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Nathan Goodyear

Association between plasma total tes... [J Clin Endocrinol Metab. 1997] - PubMed - NCBI - 0 views

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    low Total Testosterone associated with increased BMI, systolic blood pressure, glucose, triglycerides, total cholesterol, LDL apolipoprotien B and A1. Low Testosterone is associated with increased cardiovascular disease.  Men at risk for cardiovascular disease must be evaluated for hormones.
Nathan Goodyear

Chronic distress and acute vascular stress r... [J Hum Hypertens. 2013] - PubMed - NCBI - 0 views

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    Low T and high cortisol associated with increased ischemic events and elevated blood pressure.
Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

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    low vitamin D associated with an increased odds ratio of elevated blood pressure and elevated triglycerides in post-menopausal women with metabolic syndrome.
wheelchairindia9

Cp Child Wheelchair - 0 views

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    young children have a different set of needs than adults. Aesthetically, devices designed for kids are often sleek and colorful, and functionally, they are typically lightweight and adjustable. As any parent knows, young people don't stay the same size for long and since a wheelchair is a major purchase -- don't want a simple growth spurt to render it useless. Wheelchair category offers models that feature seat width and depth adjustability, elevating legrests, and other versatile features. As a weight-bearing activity is critical to proper physical and mental function-which is why children with cerebral palsy, who may sit for stretches in a wheelchair and typically are unable to stand on their own, can benefit greatly from pediatric standers as part of a comprehensive pediatric rehabilitation program. Pediatric standers are offered in passive, active and mobile formats: Passive standers stay in one place and feature a support surface, active standers allow reciprocal movement of the extremities while in a standing position, and mobile standers enable users to self-propel. Cerebral Palsy Wheelchair: Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame. Seat Width 38 cms (15"). Net Weight: 18.5 kgs. Epoxy powder coated frame. Detachable arm rest & foot rest provided. Elevated and swinging foot rest. Elevated foot rest provided to elevate leg angle. Height adjustable and detachable head rest. Hydraulic reclining high back for a comfortable posture. Hydraulic adjustable seat angle. Detachable back and seat pad. Extra cushion upholstery provided to under arm, head & calg Foldable. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cloth look like water proof upholstery. Anti wheels for better safety and stability. Extra cushion upholstery provided to under arm, head & leg. Folding action. Lever and paddle brakes provide
Nathan Goodyear

Effects of Whey Peptides on Cardiovascular Disease Risk Factors - Pins - 2007 - The Jou... - 0 views

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    whey protein lowers blood pressure
Nathan Goodyear

ScienceDirect - Free Radical Biology and Medicine : Effect of eicosapentaenoic acid and... - 0 views

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    DHA >EPA in reducing oxidative stress in those with high blood pressure and diabetes; though both effective
Nathan Goodyear

Metabolic Effects of Fructose and the Worldwide Increase in Obesity - 0 views

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    high fructose intake results in insulin resistance, obesity, type II DM, and high blood pressure
Nathan Goodyear

ScienceDirect - The Breast : Amlodipine gynaecomastia - 0 views

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    common blood pressure medication linked to gynecomastia in men. This reveals that amlodipine interferes with testosterone and estrogen balance
Nathan Goodyear

Hypertension and the cortisol-cortis... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

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    Abstract only available.  Cortisol-cortisone shuttle play a role in hypertension.  Those with 11betaHSD type II defects will have elevated blood pressure due to increase in mineralcorticoids.
Nathan Goodyear

Growth hormone treatment of abdomina... [J Clin Endocrinol Metab. 1997] - PubMed - NCBI - 0 views

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    Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure.
Nathan Goodyear

Effects of Long-Term Testosterone Therapy on Patients with "Diabesity": Results of Obse... - 0 views

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    Six years of Testosterone therapy in men with obesity, low T, and type II Diabetes was found to decrease waist circumference, decrease weight, decrease fasting glucose, decrease in HgbA1c and improved systolic/diastolic blood pressure, lipids, CRP, and liver enzymes.
Nathan Goodyear

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and o... - 0 views

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    Animal study finds the combination of coconut oil and exercise training reduced oxidative stress and lowered blood pressure.
star yu

How to Deal with it When Blood Pressure Falls During Dialysis - 0 views

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    "Dear, doctor. Is there natural home remedies for kidney disease, especially for Creatinine 8.1 patients. Many patients asked about what to do when blood pressure falls during dialysis and consequences of doing dialysis. My father is a CKD stage 3 and sufferer from pain on his left side between and left hip and last rib. How to alleviate it?"
Nathan Goodyear

Endothelium and control of vascular function. State of the Art lecture. - PubMed - NCBI - 0 views

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    vitamin C, absorbed via the endothelium, increases NO.  This will have a positive effect in lowering the blood pressure.
Nathan Goodyear

Acute Cannabigerol Administration Lowers Blood Pressure in Mice - PMC - 0 views

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    10 mg/kg significantly lowers blood pressure in mice.
Nathan Goodyear

Articles | Physiological Reports - 0 views

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    4 grams of daily n-3 decreased pulse wave velocity--decreased arteriosclerosis.  No change in blood pressure noted through the change in central pulse pressure.
Nathan Goodyear

Docosahexaenoic Acid but Not Eicosapentaenoic Acid Lowers Ambulatory Blood Pressure and... - 0 views

  • The results of this study suggest that DHA is the principal 3 fatty acid in fish and fish oils that is responsible for their BP- and HR-lowering effects in humans.
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    Omega-3, DHA lowers pressure and heart rate
wheelchairindia9

Knee Cap Open Patella - 0 views

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    Tynor Knee Cap Open Patella Knee Cap open patella is a compression tubular support used in orthopaedic practice to provide firm compression warmth & support to the limbs and joints, to allay pain and inflammation, generally associated with old age, arthritis, sports injury etc. Silicon patellar insert Four way stretch Freely breathable Soft and comfortable Tynor Knee Cap Open Patella Features Made from high quality nylon Ensures longer life. Appealing aesthetics Offers color fastness. Four-way stretch ability Good grip and compression Snug fitting No bunching at the back. Better comfort.. Special interlocking weave and single spiral elastic yarn , double layered Uniform compression even on uneven limb surface. Warmth improves healing. Provides firm support and gentle compression. Anterior patellar opening Relieves patellar pressure. Positions patella in patellar dislocations. Silicon patellar padding Propioception. Massages, increases blood flow, quick healing. Compresses and supports patellar tendon.
Nathan Goodyear

Testosterone Deficiency, Cardiac Health, and Older Men - 0 views

  • Studies have shown pharmacological doses of testosterone to relax coronary arteries when injected intraluminally [39] and to produce modest but consistent improvement in exercise-induced angina and reverse associated ECG changes [40]. The mechanism of action is via blockade of calcium channels with effect of similar magnitude to nifedipine
    • Nathan Goodyear
       
      This directly refutes the recent studies (3) that Testosterone therapy increases cardiovascular events.
    • Nathan Goodyear
       
      Testosterone acts as a calcium channel blocker inducing vasodilation.
  • men with chronic stable angina pectoris, the ischaemic threshold increased after 4 weeks of TRT and a recent study demonstrates improvement continuing beyond 12 months [
  • Exercise capacity in men with chronic heart failure increased after 12 weeks
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  • Studies have shown an inverse relationship between serum testosterone and fasting blood glucose and insulin levels
  • Medications such as chronic analgesics, anticonvulsants, 5ARIs, and androgen ablation therapy are associated with increased risk of testosterone deficiency and insulin resistance
  • Women with T2D or metabolic syndrome characteristically have low SHBG and high free testosterone
    • Nathan Goodyear
       
      This stands in polar opposite of that with men.
  • Hypogonadism is a common feature of the metabolic syndrome
  • The precise interaction between insulin resistance, visceral adiposity, and hypogonadism is, as yet, unclear but the important mechanisms are through increased aromatase production, raised leptin levels, and increase in inflammatory kinins
  • levels of testosterone are reduced in proportion to degree of obesity
  • Men should be encouraged to combine aerobic exercise with strength training. As muscle increases, glucose will be burned more efficiently and insulin levels will fall. A minimum of 30 minutes exercise three times weekly should be advised
  • Testosterone increases levels of fast-twitch muscle fibres
  • By increasing testosterone, levels of type 2 fibres increase and glucose burning improves
  • Weight loss will increase levels of testosterone
  • studies now clearly show that low testosterone leads to visceral obesity and metabolic syndrome and is also a consequence of obesity
  • In the case of MMAS [43], a baseline total testosterone of less than 10.4 nmol/L was associated with a greater than 4-fold incidence of type 2 diabetes over the next 9 years
  • There is high level evidence that TRT improves insulin resistance
  • Low testosterone predicts increased mortality and testosterone therapy improves survival in 587 men with type 2 diabetes
  • A similar retrospective US study involved 1031 men with 372 on TRT. The cumulative mortality was 21% in the untreated group versus 10% ( ) in the treated group with the greatest effect in younger men and those with type 2 diabetes
  • the presence of ED has been shown to be an independent risk factor, particularly in hypogonadal men, increasing the risk of cardiac events by over 50%
  • A recent online publication on ischaemic heart disease mortality in men concluded optimal androgen levels are a biomarker for survival
  • inverse associations between low TT or FT (Table 2) and the severity of CAD
  • A recent 10 year study from Western Australia involving 3690 men followed up from 2001–2010 concluded that TT and FT levels in the normal range were associated with decreased all-cause and cardiovascular mortality, for the first time suggesting that both low and DHT are associated with all-cause mortality and higher levels of DHT reduced cardiovascular risk
  • TDS is associated with increased cardiovascular and all-cause mortality
  • The effect of treatment with TRT reduced the mortality rate of treated cohort (8.4%) to that of the eugonadal group whereas the mortality for the untreated remained high at 19.2%
  • hypogonadal men had slightly increased triglycerides and HDL
  • Men with angiographically proven CAD (coronary artery disease) have significantly lower testosterone levels [29] compared to controls ( ) and there was a significant inverse relationship between the degree of CAD and TT (total testosterone) levels
  • TRT has also been shown to reduce fibrinogen to levels similar to fibrates
  • men treated with long acting testosterone showed highly significant reductions in TC, LDL, and triglycerides with increase in HDL, associated with significant reduction in weight, BMI, and visceral fat
  • Low androgen levels are associated with an increase in inflammatory markers
  • In the Moscow study, C-reactive protein was reduced by TRT at 30 weeks versus placebo
  • In some studies, a decline in diastolic blood pressure has been observed, after 3–9 months [24, 26] and in systolic blood pressure
  • A decline was noted in IL6 and TNF-alpha
  • No studies to date show an increase in LUTS/BPH symptoms with higher serum testosterone levels
  • TRT has been shown to upregulate PDE5 [65] and enhance the effect of PDE5Is (now an accepted therapy for both ED and LUTS), it no longer seems logical to advice avoidance of TRT in men with mild to moderate BPH.
    • Nathan Goodyear
       
      What about just starting with normalization of Testosterone levels first.
  • Several meta-analyses have failed to show a link between TRT and development of prostate cancer [66] but some studies have shown a tendency for more aggressive prostate cancer in men with low testosterone
    • Nathan Goodyear
       
      And if one would have looked at their estrogen levels, I guarantee they would have been found to be elevated.
  • low bioavailable testosterone and high SHBG were associated with a 4.9- and 3.2-fold risk of positive biopsy
  • Current EAU, ISSAM, and BSSM guidance [1, 2] is that there is “no evidence TRT is associated with increased risk of prostate cancer or activation of subclinical cancer.”
  • Men with prostate cancer, treated with androgen deprivation, develop an increase of fat mass with an altered lipid profile
  • Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
Nathan Goodyear

JAMA Network | JAMA: The Journal of the American Medical Association | Effects of Prote... - 0 views

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    In this study, a high carbohydrate diet was replaced with a diet higher in monosaturated fats.  The result was: a lower carb diet with resultant increase in monosaturated fats resulted in a reduction in triglycerides, reduction in systolic B/P, increase in HDL, and resultant decrease in CVD risk
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