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Nathan Goodyear

The Epidemiology of Uric Acid and Fructose - 0 views

www.ncbi.nlm.nih.gov/...PMC3197219

uric acid fructose metabolic syndrome inflammation vitamin C IV vitamin C

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Previous studies have found that high doses of vitamin C supplementation lower serum uric acid via a uricosuric effect
  • fructose consumption coincided with the increasing trend of serum uric acid
  • Fructose is known to induce uric acid production by increasing ATP degradation to AMP, a uric acid precursor (85, 93, 94) and thus, within minutes after fructose infusion, serum uric acid levels rise
  • Nathan Goodyear on 17 Sep 13
     
    fructose intake, metabolic dysfunction, and elevated uric acid.
Nathan Goodyear

Vitamin C intake and serum uric acid concentrati... [J Rheumatol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18464304

vitamin C gout uric acid xanthine oxidase

shared by Nathan Goodyear on 17 Jan 12 - No Cached
  • Nathan Goodyear on 17 Jan 12
     
    Vitamin C shown to be inversely associated with uric acid. This has implications in those with gout, which is caused from xanthine oxidase production of uric acid.  Vitamin C can be used in those at risk for elevated uric acid levels and gout.
Nathan Goodyear

Prevalence of Hyperuricemia and the Relationship between Serum Uric Acid and Metabolic ... - 0 views

www.jstage.jst.go.jp/..._article

uric acid metabolic syndrome triglycerides waist circumference hormones hormone inflammaiton

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    Waist circumference and triglycerides correlate with serum uric acid levels.  Men in this study had higher hyperuricemic rates compared to women.  Elevated uric acid levels were associated with increased MetS in both sexes and higher normal uric acid levels were also associated with a higher risk of MetS.
Nathan Goodyear

Diabetology & Metabolic Syndrome | Full text | High plasma uric acid concentration: cau... - 0 views

www.dmsjournal.com/12

metabolic syndrome uric acid

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • Nathan Goodyear on 24 Aug 14
     
    Uric acid and its role in metabolic syndrome.  The elevated uric acid is likely the result of the metabolic dysfunction that leads to metabolic syndrome.
Nathan Goodyear

Association of serum uric acid levels to in... [Pediatr Diabetes. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25131560

obesity obese children uric acid CRP inflammation

shared by Nathan Goodyear on 19 Aug 14 - No Cached
  • Nathan Goodyear on 19 Aug 14
     
    Obese children found to have elevated uric acid and CRP levels.  The serum uric acid levels were associated with inflammatory biomarkers.
Nathan Goodyear

Higher dietary fructose is associated with impaired hepatic adenosine triphosphate home... - 0 views

onlinelibrary.wiley.com/...7A09FEEBBB7F7951B7A9695.f03t01

fructose uric acid nutrition ATP diabetes mitochondria

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    uric acid used to monitor liver's response to fructose.  Some have called it fructose toxicity.  The point, is that a high uric acid points to poor ATP recovery (mitochondria) in the fact of fructose.
Nathan Goodyear

Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension - 0 views

www.hindawi.com/...682673

fructose uric acid metabolic syndrome sugar

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • HFCS consists of fructose and glucose mixed in a variety of concentrations, but most commonly as 55% fructose and 45% glucose
  • In the United States, HFCS and sucrose are the major sources of fructose in the diet, and HFCS is a major ingredient in soft drinks, pastries, desserts, and various processed foods
  • fructose and glucose are metabolized in completely different ways and utilize different GLUT transporters
  • ...9 more annotations...
  • In the liver, fructose bypasses the two highly regulated steps of glycolysis, catalyzed by glucokinase/hexokinase and phosphofructokinase both of which are inhibited by increasing concentrations of their byproducts. Instead, fructose enters the pathway at a level that is not regulated and is metabolized to fructose-1-phosphate primarily by fructokinase or ketohexokinase
  • Fructokinase has no negative feedback system, and ATP is used for the phosphorylation process. As a result, continued fructose metabolism results in intracellular phosphate depletion, activation of AMP deaminase, and uric acid generation which is harmful at the cellular level
  • Uric acid, a byproduct of fructose degradation,
  • Uric acid inhibits endothelial NO both in vivo and in vitro, [15] and directly induces adipocyte dysfunction
  • Serum uric acid increases rapidly after ingestion of fructose, resulting in increases as high as 2 mg/dL within 1 hour
  • Uncontrolled fructose metabolism leads to postprandial hypertriglyceridemia, which increases visceral adipose deposition. Visceral adiposity contributes to hepatic triglyceride accumulation, protein kinase C activation, and hepatic insulin resistance by increasing the portal delivery of free fatty acids to the liver
  • Several reviews have concluded that intake of both fructose and HFCS by children and adults was associated with an increased risk of obesity and metabolic syndrome
  • Sucrose is a disaccharide that is comprised of fructose and glucose
  • Figure 2
  • Nathan Goodyear on 24 Aug 14
     
    great read and review of the role of fructose in metabolic syndrome.
Nathan Goodyear

High plasma uric acid concentration: causes and consequences - 0 views

www.ncbi.nlm.nih.gov/...PMC3359272

uric acid

shared by Nathan Goodyear on 22 Sep 16 - No Cached
  • Nathan Goodyear on 22 Sep 16
     
    good review on uric acid
Nathan Goodyear

Is Serum Uric Acid Level Correlated with Erectile Dysfunction in Coronary Artery Diseas... - 0 views

www.ncbi.nlm.nih.gov/...27107521

CAD coronary artery disease heart disease ED uric acid lipoprotein a

shared by Nathan Goodyear on 26 Apr 16 - No Cached
  • Nathan Goodyear on 26 Apr 16
     
    Only abstract available here.  High uric acid and lipoprotein A levels associated with ED in men with CAD.
Nathan Goodyear

Early onset of hyperuricaemia and gout following treatment for female to male gender re... - 0 views

rheumatology.oxfordjournals.org/...1840.full

gout sex hormones

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    sex hormones play a role in the gout.  It appears that testosterone therapy increases uric acid levels and estradiol decreases uric acid levels.  Though, I question this based on the use of serum levels and thus inadequate assessment of aromatase activity.  Aromatase activity does not occur in the serum, it occurs in the tissue, thus saliva would be the best tool.
Nathan Goodyear

Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Developmen... - 0 views

www.ncbi.nlm.nih.gov/...PMC3480441

non-alcoholic fatty liver fatty liver fructose uric acid

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Vicious cycle.  High fructose intake increases uric acid production.  Hyperuricemia then leads to further Fructose metabolism.  This study finds that hyperuricemia upregulates the fructokinase enzyme that is the first step in fructose metabolism.  This upregulation will increase fructose metabolism and increase fat accumulation in the liver.
Nathan Goodyear

Uric acid induces hepatic steatosis by generatio... [J Biol Chem. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23035112

uric acid mitochondria non-alcoholic fatty liver fructose triglyceride oxidative stress fatty liver liver ATP

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Elevated uric acid levels up regulate fructose metabolism to triglycerides and fatty liver.  This study finds that liver mitochondrial oxidative stress is also evident.  This mitochondrial dysfunction also leads to compromised ATP production and fat accumulation specifically through inhibition of aconitase..
Nathan Goodyear

Independent impact of gout on the risk of diabetes mellitus among women and men: a popu... - 0 views

ard.bmj.com/...annrheumdis-2014-205827.short

gout diabetes cardiovascular risk

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    This population study finds increased risk, significantly more for women vs men, of type II Diabetes with gout.  This should come as no surprise as the underlying pathophysiology is the same.  Fructose increases Uric acid.  Uric acid is a biomarker of MetS.  Fructose increases abdominal adiposity and eventually inflammation which leads to diabetes.  
Nathan Goodyear

Uric acid and inflammatory markers - 0 views

eurheartj.oxfordjournals.org/...1174.short

uric acid inflammation CRP IL-6

shared by Nathan Goodyear on 15 Aug 11 - No Cached
  • Nathan Goodyear on 15 Aug 11
     
    uric acid increases CRP and IL-6
Nathan Goodyear

Uric acid in chronic heart failure: a marker of chronic inflammation - 0 views

eurheartj.oxfordjournals.org/...1814.full

uric acid heart failure inflammation

shared by Nathan Goodyear on 15 Aug 11 - No Cached
  • Nathan Goodyear on 15 Aug 11
     
    uric acid is inflammatory marker associated with chronic heart failure
Nathan Goodyear

Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference... - 0 views

www.ncbi.nlm.nih.gov/...PMC4129973

uric acid metabolic syndrome inflammation

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • We found that higher SUA level, even within normal range, was associated with an increased prevalence of MetS even after adjusting for confounding factors. This association of MetS risk by SUA levels was more robust in women than in men.
  • Just in the past decade, prevalence of MetS in China has increased about 8%
  • Nathan Goodyear on 27 Aug 14
     
    Increasing uric acid levels, even in the normal range, are associated with increased incidence of metabolic syndrome. This was found more prevalent in women, but positive correlations were seen in both sexes.
Nathan Goodyear

A causal role for uric acid in fructose-induced metabolic syndrome | Renal Physiology - 0 views

ajprenal.physiology.org/...F625

fructose diet nutrition metabolic syndrome uric acid obesity

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • Nathan Goodyear on 24 Aug 14
     
    Article discusses the metabolic mechanism of fructose induced elevation of uric acid and the associated increased risk of metabolic syndrome.
Nathan Goodyear

Uric Acid, the Metabolic Syndrome, and Renal Disease - 0 views

jasn.asnjournals.org/...S165.full

uric acid metabolic syndrome

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • Nathan Goodyear on 24 Aug 14
     
    Uric acid is positively correlated with Metabolic syndrome risk.
Nathan Goodyear

Relationship between serum uric acid and metastatic and nonmetastatic rectal cancer pat... - 0 views

www.ncbi.nlm.nih.gov/...PMC5134885

uric acid CRP colorectal cancer CEA

shared by Nathan Goodyear on 29 Aug 19 - No Cached
  • Nathan Goodyear on 29 Aug 19
     
    Increased uric acid, CEA, and CRP associated with increased lymphatic metastasis.
Nathan Goodyear

Hyperuricemia at The Time Of Diagnosis is a Factor for Poor Prognosis in Patients With ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5454747

colorectal cancer uric acid

shared by Nathan Goodyear on 29 Aug 19 - No Cached
  • Nathan Goodyear on 29 Aug 19
     
    Small cross-sectional study finds that increased uric acid is associated with early Mets and poor prognosis.
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