is also known as Healing Clay which has a high concentration of minerals including silica, calcium, magnesium, sodium, iron, and potassium. You can even drink or eat calcium bentonite clay to receive all of its fantastic health benefits. Learn how to detox with bentonite clay.
Calcium increases cardiovascular events in postmenopausal women. Levels must be checked for any nutrient prior to starting therapy to ensure appropriate therapy.
Until well designed, well executed, and well analyzed studies demonstrate a net benefit in morbidity, mortality, and cost, recommendations supporting the widespread use of calcium supplementation remain belief-based and not evidence-based
Clay has always been known for its versatility since ancient times, but right now, it is rage. Clay, especially Calcium Bentonite Clay has medical, therapeutic as well as cosmetic uses. Clay is very beneficial for detoxifying the body inside-out, as it also helps in aiding digestive problems.
Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium
As compared with individuals not taking statins, those taking statins possessed a significantly higher prevalence of obstructive CAD, as well as higher numbers of vessels with obstructive CAD
non-calcified (NCP), mixed (MP), or calcified (CP) plaque
statin use was each associated with a significantly higher prevalence of NCP, MP and CP
statin use was associated with increased presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27–1.68, p < 0.001] and CP (OR 1.54, 95% CI 1.36–1.74, p < 0.001], but not NCP
statin use was associated with increasing numbers of coronary segments possessing MP and CP but not associated with increasing numbers of coronary segments possessing NCP
North America, Europe and Asia
A total of 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) comprised the study population
we identified a strong association of statin use to coronary artery plaque features
statin use was associated with a differentially increased prevalence and extent of MP and CP
one potential unifying hypothesis is that rather than regression of coronary plaque, statins may contribute to the conversion of coronary plaque constituents, perhaps by conversion of NCP to plaque possessing calcium
Coronary computed tomographic angiography (CCTA)
Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive CAD
The androgens testosterone and DHT elicit vasodilation via calcium and potassium channel activation. The vasodilatory effect of the androgens is through, in part, due to K activated Ca channels. Also of note, DHT had the same effect and DHT cannot be aromatized to estrogen.