Krieger NS, Parker WR, Alexander KM, Bushinsky DA.
Prostaglandins regulate acid-induced cell-mediated bone resorption.
Am J Physiol Renal Physiol. 2000 Dec;279(6):F1077-82. Erratum in: Am J Physiol Renal Physiol 2001 Sep;281(3):section F following tabl
Maurer M, Riesen W, Muser J, Hulter HN, Krapf R.
Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans.
Am J Physiol Renal Physiol. 2003 Jan;284(1):F32-40. Epub 2002 Sep 24.
PMID: 12
Jehle S, Zanetti A, Muser J, Hulter HN, Krapf R.
Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia.
J Am Soc Nephrol. 2006 Nov;17(11):3213-22. Epub 2006 Oct 11
Zwart SR, Hargens AR, Smith SM.
The ratio of animal protein intake to potassium intake is a predictor of bone resorption in space flight analogues and in ambulatory subjects.
Am J Clin Nutr. 2004 Oct;80(4):1058-65.
PMID: 15447920
Bushinsky DA, Parker WR, Alexander KM, Krieger NS. Metabolic, but not respiratory, acidosis increases bone PGE(2) levels and calcium release.
Am J Physiol Renal Physiol. 2001 Dec;281(6):F1058-66.
PMID: 11704556 [PubMed - indexed for MEDLINE]
Holick MF.
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.
Am J Clin Nutr. 2004 Dec;80(6 Suppl):1678S-88S. Review.
PMID: 15585788 [PubMed - indexed for MEDLINE]
Valimaki VV, Alfthan H, Lehmuskallio E, Loyttyniemi E, Sahi T, Stenman UH, Suominen H, Valimaki MJ.
Vitamin D status as a determinant of peak bone mass in young Finnish men.
J Clin Endocrinol Metab. 2004 Jan;89(1):76-80.
PMID: 14715830 [PubMed - indexe
The acid-base hypothesis: diet and bone in the Framingham Osteoporosis Study.
Tucker KL, Hannan MT, Kiel DP.
Eur J Nutr. 2001 Oct;40(5):231-7.
PMID: 11842948
Calcium, protein, and fruit and vegetables as dietary determinants of bone health.
New SA, Millward DJ.
Am J Clin Nutr. 2003 May;77(5):1340-1; author reply 1341.
PMID: 12716695
Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats.
Mühlbauer RC, Lozano A, Reinli A, Wetli H.
J Nutr. 2003 Nov;133(11):3592-7.
PMID: 14608079
[Low levels of 25-hydroxyvitamin D (25OHD) in patients with inflammatory bowel disease and its correlation with bone mineral density]
Souza HN, Lora FL, Kulak CA, Mañas NC, Amarante HM, Borba VZ.
Arq Bras Endocrinol Metabol. 2008 Jun;52(4):684-91. Portuguese.
PMID: 18604382
Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial.
Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F.
Am J Clin Nutr. 2005 Nov;82(5):1115-26; quiz 1147-8.
PMID: 16280447
Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits.
Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R, Thompson K.
J Bone Miner Res. 2008 May;23(5):741-9.
PMID: 18433305
doi: 10.1359/jbmr.080102
Conclusions: Generalizing the findings to the population of 14,416 women who entered basic training at the Great Lakes during the 24 mo of recruitment, calcium and vitamin D supplementation for the entire cohort would have prevented 187 persons from fracturing. Such a decrease in SFx would be associated with a significant decrease in morbidity and financial costs.
Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis-connections so strong that the presence of one type of pathology is considered a likely predictor of the other. This potentially causal relationship has led to the hypothesis that these conditions share core mechanisms. Recent advances in our understanding of the complimentary roles played by vitamin D3 and vitamin K2 in vascular and bone health provide support for this hypothesis, along with insight into key metabolic dysfunctions underlying cardiovascular disease and osteoporosis.
Part I of this review summarizes current research linking vitamin D deficiency to cardiovascular disease, the physiological mechanisms underlying vitamin D's cardiovascular effects, and leading vitamin D researchers' recommendations for significantly higher supplemental doses of the pro-hormone. Part II reviews the vitamin K connection to cardiovascular disease; the ways in which vitamin D and vitamin K pair up to prevent inflammation, vascular calcification and osteoporosis; and the necessity of providing vitamin K along with vitamin D to preclude adverse effects associated with hypervitaminosis D, which include vascular and other soft tissue calcification.
RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis.
Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE.
FASEB J. 2006 Feb;20(2):401-3. Epub 2005 Dec 22.
PMID: 16373400
doi:10.1096/fj.05-4724fje
Many postmenopausal women are looking for alternatives to hormone therapy, especially in light of research findings in 2003 from the Women's Health Initiative. With major funding from the National Institutes of Health, this initiative studied the risks of combined estrogen and progestin therapy, among other health issues of critical importance to postmenopausal women. Of particular interest are phytoestrogens, which have been gaining popularity because they are marketed as "natural," because of the alleged health benefits they provide, and because they are available in a wide range of foods and supplements. This fact sheet provides an overview of phytoestrogens and discusses their potential role in osteoporosis prevention and treatment.
The balance of bone health: tipping the scales in favor of potassium-rich, bicarbonate-rich foods.
Lanham-New SA.
J Nutr. 2008 Jan;138(1):172S-177S. Review.
PMID: 18156420
