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Nathan Goodyear

Salivary testosterone diurnal variation and psychopathology in adolescent males and fem... - 0 views

www.researchgate.net/...nces_and_developmental_effects

saliva salivary testosterone hormones hormone

shared by Nathan Goodyear on 30 Oct 12 - No Cached
  • Nathan Goodyear on 30 Oct 12
     
    low testosterone in boys associated with anxiety/depression and attention problems.  Disruptive behavior found in girls with low testosterone.  All determined by salivary testing.
buha3351

AT LAST A LIFE - 0 views

atlastalifereview.com

PANIC ATTACK TREATMENT

shared by buha3351 on 15 Sep 13 - No Cached
  • buha3351 on 15 Sep 13
     
    ARE YOU FELLING GUILTY? MOST PEOPLE WHO HAVE ANXIETY AND PANIC ATTACKS OFTEN FIND THEMSELVES WITH OUT A RESOURCE ON HOW TO GET HELP OR HOW TO HELP THEMSELVES TO FEEL BETTER. ANXIETY AND PANIC ARE A VERY REAL SUBJECT AND SHOULD BE ADDRESSED IN A TIMELY FASHION TO HELP IMPROVE YOUR QUALITY OF LIFE; THEY CAN AFFECT ANYONE AT ANY TIME. SO IF YOU ARE FEELING LIKE IT'S THE LAST DAY OF YOUR LIFE, YOUR NOT ALONE, JUST UNDERSTAND THAT THERE'S HELP THROUGH SELF KNOWLEDGE AND READING. THAT WHY I AM RECOMMENDING THIS BOOK "AT LAST A LIFE." BY PAUL DAVID.
Jessica Wilton

Know About 5 Common Myths Regarding Counselling - 0 views

www.apsense.com/...ths-regarding-counselling.html

Psychologist Bondi Counsellor Bondi Counselling Bondi

shared by Jessica Wilton on 08 Jul 15 - No Cached
  • Jessica Wilton on 08 Jul 15
     
    People are getting much busier day by day in their lives. They get minimum time to spend with their loved ones, which sometimes lead to a serious problem like a broken relationship or any kind of health disorders, like anxiety or depressions. But to overcome these problems counselling can be a very convenient option and is beneficial at the same time.
Nathan Goodyear

Reduced anxiety-like behavior and central neurochemical change in germ-free mice - Neuf... - 0 views

onlinelibrary.wiley.com/...abstract

anxiety mood Gut bacteria intestinal microbial balance dysbiosis

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • Nathan Goodyear on 12 Apr 11
     
    Gut health linked to brain health
tapforfreedom

What is EFT Emotional Freedom Techniques - 0 views

tapforfreedom.com/what-is-eft

shared by tapforfreedom on 23 May 14 - No Cached
  • tapforfreedom on 23 May 14
     
    What is EFT, weight loss, emotional freedom, anxiety, tapping, matrix reimprinting, Emotional Freedom Techniques, EFT Therapy, EFT Practitioners, Kalleen Henderson. Want to learn about EFT - Emotional Freedom Techniques? TapForFreedom Offering compassionate assistance to those seeking positive emotional shift. Contact EFT/Matrix Practitioner - Kalleen Henderson, and get the consultation session for your emotional healing.
  • tapforfreedom on 23 May 14
     
    What is EFT, weight loss, emotional freedom, anxiety, tapping, matrix reimprinting, Emotional Freedom Techniques, EFT Therapy, EFT Practitioners, Kalleen Henderson. Want to learn about EFT - Emotional Freedom Techniques? TapForFreedom Offering compassionate assistance to those seeking positive emotional shift. Contact EFT/Matrix Practitioner - Kalleen Henderson, and get the consultation session for your emotional healing.
  • tapforfreedom on 06 Jun 14
     
    Have you any emotional or physical issues with your health? Get the EFT emotional freedom techniques and matrix reimprinting consultation session from Kalleen Henderson. http://tapforfreedom.com
Nathan Goodyear

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer | Nutr... - 0 views

nutritionandmetabolism.biomedcentral.com/...s12986-017-0178-2

ketogenic diet ketogenic press-pulse hyperbaric oxygen therapy HBOTnutrition diet cancer HBOT IVC IV vitamin C DCA dichloracetic acid cancer therapy cancer treatment alternative cancer treatment

shared by Nathan Goodyear on 09 Jul 17 - No Cached
mamdouh_hfz liked it
  • A “press” disturbance was considered a chronic environmental stress on all organisms in an ecological community
  • “pulse” disturbances were considered acute events that disrupted biological communities to produce high mortality
  • Neoplasia involving dysregulated cell growth is the biological endpoint of the disease
  • ...84 more annotations...
  • Data from the American Cancer Society show that the rate of increase in cancer deaths/year (3.4%) was two-fold greater than the rate of increase in new cases/year (1.7%) from 2013 to 2017
  • cancer is predicted to overtake heart disease as the leading cause of death in Western societies
  • cancer can also be recognized as a metabolic disease.
  • glucose is first split into two molecules of pyruvate through the Embden–Meyerhof–Parnas glycolytic pathway in the cytosol
  • Aerobic fermentation, on the other hand, involves the production of lactic acid under normoxic conditions
  • persistent lactic acid production in the presence of adequate oxygen is indicative of abnormal respiration
  • Otto Warburg first proposed that all cancers arise from damage to cellular respiration
  • The Crabtree effect is an artifact of the in vitro environment and involves the glucose-induced suppression of respiration with a corresponding elevation of lactic acid production even under hyperoxic (pO2 = 120–160 mmHg) conditions associated with cell culture
  • the Warburg theory of insufficient aerobic respiration remains as the most credible explanation for the origin of tumor cells [2, 37, 51, 52, 53, 54, 55, 56, 57].
  • The main points of Warburg’s theory are; 1) insufficient respiration is the predisposing initiator of tumorigenesis and ultimately cancer, 2) energy through glycolysis gradually compensates for insufficient energy through respiration, 3) cancer cells continue to produce lactic acid in the presence of oxygen, and 4) respiratory insufficiency eventually becomes irreversible
  • Efraim Racker coined the term “Warburg effect”, which refers to the aerobic glycolysis that occurs in cancer cells
  • Warburg clearly demonstrated that aerobic fermentation (aerobic glycolysis) is an effect, and not the cause, of insufficient respiration
  • all tumor cells that have been examined to date contain abnormalities in the content or composition of cardiolipin
  • The evidence supporting Warburg’s original theory comes from a broad range of cancers and is now overwhelming
  • respiratory insufficiency, arising from any number mitochondrial defects, can contribute to the fermentation metabolism seen in tumor cells.
  • data from the nuclear and mitochondrial transfer experiments suggest that oncogene changes are effects, rather than causes, of tumorigenesis
  • Normal mitochondria can suppress tumorigenesis, whereas abnormal mitochondria can enhance tumorigenesis
  • In addition to glucose, cancer cells also rely heavily on glutamine for growth and survival
  • Glutamine is anapleurotic and can be rapidly metabolized to glutamate and then to α-ketoglutarate for entry into the TCA cycle
  • Glucose and glutamine act synergistically for driving rapid tumor cell growth
  • Glutamine metabolism can produce ATP from the TCA cycle under aerobic conditions
  • Amino acid fermentation can generate energy through TCA cycle substrate level phosphorylation under hypoxic conditions
  • Hif-1α stabilization enhances aerobic fermentation
  • targeting glucose and glutamine will deprive the microenvironment of fermentable fuels
  • Although Warburg’s hypothesis on the origin of cancer has created confusion and controversy [37, 38, 39, 40], his hypothesis has never been disproved
  • Warburg referred to the phenomenon of enhanced glycolysis in cancer cells as “aerobic fermentation” to highlight the abnormal production of lactic acid in the presence of oxygen
  • Emerging evidence indicates that macrophages, or their fusion hybridization with neoplastic stem cells, are the origin of metastatic cancer cells
  • Radiation therapy can enhance fusion hybridization that could increase risk for invasive and metastatic tumor cells
  • Kamphorst et al. in showing that pancreatic ductal adenocarcinoma cells could obtain glutamine under nutrient poor conditions through lysosomal digestion of extracellular proteins
  • It will therefore become necessary to also target lysosomal digestion, under reduced glucose and glutamine conditions, to effectively manage those invasive and metastatic cancers that express cannibalism and phagocytosis.
  • Previous studies in yeast and mammalian cells show that disruption of aerobic respiration can cause mutations (loss of heterozygosity, chromosome instability, and epigenetic modifications etc.) in the nuclear genome
  • The somatic mutations and genomic instability seen in tumor cells thus arise from a protracted reliance on fermentation energy metabolism and a disruption of redox balance through excess oxidative stress.
  • According to the mitochondrial metabolic theory of cancer, the large genomic heterogeneity seen in tumor cells arises as a consequence, rather than as a cause, of mitochondrial dysfunction
  • A therapeutic strategy targeting the metabolic abnormality common to most tumor cells should therefore be more effective in managing cancer than would a strategy targeting genetic mutations that vary widely between tumors of the same histological grade and even within the same tumor
  • Tumor cells are more fit than normal cells to survive in the hypoxic niche of the tumor microenvironment
  • Hypoxic adaptation of tumor cells allows for them to avoid apoptosis due to their metabolic reprograming following a gradual loss of respiratory function
  • The high rates of tumor cell glycolysis and glutaminolysis will also make them resistant to apoptosis, ROS, and chemotherapy drugs
  • Despite having high levels of ROS, glutamate-derived from glutamine contributes to glutathione production that can protect tumor cells from ROS
    • Nathan Goodyear
      Nathan Goodyear on 08 Feb 18
       
      reason to eliminate glutamine in cancer patients and even GSH with cancer patients
  • It is clear that adaptability to environmental stress is greater in normal cells than in tumor cells, as normal cells can transition from the metabolism of glucose to the metabolism of ketone bodies when glucose becomes limiting
  • Mitochondrial respiratory chain defects will prevent tumor cells from using ketone bodies for energy
  • glycolysis-dependent tumor cells are less adaptable to metabolic stress than are the normal cells. This vulnerability can be exploited for targeting tumor cell energy metabolism
  • In contrast to dietary energy reduction, radiation and toxic drugs can damage the microenvironment and transform normal cells into tumor cells while also creating tumor cells that become highly resistant to drugs and radiation
  • Drug-resistant tumor cells arise in large part from the damage to respiration in bystander pre-cancerous cells
  • Because energy generated through substrate level phosphorylation is greater in tumor cells than in normal cells, tumor cells are more dependent than normal cells on the availability of fermentable fuels (glucose and glutamine)
  • Ketone bodies and fats are non-fermentable fuels
  • Although some tumor cells might appear to oxidize ketone bodies by the presence of ketolytic enzymes [181], it is not clear if ketone bodies and fats can provide sufficient energy for cell viability in the absence of glucose and glutamine
  • Apoptosis under energy stress is greater in tumor cells than in normal cells
  • A calorie restricted ketogenic diet or dietary energy reduction creates chronic metabolic stress in the body
  • . This energy stress acts as a press disturbance
  • Drugs that target availability of glucose and glutamine would act as pulse disturbances
  • Hyperbaric oxygen therapy can also be considered another pulse disturbance
  • The KD can more effectively reduce glucose and elevate blood ketone bodies than can CR alone making the KD potentially more therapeutic against tumors than CR
  • Campbell showed that tumor growth in rats is greater under high protein (>20%) than under low protein content (<10%) in the diet
  • Protein amino acids can be metabolized to glucose through the Cori cycle
  • The fats in KDs used clinically also contain more medium chain triglycerides
  • Calorie restriction, fasting, and restricted KDs are anti-angiogenic, anti-inflammatory, and pro-apoptotic and thus can target and eliminate tumor cells through multiple mechanisms
  • Ketogenic diets can also spare muscle protein, enhance immunity, and delay cancer cachexia, which is a major problem in managing metastatic cancer
  • GKI values of 1.0 or below are considered therapeutic
  • The GKI can therefore serve as a biomarker to assess the therapeutic efficacy of various diets in a broad range of cancers.
  • It is important to remember that insulin drives glycolysis through stimulation of the pyruvate dehydrogenase complex
  • The water-soluble ketone bodies (D-β-hydroxybutyrate and acetoacetate) are produced largely in the liver from adipocyte-derived fatty acids and ketogenic dietary fat. Ketone bodies bypass glycolysis and directly enter the mitochondria for metabolism to acetyl-CoA
  • Due to mitochondrial defects, tumor cells cannot exploit the therapeutic benefits of burning ketone bodies as normal cells would
  • Therapeutic ketosis with racemic ketone esters can also make it feasible to safely sustain hypoglycemia for inducing metabolic stress on cancer cells
    • Nathan Goodyear
      Nathan Goodyear on 08 Feb 18
       
      Ketones are much more than energy adaptabilit, but actually are therapeutic.
  • ketone bodies can inhibit histone deacetylases (HDAC) [229]. HDAC inhibitors play a role in targeting the cancer epigenome
  • Therapeutic ketosis reduces circulating inflammatory markers, and ketones directly inhibit the NLRP3 inflammasome, an important pro-inflammatory pathway linked to carcinogenesis and an important target for cancer treatment response
  • Chronic psychological stress is known to promote tumorigenesis through elevations of blood glucose, glucocorticoids, catecholamines, and insulin-like growth factor (IGF-1)
  • In addition to calorie-restricted ketogenic diets, psychological stress management involving exercise, yoga, music etc. also act as press disturbances that can help reduce fatigue, depression, and anxiety in cancer patients and in animal models
  • Ketone supplementation has also been shown to reduce anxiety behavior in animal models
  • This physiological state also enhances the efficacy of chemotherapy and radiation therapy, while reducing the side effects
  • lower dosages of chemotherapeutic drugs can be used when administered together with calorie restriction or restricted ketogenic diets (KD-R)
  • Besides 2-DG, a range of other glycolysis inhibitors might also produce similar therapeutic effects when combined with the KD-R including 3-bromopyruvate, oxaloacetate, and lonidamine
    • Nathan Goodyear
      Nathan Goodyear on 08 Feb 18
       
      oxaloacetate is a glycolytic inhibitor, as is doxycycline, and IVC.
  • A synergistic interaction of the KD diet plus radiation was seen
  • It is important to recognize, however, that the radiotherapy used in glioma patients can damage the respiration of normal cells and increase availability of glutamine in the microenvironment, which can increase risk of tumor recurrence especially when used together with the steroid drug dexamethasone
  • Poff and colleagues demonstrated that hyperbaric oxygen therapy (HBOT) enhanced the ability of the KD to reduce tumor growth and metastasis
  • HBOT also increases oxidative stress and membrane lipid peroxidation of GBM cells in vitro
  • The effects of the KD and HBOT can be enhanced with administration of exogenous ketones, which further suppressed tumor growth and metastasis
  • Besides HBOT, intravenous vitamin C and dichloroacetate (DCA) can also be used with the KD to selectively increase oxidative stress in tumor cells
  • Recent evidence also shows that ketone supplementation may enhance or preserve overall physical and mental health
  • Some tumors use glucose as a prime fuel for growth, whereas other tumors use glutamine as a prime fuel [102, 186, 262, 263, 264]. Glutamine-dependent tumors are generally less detectable than glucose-dependent under FDG-PET imaging, but could be detected under glutamine-based PET imaging
  • GBM and use glutamine as a major fuel
  • Many of the current treatments used for cancer management are based on the view that cancer is a genetic disease
  • Emerging evidence indicates that cancer is a mitochondrial metabolic disease that depends on availability of fermentable fuels for tumor cell growth and survival
  • Glucose and glutamine are the most abundant fermentable fuels present in the circulation and in the tumor microenvironment
  • Low-carbohydrate, high fat-ketogenic diets coupled with glycolysis inhibitors will reduce metabolic flux through the glycolytic and pentose phosphate pathways needed for synthesis of ATP, lipids, glutathione, and nucleotides
  • Nathan Goodyear on 09 Jul 17
     
    Cancer is a mitochondrial disease? So says the well published Dr Seyfried. Glucose and glutamine drive cancer growth.
freshbombsusa

How to Find Quality CBD Products- Fresh Bombs - 0 views

freshbombsusa.over-blog.com/...e-quality-of-cbd-products.html

cbd products cbd wholesale cbd edibles cbd oil cbd hemp oil made in usa ecofriendly nature handmade beauty skincare

shared by freshbombsusa on 01 May 20 - No Cached
  • freshbombsusa on 01 May 20
     
    Cannabidiol or CBD is found in marijuana and is used to reduce the symptoms of seizures, pain, and anxiety. It is very essential to choose qualitative CBD products from the trustable store. You can also search 'Fresh Bombs' on a reliable search engine to buy quality CBD-infused products. To know more about how to choose quality CBD products then read our blog.
ashleyobama

Nembutal Liquid | pills nembutal |Nembutal Liquid | - 0 views

www.roidsmeds.com/...nembutal-liquid

shared by ashleyobama on 28 May 20 - No Cached
  • ashleyobama on 28 May 20
     
    Nembutal Liquid is best quality and prices at First Trust Chemicals. Visit our website and place your order online. Nembutal Liquid Pentobarbital (trade name: Nembutal) is a drug from the barbiturate class. It was widely used during the 1940s and 1950s as a sleeping pill (i.e. hypnotic) or anti-anxiety drug (i.e. sedative). Unlike modern sleeping pills, Nembutal is highly lethal in overdose. Because it is very reliable and brings about peaceful death, it is one of drugs of choice for assisted suicide. Nembutal is used by euthanasia organizations in the United States (Oregon Death With Dignity Act), Switzerland (Dignitas) and The Netherlands. Nembutal Liquid Since it was so easy to overdose on Nembutal (whether accidentally or intentionally), it was almost universally taken off the market and replaced by safer sleeping pills. Nembutal was removed from the Australian prescribing schedule in 1998. However, Nembutal remains in use by veterinary surgeons in order to euthanase bigger animals. Many people were successful in obtaining veterinary Nembutal for their suicide. The famous American actress Marilyn Monroe supposedly used Nembutal to end her life. The brand name "Nembutal" was coined by Dr. John S. Lundy, who started using it in 1930, from the structural formula of the sodium salt-Na (sodium) + ethyl + methyl + butyl + al (common suffix for barbiturates). Nembutal is trademarked and manufactured by the Danish pharmaceutical company Lundbeck
ashleyobama

Roids Meds - 0 views

www.evernote.com/...ee11de246aed65b74fcac6dfadd372

adderall ketamine painkillers methadone therapy teherapy cancer cancerin codeine

shared by ashleyobama on 28 May 20 - No Cached
  • ashleyobama on 28 May 20
     
    Roids Meds is a reputable online pharmacy among all online pharmacies. We deliver prescription of anti-anxiety drugs pills, Nembutal, and pain killers to almost every part of the world at the cheapest prices. Buy cheap medication online, The quality of our medicines is not less than any medicine available at a top-ranked physical drugstore. We guarantee online medicine delivery and the quantity of our products. Buying your medications online can be a smart move.
pharmacybiz

NHS New Campaign To Promote Better Care For Mental Health - 0 views

www.pharmacy.biz/-better-care-for-mental-health

NHS-Better-Health-campaign pharmacy-business NHS-Better-Health-app NHS-healthy-eating NHS-Better-Health-lose-weight NHS-Better-health-every-Mind-matters

shared by pharmacybiz on 18 Jan 22 - No Cached
  • pharmacybiz on 18 Jan 22
     
    The NHS is going to launch a new campaign using the iconic Beatles song 'Help!" to encourage people to take better care of their mental health. The campaign, being launched today (January 17), is backed by some of the UK's biggest artists, urging people to seek support for their mental wellbeing. Since the beginning of the pandemic around 2.3 million people have come forward for NHS talking therapies, with over 50 per cent being concerned about their mental health last year. The NHS is encouraging anybody experiencing anxiety, depression, or other common mental health concerns to experience how talking therapies can help them. NHS mental health talking therapies are a confidential service run by fully trainedexperts that can be accessed through self-referral or GP practice.
Nathan Goodyear

Mood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus | ... - 0 views

www.academia.edu/..._as_a_Pathophysiological_Nexus

obesity overweight mood disorders depression anxiety weight loss' leptin adiponectin inflammation cytokines

shared by Nathan Goodyear on 22 Jan 13 - No Cached
  • Nathan Goodyear on 22 Jan 13
     
    good review of the interaction between the immune system and the neuroendocrine system in obesity and mood disorders.  
Nathan Goodyear

PsychiatryOnline | The Journal of Neuropsychiatry and Clinical Neurosciences | Can Trau... - 0 views

neuro.psychiatryonline.org/article.aspx

TBI traumatic brain injury psychiatric disorders depression anxiety schizophrenia insomnia

shared by Nathan Goodyear on 16 Feb 12 - No Cached
  • Nathan Goodyear on 16 Feb 12
     
    research, though limited, supports the hypothesis that TBI contributes to psychiatric disorders.
Nathan Goodyear

Nutritional therapies for mental disorders - 0 views

www.ncbi.nlm.nih.gov/...PMC2248201

vitamins nutritional therapy vitamin mood disorders depression anxiety bipolar shizophrenia OCD

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    Nutritional therapies for mood disorders.
Nathan Goodyear

SLC6A4 methylation modifies the effect of the number of traumatic events on risk for po... - 0 views

onlinelibrary.wiley.com/...abstract

methylation SAMe PTSD stress depression

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    lower methylation status increases risk of PTSD.  Those with PTSD should be evaluated for methylation status.
Nathan Goodyear

Estrogen Levels Are Associated with Extinction Deficits in Women with Posttraumatic Str... - 0 views

www.biologicalpsychiatryjournal.com/...abstract

estrogen Estradiol E2 anxiety PTSD mood disorders posttraumatic stress disorder women stress

shared by Nathan Goodyear on 15 Jul 13 - No Cached
  • Nathan Goodyear on 15 Jul 13
     
    Women with lower estrogen levels more likely to develop PTSD.  This study looked at estradiol.  So, when this study references estrogen, it is referencing estradiol.
Nathan Goodyear

Social support and oxytocin interact to suppress cortisol and subjective responses to p... - 0 views

www.sciencedirect.com/...S0006322303004657

oxytocin cortisol stress hormone hormones anxiety

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    Oxytocin shown to suppress cortisol release in response to psychosocial stressors.  The question is where does this modulation occur.
Nathan Goodyear

Neurobiological effects of the green tea constituent theanine and its potential role in... - 0 views

www.maneyonline.com/...1476830513Y.0000000079

green tea tea l-theanine anxiety brain mood BDNF

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Only abstract available: l-Theanine appears to be a glutamate receptor antagonist.  The effects of l-Theanine have shown to be positive with mood disorders, psychiatric conditions, and neurodegenerative diseases.  L-Theanine increases BDNF.
Nathan Goodyear

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and... - 0 views

www.gastrojournal.org/...abstract

behavior Gut intestinal microbiota anxiety mood depression

shared by Nathan Goodyear on 25 May 11 - No Cached
  • Nathan Goodyear on 25 May 11
     
    Gut and Brain linked together
Nathan Goodyear

Think Twice: How the Gut's "Second Brain" Influences Mood and Well-Being: Scientific Am... - 0 views

www.scientificamerican.com/article.cfm

Gut GI system mood depression anxiety

shared by Nathan Goodyear on 25 May 11 - Cached
  • Nathan Goodyear on 25 May 11
     
    Gut: as a second brain?  
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