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Nathan Goodyear

The telomerase activator TA-65 elongates short telomeres and increases health span of a... - 0 views

www.ncbi.nlm.nih.gov/...PMC3627294

TA-65 telomere Telomerase telomerase activator aging natural wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • studies have demonstrated that the shortest telomeres are causal of reduced cell viability
  • a stable and enforced expression of telomerase leads to an improved health-span, accompanied by an extension of lifespan
  • TA-65 influences the percentage of cellular short telomeres through the activation of telomerase
  • ...17 more annotations...
  • TA-65 administration during 4 months significantly improved the capacity to uptake glucose after a glucose pulse
  • liver protective action of TA-65
  • A disadvantage of mTERT potentiation could be associated to its capacity to favor proliferation of cancerous cells in murine models
  • TA-65 treated mice presented a similar incidence of malignant cancers at time of death, with a tendency to show decreased sarcomas and slightly increased lymphomas
  • We demonstrate here that TA-65 leads to a significant rescue of short telomeres through telomerase activation
  • TA-65 treatment increases proliferation and mobilization potential of mouse keratinocytes in vitro, a situation mimicking telomerase overexpression
  • TAT2, a similar molecule, have beneficial effects in the activation of CD8+ T lymphocytes from HIV-infected patients where they observe an increase of the proliferative potential and enhancement of cytokine/chemokine production
  • TA-65 resulted in a similar rescue of short telomeres in leukocytes post-treatment as observed with humans, most likely through an activation of telomerase
  • we observe that TA-65 lead to 10 fold increase of telomerase RNA levels in the liver of treated mice comparing to the non-treated same-age cohorts
  • TA-65 regulates telomerase at the transcription level, probably through the regulation of the MAPK pathway
  • TA-65 dependent telomerase activation results in a better organ fitness as demonstrated by the improved scores at the glucose tolerance test and insulin levels at fasting
  • TA-65 supplemented mice also present modest enhancement of the subcutaneous and epidermal thickness, as well as higher bone density, representative of an overall fitness status improvemen
  • TA-65 treated mice present higher levels of RBC and hemoglobin comparing to the control cohorts
  • improved health-span of TA-65 treated mice is not accompanied by increased cancer incidence, which may be related to the fact that TERT levels are very modestly increased in all tissues tested except for the liver
  • systemic telomerase overexpression from the germline leads to protection from aging associated pathologies
  • similar situation could be mimicked expressing telomerase late in life in a telomerase deficient background
  • we observed a higher proliferation rate and a partial protection from cell death in some tissues of TA65 treated mice
  • Nathan Goodyear on 16 May 16
     
    TA-65 shown to increase telomerase activity, and thus telomere length of short telomeres, in mouse study.  
Nathan Goodyear

Prevention of diabetes, hepatic injury, and colon cancer with dehyd... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12943737

DHEA dehydroepiandrosterone cancer colon colon cancer diabetes liver insulin hormone hormones

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    This article focus' more on the liver and insulin effect of DHEA, but highlights the 2002 study of DHEA and decreased aberrant crypt foci in potential cancer prevention.
Nathan Goodyear

Importance of serum prolactin determinations in metastatic breast cancer patients | Ham... - 0 views

www.academia.edu/...astatic_breast_cancer_patients

cancer breast cancer liver prolactin

shared by Nathan Goodyear on 11 May 18 - No Cached
  • Nathan Goodyear on 11 May 18
     
    Prolactin is a useful marker for prognosis and metastatic potential for women with breast cancer and liver mets risk.
Nathan Goodyear

Phase II Randomized Trial of Autologous Formalin-Fixed Tumor Vaccine for Postsurgical R... - 0 views

clincancerres.aacrjournals.org/...1574

immunotherapy cancer hepatocellular cancer liver cancer

shared by Nathan Goodyear on 24 May 18 - No Cached
  • Nathan Goodyear on 24 May 18
     
    Specific immunotherapy from patient the specific antigens of cancer cells fixed in formalin improves survival in hepatocellular cancer.
Nathan Goodyear

Probiotics and gut health: A special focus on liver diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC2811790

probiotic probiotics liver cancer disease IBD IBS cirrhosis NAFLD gut health

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    Probiotics are not just for disease prevention, but also can be utilized as adjuncts for different liver disease states.  This review article highlights probiotics in IBD, IBS, surgery, NAFLD, cancer, and cirrhosis.
Nathan Goodyear

Interpreting raised serum ferritin levels | The BMJ - 1 views

www.bmj.com/...bmj.h3692

ferritin liver cancer inflammation liver disease renal failure metabolic syndrome

shared by Nathan Goodyear on 23 Aug 18 - No Cached
  • Nathan Goodyear on 23 Aug 18
     
    good read, though only abstract available here.  Elevated Ferritin is usually caused by inflammation, chronic alcohol use, liver disease, renal failure, MetS, or cancer.
Nathan Goodyear

High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals corre... - 0 views

www.ncbi.nlm.nih.gov/...PMC2833250

colon cancer colorectal cancer cancer LPS lipopolysaccharides

shared by Nathan Goodyear on 11 Sep 17 - No Cached
  • Nathan Goodyear on 11 Sep 17
     
    High TLR4 and MyD88 expression on the surface of colorectal cancer cells associated with increase liver mets potential and worsened prognosis.  LPS works through TLR4 and MyD88.
Nathan Goodyear

Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific... - 0 views

www.bmj.com/bmj.k671

vitamin D cancer

shared by Nathan Goodyear on 15 Mar 18 - No Cached
  • Nathan Goodyear on 15 Mar 18
     
    New Study from BMJ finds that higher vitamin D levels are associated with a decreased relative risk for total cancer.  The most significant inverse association was found with risk of liver cancer. The study divided the vitamin D levels into quartiles.
Nathan Goodyear

High Dose IV Vitamin C and Metastatic Breast Cancer: A Case Report - ISOM - 0 views

isom.ca/...atic-breast-cancer-case-report

metastasis breast cancer High dose IV vitamin C cancer IV vitamin C vitamin C high dose vitamin C

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    Case study of vitamin C IV up to 75 grams IV effective in stabilizing breast cancer with mets to liver.
Nathan Goodyear

Long‐acting octreotide versus placebo for treatment of advanced HCC: A random... - 0 views

aasldpubs.onlinelibrary.wiley.com/...hep.21468

octreotide GH growth hormone cancer liver cancer

shared by Nathan Goodyear on 09 Jul 18 - No Cached
  • Nathan Goodyear on 09 Jul 18
     
    Octreotide, GH inhibitor, no better than placebo in liver cancer.
Nathan Goodyear

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatoce... - 0 views

aasldpubs.onlinelibrary.wiley.com/...hep.23054

MDSC liver cancer NK cells cancer hepatocellular carcinoma myeloid-derived suppressor cells

shared by Nathan Goodyear on 11 Nov 20 - No Cached
  • Nathan Goodyear on 11 Nov 20
     
    In liver cancer, MDSCs suppress NK cells. Other studies show this effect is more than Treg cells.
Nathan Goodyear

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydrox... - 0 views

www.ncbi.nlm.nih.gov/...PMC154104

progesterone metabolites breast cancer 5alpha-reductase 5-alpha pregnene 5-alpha pregnenes 4-pregnene 4-pregnenes

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Exposure of human breast cell lines (MCF-7, MCF-10A, and ZR-75-1) to 5α-pregnanes results in changes associated with neoplasia, including increased proliferation and decreased attachment [1], depolymerization of F-actin [2] and decreases in adhesion plaque-associated vinculin
  • Exposure to 4-pregnenes results, in general, in opposite (anti-cancer-like) effects
  • 5αR1 has been detected in various androgen-independent organs, such as the liver and brain
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  • 5αR2 has been found predominantly in androgen-dependent organs, such as epididymis and prostate
  • The 5α-pregnanes:4-pregnenes ratio was about 8-fold higher in tumorous than in nontumorous breast tissue after an 8-hour incubation with [14C]progesterone
  • Studies with breast cell lines, showing that 5α-pregnanes stimulate proliferation and decrease attachment of cells
  • both tissue and breast cell line studies suggest that an elevated level of progesterone 5α-reductase activity may be an indicator of breast tumorigenesis, regardless of presence or absence of ER and/or PR
  • 5αR1 is the main isoform expressed in human breast carcinomas [29] and that 5αR2 may not be associated with risk of breast cancer
  • the differences in 5α-pregnane production between the cells is due primarily to a difference in 5αR1 expression
  • As in the case of 5α-reductase activity, the presence or absence of ER and PR do not appear to be related to 5α-reductase expression.
  • the conversion of progesterone to the cancer promoting 5α-pregnanes is significantly higher in the human tumorigenic breast cell lines
  • lthough both 5αR1 and 5αR2 are expressed by these cells, the elevated 5α-reductase activity appears to be the result of significantly greater expression of 5αR1
  • Changes in progesterone metabolizing enzyme expression (resulting in enzyme activity changes) may be responsible for promoting breast cancer progression due to increased production of tumor-promoting 5α-pregnanes and decreased production of anti-cancer 20α – and 3α-4-pregnenes
  • Nathan Goodyear on 30 Jan 14
     
    balance of enzyme production between 5alpha-reductase and 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductase play role in carcinogenesis and proliferation in the balance of production of progesterone metabolites. The 5alpha pregnenes are pro carcinogenic  and the 4-pregnenes are anti carcinogenic.
Nathan Goodyear

LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases β1 Inte... - 0 views

cancerres.aacrjournals.org/...1989

cancer colon cancer colorectal cancer LPS lipopolysaccharides

shared by Nathan Goodyear on 11 Sep 17 - No Cached
  • Nathan Goodyear on 11 Sep 17
     
    cull culture study finds inhibition of LPS activated TLR4 in colorectal cancer cells decreased metastasis.
Nathan Goodyear

Local ablation for solid tumor liver metastases: techniques and treatment efficacy - 1 views

www.moffitt.org/...30.pdf

cancer liver cancer metastasis RFA radio frequency ablation

shared by Nathan Goodyear on 20 Jul 18 - No Cached
  • Nathan Goodyear on 20 Jul 18
     
    Good review of ablative treatment techniques in liver metastases.
Nathan Goodyear

Transarterial Chemoembolization With Doxorubicin-Eluting Microspheres for Inoperable He... - 0 views

www.ncbi.nlm.nih.gov/...PMC3070282

TACE DEB-TACE liver liver cancer cancer

shared by Nathan Goodyear on 26 Jul 18 - No Cached
  • Nathan Goodyear on 26 Jul 18
     
    Transarterial chemoembolization with micropheres called DEB-TACE for liver tumors.
Nathan Goodyear

Perillyl alcohol: applications in oncology. [Altern Med Rev. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9855569

perillyl alcohol cancer

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Nathan Goodyear on 11 Feb 11
     
    Perillyl alcohol inhibits cancer growth and increases cell death in colon, breast, and liver cancer
Nathan Goodyear

N-acetylcysteine improves antitumoural response of Interferon alpha by NF-kB downregula... - 0 views

www.ncbi.nlm.nih.gov/...PMC3539937

IFN-alpha N-acetylcysteine hepatocellular cancer liver cancer NAC hepatocellular carcinoma

shared by Nathan Goodyear on 03 Mar 21 - No Cached
  • Nathan Goodyear on 03 Mar 21
     
    NAC for treatment of hepatocellular cancer.
Nathan Goodyear

The effect of long-term supplementation with branched-chain amino acid granules in pati... - 0 views

www.ncbi.nlm.nih.gov/...23090049

BCAA amino acids HCV hepatitis hepatitis C liver disease cancer hepatocellular

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    BCAA improve overall survival in HCV related liver cancer.
Nathan Goodyear

Metformin in cancer prevention and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4200668

Metformin cancer mTOR IGF-1 insulin

shared by Nathan Goodyear on 27 Nov 17 - No Cached
  • relative risks imparted by diabetes are greatest (about two fold or higher) for cancers of the liver, pancreas, and endometrium, and lesser (about 1.2-1.5 fold) for cancers of the colon and rectum, breast, and bladder
  • Nathan Goodyear on 27 Nov 17
     
    Metformin useful in the prevention of cancer, but also on the treatment as an adjunct.  Good review through possible mechanisms, mToR, insulin, IGF-1...
Nathan Goodyear

High-Dose Vitamin C for Cancer Therapy - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC9231292

vitamin C cancer

shared by Nathan Goodyear on 27 Jul 22 - No Cached
  • diabetes [8], atherosclerosis [9], the common cold [10], cataracts [11], glaucoma [12], macular degeneration [13], stroke [14], heart disease [15], COVID-19 [16], and cancer.
  • 1–5% of the Vit-C inside the human cells
  • interaction between Fe(II) and H2O2 produces OH− through the Fenton reaction
  • ...35 more annotations...
  • metabolic activity, oxygen transport, and DNA synthesis
  • Iron is found in the human body in the form of haemoglobin in red blood cells and growing erythroid cells.
  • macrophages contain considerable quantities of iron
  • iron is taken up by the majority of cells in the form of a transferrin (Tf)-Fe(III) complex that binds to the cell surface receptor transferrin receptor 1 (TfR1)
  • excess iron is retained in the liver cells
  • the endosomal six transmembrane epithelial antigen of the prostate 3 (STEAP3) reduces Fe(III) (ferric ion) to Fe(II) (ferrous ion), which is subsequently transferred across the endosomal membrane by divalent metal transporter 1 (DMT1)
  • labile iron pool (LIP)
  • LIP is toxic to the cells owing to the production of massive amounts of ROS.
  • DHA is quickly converted to Vit-C within the cell, by interacting with reduced glutathione (GSH) [45,46,47]. NADPH then recycles the oxidized glutathione (glutathione disulfide (GSSG)) and converts it back into GSH
  • Fe(II) catalyzes the formation of OH• and OH− during the interaction between H2O2 and O2•− (Haber–Weiss reaction)
  • Ascorbate can efficiently reduce free iron, thus recycling the cellular Fe(II)/Fe(III) to produce more OH• from H2O2 than can be generated during the Fenton reaction, which ultimately leads to lipid, protein, and DNA oxidation
  • Vit-C-stimulated iron absorption
  • reduce cellular iron efflux
  • high-dose Vit-C may elevate cellular LIP concentrations
  • ascorbate enhanced cancer cell LIP specifically by generating H2O2
  • Vit-C produces H2O2 extracellularly, which in turn inhibits tumor cells immediately
  • tumor cells have a need for readily available Fe(II) to survive and proliferate.
  • Tf has been recognized to sequester most labile Fe(II) in vivo
  • Asc•− and H2O2 were generated in vivo upon i.v Vit-C administration of around 0.5 g/kg of body weight and that the generation was Vit-C-dose reliant
  • free irons, especially Fe(II), increase Vit-C autoxidation, leading to H2O2 production
  • iron metabolism is altered in malignancies
  • increase in the expression of various iron-intake pathways or the downregulation of iron exporter proteins and storage pathways
  • Fe(II) ion in breast cancer cells is almost double that in normal breast tissues
  • macrophages in the cancer microenvironment have been revealed to increase iron shedding
  • Advanced breast tumor patients had substantially greater Fe(II) levels in their blood than the control groups without the disease
  • increased the amount of LIP inside the cells through transferrin receptor (TfR)
  • Warburg effect, or metabolic reprogramming,
  • Warburg effect is aided by KRAS or BRAF mutations
  • Vit-C is supplied, it oxidizes to DHA, and then is readily transported by GLUT-1 in mutant cells of KRAS or BRAF competing with glucose [46]. DHA is quickly converted into ascorbate inside the cell by NADPH and GSH [46,107]. This decrease reduces the concentration of cytosolic antioxidants and raises the intracellular ROS amounts
  • increased ROS inactivates glyceraldehyde 3-phosphate dehydrogenase (GAPDH)
  • ROS activates poly (ADP-ribose) polymerase (PARP), which depletes NAD+ (a critical co-factor of GAPDH); thus, further reducing the GAPDH associated with a multifaceted metabolic rewiring
  • Hindering GAPDH can result in an “energy crisis”, due to the decrease in ATP production
  • high-dose Vit-C recruited metabolites and increased the enzymatic activity in the pentose phosphate pathway (PPP), blocked the tri-carboxylic acid (TCA) cycle, and increased oxygen uptake, disrupting the intracellular metabolic balance and resulting in irreversible cell death, due to an energy crisis
  • mega-dose Vit-C influences energy metabolism by producing tremendous amounts of H2O2
  • Due to its great volatility at neutral pH [76], bolus therapy with mega-dose DHA has only transitory effects on tumor cells, both in vitro and in vivo.
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