In this animal study, estradiol is added to Testosterone to increase prostate carcinogenesis. Previous rat studies have shown that adding estradiol to Testosterone, which occurs naturally, increases prostate cancer risk.
Azad et al [15] used single photon emission computed tomography and showed that, after 3~5 weeks of TRT, cerebral perfusion was increased in the midbrain and the superior frontal gyrus in seven men with hypogonadism
After 12~14 weeks, increased perfusion was still observed in the midbrain as well as in the midcingulate gyrus
TDS patients who received TRT showed significant improvement in cognitive function only if mild cognitive impairment was present at baseline
Cherrier et al [17] evaluated a sample of 32 subjects, which included 17 men with mild cognitive impairment and 15 with Alzheimer's disease. At the 6-week follow-up, patients who received TRT showed significantly better scores regarding spatial memory, constructional abilities, and verbal memory compared to those noted in the placebo group. Taken together, these results suggest that TRT has a beneficial effect on cognitive function
TRT improved mood and well-being, and reduced fatigue and irritability in hypogonadal men
The study by Pope et al [20] involved men with depression refractory to standard anti-depressants, and found that TRT lowered the Hamilton Depression score,
depression tends to increase as testosterone levels decrease [21], it is highly likely that TRT improved symptoms of depression by increasing testosterone levels.
study that looked at men with refractory depression symptoms on depression meds with low Testosterone finds Testosterone therapy improved depression symptoms.
when looking at men, Testosterone levels, diabetes, and death: this study found a U shaped pattern of risk; low and high-normal total Testosterone levels were associated with increased death. No association was found with free Testosterone and SHBG.
As I have been saying for awhile now, low Testosterone is the effect not the cause: new study finds that low T is a biomarker of diabetes and not a cause.
This study looked at a small number of men with low T. Therapy was abruptly stopped and the effects were followed. Insulin function declined. There was a trend to increased glucose and IL-6.
Testosterone therapy lowered HgbA1c in poorly controlled Diabetics. These patients were followed out to 52 weeks. Testosterone therapy, as is lifestyle change, a long term strategy of Diabetes control. Studies in controlled Diabetics have not shown a reduction in HgbA1c consistently. Total cholesterol and waist circumference were also reduced.
Review of xenoestrogens and techniques for evaluation. Brief discussion of the different EDCs is included, but the majority of the study is to evaluate the different testing techniques.
Phthalates have both central inhibition and peripheral effects. This article highlights the peripheral anti-androgen effects of phthalates and phthalate metabolites.
Interesting study finds that men with low serum Total Testosterone, elevated RBP4 and low SHBG at baseline predict weight regain. Thus Testosterone should be used as a biomarker of failure in weight loss and if low, Testosterone therapy should be employed to improved metabolic function. Other parameters, such as leptin, adiponectin, prolactin, progesterone...were not predictive.
Study looked at aromatase activity in androgen production in older men. The study found that aromatase inhibition with arimidex increased Testosterone production. PSA was also monitored and PSA increased in the smaller dose group versus the high dose group.