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Nathan Goodyear

Testosterone replacement therapy improves i... [Eur J Endocrinol. 2006] - PubMed - NCBI - 0 views

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    In obese men with low T and type 2 diabetes, Testosterone replacement improves insulin sensitivity.  Glycated hemoglobin was also improved.  In this study group, a decrease in visceral adiposity and TC was seen.
Nathan Goodyear

Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome ... - 0 views

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    low SHBG found to be more associated with metabolic syndrome in older men than low Testosterone.  The study consisted of 2502 men older than 70.  The authors proposed this occurs through the relationship between SHBG and insulin sensitivity.  I think that is a little too simplistic.
Nathan Goodyear

Inverse association between serum insulin and sex hormone-binding globulin in a populat... - 0 views

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    Low SHBG associated with elevated insulin levels. This was found in both sexes.  Low SHBG associated with type II Diabetes, but Increased SHBG found to be associated with Type I Diabetes.
Nathan Goodyear

Associations between sex hormone binding globulin and metabolic syndrome parameters in ... - 0 views

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    Low SHGB associated with increased association with metabolic syndrome components.  Low SHBG particuraliy associated with increased obesity (visceral) and glucose dysmetabolism. This study looked at premenopausal women.
Nathan Goodyear

A new era of testosterone and prostate cancer: from... [Eur Urol. 2014] - PubMed - NCBI - 0 views

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    The tide is beginning to shift on testosterone and Prostate Cancer.  A literature review finds no support for Testosterone and Prostate carcinogenesis or low Testosterone providing any protection against prostate cancer.  
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    a good read!
Nathan Goodyear

PLOS ONE: Testosterone, Sex Hormone-Binding Globulin and the Metabolic Syndrome in Men:... - 0 views

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    Association of low TT, SHBG, and free Testosterone with MetS was found in this study on men.  The association was influenced by BMI i.e. the overweight were found to have a higher association than the normal BMI.
Nathan Goodyear

Both total testosterone and sex hormone-binding globulin are independent risk factors f... - 0 views

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    Study of 2361 Chinese men found that men with MetS had lower TT, bioavailable Testosterone, free Testosterone and SHBG than those men without MetS.  Additionally, Total Testosterone and SHBG were both inversely associated with the risk of MetS.  This inverse association stood for both after adjusting for the other.
Nathan Goodyear

http://care.diabetesjournals.org/content/33/7/1618.full.pdf - 0 views

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    Men with low T and low SHBG have a significantly elevated risk of metabolic syndrome.  Other studies have actually shown that low SHBG is more associated and that TT is more than free Testosterone.
Nathan Goodyear

Long-term stability of salivary cort... [Scand J Clin Lab Invest. 2005] - PubMed - NCBI - 0 views

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    Salivary cortisol samples shown to be stable for long length of time.
Nathan Goodyear

Measurement of steroid hormones in s... [Scand J Clin Lab Invest. 2013] - PubMed - NCBI - 0 views

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    Study deals with the storage temp of salivary hormone samples.
Nathan Goodyear

Estradiol concentrations and workin... [Psychoneuroendocrinology. 2013] - PubMed - NCBI - 0 views

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    women with high E2 versus low E2 had better cognitive function.
Nathan Goodyear

Lipoprotein(a) as a cardiovascular risk factor: current status - 0 views

  • Lipoprotein(a) is a plasma lipoprotein consisting of a cholesterol-rich LDL particle with one molecule of apolipoprotein B100 and an additional protein, apolipoprotein(a)
  • Elevated Lp(a) levels can potentially increase the risk of CVD (i) via prothrombotic/anti-fibrinolytic effects as apolipoprotein(a) possesses structural homology with plasminogen and plasmin but has no fibrinolytic activity and (ii) via accelerated atherogenesis as a result of intimal deposition of Lp(a) cholesterol, or both
  • evidence suggests that apolipoprotein(a) adducts extracellularly and covalently to apolipoprotein B100-containing lipoproteins, predominantly LDL
  • ...2 more annotations...
  • Lp(a) is relatively refractory to both lifestyle and drug intervention.
  • Other agents reported to decrease Lp(a) to a minor degree (<10%) include aspirin, l-carnitine, ascorbic acid combined with l-lysine, calcium antagonists, angiotensin-converting enzyme inhibitors, androgens, oestrogen, and its replacements (e.g. tibolone), anti-estrogens (e.g. tamoxifen), and thyroxine replacement in hypothyroid subjects
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    full article on the previously posted abstract on Lp(a).  
Nathan Goodyear

Lipoprotein(a) as a cardiovascular risk factor: ... [Eur Heart J. 2010] - PubMed - NCBI - 0 views

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    Lp(a) is a useful biomarker in the overall assessment of those at moderate to high risk of CVD.
Nathan Goodyear

Low Sex-Hormone Binding Globulin is Associated with the Metabolic Syndrome in Postmenop... - 0 views

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    low SHBG in post-menopausal women correlates with increased risk of metabolic syndrome.  More than that, there is an inverse correlation with SHBG in women and metabolic syndrome components.  Also, Increasing components of MetS was correlated with Testosterone and free androgen index.
Nathan Goodyear

Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation i... - 0 views

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    Interesting study finds hyperandrogenism stimulates excessive inflammatory response to glucose intake.  This study was done in otherwise healthy women not in women with PCOS.  The inflammatory cytokine production was via NF-KappaB activation.  Again, this has negative implications in women being doped with Testosterone.
Nathan Goodyear

Inflammation in Polycystic Ovary Syndrome: Underpinning of insulin resistance and ovari... - 0 views

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    Study points to inflammation causing hyperandrogenism via ovarian theca stimulation.
Nathan Goodyear

Hyperandrogenism induces a proinflam... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

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    Very insightful study.  Study looked at hyperadrogenism and inflammation in women on the orders of PCOS.  The study subjects did not have PCOS, but hyperandrogenism via 130 mg DHEA was associated with an increase in TNF-alpha in these lean o/w healthy women.  We know this is due to hyperandrogenism as elevated Testosterone, DHEA, and androstenedione were documented with treatment. Take home:  androgens promote inflammation in women.  I believe this has serious negative implications about the massive Testosterone doping that is occurring in women today.
Nathan Goodyear

Androgens and cardiac diseases. [Monaldi Arch Chest Dis. 2013] - PubMed - NCBI - 0 views

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    Abstract only available here.  Take home: individuals at risk for CVD should have T levels evaluated.
Nathan Goodyear

Testosterone in Men with Advanced Li... [J Gastroenterol Hepatol. 2014] - PubMed - NCBI - 0 views

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    published ahead of print.  The authors conclude that the Testosterone therapy in hypogonadal men with cirrhosis requires further study.  They, the authors, state that the risk of Testosterone and hepatocellular carcinoma is overstated.  This risk is associated with oral Testosterone replacement and thus in that light is not overstated.  The majority of treatment strategies today employ none oral routes of administration which would support their statement.
Nathan Goodyear

Probiotics and gut health: A special focus on liver diseases - 0 views

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    Probiotics are not just for disease prevention, but also can be utilized as adjuncts for different liver disease states.  This review article highlights probiotics in IBD, IBS, surgery, NAFLD, cancer, and cirrhosis.
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