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Nathan Goodyear

Testosterone therapy affects Mexican American men differently - UNT Health Science Cent... - 0 views

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    This is the public announcement of a article yet to be published.  The study, yet unread, points to increase damage to brain health in those caucasian men with oxidative stress.  This was not found in mexican-Americans.  Until I read this study, that is all I will say here.  
Nathan Goodyear

Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments b... - 0 views

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    Rat model induced inflammatory reaction in brain via LPS injection.  The result was impaired memory.  RG3 from panax ginseng was shown to reduce inflammation, TNF-alpha, IL-1beta, cox-2, thus improving memory and cognitive function.
Nathan Goodyear

Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acry... - 0 views

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    RG3, an extract from panax ginseng, found to protect against the neurotoxin acrylamide.  

    Also of interest, is that serotonin, corticosterone, T3, T4, estradiol, progesterone and epinephrine were all decreased in this acrylamide rat model.
Nathan Goodyear

Patches of Disorganization in the Neocortex of Children with Autism - NEJM - 0 views

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    New study suggests that intra-uterine exposure effects prefrontal cortex development that leads to autism.  This study was conducted of postmortem samples of children with autism ranging from 2 to 15. Intra-pregnancy exposure of what?  That is the question.  Environmental toxins: whether it is all the xenoestrogens (autism at rate of 5:1 in boys), PCBs, heavy metals, and yes (lead author) preservatives, metals (Al and thermeresol) in vaccines--particularly the flu vaccine which ACOG is almost mandating during pregnancy.
Nathan Goodyear

The molecular basis of neurodegeneration in multiple sclerosis - 0 views

  • Inflammation is the most predominant feature during the early (relaping) phases of the disease and declines with aging of the patients and disease duration
  • in the process of oligodendrocyte destruction and demyelination in MS lesions iron is liberated from its intracellular ferritin bound stores into the extracellular space, where it is taken up by microglia and macrophages and again stored together with ferritin. When this happens in MS lesions in an environment, where free radicals are produced by oxidative burst, iron can be liberated from ferritin and transformed into reactive Fe++[114], which reacts with hydrogen peroxide to generate highly reactive hydroxyl radicals [36] and thus amplifies oxidative damage and associated cellular injury
  • anti-inflammatory or immunomodulatory treatments are effective in the relapsing stage, but the benefit is lost when the patients have entered the progressive phase
  • ...1 more annotation...
  • Inflammation will remain a key target, since the data suggest that microglia activation and oxidative burst is driven by inflammation throughout all stages of the disease.
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    Very nice review of the neurodegenerative process in MS.  
Nathan Goodyear

Progesterone neuroprotection in trauma... [Front Neuroendocrinol. 2009] - PubMed - NCBI - 0 views

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    Progesterone has a neuroprotective and promyelinating effects in the nervous system.  Progesterone increases BDNF.  Progesterone increases proliferation and differentiation of oligodendrocyte progenitor cells which will increase myelin production.
Nathan Goodyear

Oxidative damage in multiple sclerosis lesions - 0 views

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    Lesions in MS, found to have extensive oxidative damage of oligodendrocytes and neurons.
Nathan Goodyear

MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an app... - 0 views

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    Interesting study on glutathione.  The study looked at glutathione levels in the brain using MR.  The authors found lower glutathione levels in the Grey matter versus normal controls and lower glutathione levels in white matter lesions.
Nathan Goodyear

Revisiting the roles of progesterone and allo... [Prog Neurobiol. 2014] - PubMed - NCBI - 0 views

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    Only the abstract is available, but this study looks at the effects of progesterone through progesterone receptors and the progesterone metabolite allopregnanolone via the GABA A receptors in the brain.
Nathan Goodyear

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may i... - 0 views

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    Progesterone and its metabolite allopregnanolone show promise in protecting the brain in TBI.
Nathan Goodyear

Acta Pharmacologica Sinica - The neuroprotective effects of progesterone on traumatic b... - 0 views

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    Good discussion and review of progesterone's role as neuroprotective in TBI.
Nathan Goodyear

The Role of Progesterone in Traumatic Brain Injury : The Journal of Head Trauma Rehabil... - 0 views

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    Progesterone useful in inflammation reduction in Traumatic Brain Injuries.  This applies to both sexes.
Nathan Goodyear

Neurobehavioural effects of developmental toxicity : The Lancet Neurology - 0 views

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    new study out of the Lancet labels Flouride as neurotoxicant, along with lead, methyl mercury, PCBs, arsenic, toluene and others.   This is not a political issue and needs to be reviewed scientifically.  These toxicants impair neurodevelopment and may be one reason for the rapidly rising conditions associated: i.e. ADD, ADHD, autism...
Nathan Goodyear

Harriet Lane Handbook: Progesterone regulates the phosphorylation of protein phosphatas... - 0 views

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    rat model finds that progesterone effects internal cell enzyme activity.  In this case, progesterone increased PP2A in the cerebellum and in the hyippocampus.  Interesting, that E2 priming decreased the effects on the hippocampus, but not the cerebellum.  This reveals a biochemical link between sex hormones, progesterone in this case, and the brain.  Studies have shown progesterone to be neuroprotective in TBI.  This may be one mechanism.
Nathan Goodyear

Sex differences in mitochondrial biogenesis determine neuronal death and survival in re... - 0 views

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    Differences in how mitochondria in men and women handle oxidative stress.  This gives insight to how sex hormones can play a role in neurodegeneration: whether protective or destructive.
Nathan Goodyear

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1337411/pdf/cmaj00058-0090.pdf - 0 views

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    Estrogen is neuroprotective in postmenopausal women.
Nathan Goodyear

ESTROGEN SIGNALING AND NEUROPROTECTION IN CEREBRAL ISCHEMIA - 0 views

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    estradiol plays an important role in neuropreservation following cerebral ischemia.  The mechanism is through ER alpha stimulation.  The result is a reduction of ROS and oxidative stress.  This occurs through the classic intranuclear and the rapid membrane receptors as well.
Nathan Goodyear

Decreased estrogen receptor-alpha expressio... [Acta Neuropathol. 2003] - PubMed - NCBI - 0 views

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    Estrogen Receptor alpha expression is decreased in the nucleus of hippocampus in Alzheimer's disease.
Nathan Goodyear

Membrane Estrogen Receptors Stimulate Intracellular Calcium Release and Progesterone Sy... - 0 views

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    Estradiol stimulates hypothalamic progesterone synthesis in astrocytes in rat model.  This occurs through activation of calcium channels and influx of calcium.  ER alpha appears to be the prominent ER involved.
Nathan Goodyear

Lower-But-Normal Serum TSH level Is Associated With the Development or Progression of C... - 0 views

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    This study points to an association between a low-normal TSH and cognitive decline in the elderly.  An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit.  The results of this study do as well.
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