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pharmacybiz

Boots welcomes job applications from LloydsPharmacy staff - 0 views

www.pharmacy.biz/ions-from-lloydspharmacy-staff

pharmacy-business boot-welcomes-job-applications Lloyds-pharmacy-closures-2022 Lloyds-Pharmacy-jobs boots-uk pharmacy-closures-uk lloyds-pharmacy-news-2022

shared by pharmacybiz on 25 Jan 23 - No Cached
  • pharmacybiz on 25 Jan 23
     
    Boots has welcomed job applications from LloydsPharmacy staff impacted by the news of closure of all its branches located in Sainsbury's before the end of 2023. The company is recruiting for more than 1,500 pharmacy roles nationwide. Vacancies span pharmacy roles at all levels - from Pharmacy Advisors (Dispensers) and Trainee Pharmacists to experienced Pharmacists looking to develop their careers. Sebastian James, Managing Director of Boots UK & ROI, said: "Pharmacies deliver vital healthcare in the heart of communities. News of the closure of LloydsPharmacy branches within Sainsbury's stores will no doubt have an impact on many talented pharmacists as well as their patients. "We have many roles available at Boots and welcome applications from LloydsPharmacy employees affected by the closures. Patients who are worried about their future pharmacy provision can check our store locator online to find out where their nearest Boots store is - our pharmacy team members are ready to help." There are over 2,200 Boots stores across the UK and 85% of the population live within 10 minutes of a Boots store.
George Thomas

China to lift ban on disposable foamed plastic tableware - 0 views

www.plasticsinfomart.com/sable-foamed-plastic-tableware

Industry Portal News Plastic Marketplace Products Jobs Community Business Directory Machineries & Machines Polymer Raw Material Chemical Prices Companies HDPE PVC LDPE Injection Molding Extrusion Fillers Masterbatches Additives Granules plastics Trade

shared by George Thomas on 23 Mar 13 - No Cached
  • George Thomas on 23 Mar 13
     
    Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com
George Thomas

TPE kills pathogens without toxins - 0 views

www.plasticsinfomart.com/kills-pathogens-without-toxins

Industry Portal News Plastic Marketplace Products Jobs Community Business Directory Machineries & Machines Polymer Raw Material Chemical Prices Companies HDPE PVC LDPE Injection Molding Extrusion Fillers Masterbatches Additives Granules plastics Trade

shared by George Thomas on 01 Apr 13 - No Cached
  • George Thomas on 01 Apr 13
     
    Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com
George Thomas

New extrusion coating line from Davis-Standard targets flexible packaging market - 0 views

www.plasticsinfomart.com/gets-flexible-packaging-market

Industry Portal News Plastic Marketplace Products Jobs Community Business Directory Machineries & Machines Polymer Raw Material Chemical Prices Companies HDPE PVC LDPE Injection Molding Extrusion Fillers Masterbatches Additives Granules plastics Trade

shared by George Thomas on 01 Apr 13 - No Cached
  • George Thomas on 01 Apr 13
     
    Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com
Nathan Goodyear

Testosterone Treatment and Sexual Function in Older Men with Low Testosterone Levels: T... - 0 views

press.endocrine.org/...jc.2016-1645

low T low Testosterone Testosterone male hormones libido ED estradiol hormones

shared by Nathan Goodyear on 13 Jul 16 - No Cached
  • Nathan Goodyear on 13 Jul 16
     
    new study finds that men >65 with low libido and Testosterone levels < 275 increase sexual function with Testosterone therapy.  Only libido was improved; no benefit to erectile function was noted--note that is likely due to depleted NO.  Given time that should improve with he increase in NO synthase and thus NO.  I have a fault with on elf the comments on this study: they point out that increased free Testosterone and estradiol levels were associated with improved sexual activity.  This lacks an understanding of the physiology.  In men with low T > 65, the majority are dealing with inflammation and excess weight; all of which increase aromatase activity and thus estradiol activity.  This does not indicate that an increase in estradiol activity is associated with improved libido in men.  How can elevated estrogen levels lead to low T and then increase levels are associated with improved libido?  This is merely a reflection of the body's dysfunctional physiology.  This observation of increased estradiol by no means shows cause and effect.  Scientists need to due a better job in vetting what they write!
Nathan Goodyear

America's Health Rankings and United Health Foundation - 0 views

www.americashealthrankings.org

health statistics

shared by Nathan Goodyear on 19 Apr 12 - Cached
  • Nathan Goodyear on 19 Apr 12
     
    very nice analysis of the statistics put together by United Health.  Give credit where it is due.  Good job United.
Nathan Goodyear

Scleroderma - 8 - Fibroblasts, Systemic Sclerosis, Calcitriol - Life Extension Health C... - 0 views

www.lef.org/...scleroderma_08.htm

scleroderma natural therapy treatment

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    nice review of natural therapies for scleroderma.  Life extensions always does a great job of supporting natural therapies with science.
Nathan Goodyear

Nutrition & Metabolism | Full text | Fructose, insulin resistance, and metabolic dyslip... - 0 views

www.nutritionandmetabolism.com/...5

fructose metabolic syndrome metabolic syndrome insulin resistance obesity nutrition metabolism

shared by Nathan Goodyear on 16 Sep 13 - Cached
  • For thousands of years humans consumed fructose amounting to 16–20 grams per day
  • daily consumptions amounting to 85–100 grams of fructose per day
  • Of key importance is the ability of fructose to by-pass the main regulatory step of glycolysis, the conversion of glucose-6-phosphate to fructose 1,6-bisphosphate, controlled by phosphofructokinase
  • ...29 more annotations...
  • Thus, while glucose metabolism is negatively regulated by phosphofructokinase, fructose can continuously enter the glycolytic pathway. Therefore, fructose can uncontrollably produce glucose, glycogen, lactate, and pyruvate, providing both the glycerol and acyl portions of acyl-glycerol molecules. These particular substrates, and the resultant excess energy flux due to unregulated fructose metabolism, will promote the over-production of TG (reviewed in [53]).
  • Glycemic excursions and insulin responses were reduced by 66% and 65%, respectively, in the fructose-consuming subjects
  • reduction in circulating leptin both in the short and long-term as well as a 30% reduction in ghrelin (an orexigenic gastroenteric hormone) in the fructose group compared to the glucose group.
  • A prolonged elevation of TG was also seen in the high fructose subjects
  • Both fat and fructose consumption usually results in low leptin concentrations which, in turn, leads to overeating in populations consuming energy from these particular macronutrients
  • Chronic fructose consumption reduces adiponectin responses, contributing to insulin resistance
  • A definite relationship has also been found between metabolic syndrome and hyperhomocysteinemia
  • the liver takes up dietary fructose rapidly where it can be converted to glycerol-3-phosphate. This substrate favours esterification of unbound FFA to form the TG
  • Fructose stimulates TG production, but impairs removal, creating the known dyslipidemic profile
  • the effects of fructose in promoting TG synthesis are independent of insulinemia
  • Although fructose does not appear to acutely increase insulin levels, chronic exposure seems to indirectly cause hyperinsulinemia and obesity through other mechanisms. One proposed mechanism involves GLUT5
  • If FFA are not removed from tissues, as occurs in fructose fed insulin resistant models, there is an increased energy and FFA flux that leads to the increased secretion of TG
  • In these scenarios, where there is excess hepatic fatty acid uptake, synthesis and secretion, 'input' of fats in the liver exceed 'outputs', and hepatic steatosis occurs
  • Carbohydrate induced hypertriglycerolemia results from a combination of both TG overproduction, and inadequate TG clearance
  • fructose-induced metabolic dyslipidemia is usually accompanied by whole body insulin resistance [100] and reduced hepatic insulin sensitivity
  • Excess VLDL secretion has been shown to deliver increased fatty acids and TG to muscle and other tissues, further inducing insulin resistance
  • the metabolic effects of fructose occur through rapid utilization in the liver due to the bypassing of the regulatory phosphofructokinase step in glycolysis. This in turn causes activation of pyruvate dehydrogenase, and subsequent modifications favoring esterification of fatty acids, again leading to increased VLDL secretion
  • High fructose diets can have a hypertriglyceridemic and pro-oxidant effect
  • Oxidative stress has often been implicated in the pathology of insulin resistance induced by fructose feeding
  • Administration of alpha-lipoic acid (LA) has been shown to prevent these changes, and improve insulin sensitivity
  • LA treatment also prevents several deleterious effects of fructose feeding: the increases in cholesterol, TG, activity of lipogenic enzymes, and VLDL secretion
  • Fructose has also been implicated in reducing PPARα levels
  • PPARα is a ligand activated nuclear hormone receptor that is responsible for inducing mitochondrial and peroxisomal β-oxidation
  • decreased PPARα expression can result in reduced oxidation, leading to cellular lipid accumulation
  • fructose diets altered the structure and function of VLDL particles causing and increase in the TG: protein ratio
  • LDL particle size has been found to be inversely related to TG concentration
  • therefore the higher TG results in a smaller, denser, more atherogenic LDL particle, which contributes to the morbidity of the metabolic disorders associated with insulin resistance
  • High fructose, which stimulates VLDL secretion, may initiate the cycle that results in metabolic syndrome long before type 2 diabetes and obesity develop
  • A high flux of fructose to the liver, the main organ capable of metabolizing this simple carbohydrate, disturbs normal hepatic carbohydrate metabolism leading to two major consequences (Figure 2): perturbations in glucose metabolism and glucose uptake pathways, and a significantly enhanced rate of de novo lipogenesis and TG synthesis, driven by the high flux of glycerol and acyl portions of TG molecules coming from fructose catabolism
  • Nathan Goodyear on 16 Sep 13
     
    Fructose and metabolic syndrome.  Good discussion of the impact of high fructose intake and metabolic dysfunction.  This study also does a great job of highlighting the historical change of fructose intake.
Nathan Goodyear

Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metas... - 0 views

www.ncbi.nlm.nih.gov/...PMC3371140

pancreatic cancer pancreatic cancer HIF-1alpha NF-kappaB GLUT4 GLUT1 Graviola Soursop Annona Muricata

shared by Nathan Goodyear on 17 Oct 13 - No Cached
  • Nathan Goodyear on 17 Oct 13
     
    New insight to new therapy for Pancreatic cancer.  This article/study does a great job of reviewing the biochemistry by which Graviola works against pancreatic cancer.  Graviola was shown to downregulate HIF-1alpha, NF-kappaB, GLUT1, GLUT4, HKII, and LDHA.  Complex 1 of the electron transport was also inhibited.
Nathan Goodyear

International Journal of Impotence Research - Clomiphene increases free testosterone le... - 0 views

www.nature.com/...3900981a.html

low T Testosterone ED erectile dysfunction climid

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    Nice study that looked at climid to restore HPA function and increase Testosterone stimulation and production.  This study also does a good job of reviewing the mechanisms of low T.  Low T is really a biomarker of poor health in men.
Nathan Goodyear

Unintended effects of statins from observational studies in the general population: sys... - 0 views

www.ncbi.nlm.nih.gov/...PMC3998050

statin therapy statins myopathy cholesterol side effects diabetes liver liver enzymes

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • A markedly increased risk of myopathy was observed
  • One cohort study (Women’s Health Initiative) of higher quality and larger sample size found stronger evidence of an increased risk of self-reported T2DM (OR=1.47; 95% CI 1.32 to 1.64) for the groups of women who reported statin use at baseline and three years later
  • Hippisley-Cox et al. found an increased risk of liver enzyme changes
  • ...5 more annotations...
  • weak evidence of an increased risk of type 2 diabetes mellitus (T2DM) was observed
  • Smeeth et al. found an increased risk of incident liver disease in the first year after the index date
  • The cumulative incidence of T2DM after three years of statin treatment was 6.25%, corresponding to an excess risk of 2.25%
  • We found no increased risk of peripheral neuropathy, depression, common eye diseases, renal disorders or arthritis associated with taking statins. Studies of higher quality did not show previously reported protective effects of statins on fractures, venous thrombo-embolism or pneumonia
  • There was evidence of an increase in myopathy, raised liver enzymes and diabetes.
  • Nathan Goodyear on 19 Mar 15
     
    Statin use associated with increased myopathy, liver dysfunction, and type II Diabetes.  The authors conclude that the absolute risk is very low, yet OR was 1.47 for type II Diabetes (translated 47% increased odds of developing Diabetes as a result of statins) and OR of 2.63 in risk of myopathy (translated 163% increased odds of developing myopathy as a result of statins).  Seems the authors "low risk" statement is just applies to those without symptoms/side effects.  Physicians need to do a better job of understanding risks and customizing therapies.
arunaraayala

No pay, no expenses, no laws for Venezuela opposition lawmakers - Locality News - 0 views

www.localitynews.com/enezuelas-opposition-lawmakers

POWER CUTS VENEZUELA OPPOSITION LAWMAKER WORLD NEWS

shared by arunaraayala on 15 Oct 16 - No Cached
  • arunaraayala on 15 Oct 16
     
    On a minor scale, congressmen say they are also being obstructed from doing their job because of lac...
Nathan Goodyear

Clinical experience with intravenous administration of ascorbic acid: achievable levels... - 0 views

www.ncbi.nlm.nih.gov/...PMC3751545

IV vitamin C dosing ascorbic acid inflammation disease cancer IV vitamin C intravenous vitamin C IV intravenous vitamin C vitamin C CRP therapy treatment alternative

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Patients with higher tumor markers are likely to have higher tumor burden, higher oxidative stress and, therefore, are more likely to have lower post IVC plasma levels.
  • Our data also showed that cancer patients with metastasis tend to have lower post-IVC vitamin C levels than those without metastasis
  • Lower peak plasma concentrations are obtained in cancer patients than in healthy subjects. Cancer patients who are deficient in vitamin C prior to therapy tend to achieve lower plasma levels post infusion.
  • ...25 more annotations...
  • Patients with higher inflammation or tumor burdens, as measured by CRP levels or tumor antigen levels, tend to show lower peak plasma ascorbate levels after IVC.
  • Patients with metastatic tumors tend to achieve lower post infusion plasma ascorbate levels than those with localized tumors.
  • Meta-analyses of clinical studies involving cancer and vitamins also conclude that antioxidant supplementation does not interfere with the efficacy of chemotherapeutic regiments
  • Most of the prostate cancer patients studied, 75±19% (95% confidence), showed reductions in PSA levels during the course of their IVC therapy
  • Laboratory studies suggest that, at high concentrations, ascorbate does not interfere with chemotherapy or irradiation and may enhance efficacy in some situations
  • Cameron and Pauling observed fourfold survival times in terminal cancer patients treated with intravenous ascorbate infusions followed by oral supplementation
  • The inflammatory microenvironment of cancer cells leads to increasing oxidative stress, which apparently depletes vitamin C, resulting in lower plasma ascorbate concentrations in blood samples post IVC infusion. Another explanation for this finding may be that cancers are themselves more metabolically active in their uptake of vitamin C, causing subjects to absorb more of the vitamin, and as a results show lower plasma ascorbate concentrations in blood post IVC infusion.
  • patients with severely elevated CRP levels attain plasma ascorbate concentrations after IVC infusions that are only 65% of those attained for subjects with normal CRP levels
  • The finding of decreased plasma ascorbate levels in cancer patients may relate to the molecular structure of ascorbic acid; in particular, the similarity of its oxidized form, dihydroascorbic acid, to glucose
  • Since tumor have increased requirement for glucose [67], transport of dehydroascorbate into the cancer cells via glucose transport molecules and ascorbate through sodium-dependent transporter may be elevated
  • Increased accumulation of ascorbic acid in the tumor site was supported by measurements of the level of ascorbic acid in tumors in animal experiments
  • patients with advanced malignancies may have lower level of ascorbic acid in tissue, creating a higher demand for the vitamin C
  • IVC therapy appears to reduce CRP levels in cancer patients.
  • CRP concentrations directly correlate with disease activity in many cases and can contribute to disease progression through a range of pro-inflammatory properties.
  • Being an exquisitely sensitive marker of systemic inflammation and tissue damage, CRP is very useful in screening for organic disease and monitoring treatment responses
  • ncreases in CRP concentrations have been associated with poorer prognosis of survival in cancer patients, particularly with advance disease independent of tumor stage
  • Regarding inflammation, 73±13% of subjects (95% confidence) showed a reduction in CRP levels during therapy. This was an even more dramatic 86±13% (95% confidence) in subjects who started therapy with CRP levels above 10&nbsp;mg/L
  • patients treated by IVC with follow-up several year showed that suppression of inflammation in cancer patients by high-dose IVC is feasible and potentially beneficial
  • Inflammation is a marker of high cancer risk, and poor treatment outcome
  • The subjects with highly elevated CRP concentrations have a three-fold elevation “all-cause” mortality risk and a twenty-eight fold increase in cancer mortality risk
  • cancer patients may need higher doses to achieve a given plasma concentration.
  • patients with lower vitamin C levels may see more distribution of intravenously administered ascorbate into tissues and thus attain less in plasma.
  • When treating patients with IVC, the first treatment likely serves to replenish depleted tissue stores, if those subjects were vitamin C deficient at the beginning of the treatment. Then, in subsequent treatments, with increasing doses, higher plasma concentrations can be attained. On-going treatments serve to progressively reduce oxidative stress in cancer patients.
  • large doses given intravenously may result in maximum plasma concentrations of roughly 30&nbsp;mM, a level that has been shown to be sufficient for preferential cytotoxicity against cancer cells
  • oral intake of vitamin C exceeded 200&nbsp;mg administered once daily, it was difficult to increase plasma and tissue concentrations above roughly 200&nbsp;μM.
  • Nathan Goodyear on 26 Aug 14
     
    Great review on the use of IV vitamin C in cancer and to reduce inflammation.  The article does a great job of discussing the mechanism of vitamin C therapy in cancer as well as the proposed reasons for low vitamin C in cancer patients.  The study also highlights the obstacles to rise in vitamin C levels post IV vitamin C in cancer patients.
healthbeyondins

Employer Sponsored Health Insurance - The Average Cost - 0 views

blog.healthbeyondinsurance.com/lth-insurance-the-average-cost

EmployerSponsoredHealthInsurance healthinsurance healthinsurancecosts SponsoredHealthInsurance

shared by healthbeyondins on 16 Oct 20 - No Cached
  • healthbeyondins on 16 Oct 20
     
    Employer-sponsored coverage is the health insurance that is offered through the job. An employer offers a choice of group health plans to the eligible workers and covers a part of the insurance premium.
pharmacybiz

People To Be 'Patient And Courteous' With Pharmacy Teams - 0 views

www.pharmacy.biz/tient-and-courteous-with-staff

Pharmacy-Business pharmacy-news-uk Pharmacy-bodies pharmacy-team Pharmacy-support-staff lateral-flow-test-shortage-uk community-pharmacies-UK

shared by pharmacybiz on 10 Jan 22 - No Cached
  • pharmacybiz on 10 Jan 22
     
    Amid the ongoing furore over shortages of Lateral Flow Device (LFD) test kits that led pharmacy staff to bear customers' wrath, the National Pharmacy Association (NPA) and Company Chemists Association (CCA) have jointly appealed the public to be "patient and courteous to pharmacy teams". In an open letter, the two organisations have urged patients and customers to be patient, courteous and safe while visiting their local pharmacies. Highlighting the efforts put in by healthcare workers to keep everyone safe through this tough winter, the two organisations said the pressure of Covid-19 and shortage of LFD kits have sometimes led to verbal abuse of pharmacy staff. Mark Lyonette, NPA chief executive said: "The vast majority of pharmacy customers and patients are polite and understanding. The supply situation with Lateral Flow Tests is stretching people's patience, but that's no excuse for abusive behaviour and people need to understand the constraints on pharmacy teams at this time." Alongside their routine job of providing medicines, health advice and a range of NHS services, pharmacies have put in extra effort to protect people during the pandemic.
Day Spa Adelaide

Gorgeous Day Spa Treatment - 1 views

Being a working mom who is also pregnant is not really easy as there are really times when you want to rest but cannot do it because you are at work. It is for this reason that I always find time t...

started by Day Spa Adelaide on 19 Dec 12 no follow-up yet
Benton Smith

Printinginn - 0 views

www.printinginn.com

Booklets Bookmarks Box Printing Brochures Business Cards Calendars CD Jackets Flyers Labels Letterheads Post Posters Rack Stickers Tickets.

shared by Benton Smith on 30 Oct 12 - No Cached
  • Benton Smith on 30 Oct 12
     
    Printinginn.com is a one-stop solution for all your printing needs. Printinginn provides full color printing in different styles, sizes and shapes using materials of your choice. We are specialized in Booklets, Bookmarks, Box Printing, Brochures, Business Cards, CD Jackets, Flyers, Labels, Letterheads, Post Cards, Posters, Rack Cards, Stickers and many more. We use the best printing methods to achieve best printing results and thus can print your jobs using a vast number of custom options.
Windows Customer Support Number

Windows support number 1-800-261-4071 - 0 views

www.adsyellowpages.com/...mber-1-800-261-4071-297755.htm

Windows technical customer services tech help

shared by Windows Customer Support Number on 07 Jul 16 - No Cached
  • Windows Customer Support Number on 07 Jul 16
     
    we have a team of best tech support help, our technician will always available in services, just dial our Windows technical support number 1-800-261-4071 for an instant solutions, you can also visit our websites as http://technicalsupportnumberforwindows.com
Nathan Goodyear

» Blog Archive » 'Bad' Cholesterol Not As Bad As People Think, Shows Texas A&... - 0 views

tamunews.tamu.edu/...ple-think-shows-texas-am-study

cholesterol HDL LDL

shared by Nathan Goodyear on 10 May 11 - No Cached
  • he bottom line is that LDL – the bad cholesterol – serves as a reminder that something is wrong and we need to find out what it is
  • “It gives us warning signs. Is smoking the problem, is it diet, is it lack of exercise that a person’s cholesterol is too high? It plays a very useful role, does the job it was intended to do, and we need to back off by always calling it ‘bad’ cholesterol because it is not totally bad.”
  • Nathan Goodyear on 10 May 11
     
    LDL cholesterol is not all bad; it is a warning signal.  We just need to be listening.
Sonny Cher

Party All You Want After Work - 1 views

My current job ends at 10 in the evening. However, it is my friend's homecoming party and he invited me to come by after work. I knew I would definitely feel exhausted after work and I am afraid I ...

stimulants

started by Sonny Cher on 17 May 11 no follow-up yet
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