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Nathan Goodyear

Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-def... - 0 views

ajpendo.physiology.org/...E1191.long

oral estrogen oral estrogen HGH human growth hormone growth hormone IGF-1 hormone hormones therapy

shared by Nathan Goodyear on 19 Feb 13 - No Cached
  • Nathan Goodyear on 19 Feb 13
     
    One really wonders if estrogen should ever be given orally at all.  Though this study is small, this is consistent with other studies that show that estrogen therapy, particularly oral therapy interferes with growth hormone signaling and thus action.  Oral estrogen decreases IGF-1, increases growth hormone binding protein, lowers metabolism and reduces protein metabolism as monitored by leucine turnover.
Nathan Goodyear

A randomized, open-label, crossover study ... [Menopause. 2007 Nov-Dec] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17507833

BHRT HRT estrogen oral transdermal therapy treatment hormones TBG thyroid liver metabolism

shared by Nathan Goodyear on 16 Nov 11 - No Cached
  • Nathan Goodyear on 16 Nov 11
     
    oral estrogen is a bad choice as it relates to BHRT or HRT for that matter.  Compared to transdermal estrogen, oral estrogen through increasing TBG and slowed liver metabolism results in decreased thyroid hormone production.  
Nathan Goodyear

Administration route-dependent effects of estrogens on IGF-I levels during fixed GH rep... - 0 views

eje-online.org/...709.long

oral estrogen therapy oral estrogen therapy IGF-1 human growth hormone HGH hormone hormones women

shared by Nathan Goodyear on 19 Feb 13 - No Cached
  • Nathan Goodyear on 19 Feb 13
     
    oral estrogen therapy decreased IGF-1 concentrations in those women taking growth hormone, requiring high dosing of HGH versus that in women using estrogen through a transdermal approach.
Nathan Goodyear

Estrogenic Potential of Progestins in Oral Contraceptives to Stimulate Human Breast Can... - 0 views

cancerres.aacrjournals.org/...6539.full.pdf+html

progestins birth controls hormones oral contraceptives

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Estrogenic Potential of Progestins in Oral Contraceptives to Stimulate Human Breast Cancer Cell Proliferation1
Nathan Goodyear

A Radioimmunoassay for 3,3',5'-L-Triiodothyronine (Reverse T3): Assessment of Thyroid G... - 0 views

jcem.endojournals.org/...660

reverse T3 estrogen pregnancy hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis.
  • Nathan Goodyear on 08 Mar 11
     
    oral estrogen supplementation increase reverse T3 and lowers metabolism and leads to weight gain
Nathan Goodyear

Hospitalization for pulmonary embolism associated with antecedent testosterone or estro... - 0 views

bmchematol.biomedcentral.com/...s12878-016-0045-9

testosterone replacement therapy testosterone therapy hormones PE DVT estrogen therapy birth control

shared by Nathan Goodyear on 30 Jul 17 - No Cached
  • Nathan Goodyear on 30 Jul 17
     
    Testosterone use in men with PE is rare: 5% in this study and 1.2% in previous study by same authors. Procoagulant thrombophilia is rare, yet the authors still suggested procoagulant tests prior to Testosterone therapy in men, Estrogen therapy in women and oral birth control in women.
Nathan Goodyear

Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Blood Coagulation and... - 0 views

atvb.ahajournals.org/...3071.short

transdermal bioidentical estrogen progesterone estradiol thromboembolism DVT

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estrogen/progesterone therapy does not increase thrombotic risk
Nathan Goodyear

Differential Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Sensitiv... - 0 views

atvb.ahajournals.org/...1671.short

oral estradiol estrogen transdermal bioidentical DVT thromboembolism

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estradiol does not increase blood clot risk, when compared with oral estradiol
Nathan Goodyear

The estrogenic activity of synthetic progestins us... [Cancer. 1993] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8431886

synthetic progestins breast cancer

shared by Nathan Goodyear on 12 Nov 10 - No Cached
  • Nathan Goodyear on 12 Nov 10
     
    The estrogenic activity of synthetic progestins used in oral contraceptives.
Nathan Goodyear

A cross-sectional study of different patterns of oral contraceptive use among premenopa... - 0 views

www.ncbi.nlm.nih.gov/...PMC3123282

birth control pills OCP contraception IGF-1 HGH pre-menopausal women human growth hormone

shared by Nathan Goodyear on 20 Feb 13 - No Cached
  • Nathan Goodyear on 20 Feb 13
     
    Birth control pills were found to reduce IGF-1 levels in the short term and long term.  Those that had used birth control pills had lower IGF-1 levels compared to those that had never used birth control pills.  This fits with the current knowledge that oral estrogen reduces HGH and IGF-1.  Those were in post-menopausal women, but this is in pre-menopaus women.  This has implications on health, weight, disease...
Nathan Goodyear

Chemistry and Structural Biology of Androgen Receptor - 0 views

www.ncbi.nlm.nih.gov/...PMC2096617

androgens Testosterone DHT dihydrotestosterone AR androgen receptors male hormones hormones

shared by Nathan Goodyear on 28 Sep 16 - No Cached
  • Healthy adult men typically produce approximately 3–10 mg of testosterone per day
  • circulating levels ranging from 300 to 700 ng/dL in eugonadal men
  • endogenous testosterone secretion is pulsatile and diurnal
  • ...15 more annotations...
  • highest concentration occurring at about 8:00 a.m. and the lowest at about 8:00 p.m.
  • Average serum concentrations and diurnal variation in testosterone diminish as men age
  • 40% is sequestered with high affinity to sex hormone-binding globulin (SHBG)
  • almost 60% is bound with low affinity to albumin
  • 2% as free, unbound hormone
  • 5α-DHT has even greater binding affinity to sex hormone-binding globulin than does testosterone
  • 5α-DHT is only about 5% as abundant in the blood as testosterone and is largely derived from peripheral metabolism of testosterone
  • Both 5α-reduction and aromatization are irreversible processes
  • Approximately 90% of an oral dose of testosterone is metabolized before it reaches the systemic circulation
  • there are three modes of action of testosterone. It may directly act through AR in target tissues where 5α-reductase is not expressed, be converted to 5α-DHT (5–10%) by 5α-reductase before binding to AR, or be aromatized to estrogen (0.2%) and act through the estrogen receptor
  • 5α-DHT is a more potent AR ligand than testosterone
  • has 2–10-fold higher potency than testosterone in androgen-responsive tissues
  • estrogen plays a major role in regulating metabolic process,74,75 mood and cognition,76 cardiovascular disease,77,78 sexual function including libido,79 and bone turnover in men
  • Free testosterone is considered the most “biologically active” form
  • testosterone is the major androgen that acts in the “DHT-independent” tissues, such as skeletal muscle, where 5α-reductase is not expressed or is expressed at a very low level
  • Nathan Goodyear on 28 Sep 16
     
    good review of androgens and AR.
Nathan Goodyear

Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syn... - 0 views

onlinelibrary.wiley.com/...abstract

HRT metabolic syndrome CRP protein S MetS

shared by Nathan Goodyear on 01 Sep 13 - No Cached
  • Nathan Goodyear on 01 Sep 13
     
    HRT improves MetS.  Oral estrogen increased CRP and protein S, but not transdermal.
Nathan Goodyear

Synthetic progestins induce proliferation of breas... [Mol Cell Endocrinol. 1994] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...7926273

hormones bioidentical progesterone progestins

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation.
Nathan Goodyear

Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone rati... - 0 views

www.ncbi.nlm.nih.gov/...PMC3039007

breast cancer 2-OH-estrone 2-OH 4-OH 2:16alpha-OHE1 2:16 estrogen metabolism

shared by Nathan Goodyear on 02 Jan 13 - No Cached
  • A recent study of nine patients concluded that the urinary EMR is a good approximation for breast tissue EMR
  • A single study in young women not using oral contraceptives found fair correlation coefficients between urinary and plasma EMR
  • All of nine properly designed epidemiological studies (six prospective case-control studies and three retrospective studies) failed to show a significant relationship between urinary or circulating EMR (2OHE1/16αOHE1) and breast cancer risk
  • ...2 more annotations...
  • premenopausal studies on urinary EMR have suggested a potentially weak inverse relationship, associations were not significantly different compared with postmenopausal or overall combined studies
  • at present, there is no evidence that the EMR can predict breast cancer risk
  • Nathan Goodyear on 02 Jan 13
     
    The 2:16 OH estrone pathway is shown to not be predictive biomarker for breast cancer.
Nathan Goodyear

Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism: Results F... - 0 views

atvb.ahajournals.org/...340

biodentical hormone therapy postmenopausal stroke

shared by Nathan Goodyear on 30 Mar 11 - No Cached
  • Transdermal estrogens alone or combined with progesterone might be safe with respect to thrombotic risk.
  • Oral but not transdermal estrogens were associated with an increased thrombotic risk
  • There was no significant association of venous thromboembolism with progesterone
  • Nathan Goodyear on 30 Mar 11
     
    bioidentical hormones do not increase stroke risk; also, route of delivery impacts stroke risk
Nathan Goodyear

Secular Decline in Male Testosterone and Sex Hormone Binding Globulin Serum Levels in D... - 0 views

jcem.endojournals.org/...4696.long

decline male testosterone hormone danish low t low Testosterone men SHBG serum levels

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Serum SHBG levels are negatively associated with obesity and various measures of insulin resistance
  • SHBG levels increase during pharmacological oral estrogen treatment
  • insulin decreases SHBG productio
  • ...5 more annotations...
  • The secular decline in SHBG and testosterone serum levels did not lead to a change in the level of free testosterone
  • existence of specific binding sites for SHBG at the cell membrane of steroid-responsive tissues has been shown
  • it is alarming that changes of this magnitude can be detected over such a relatively short time
  • Sex steroids stimulate SHBG production and secretion in vitro
  • Serum testosterone levels decreased and SHBG levels increased with increasing age
  • Nathan Goodyear on 10 Dec 12
     
    lower levels of SHBG and serum testosterone were found in more recently born men.  Preceding generations of men produced higher testosterone levels than men born in more recent generations.
Nathan Goodyear

ScienceDirect - The Journal of Steroid Biochemistry and Molecular Biology : Effects of ... - 0 views

www.sciencedirect.com/science

progestins HRT OCPs breast cancer

shared by Nathan Goodyear on 05 Nov 10 - No Cached
  • indicate that the use of t
  • e compounds at very high concentrations may be unfavourable, but do not support a role for them in directly stimulating
  • breast tumor proliferation at the low progestin concentration which are reached in the serum in oral contraceptive users
  • Nathan Goodyear on 05 Nov 10
     
    progestins in high dose increase risk of breast cancer
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