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Nathan Goodyear

Effects of testosterone administration on cognitive function in hys... - PubMed - NCBI - 0 views

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    Testosterone therapy in women post-hysterectomy, with low total and low free Testosterone, provides no benefit in cognitive function.
Nathan Goodyear

Effects of the FITKids Randomized Controlled Trial on Executive Control and Brain Function - 0 views

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    After school fitness/exercise improved focus, attention, and cognition of children.
Nathan Goodyear

Slow CCL2-dependent translocation of biopersistent particles from muscle to brain - 0 views

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    Study finds translocation of alum from vaccines from muscle to brain in some individuals.  This leads to the neurologically condition termed Macrophagic myofasciitis.  Study after study has shown this connection and now studies are showing this translocation of immune cells to the brain resulting in neuro-inflammation.  All I hear from pro vaccinators is vitriol.  Here is science.
Nathan Goodyear

Thyroid hormone treated astrocytes induce maturation of cerebral cortical neurons throu... - 0 views

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    T3 plays a significant role in astrocyte maturation.  This has significant cognitive and disease impact.
Nathan Goodyear

Nerve growth factor receptor immunoreactivit... [Mech Ageing Dev. 1993] - PubMed - NCBI - 0 views

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    alpha-GPC appears to increase nerve growth factor receptors in rat brains. 
Nathan Goodyear

Behavioral effects of L-alpha-glycer... [Pharmacol Biochem Behav. 1992] - PubMed - NCBI - 0 views

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    animal study finds improvement in learning and memory with alpha-GPC after 20 days of therapy.
Nathan Goodyear

Effect of treatment with choline alphoscerate on h... [Brain Res. 2006] - PubMed - NCBI - 0 views

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    alpha-GPC, in rat model found to protect brain from glial reaction damage in cerebrovascular disease.
Nathan Goodyear

Multicentre study of l-alpha-glyceryl-ph... [Drugs Aging. 1993 Mar-Apr] - PubMed - NCBI - 0 views

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    alpha-GPC and to a lesser degree acetyl-l-carnitine improved dementia in multi-center trial.
Nathan Goodyear

Associations between brain-derived neu... [Neuro Endocrinol Lett. 2014] - PubMed - NCBI - 0 views

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    BDNF correlates with Estradiol in women.
Nathan Goodyear

Neuropsychopharmacology - Striatal Dopaminergic and Serotonergic Markers in Human Heroi... - 0 views

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    study points to a modest decrease in dopamine and serotonin production in heroic users.  There appears to be a decrease in dopamine production, which could be via a down regulation of tyrosine hydroxylase enzyme and thus release.  Decreased homovanillate also noted.  Other studies have pointed to a decrease/downregulation of D2/D3 receptors.
Nathan Goodyear

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway: Cell Metabo... - 0 views

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    Brain benefits of exercise explained.  Exercise increases hippocampal BDNF via PGC-1alpha from skeletal muscle.
Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper14285.html - 0 views

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    Statin use found to be associated with cognitive decline.  The authors defined use as long-term, though 2 years of use was found to be associated with decline.   interestingly, metabolic syndrome was not found to be associated with cognitive decline.
Nathan Goodyear

Progesterone induces the growth and infiltrat... [Biomed Res Int. 2014] - PubMed - NCBI - 0 views

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    Progesterone shown to stimulate growth and migration of astrocytes in the brain.  The has both implications in cancer, such as in astrocytomas, but also in TBI.  The study also found that the Progesterone antagonist RU486 inhibited this effect.  A more thorough evaluation would have included the pregnane metabolites.
Nathan Goodyear

Early repeated administration of progesterone improves the recovery of neuropathic pain... - 0 views

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    Very interesting article.  Early Progesterone treatment, in animal model, shown to improve neuropathic pain recovery.  This is by no means the first study to show this.  This has been shown numerous times in TBI, but the timing of therapy was the purpose of this article.  What is very interesting here is that the metabolites implicated here in the recovery are the same metabolites implicated in an increased tumor potential.
Nathan Goodyear

Hormonal changes and their impact on cognition and... [Maturitas. 2014] - PubMed - NCBI - 0 views

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    low T appears to be associated with cognitive decline in men.  If low T is present on testing, then therapy is appropriate to improve cognition.
Nathan Goodyear

Ginkgo biloba is not a smart drug: an up... [Hum Psychopharmacol. 2007] - PubMed - NCBI - 0 views

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    Meta analysis finds no benefit for Ginkgo biloba for memory in "healthy" individuals.
Nathan Goodyear

The memory enhancing effects of a ... [Psychopharmacology (Berl). 2000] - PubMed - NCBI - 0 views

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    Combination Ginkgo and Panax ginseng improves memory quality in small study of healthy middle-aged adults.
Nathan Goodyear

DHEA effects on brain and behavio... [J Steroid Biochem Mol Biol. 2014] - PubMed - NCBI - 0 views

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    Interesting animal study finds that the brain can make sex hormones, DHEA and Testosterone in this article, de novo from cholesterol.  This is one mechanism by which the body can adapt to low T.  This also brings to light the effects that low adrenal output can have on T as well.
Nathan Goodyear

Frontiers | Performance enhancement at the cost of potential brain plasticity: neural r... - 0 views

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    Great article on the detriment of prescription stimulants for cognitive enhancement.  The authors describe an inverted "U" efficacy curve.
Nathan Goodyear

Microglia express functional 11 beta-hydroxysteroid deh... [Glia. 2010] - PubMed - NCBI - 0 views

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    microglia in the brain express 11 beta-hydroxysteroid dehydrogenase type 1 only.  This consistent with the brain as a whole.
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