There is just no reason to take SSRIs during pregnancy. SSRIs increase risk of miscarriage, birth defects, preterm birth, newborn behavior problems, pulmonary hypertension...All women considering pregnancy should removed, yet SSRIs are prescribed as if they are candy.
Interesting study. They found a "significant reduction of T(3) after 15 and 30 days" with SSRI use, yet their conclusion is SSRI is safe in hypothyroid. The take is that part of the weight gain associated with SSRI use is through dysfunction of thyroid hormone production as the effects were also found with T4.
SSRI increase serotonin levels rapidly after initiation of therapy; to rapid to explain the therapeutic latency associated with re-uptake inhibition only
amazingly, up to 20% of patents with depression do worse on anti-depressant therapy (SSRI). These are labeled non-responders, but when compared to placebo, the difference was significant. Maybe, we should check their neurotransmitters first?
paroxetine, SSRI, shown to improve depressive symptoms without altering kynurenine levels. Revealing underlying issue of depression in many individuals is disordered tryptophan metabolism due to inflammation
analysis of 3 clinical trials found that up to 40% of 447 women that were treated with antidepressant therapy found no benefit. Physical symptoms were provided little, if any benefit.