Licorice root extract, also known as glycyrrhizic acid, found to quickly reduce endogenous Testosterone production in women. The proposed mechanism is via inhibition of 17-hydroxysteroid dehydrogenase and 17-20 Lyase. This is a good adjuvant in the treatment of PCOS.
Interesting study finds hyperandrogenism stimulates excessive inflammatory response to glucose intake. This study was done in otherwise healthy women not in women with PCOS. The inflammatory cytokine production was via NF-KappaB activation.
Again, this has negative implications in women being doped with Testosterone.
small study finds marjoram daily intake reduced DHEA and insulin and improved insulin sensitivity (when compared to placebo group) in women with PCOS. This study too is ahead of print and only abstract is available.
Cochran review of 6 studies of only 164 women found lifestyle interventions improved body composition, mostly fat loss, decreased the hyperandrogen status and improved insulin resistance in women with PCOS.
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Quercetin found to increase adiponectin levels within women with PCOS with insulin resistance. Adiponectin has been shown to be inversly associated with insulin and insulin resistance.
Study found that PCOS was associated with increased glycolysis, reduced kreb's cycle activity, and decreased gluconeogenesis. Also found a decrease in the BCAA/AAA ratio.
higher Testosterone levels, in conjunction with lower progesterone levels, found in premenopausal women with breast hyperplasia and breast cancer. The authors point to elevated androgens in breast cancer induction and development. This same hormone patter, low progesterone/elevated Testosterone, is associated with PCOS in women.
The literature on Testosterone and breast cancer is confusing at best, but just like therapy in men, it needs to be individualized. This prospective case study found a significant increased odds of breast cancer in women with higher levels of free Testosterone. Statistical significance was not found with Total Testosterone. These were endogenous hormones. The women in this study had "regular menstrual cycles" suggesting these women lacked PCOS.
significant weight loss (and leptin reduction) (P < 0.01) was recorded in the myo-inositol group, whereas the placebo group actually increased weight
hese data support a beneficial effect of myo-inositol in women with oligomenorrhea and polycystic ovaries in improving ovarian function.