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Nathan Goodyear

Review on herbal medicine on brain ischemia and reperfusion - ScienceDirect - 0 views

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    Good review of a few herbal therapies and their effect on reperusion injury and oxidative stress.
Nathan Goodyear

Age-Related White Matter Changes - 0 views

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    Good review of White matter changes associated with aging and associated risks and treatments.
Nathan Goodyear

White matter dementia - 0 views

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    white matter dimentia
Nathan Goodyear

Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex - 0 views

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    Oleic acid from olive oil found to play role in regulation of RNA transcription, even positively effecting the miR-7, a tumor suppressor.
Nathan Goodyear

Mediterranean diet, cognitive function, and dementia: a systematic review. - PubMed - NCBI - 0 views

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    review finds Mediterranean diet may slow cognitive decline and decrease risk of Alzheimer's disease.
Nathan Goodyear

Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after... - 0 views

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    animal study finds that HBOT reduced stroke infarct size, increased neurogenesis, increased BDNF, and reduced MPO.
Nathan Goodyear

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? - 0 views

  • Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
  • HIF-1α is the principal mediator of cellular hypoxia adaptations
  • activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
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  • The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
  • Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
  • McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
  • The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
  • Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
  • To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
  • HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
  • Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
  • Hormesis
  • process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
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    great review of hbot, brain injury, neuroplasticity and neurogenesis.
Nathan Goodyear

Hyperbaric oxygen therapy for traumatic brain injury - 0 views

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    great review article on the positive effects of hbot in TBI
Nathan Goodyear

Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind,... - 0 views

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    study finds hyperbaric therapy improves children with autism.
Nathan Goodyear

Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against trauma... - 0 views

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    abstract of animal study finds that hyperbaric therapy provides neuroprotection via increase in IL-10; improved blood-brain barrier, improved tight junctions were about of the benefit found.
Nathan Goodyear

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumat... - 0 views

  • The changes in SPECT images after treatment indicate that HBOT led to reactivation of neuronal activity in stunned areas that seemed normal under CT and MRI imaging. While SPECT imaging has a limited spatial resolution (compared, for example, to fMRI), the changes in activity were sufficiently robust to be clearly detected by the SPECT images.
  • HBOT might initiate a cellular and vascular repair mechanism and improve cerebral vascular flow
  • HBOT induces regeneration of axonal white matter , , , , has positive effect upon the myelinization and maturation of injured neural fibers , and can stimulate axonal growth and increase the ability of neurons to function and communicate with each other
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  • HBOT was found to have a role in initiation and/or facilitation of angiogenesis and cell proliferation processes needed for axonal regeneration .
  • The observed reactivation of neuronal activity in the stunned areas found here, along with similar results in post-stroke patients
  • At the cellular level, HBOT can improve cellular metabolism, reduce apoptosis, alleviate oxidative stress and increase levels of neurotrophins and nitric oxide through enhancement of mitochondrial function (in both neurons and glial cells)
  • HBOT may promote the neurogenesis of endogenous neural stem cells
  • With regard to secondary injury mechanisms in mTBI, HBOT can initiate vascular repair mechanism and improve cerebral vascular flow , , , , promote blood brain barrier integrity and reduce inflammatory reactions as well as brain edema
  • It might be possible that HBOT enables the metabolic change simply by supplying the missing energy/oxygen needed for those regeneration processes.
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    Hbot therapy, according to study, induces neuroplasticity and improves brain function in post concussion syndrome and those with mTBI.  The important point about this study was that the study was done years after the injury; what if the therapy was employed immediately after...
Nathan Goodyear

http://www.isom.ca/wp-content/uploads/2013/01/Memory-Loss-and-Response-to-Hyperbaric-Ox... - 0 views

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    Interesting short case study of hyperbaric oxygen in patient with memory loss.
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Nathan Goodyear

Home: Cell Press - 0 views

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    study finds that omega 3, particularly DHA, protects and preserves the blood brain barrier
Nathan Goodyear

Neuroendocrine androgen action is a key extraovarian mediator in the development of pol... - 0 views

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    Androgen receptors in the brain may be key in metabolic effects found in PCOS
Nathan Goodyear

Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin A... - 0 views

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    Heroin use, and yes prescription opiate use, alters glutamate pathways.  Opiates change the brain.  
Nathan Goodyear

The Mediterranean Diet and ADHD in Children and Adolescents | Articles | Pediatrics - 0 views

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    Is ADHD simply a reflection of poor diet?
Nathan Goodyear

Molecular Psychiatry - Estrogen-dependent association of HDAC4 with fear in female mice... - 0 views

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    New study suggests estrogen may protect a woman's brain at times of stress.
Nathan Goodyear

http://www.drperlmutter.com/wp-content/uploads/2015/12/Pandit_et_al-Acta_Neurologica_Sc... - 0 views

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    study finds significant increase in risk of intracerebral (brain) hemorrhage with high dose statin therapy.  The "high dose" seems to be a fairly regular dose by the patients that walk through my office doors.  This is a meta-analysis
Nathan Goodyear

Testosterone Treatment Enhances Regional Brain Perfusion in Hypogonadal Men: The Journa... - 0 views

  • it is established that androgen modulates various neurotransmitters in the CNS. Testosterone decreases γ-aminobutyric acid concentration in the hypothalamus, which is blocked by flutamide, a testosterone receptor blocker (14, 15). Testosterone, probably by its conversion to estradiol, increases serotonin transporter mRNA expression in dorsal raphe nucleus (16), and it also increases the density of 5-hydroxytryptamine receptors and serotonin transporter sites in the forebrain (3, 16) of castrated male rats.
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    very interesting study of 7 men.  Increase brain perfusion found and symptom improvement as a result of Testosterone therapy in men ages 58-72.  Specific increase perfusion by SPECT scans were in the midbrain and Brodman areas 8 and 24 of the cerebral cortex.
Nathan Goodyear

High School Football and Risk of Neurodegeneration: A Community-Based Study - Mayo Clin... - 0 views

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    Study finds increased TBI in high school football players, but not an increase in neurodegenerative disease.
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