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Matti Narkia

Fish intake is associated with a reduced progression of coronary artery ather... - 0 views

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    Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease.
    Erkkilä AT, Lichtenstein AH, Mozaffarian D, Herrington DM.
    Am J Clin Nutr. 2004 Sep;80(3):626-32.
    PMID: 15321802

    Conclusions: Consumption of fish is associated with a significantly reduced progression of coronary artery atherosclerosis in women with coronary artery disease.
Matti Narkia

Role of vitamin K2 in the treatment of postmenopausal osteoporosis. - Curr Drug Saf. 20... - 0 views

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    Role of vitamin K2 in the treatment of postmenopausal osteoporosis.
    Iwamoto J, Takeda T, Sato Y.
    Curr Drug Saf. 2006 Jan;1(1):87-97. Review.
    PMID: 18690918
Matti Narkia

Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal J... - 0 views

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    Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
    Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y.
    J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21.
    PMID: 19352059

    It has been reported that treatment with a pharmacological dose (45 mg/d) of menaquinone-4 (MK-4) prevents bone loss in postmenopausal women. However, it is not known whether supplementation with low dose MK-4 has beneficial effects on bone metabolism in healthy women. The aim of this study is to examine the effects of the supplementation of 1.5 mg/d MK-4 for 4 wk on bone and lipid metabolism in healthy postmenopausal Japanese women. The study was performed as a randomized double blind placebo-controlled trial. The participants aged 53-65 y were randomly assigned to 2 groups and supplemented with 1.5 mg/d of MK-4 or a placebo for 4 wk (n=20 for each group). The most marked effects of MK-4 intake were observed on serum osteocalcin (OC) concentrations. Serum undercarboxylated OC (ucOC) concentration decreased, and the gamma-carboxylated OC (GlaOC) and GlaOC/GlaOC+ucOC ratio that indicates the degree of OC gamma-carboxylation increased significantly at 2 and 4 wk compared with that at baseline in the MK-4 group. The serum ucOC and GlaOC concentrations in the MK-4 group were significantly different from those in the placebo group at 2 wk. These results suggest that supplementation with 1.5 mg/d MK-4 accelerated the degree of OC gamma-carboxylation. The concentrations of serum lipids and other indices were not different between the groups at either intervention period. Thus, the additional intake of MK-4 might be beneficial in the maintenance of bone health in postmenopausal Japanese women.
Matti Narkia

Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sun... - 0 views

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    Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
    Pignotti GA, Genaro PS, Pinheiro MM, Szejnfeld VL, Martini LA.
    Eur J Nutr. 2009 Nov 28. [Epub ahead of print]
    PMID: 19946776

    CONCLUSION: The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health.
Matti Narkia

Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-... - 0 views

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    Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study.
    Kim J, Lim SY, Shin A, Sung MK, Ro J, Kang HS, Lee KS, Kim SW, Lee ES.
    BMC Cancer. 2009 Jun 30;9:216.
    PMID: 19566923
    doi: 10.1186/1471-2407-9-216

    Conclusion
    These results suggest that high consumption of fatty fish is associated with a reduced risk for breast cancer, and that the intake of omega-3 fatty acids from fish is inversely associated with postmenopausal breast cancer risk
Matti Narkia

Long-term vitamin D3 supplementation may have adverse effects on serum lipids during po... - 0 views

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    Long-term vitamin D3 supplementation may have adverse effects on serum lipids during postmenopausal hormone replacement therapy.
    Heikkinen AM, Tuppurainen MT, Niskanen L, Komulainen M, Penttilä I, Saarikoski S.
    Eur J Endocrinol. 1997 Nov;137(5):495-502.
    PMID: 9405029

    CONCLUSIONS: Our results confirm the positive long-term effect of HRT with sequential estradiol valerate and cyproterone acetate on serum lipid concentrations. In addition, the results suggest that vitamin D3 supplementation may have unfavorable effects on lipids in postmenopausal women. Pure vitamin D3 treatment was associated with increased serum LDL cholesterol. Furthermore, the beneficial effects of HRT on serum LDL cholesterol content were reduced when estradiol valerate was combined with vitamin D3. However, the relevance of these associations to cardiovascular morbidity remains to be established.
Matti Narkia

Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal J... - 0 views

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    Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
    Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y.
    J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21.
    PMID: 19352059

    These results suggest that supplementation with 1.5 mg/d MK-4 accelerated the degree of OC gamma-carboxylation. The concentrations of serum lipids and other indices were not different between the groups at either intervention period. Thus, the additional intake of MK-4 might be beneficial in the maintenance of bone health in postmenopausal Japanese women.
Matti Narkia

Serum Levels of Vitamin D Metabolites and Breast Cancer Risk in the Prostate, Lung, Col... - 0 views

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    Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial.

    Freedman DM, Chang SC, Falk RT, Purdue MP, Huang WY, McCarty CA, Hollis BW, Graubard BI, Berg CD, Ziegler RG.
    Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):889-94. Epub 2008 Apr 1.
    PMID: 18381472
    doi: 10.1158/1055-9965.EPI-07-2594

    In this prospective study of postmenopausal women, we did not observe an inverse association between circulating 25(OH)D or 1,25(OH)2D and breast cancer risk, although we cannot exclude an association in younger women or with long-term or earlier exposure
Matti Narkia

Vitamin K Supplementation in Postmenopausal Women with Osteopenia (ECKO Trial): A Rando... - 0 views

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    Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.
    Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, Hu H, Vieth R, Thompson L, Jamal S, Josse R.
    PLoS Med. 2008 Oct 14;5(10):e196. Erratum in: PLoS Med. 2008 Dec;5(12):e247.
    PMID: 18922041

    CONCLUSIONS: Daily 5 mg of vitamin K1 supplementation for 2 to 4 y does not protect against age-related decline in BMD, but may protect against fractures and cancers in postmenopausal women with osteopenia. More studies are needed to further examine the effect of vitamin K on fractures and cancers. Trial registration: ClinicalTrials.gov (#NCT00150969) and Current Controlled Trials (#ISRCTN61708241)
Matti Narkia

A Positive Association of Lumbar Spine Bone Mineral Density with Dietary Protein Is Sup... - 0 views

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    A positive association of lumbar spine bone mineral density with dietary protein is suppressed by a negative association with protein sulfur.
    Thorpe M, Mojtahedi MC, Chapman-Novakofski K, McAuley E, Evans EM.
    J Nutr. 2008 Jan;138(1):80-5.
    PMID: 18156408

    Results suggest that protein intake is positively associated with aBMD, but benefit at the LS is offset by a negative impact of the protein sulfur acid load. If validated experimentally, these findings harmonize conflicting theories on the role of dietary protein in bone health.
Matti Narkia

NEJM -- Calcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer - 0 views

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    Calcium plus vitamin D supplementation and the risk of colorectal cancer.
    Wactawski-Wende J, Kotchen JM, Anderson GL, Assaf AR, Brunner RL, O'Sullivan MJ, Margolis KL, Ockene JK, Phillips L, Pottern L, Prentice RL, Robbins J, Rohan TE, Sarto GE, Sharma S, Stefanick ML, Van Horn L, Wallace RB, Whitlock E, Bassford T, Beresford SA, Black HR, Bonds DE, Brzyski RG, Caan B, Chlebowski RT, Cochrane B, Garland C, Gass M, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Jackson RD, Johnson KC, Judd H, Kooperberg CL, Kuller LH, LaCroix AZ, Lane DS, Langer RD, Lasser NL, Lewis CE, Limacher MC, Manson JE; Women's Health Initiative Investigators.
    N Engl J Med. 2006 Feb 16;354(7):684-96. Erratum in: N Engl J Med. 2006 Mar 9;354(10):1102.
    PMID: 16481636

    Conclusions Daily supplementation of calcium with vitamin D for seven years had no effect on the incidence of colorectal cancer among postmenopausal women. The long latency associated with the development of colorectal cancer, along with the seven-year duration of the trial, may have contributed to this null finding. Ongoing follow-up will assess the longer-term effect of this intervention.
Matti Narkia

Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving ... - 0 views

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    Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy.
    Holick MF, Siris ES, Binkley N, Beard MK, Khan A, Katzer JT, Petruschke RA, Chen E, de Papp AE.
    J Clin Endocrinol Metab. 2005 Jun;90(6):3215-24. Epub 2005 Mar 29.
    PMID: 15797954
    doi:10.1210/jc.2004-2364

    Conclusions: More than half of North American women receiving therapy to treat or prevent osteoporosis have vitamin D inadequacy, underscoring the need for improved physician and public education regarding optimization of vitamin D status in this population.
Matti Narkia

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized tria... - 0 views

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    Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial.
    Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.
    Am J Clin Nutr. 2007 Jun;85(6):1586-91. Erratum in: Am J Clin Nutr. 2008 Mar;87(3):794.
    PMID: 17556697

    Conclusions: Improving calcium and vitamin D nutritional status substantially reduces all-cancer risk in postmenopausal women.
Matti Narkia

Dose response to vitamin D supplementation among postmenopausal African American women.... - 0 views

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    Dose response to vitamin D supplementation among postmenopausal African American women.\nTalwar SA, Aloia JF, Pollack S, Yeh JK.\nAm J Clin Nutr. 2007 Dec;86(6):1657-62.\nPMID: 18065583
Matti Narkia

A high menaquinone reduces the incidence of coronary heart disease in women - 0 views

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    A high menaquinone reduces the incidence of coronary heart disease in women.\nGast GC, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT.\nNutr Metab Cardiovasc Dis. 2009 Jan 27. [Epub ahead of print]\nPMID: 19179058 \ndoi: 10.1016/j.numecd.2008.10.004\n
Matti Narkia

Vitamin K2, but not K1, effective for heart health benefits: Study - 0 views

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    Increased intakes of vitamin K2, but not vitamin K1, may decrease the risk of coronary heart disease in postmenopausal women, says a new study.\nFor every 10 microgram increase in the amount of vitamin K2 consumed, researchers from the Netherlands report a 9 per cent reduction in the risk of developing coronary heart disease (CHD).
Matti Narkia

Sham vs. Wham: The Health Insider: Possible Grapefruit link to Breast Cancer for Post-M... - 0 views

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    The study of 50,000 women states that eating Grapefruit can increase the risk of breast cancer. The fruit is believed to boost blood levels of estrogen, the hormone associated with increased risk of the illness
Matti Narkia

Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Healt... - 0 views

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    Robien K, Cutler GJ, Lazovich D.
    Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Health Study.
    Cancer Causes Control. 2007 Sep;18(7):775-82. Epub 2007 Jun 5.
    PMID: 17549593 [PubMed - in process]
Matti Narkia

Prevalence of vitamin D inadequacy in European postmenopausal women - Curr Med Res Opin... - 0 views

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    Reginster JY.
    Prevalence of vitamin D inadequacy in European postmenopausal women.
    Curr Med Res Opin. 2007 Jul 12; [Epub ahead of print]
    PMID: 17631697 [PubMed - as supplied by publisher]
Matti Narkia

High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with no... - 0 views

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    Gonzalez G, Alvarado JN, Rojas A, Navarrete C, Velasquez CG, Arteaga E.
    High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with normal sun exposure: additional evidence for a worldwide concern.
    Menopause. 2007 May-Jun;14(3
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