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Matti Narkia

NephroPal: Summer vs Winter Mode: Explaining AMPK - 0 views

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    "Summer vs Winter Mode: Explaining AMPK
    Last year I read an article which made a statement that has not left my mind. The statement went as follows: "You are only good as your mitochondria." In fact, the more a dwell into the details of human metabolism, the more I sense that this is true - especially with the metabolic syndrome.

    For those who are not familiar with the concept of mitochondria, they are the tiny energy factories within the cells that produce cellular energy through aerobic means (meaning oxygen). Mitochondria utilize oxygen to ultimately produce Adenosine Triphosphate or simply ATP. ATP relays energy by donating a phosphate bond resulting in Adenosine Diphosphate (ADP). Another phosphate release would entail Adenosine Monophosphate or AMP. ATP is one of the main sources of cellular energy in the body."
Matti Narkia

Tissue Phylloquinone and Menaquinones in Rats Are Affected by Age and Gender -- Huber e... - 0 views

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    Tissue phylloquinone and menaquinones in rats are affected by age and gender.
    Huber AM, Davidson KW, O'Brien-Morse ME, Sadowski JA.
    J Nutr. 1999 May;129(5):1039-44.
    PMID: 10222397

    The results suggest that in extrahepatic tissues, certain menaquinones may be the predominant form of vitamin K. The specific tissue distribution and the general decline of MK-4 and MK-6 in extrahepatic tissues during aging suggest a vitamin K tissue dynamic that is affected not only by diet, but also by gender, age and the specific roles of phylloquinone, MK-4 and MK-6 in metabolism. All of these factors must be taken into account in establishing the nutrient requirement for vitamin K.
Matti Narkia

Age and Dietary Form of Vitamin K Affect Menaquinone-4 Concentrations in Male Fischer 3... - 0 views

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    Age and dietary form of vitamin K affect menaquinone-4 concentrations in male Fischer 344 rats.
    Booth SL, Peterson JW, Smith D, Shea MK, Chamberland J, Crivello N.
    J Nutr. 2008 Mar;138(3):492-6.
    PMID: 18287355

    These data suggest that dihydrophylloquinone, which differs from phylloquinone in its side phytyl chain, is absorbed but its intake results in less MK-4 in certain tissues. Dihydrophylloquinone may be used in models for the study of tissue-specific vitamin K deficiency
Matti Narkia

Higher serum vitamin D concentrations are associated with longer leukocyte telomere len... - 0 views

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    Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.
    Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A.
    Am J Clin Nutr. 2007 Nov;86(5):1420-5.
    PMID: 17991655
Matti Narkia

Plasma Vitamin D and 25OHD Responses of Young and Old Men to Supplementation with Vitam... - 0 views

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    Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3.
    Harris SS, Dawson-Hughes B.
    J Am Coll Nutr. 2002 Aug;21(4):357-62.
    PMID: 12166534

    Conclusions: There appears to be no age-related impairment among men in the absorption or metabolism of 20 µg/day of vitamin D3 taken orally for at least eight weeks.
Matti Narkia

25(OH)D Serum Levels Decline With Age Earlier in Women Than in Men and Less Efficiently... - 0 views

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    25(OH)D Serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults.
    Maggio D, Cherubini A, Lauretani F, Russo RC, Bartali B, Pierandrei M, Ruggiero C, Macchiarulo MC, Giorgino R, Minisola S, Ferrucci L.
    J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1414-9.
    PMID: 16339327

    Conclusions. These findings suggest that the age-associated fall of serum 25(OH)D starts earlier in women than in men and that higher levels of 25(OH)D are required in older compared to younger persons to avoid the age-associated compensatory hyperparathyroidism.
Matti Narkia

Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship ... - 0 views

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    Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D.
    Vieth R, Ladak Y, Walfish PG.
    J Clin Endocrinol Metab. 2003 Jan;88(1):185-91.
    PMID: 12519850

    This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function
Matti Narkia

Aging decreases the capacity of human skin to produce vitamin D3. - Journal of Clinical... - 0 views

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    Aging decreases the capacity of human skin to produce vitamin D3.
    MacLaughlin J, Holick MF.
    J Clin Invest. 1985 Oct;76(4):1536-8.
    PMID: 2997282
    doi:10.1172/JCI112134

    An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
Matti Narkia

The Dependency of Vitamin D Status on Body Mass Index, Gender, Age and Season - Antican... - 0 views

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    The dependency of vitamin D status on body mass index, gender, age and season.
    Lagunova Z, Porojnicu AC, Lindberg F, Hexeberg S, Moan J.
    Anticancer Res. 2009 Sep;29(9):3713-20.
    PMID: 19667169

    CONCLUSION: The 25(OH)D3 level, as well as its seasonal variation and the prevalence of vitamin D deficiency, are all dependent on BMI, and age separately. The results of the study suggest that 1 in 3 women and 1 in 2 men with BMI > or = 40 are vitamin D deficient.
Matti Narkia

Vitamin D in the Spotlight; This critical nutrient builds bones, helps fight infection ... - 0 views

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    For many years, vitamin D was boring--even to doctors. Because it was considered good for bones and not much else, multitaskers like vitamin A, B vitamins and vitamin E hogged all the press. But recent studies have thrust this long-neglected nutrient into the spotlight. Scientists now think vitamin D may affect everything from diabetes to cancer. They're also finding that many people don't have enough of it.
Matti Narkia

The Pathobiology of Diabetic Complications: a unifying mechanism. - Diabetes - 0 views

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    The pathobiology of diabetic complications: a unifying mechanism.
    Brownlee M.
    Diabetes. 2005 Jun;54(6):1615-25.
    PMID: 15919781
    doi: 10.2337/diabetes.54.6.1615
Matti Narkia

Benfotiamine.Net - Diabetic Nutritional Supplement, Neuropathy Treatment, Enzyme Transk... - 0 views

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    This site was established to provide visitors with comprehensive information about benfotiamine, a synthetic derivative of thiamine (vitamin B-1) which shows promise in treating a number of neurological and vascular conditions. Benfotiamine also appears to have beneficial anti-aging qualities, protecting human cells from harmful metabolic end products.

    Benfotiamine is not just for diabetics. Any population suffering from conditions brought about by unknown or inadvertent thiamine deficiencies should respond well to benfotiamine. Benfotiamine is emerging as the most effective of the thiamine compounds.
Matti Narkia

Benfotiamine - Wikipedia, the free encyclopedia - 0 views

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    Benfotiamine (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamine B1). After absorption, benfotiamine can be dephosphorylated by cells bearing an ecto-alkaline phosphatase to the lipid-soluble S-benzoylthiamine.

    The primary use of this antioxidant is as an "anti-AGE" supplement.[3] In a trial, benfotiamine lowered AGE by 40%.[4] However, in Germany doctors have been known to combine benfotiamine with pyridoxine hydrochloride and use it to treat patients with nerve damage and nerve pain such as sciatica.
    At high doses, benfotiamine was shown to be effective for the treatment of diabetic retinopathy, neuropathy, and nephropathy. I
Matti Narkia

50 Great Things About Women Over 50 - 0 views

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    Why Women Over 50 Love Their Age
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