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Nathan Goodyear

Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex - App... - 0 views

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    exercise found to reduce glutamate excitotoxicity in mouse study.
Nathan Goodyear

Cognition, mood, and physiological concentrations of sex hormones in the early and late... - 0 views

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    Medical dogma tells us that menopause is simply an estrogen deficiency.  This new study points to correlation between progesterone decline and cognitive decline in menopausal women.
Nathan Goodyear

Wiley: Regular Exercise May Boost Brain Health in Adults - 0 views

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    Study finds that exercise increases cognitive function through increased blood flow in brain.  This study only looked at women.  Now we know why we do our best thinking when we exercise.
Nathan Goodyear

Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot tr... - 0 views

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    Human study: creatine helpful in Parkinson's disease.  Of note, less dopaminergic support was needed with creatine supplementation.
Nathan Goodyear

Creatine supplementation lowers brain glutamate levels in Huntington's disease. - PubMe... - 0 views

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    Creatine helpful in decreasing glutamate levels in Huntington's disease.
Nathan Goodyear

Vitamin E Protects Against Oxidative Damage and Learning Disability After Mild Traumati... - 0 views

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    Animal study: vitamin E protects against mild TBI
Nathan Goodyear

https://www.cns.org/sites/default/files/clinical_neuro/Chapter18_0.pdf - 0 views

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    Human study: High dose IV vitamin C and IM vitamin E shown to improve outcome.
Nathan Goodyear

Time-level relationship for lipid peroxidation and the protective effect of alpha-tocop... - 0 views

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    Animal study: vitamin E (alpha tocopherol only therapy) protected against lipid oxidation in mild and severe TBI.
Nathan Goodyear

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following ... - 0 views

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    animal model: vitamin E reduced brain lipid oxidation post TBI.
Nathan Goodyear

Targeting Dopamine in Acute Traumatic Brain Injury - 0 views

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    great read on the current understanding of dopamine in TBI--essentially an excitotoxic story.
Nathan Goodyear

Neuroprotective and disease-modifying effects of the ketogenic diet - 0 views

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    great review of the ketogenic diet in neuroprotective and treatment of excitotoxic disease.
Nathan Goodyear

Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain Injury - 0 views

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    DHA plays important role in TBI risk and recovery.
Nathan Goodyear

A combination of green tea extract and l-theanine improves memory and attention in subj... - 0 views

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    combination of l-Theanine and EGCT improve cognition.
Nathan Goodyear

Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dys... - 0 views

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    study proposes that arachidonic acid and DHA improve cognition in individuals with age related cognition changes and organic brain damage (Alzheimer's, brain lesions...)
Nathan Goodyear

Tissue levels of polyunsaturated fatty acids during early human development. - PubMed -... - 0 views

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    DHA is the most abundant polyunsaturated fatty acid.
Nathan Goodyear

Neurological benefits of omega-3 fatty acids. - PubMed - NCBI - 0 views

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    EPA/DHA are highly concentrated in neuronal synapse.
Nathan Goodyear

Stuck at the bench: Potential natural neuroprotective compounds for concussion - 0 views

  • Long-chain polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are highly enriched in neuronal synaptosomal plasma membranes and vesicles
  • The predominant CNS polyunsaturated fatty acid is DHA
  • effective supplementation and/or increased ingestion of dietary sources rich in EPA and DHA, such as cold-water fish species and fish oil, may help improve a multitude of neuronal functions, including long-term potentiation and cognition.
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  • multiple preclinical studies have suggested that DHA and/or EPA supplementation may have potential benefit through a multitude of diverse, but complementary mechanisms
  • pre-injury dietary supplementation with fish oil effectively reduces post-traumatic elevations in protein oxidation
  • The benefits of pre-traumatic DHA supplementation have not only been independently confirmed,[] but DHA supplementation has been shown to significantly reduce the number of swollen, disconnected and injured axons when administered following traumatic brain injury.
  • DHA has provided neuroprotection in experimental models of both focal and diffuse traumatic brain injury
  • potential mechanisms of neuroprotection, in addition to DHA and EPA's well-established anti-oxidant and anti-inflammatory properties
  • Despite abundant laboratory evidence supporting its neuroprotective effects in experimental models, the role of dietary DHA and/or EPA supplementation in human neurological diseases remains uncertain
  • Several population-based, observational studies have suggested that increased dietary fish and/or omega-3 polyunsaturated fatty acid consumption may reduce risk for ischemic stroke in several populations
  • Randomized control trials have also demonstrated significant reductions in ischemic stroke recurrence,[] relative risk for ischemic stroke,[] and reduced incidence of both symptomatic vasospasm and mortality following subarachnoid hemorrhage
  • Clinical trials in Alzheimer's disease have also been largely ineffective
  • The clinical evidence thus far appears equivocal
  • curcumin has gained much attention from Western researchers for its potential therapeutic benefits in large part due to its potent anti-oxidant[,,] and anti-inflammatory properties
  • Curcumin is highly lipophilic and crosses the blood-brain barrier enabling it to exert a multitude of different established neuroprotective effects
  • in the context of TBI, a series of preclinical studies have suggested that pre-traumatic and post-traumatic curcumin supplementation may bolster the brain's resilience to injury and serve as a valuable therapeutic option
  • Curcumin may confer significant neuroprotection because of its ability to act on multiple deleterious post-traumatic, molecular cascades
  • studies demonstrated that both pre- and post-traumatic curcumin administration resulted in a significant reduction of neuroinflammation via inhibition of the pro-inflammatory molecules interleukin 1β and nuclear factor kappa B (NFκB)
  • no human studies have been conducted with respect to the effects of curcumin administration on the treatment of TBI, subarachnoid or intracranial hemorrhage, epilepsy or stroke
  • studies have demonstrated that resveratrol treatment reduces brain edema and lesion volume, as well as improves neurobehavioral functional performance following TBI
  • green tea consumption or supplementation with its derivatives may bolster cognitive function acutely and may slow cognitive decline
  • At least one population based study, though, did demonstrate that increased green tea consumption was associated with a reduced risk for Parkinson's disease independent of total caffeine intake
  • a randomized, placebo-controlled trial demonstrated that administration of green tea extract and L-theanine, over 16 weeks of treatment, improved indices of memory and brain theta wave activity on electroencephalography, suggesting greater cognitive alertness
  • Other animal studies have also demonstrated that theanine, another important component of green tea extract, exerts a multitude of neuroprotective benefits in experimental models of ischemic stroke,[,] Alzheimer's disease,[] and Parkinson's disease
  • Theanine, like EGCG, contains multiple mechanisms of neuroprotective action including protection from excitotoxic injury[] and inhibition of inflammation
  • potent anti-oxidant EGCG which is capable of crossing the blood-nerve and blood-brain barrier,
  • Epigallocatechin-3-gallate also displays neuroprotective properties
  • More recent research has suggested that vitamin D supplementation and the prevention of vitamin D deficiency may serve valuable roles in the treatment of TBI and may represents an important and necessary neuroprotective adjuvant for post-TBI progesterone therapy
  • Progesterone is one of the few agents to demonstrate significant reductions in mortality following TBI in human patients in preliminary trials
  • in vitro and in vivo studies have suggested that vitamin D supplementation with progesterone administration may significantly enhance neuroprotection
  • Vitamin D deficiency may increase inflammatory damage and behavioral impairment following experimental injury and attenuate the protective effects of post-traumatic progesterone treatment.[]
  • emerging evidence has suggested that daily intravenous administration of vitamin E following TBI significantly decreases mortality and improves patient outcomes
  • high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment
  • it has been speculated that combined vitamin C and E therapy may potentiate CNS anti-oxidation and act synergistically with regards to neuroprotection
  • one prospective human study has found that combined intake of vitamin C and E displays significant treatment interaction and reduces the risk of stroke
  • Pycnogenol has demonstrated the ability to slow or reduce the pathological processes associated with Alzheimer's disease
  • Pcynogenol administration, in a clinical study of elderly patients, led to improved cognition and reductions in markers of lipid peroxidase
  • One other point of consideration is that in neurodegenerative disease states like Alzheimer's disease and Parkinson's disease, where there are high levels of reactive oxygen species generation, vitamin E can tend to become oxidized itself. For maximal effectiveness and to maintain its anti-oxidant capacity, vitamin E must be given in conjunction with other anti-oxidants like vitamin C or flavonoids
  • These various factors might account for the null effects of alpha-tocopherol supplementation in patients with MCI and Alzheimer's disease
  • preliminary results obtained in a pediatric population have suggested that post-traumatic oral creatine administration (0.4 g/kg) given within four hours of traumatic brain injury and then daily thereafter, may improve both acute and long-term outcomes
  • Acutely, post-traumatic creatine administration seemed to reduce duration of post-traumatic amnesia, length of time spent in the intensive care unit, and duration of intubation
  • At three and six months post-injury, subjects in the creatine treatment group demonstrated improvement on indices of self care, communication abilities, locomotion, sociability, personality or behavior and cognitive function when compared to untreated controls
  • patients in the creatine-treatment group were less likely to experience headaches, dizziness and fatigue over six months of follow-up
  • CNS creatine is derived from both its local biosynthesis from the essential amino acids methionine, glycine and arginine
  • Studies of patients with CNS creatine deficiency and/or murine models with genetic ablation of creatine kinase have consistently demonstrated significant neurological impairment in the absence of proper creatine, phosphocreatine, or creatine kinase function; thus highlighting its functional importance
  • chronic dosing may partially reverse neurological impairments in human CNS creatine deficiency syndromes
  • Several studies have suggested that creatine supplementation may also reduce oxidative DNA damage and brain glutamate levels in Huntington disease patients
  • Another study highlighted that creatine supplementation marginally improved indices of mood and reduced the need for increased dopaminergic therapy in patients with Parkinson's disease
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    great review of natural therapies in the treatment of concussions
Nathan Goodyear

Diminished brain resilience syndrome: A modern day neurological pathology of increased ... - 0 views

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    concussions
Nathan Goodyear

Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic... - 0 views

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    Proof of concept study in Alzheimer's model finds high fat diet improves brain cholinergic synapses, targeting directly the neurotransmission deficits in Alzheimer's disease
Nathan Goodyear

Hypopituitarism after traumatic brain injury. - PubMed - NCBI - 0 views

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    TBI results in isolated or complete pituitary failure (PTHP) in up to 40% of those with TBI.  
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