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Matti Narkia

Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms -- Larsson et al. 79 (6): 935 -- American Journal of Clinical Nutrition - 0 views

www.ajcn.org/...935

2004 June ajcn study review nutrition medline diet cancer omega-3 EPA DHA AA mechanism mechanisms alpha-linolenic_acid ALA carcinogenesis eicosanoids fish prevention fish_oil cancer_prevention

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    Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A. Am J Clin Nutr. 2004 Jun;79(6):935-45. Review. PMID: 15159222
Matti Narkia

Controlling inflammation: a fat chance? -- Flower and Perretti 201 (5): 671 -- The Journal of Experimental Medicine - 0 views

www.jem.org/...671

2005 March study review health nutrition arachidonic_acid omega-6 AA omega-3 EPA inflammation anti-inflammatory COX-2 resolvin resolvins resolvin_ E1 RvE1 NF-kappaB NF-kB fish_oil medline

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    Controlling inflammation: a fat chance? Flower RJ, Perretti M. J Exp Med. 2005 Mar 7;201(5):671-4. Review. PMID: 15753201 doi:10.1084/jem.20050222
Matti Narkia

Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients - Br J Nutr. 2004 May (full text) - 0 views

journals.cambridge.org/...displayFulltext

2004 May bjn study research clinical_trial rct humans elderly older old omega-3 DHA omega-6 AA omega-3-eggs eggs egg DHA-enriched DHA-enriched_eggs egg-yolk powder DHGLA DGLA yolk nutrition medline supplementation CVD

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    Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients. Payet M, Esmail MH, Polichetti E, Le Brun G, Adjemout L, Donnarel G, Portugal H, Pieroni G. Br J Nutr. 2004 May;91(5):789-96. PMID: 15137931 doi:10.1079/BJN20041106
Matti Narkia

Targeting lipoxygenases with care. - ScienceDirect - Chemistry & Biology 2006 Nov - 0 views

www.sciencedirect.com/science

2006 November study research fish_oil omega-3 EPA resolvin E2 resolvins resolvin_E2 RvE2 5-LOX LOX lipoxins lipoxin omega-6 AA lipoxin_A4 LXA4 lipoxin_B4 LXB4 aspirin COX-2 12-LOX 15R-HETE 5S-HEPE nutrition medline COX RvE1

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    Targeting lipoxygenases with care. de Souza PM, Newson J, Gilroy DW. Chem Biol. 2006 Nov;13(11):1121-2. PMID: 17113992 doi:10.1016/j.chembiol.2006.11.002  
Matti Narkia

Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells. - .[Int J Oncol. 2003] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...14612948

2003 December study research in_vitro omega-3 EPA omega-6 AA IkappaBalpha NF-kappaB activation pancreatic cancer pancreatic_cancer nutrition medline NF-KB

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    Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells. Ross JA, Maingay JP, Fearon KC, Sangster K, Powell JJ. Int J Oncol. 2003 Dec;23(6):1733-8. PMID: 14612948
Matti Narkia

A lipidomic analysis of nonalcoholic fatty liver disease. - Hepatology. 2007 Oct - Wiley InterScience :: Session Cookies - 0 views

www3.interscience.wiley.com/...HTMLSTART

2007 October Hepatology study research epidemiological humans non-alcoholic fatty liver disease non-alcoholic_fatty_liver_disease NAFLD NASH omega-3 AA EPA DHA lipds nutrition medline

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    A lipidomic analysis of nonalcoholic fatty liver disease. Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, Cheung O, Sargeant C, Contos MJ, Sanyal AJ. Hepatology. 2007 Oct;46(4):1081-90. PMID: 17654743 DOI: 10.1002/hep.21763
Matti Narkia

Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response. - .[Neuro Endocrinol Lett. 2007] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...18063921

2007 December study research clinical_trial ex_vivo humans omega-3 fish_oil EPA DHA omega-6 AA depression immune function immunity IFN-gamma IL-10 IFN-gamma_IL-10 IFN-gamma:IL-10 ratio nutrition medline Th1 TNF-alpha fish oil

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    Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response. Maes M, Mihaylova I, Kubera M, Bosmans E. Neuro Endocrinol Lett. 2007 Dec;28(6):875-80. PMID: 18063921
Matti Narkia

15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. - J Exp Med. 2004 Jul 5;200(1):69-78. (full text) - 0 views

jem.rupress.org/...69

2004 July study research in_vivo animal_study leukocytes resolution NSAID NSAIDs epi-lipoxins endothelium aspirin anti_inflammatory_lipid_mediators 15-epi-lipoxin_A4 lipoxin lipoxins NO nitric_oxide nutrition medline omega-6 AA

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    15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, Cooper D, Gilroy DW. J Exp Med. 2004 Jul 5;200(1):69-78. PMID: 15238606
Matti Narkia

Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. - .[J Natl Cancer Inst. 1986] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...3464797

1986 November JNCI study research in_vitro omega-3 omega-6 cancer normal cells carcinoma differential killing cytotoxic EPA GLA AA PUFA PUFAs nutrition medline

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    Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. Bégin ME, Ells G, Das UN, Horrobin DF. J Natl Cancer Inst. 1986 Nov;77(5):1053-62. PMID: 3464797
Matti Narkia

Eating Your Way to Prostate Cancer - Life Extension - 0 views

www.lef.org/...feb2007_cover_prostate_01.htm

2007 February lef le magazine review report prostate cancer prostate_cancer PCa omega-3 omega-6 aa 5-LOX inhibitor inhibition nutrition 5-LOXIN 5-HETE TNF-alpha VEGF EGF Boswellia AKBA COX-1 COX-2

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    A plethora of research documents the role of chronic inflammatory mediators such as 5-lipooxygenase (5-LOX) and tumor necrosis factor-alpha (TNF-α) in the manifestation and progression of prostate and other cancers.7-19,30,31,33,49,52-54,87,88 The typical American diet is high in omega-6 fatty acids, saturated fats, and arachidonic acid. Over-consumption of these foods, and under-consumption of omega-3 fatty acids, contribute significantly to systemic chronic inflammatory states. Boswellia extracts have been thoroughly studied as natural remedies for inflammatory disorders. A patented extract from boswellia called 5-LOXIN® has potent ability to inhibit the enzyme 5-LOX, preventing the formation of protein-degrading enzymes, and protecting against inflammation-induced events that can promote tumor angiogenesis.
Matti Narkia

Immunomodulation by omega-3 fatty acids - Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec - 0 views

www.plefa.com/...abstract

2007 November study review immunomodulation omega-3 EPA DHA docosanoids resolvins resolvin immune cells cell membrane membranes anti-iflammatory lipid_mediators nutrition medline omega-6 AA eicosanoids

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    Immunomodulation by omega-3 fatty acids. Calder PC. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):327-35. Epub 2007 Nov 26. Review. PMID: 18032006 doi:10.1016/j.plefa.2007.10.015
Matti Narkia

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators : Abstract : Nature Reviews Immunology - 0 views

www.nature.com/...nri2294.html

2008 May study review anti-inflammatory pro-resolution resolution resolving inflammation lipid mediators lipid_mediators resolvins resolvin protectins lipoxins lipoxin nutrition medline omega-3 EPA DHA omega-6 AA eicosanoids

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    Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Serhan CN, Chiang N, Van Dyke TE. Nat Rev Immunol. 2008 May;8(5):349-61. Review. PMID: 18437155 doi:10.1038/nri2294
Matti Narkia

The relationship between the fatty acid composition of immune cells and their function - Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov - 0 views

www.plefa.com/...abstract

2008 October study review omega-3 EPA DHA omega-6 AA fish_oil inflammation resolution eicosanoids cytokine macrophages lymphocytes resolvins resolvin nutrition medline immune cells immune_cells anti-inflammatory lipid_mediators

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    The relationship between the fatty acid composition of immune cells and their function. Calder PC. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):101-8. Epub 2008 Oct 23. Review. PMID: 18951005 doi:10.1016/j.plefa.2008.09.016
Matti Narkia

Novel omega -- 3-derived local mediators in anti-inflammation and resolution. - ScienceDirect - Pharmacology & Therapeutics : - 0 views

www.sciencedirect.com/science

2005 January study review anti-inflammatory lipid_mediators omega-3 EPA DHA fish_oil leukocytes eicosanoids aspirin inflammation resolution lipoxin lipoxins omega-6 AA resolvins resolvin docosatrienes neuroprotectins neuroprotectin nutrition medline

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    Novel omega -- 3-derived local mediators in anti-inflammation and resolution. Serhan CN. Pharmacol Ther. 2005 Jan;105(1):7-21. Review. PMID: 15626453 doi:10.1016/j.pharmthera.2004.09.002
Matti Narkia

Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. - J Lipid Res. 2003 Mar - 0 views

www.jlr.org/...601

2003 March study research in_vitro AA EPA DHA PLA2 sPLA2 cPLA2 smooth_muscle_cells nutrition medline omega-3 omega-6 IL-1beta PGE2 COX-2

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    Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. Bousserouel S, Brouillet A, Béréziat G, Raymondjean M, Andréani M. J Lipid Res. 2003 Mar;44(3):601-11. Epub 2003 Jan 1. PMID: 12562859 doi:10.1194/jlr.M200092-JLR200
Matti Narkia

Prostacyclin - Wikipedia, the free encyclopedia - 0 views

en.wikipedia.org/...Prostacyclin

prostacyclin PGI2 info reference wikipedia PGI3 omega-6 AA omega-3 EPA vasodilator COX COX-1 COX-2 endothelial_cells nutrition eicosanoid eicosanoids

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    Prostacyclin (or PGI2) is a member of the family of lipid molecules known as eicosanoids.\nAs a drug, it is also known as "epoprostenol".[1] The terms are sometimes used interchangeably Prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). It is also an effective vasodilator. Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage.
Matti Narkia

Thromboxane B2 - Wikipedia, the free encyclopedia - 0 views

en.wikipedia.org/...Thromboxane_B2

thromboxane B2 thromboxane_B2 TXB2 info reference wikipedia inactive COX omega-6 AA nutrition COX-1

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    Thromboxane B2 is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine. It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets).
Matti Narkia

Thromboxane A2 - Wikipedia, the free encyclopedia - 0 views

en.wikipedia.org/...Thromboxane_A2

thromboxane A2 thromboxane_A2 TXA2 info reference wikipedia blood_clots aspirin COX-1 COX unstable omega-6 AA nutrition

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    Thromboxane A2 (TXA2) is a thromboxane. It is generated from prostaglandin H2 by thromboxane-A synthase. It is also a major component of blood clots. Aspirin irreversibly inhibits platelet cyclooxygenase 1 preventing the formation of prostaglandin H2, and therefore thromboxane A2. TXA2 is very unstable in aqueous solution, since it is hydrolyzed within about 30 seconds to the biologically inactive thromboxane B2. Due to its very short half life, TXA2 primarily functions as an autocrine or paracrine mediator in the nearby tissues surrounding its site of production.
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