Statins use and coronary artery plaque composition: Results from the International Mult... - 0 views
www.ncbi.nlm.nih.gov/...PMC4277888
statin statins plaque CAD coronary artery disease coronary artery calcium cardiovascular disease
shared by Nathan Goodyear on 17 Oct 17
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Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium
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As compared with individuals not taking statins, those taking statins possessed a significantly higher prevalence of obstructive CAD, as well as higher numbers of vessels with obstructive CAD
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statin use was associated with increased presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27–1.68, p < 0.001] and CP (OR 1.54, 95% CI 1.36–1.74, p < 0.001], but not NCP
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statin use was associated with increasing numbers of coronary segments possessing MP and CP but not associated with increasing numbers of coronary segments possessing NCP
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A total of 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) comprised the study population
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one potential unifying hypothesis is that rather than regression of coronary plaque, statins may contribute to the conversion of coronary plaque constituents, perhaps by conversion of NCP to plaque possessing calcium
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Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive CAD