Skip to main content

Home/ Seasons Wellness/ Group items tagged brain

Rss Feed Group items tagged

Nathan Goodyear

Minimal Penetration of Lipopolysaccharide Across the Murine Blood-brain Barrier - 0 views

  •  
    Study finds very small % of LPS actually is able to penetrate BBB, yet based on other studies, this is enough to trigger microglial activation and damage/death to astrocytes and other brain cells.
Nathan Goodyear

Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cel... - 0 views

  •  
    good review of proposed mechanism of how LPS aids in cell death of astrocytes in vivo: LPS damages the endothelium of the BBB, leading to increase permeability.  This exposes astrocytes to LPS directly.  LPS suppressed genetic expression of antioxidant genes.  LPS stimulates cytokine production, including the production of H2O2 from microglial cells in the brain.  An up regulation of iNOS occurs and in the presence of weakened ability to protect against NO and its metabolites occurs.  
Nathan Goodyear

Neuroimaging of sport concussion: persistent alterations in brain structure and functio... - 0 views

  •  
    New study suggest brain healing lags far behind in concussion recovery.
Nathan Goodyear

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice: Cell Metabolism - 0 views

  •  
    study of mice finds that high fat diet changes genetic expression, epigenetics, to increase lifespan of mice by 13%.
Nathan Goodyear

Epigenetics of stress adaptations in the brain - ScienceDirect - 0 views

  •  
    Stress impacts your genome = epigenetic.
Nathan Goodyear

Amygdala - Scholarpedia - 0 views

  •  
    Great article on the amygdala and its processing of the stress response.
Nathan Goodyear

Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates p... - 0 views

  •  
    vitamin C does not cross the BBB, but its oxidize form, dehydroascorbic acid does.  This experimental model looked at IV DHA. The findings was that IV DHA resulted in higher brain C levels compared to IV vitamin C.
Nathan Goodyear

Potentiation of 17β-estradiol synthesis in the brain and elongation of seizur... - 0 views

  •  
    DHA supplementation increases brain estrogen in animal study. In this study, both blunted seizure induction in the animals. This has significant implications for DHA supplementation and dietary intake of fish high in DHA for the brain through estrogen.
Nathan Goodyear

Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT... - 0 views

  •  
    Another animal study finds CBD is neuroprotective.  This study actually found that CBD reduced excitotoxicity, inflammation, and oxidative stress.
Nathan Goodyear

Cannabidiol, neuroprotection and neuropsychiatric disorders - ScienceDirect - 0 views

  •  
    CBD is neuroprotective, neuroplastic, and neurogenic. CBD reduces oxidative stresses well.
Nathan Goodyear

Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recov... - 0 views

  •  
    CBD increases BDNF--neuroplasticity.
Nathan Goodyear

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-indu... - 0 views

  •  
    Omega 3 supplementation found to blunt microglial TBI inflammation. 
Nathan Goodyear

Review on herbal medicine on brain ischemia and reperfusion - ScienceDirect - 0 views

  •  
    Good review of a few herbal therapies and their effect on reperusion injury and oxidative stress.
Nathan Goodyear

Age-Related White Matter Changes - 0 views

  •  
    Good review of White matter changes associated with aging and associated risks and treatments.
Nathan Goodyear

White matter dementia - 0 views

  •  
    white matter dimentia
Nathan Goodyear

Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex - 0 views

  •  
    Oleic acid from olive oil found to play role in regulation of RNA transcription, even positively effecting the miR-7, a tumor suppressor.
Nathan Goodyear

Mediterranean diet, cognitive function, and dementia: a systematic review. - PubMed - NCBI - 0 views

  •  
    review finds Mediterranean diet may slow cognitive decline and decrease risk of Alzheimer's disease.
Nathan Goodyear

Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after... - 0 views

  •  
    animal study finds that HBOT reduced stroke infarct size, increased neurogenesis, increased BDNF, and reduced MPO.
Nathan Goodyear

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? - 0 views

  • Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
  • HIF-1α is the principal mediator of cellular hypoxia adaptations
  • activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
  • ...10 more annotations...
  • The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
  • Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
  • McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
  • The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
  • Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
  • To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
  • HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
  • Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
  • Hormesis
  • process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
  •  
    great review of hbot, brain injury, neuroplasticity and neurogenesis.
Nathan Goodyear

Hyperbaric oxygen therapy for traumatic brain injury - 0 views

  •  
    great review article on the positive effects of hbot in TBI
1 - 20 of 307 Next › Last »
Showing 20 items per page