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Nathan Goodyear

PLOS ONE: Mast Cell-Derived Histamine Mediates Cystitis Pain - 0 views

journals.plos.org/...article

IC interstitial cystitis mast cells inflammation bladder

shared by Nathan Goodyear on 12 May 15 - No Cached
  • Nathan Goodyear on 12 May 15
     
    Mast cells contribute/cause the pro inflammatory response that results in pain in people with interstitial cystitis.  This is mediated via Histamine type I and type II receptors.
Nathan Goodyear

The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. - Pub... - 0 views

www.ncbi.nlm.nih.gov/...17462477

IC interstitial cystitis mast cells bladder

shared by Nathan Goodyear on 12 May 15 - No Cached
  • Nathan Goodyear on 12 May 15
     
    Only abstract available here.  IC is driven by histamine from mast cells.
Nathan Goodyear

Mast cell involvement in interstitial cystitis: a review of human and experimental evid... - 0 views

www.ncbi.nlm.nih.gov/...11378050

IC interstitial cystitis histamine bladder

shared by Nathan Goodyear on 12 May 15 - No Cached
  • Nathan Goodyear on 12 May 15
     
    Interstitial Cystitis is a histamine mediated inflammatory process.
Nathan Goodyear

Histamine and mucosal mast cells in interstitial cystitis. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2750582

IC interstitial cystitis histamine mast cells bladder

shared by Nathan Goodyear on 12 May 15 - No Cached
  • Nathan Goodyear on 12 May 15
     
    Interstitial cystitis is a histamine/mast cell mediated event.
Nathan Goodyear

Review article: biofilm formation by Helicobacter pylori as a target for eradication of... - 0 views

onlinelibrary.wiley.com/...full

biofilms H. Pylori helicobacter pylori curcumin boswellia NAC

shared by Nathan Goodyear on 11 May 15 - No Cached
  • Nathan Goodyear on 11 May 15
     
    good discussion of biofilms and H.pylori.  This article reviews the literature behind some of the natural and traditional therapies to reduce biofilms.
Nathan Goodyear

Protection against Helicobacter pylori and Other Bacterial Infections by Garlic - 0 views

jn.nutrition.org/...1106S.full

allicin garlic H. Pylori helicobacter pylori gut

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  • Nathan Goodyear on 11 May 15
     
    review of activity of garlic against H.pylori.  Most of the studies are in vitro.  Most of the activity against H.pylori is via allicin, though studies have have shown poor bioavailability with allicin.
Nathan Goodyear

Antibacterial effect of garlic and omeprazole on Helicobacter pylori - 0 views

jac.oxfordjournals.org/...837.full

garlic natural H. Pylori helicobacter pylori gut

shared by Nathan Goodyear on 11 May 15 - No Cached
  • Nathan Goodyear on 11 May 15
     
    Garlic to treat H.pylori.
Nathan Goodyear

BMC Microbiology | Full text | The Firmicutes / Bacteroidetes ratio of the human microb... - 0 views

www.biomedcentral.com/...123

gut flora gut microbiome gut microbiota firmicutes bacteroidetes firmicutes_bacteroidetes health gut microbiome

shared by Nathan Goodyear on 06 May 15 - No Cached
  • The microbiota of the large intestine plays an important role in host metabolism and maintenance of host health
  • Our results defining a standard adult profile, together with previous reports, showed that C. leptum, C. coccoides, Bacteroides and Bifidobacterium represent the four dominant groups of the adult fecal microbiota
  • Sub-dominant groups are Lactobacilli Enterobacteriaceae, Desulfovibrio, Sporomusa, Atopobium as well as other bacterial groups including Clostridium clusters XI, XIVb, and XVIII
  • ...12 more annotations...
  • In infant fecal microbiota, we observed Bifidobacterium as the dominant group
  • this observation is strongly related to diet, being enhanced by breast feeding
  • Significant higher numbers of Bifidobacterium were observed in infants versus adults and seniors
  • the gastrointestinal tract is first colonized by facultative anaerobes, such as E. coli
  • Strict anaerobes, such as Clostridium, colonize at later stages, as can be seen by the relatively low levels of C. leptum and C. coccoides in infants
  • diet change must be considered among the primary causes for such a shift of microbiota between infants and adults.
  • In the case of elderly subjects, our qPCR results indicated a significant increase in the counts of E. coli when compared to adults. This data is consistent with other publications indicating that elderly subjects harbor a different E. coli microbiota profile compared to younger adults
  • a number of authors reported a reduction in the numbers and diversity of many protective commensal anaerobes, such as Bacteroides and Bifidobacteria
  • The Firmicutes to Bacteroidetes ratio was already shown to be of significant relevance in signaling human gut microbiota status
  • Our measurements of the Firmicutes/Bacteroidetes ratio in adults obtained by our species-specific qPCR are in agreement with those obtained by Ley et al
  • Compared with young adults, the elderly have a different digestive physiology, characterized at a physiological level by a reduction in transit and of digestive secretions
  • The Firmicutes/Bacteroidetes ratio undergoes an increase from birth to adulthood and is further altered with advanced age
  • Nathan Goodyear on 06 May 15
     
    Good discussion of the gut microbiome.  Age effects the gut bacteria balance.  The Firmicutes/Bacteroidetes ratio increases from young, to young adult, to the elderly in this study.  Is this simply a reflection of aging or is the a biomarker that can be changed through diet and targeted probiotics?
Nathan Goodyear

Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views

mbio.asm.org/...e00271-10.full

gut flora gut microbiome gut microbiota CYP450 metabolism

shared by Nathan Goodyear on 06 May 15 - No Cached
  • he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
  • Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
  • The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
  • ...11 more annotations...
  • modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites
  • Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
  • The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
  • colonization of a germfree gut was rapid and remarkably stable, establishing within only a week after first exposure
  • a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary to obtain a stabilization and “normalization”
  • the microbiota status affects the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver and the kidney
  • Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis
  • Gut colonization alters bile acid metabolite profiles via modulation of hepatic Cyp8b1 expression
  • Bile acids are well-known contributors to glucose and lipid metabolism in the liver
  • GM is known to alter bile metabolism
  • GM is also known to exert a strong influence on the metabolism of xenobiotics
  • Nathan Goodyear on 06 May 15
     
    The effects of gut microbiome are not confined to the gut.  They alter bile acid metabolism and thus lipid/glucose metabolism.  They alter CYP450 activity.  They effect metabolism.  They effect the metabolism, and thus effects, of other drugs. 
Nathan Goodyear

Proton pump inhibitors decrease diversity in gut microbiome, increase risk for complica... - 0 views

www.sciencedaily.com/...141125074656.htm

PPIs proton pump inhibitors gut flora gut microbiome gut microbiota gut health biodiversity diversity

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  • Nathan Goodyear on 06 May 15
     
    Remember those PPIs that you have been taking for years (though the black box label is for 12 weeks)?  Those same PPIs decrease gut microbiome biodiversity.
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

press.endocrine.org/...jc.2014-2222

gut flora gut microbiome gut microbiota estrogen metabolites metabolism hormone hormones women gut

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  • Nathan Goodyear on 06 May 15
     
    women with increased gut microbiome diversity found to have increased estrogen metabolites compared to parent estrogen i.e. gut microbiome diversity in women effects estrogen metabolism. 
Nathan Goodyear

Normal Flora - Medical Microbiology - NCBI Bookshelf - 0 views

www.ncbi.nlm.nih.gov/...NBK7617

flora gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 05 May 15 - No Cached
  • Concentrations of 109 to 1011 bacteria/g of contents are frequently found in human colon
  • more than 400 species have been identified
  • 95 to 99 percent belong to anaerobic genera such as Bacteroides, Bifidobacterium, Eubacterium, Peptostreptococcus, and Clostridium
  • ...2 more annotations...
  • hese genera proliferate, occupy most available niches, and produce metabolic waste products such as acetic, butyric, and lactic acids
  • Anaerobic bacteria can then deconjugate bile acids in this region and bind available vitamin B12 so that the vitamin and fats are malabsorbed
  • Nathan Goodyear on 05 May 15
     
    normal flora of the body
Nathan Goodyear

Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 years later - 0 views

ivvitaminc.us/..._and_Cancer_25_Years_Later.pdf

IV vitamin C cancer intravenous vitamin C vitamin C vitamin C ascorbic acid

shared by Nathan Goodyear on 26 May 13 - No Cached
  • Nathan Goodyear on 26 May 13
     
    Great review of the literature on vitamin C and cancer. No opinion. No hear say. Just a review of the literature.
Nathan Goodyear

A High-Protein Breakfast Induces Greater Insulin and Glucose-Dependent Insulinotropic P... - 0 views

jn.nutrition.org/...452

protein diabetes breakfast diet nutrition glucose

shared by Nathan Goodyear on 04 May 15 - No Cached
  • Nathan Goodyear on 04 May 15
     
    Study finds a high protein breakfast blunts and better controls glucose levels throughout the day when compared to a high carbohydrate breakfast.  The impact was seen, not just following breakfast, but at the following meal as well.
Nathan Goodyear

Serum levels of sex hormone-binding globulin (SHBG) are not associated with lower level... - 0 views

www.ncbi.nlm.nih.gov/...15807883

SHBG Testosterone men male hormone hormones

shared by Nathan Goodyear on 01 May 15 - No Cached
  • Nathan Goodyear on 01 May 15
     
    Age increases SHBG.  This study doesn't find a correlation with non-SHBG Testosterone in "health" men.  The term health is probably key.
Nathan Goodyear

Taylor & Francis Online :: The microbiome as a target for endocrine disruptors: Novel c... - 0 views

www.tandfonline.com/...23273739.2014.964539

EDC endocrine disrupting chemicals gut flora gut microbiome gut microbiota Testosterone autoimmune disease

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    EDCs are proposed to disrupted gut micro biome and thus effect androgen production and autoimmune risk.
Nathan Goodyear

PLOS ONE: The Gut Microbiota and Developmental Programming of the Testis in Mice - 0 views

journals.plos.org/...article

hormone hormones Testosterone gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • The intra-testicular level of testosterone in GF mice was found to be significantly lower than in SPF and CBUT mice
  • Manipulation of the gut microbiotia through dietary modification, pre- and probiotics can therefore be beneficial for the host's reproductive health.
  • Absence of the normal microbiota influences the formation and the integrity of the BTB as well as the intra-testicular levels of testosterone and serum levels of LH and FSH.
  • ...8 more annotations...
  • Nutritional, socioeconomic, lifestyle and environmental factors (among others) are involved in the regulation of normal spermatogenesis.
  • he gut microbiota is one such potential source of environmental factors/products that has developed an intimate symbiotic relationship with host's physiology.
  • This study establishes a novel role for the commensal gut microbiota in the regulation of testicular development and function
  • In the current study, colonizing GF mice with CBUT resulted in an increased sperm production, suggesting that bacterial products, e.g. of fermentation, directly or indirectly, can affect the testis.
  • the absence of gut microbiota influenced testosterone levels
  • A recent study demonstrated that dietary supplementation of the probiotics Lactobacillus reuteri increased and restored testosterone levels in aging mice
  • bacterial metabolites such as butyrate have been shown to increase the levels of LH [43] and FSH
  • This suggests that butyrate most likely regulates testosterone production at the testicular level by stimulation of gene expression in Leydig cells and with little or no effect at the pituitary- hypothalamic levels.
  • Nathan Goodyear on 30 Apr 15
     
    gut micro biome effects spermatogenesis, Testosterone production, and the brain-testicle-barrier.
Nathan Goodyear

Testosterone: More Than Having the Guts to Win the Tour de France - 0 views

www.sciencedirect.com/...S1074761313003439

Testosterone gut flora gut microbiome gut microbiota autoimmune disease diabetes

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • female adult mice have microbiomes similar to those of prepubescent mice of both sexes;
  • the commensal microbial community in adult male mice significantly deviates from this shared initial pool.
  • the microbiome in castrated adult males clearly shifts away from that of normal adult males and is closer to the microbiome of females
  • ...10 more annotations...
  • The incidence of T1D in these mice is positively correlated with the “femaleness” of the microbiota
  • These results support the hypothesis that the host androgen level is influential in determining the composition of the microbiota, which in turn affects T1D initiation and progression
  • a high testosterone level enriches the microbiota for specific organisms such as segmented filamentous bacteria (SFB) and Escherichia coli or Shigella–like (SECS) strains.
  • A minimum level of testosterone and specific male-enriched microbes working together upregulate M2 macrophage and IFN-γ producing T cells in pancreatic lymph nodes. Microarray data show that both the IFN-γ and IL-1β pathways are also stimulated.
  • These microbes also upregulate host testosterone
  • In four independent experiments, the authors found no universal unique “male microbiome”
  • they did find that four distinct combinations of microbial groupings (with an interesting lack of overlap at the individual family level in the four experiments) were enhanced by androgen
  • one species consists of the segmented filamentous bacteria (SFB) and belongs to the Firmicutes, whereas the other is an Escherichia coli or Shigella–like (SECS) strain belonging to the Proteobacteria
  • colonization with protective microbiomes—e.g., SPF microbiota, SFB, and SECS—is positively correlated with high blood testosterone levels in male mice
  • A direct implication of this study is that probiotic administration or fecal transplantation is a theoretically possible approach to protection against T1D
  • Nathan Goodyear on 30 Apr 15
     
    nice summary of article on the relationship between Testosteorne and gut microbiome in autoimmune disease.
Nathan Goodyear

Entropy | Free Full-Text | Glyphosate's Suppression of Cytochrome P450 Enzymes and Amin... - 0 views

www.mdpi.com/...1416

glyphosate CYP CYP450 detoxification gut microbiome gut flora gut microbiota

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    Glyphosate disrupts CYP450 pathways.
Nathan Goodyear

ftp://www.bf.lu.lv/grozs/MolekularasBiologijas/Imunol%20II/Publik%C4%81cijas%20semin%C4... - 0 views

www.bf.lu.lv/...ent%20regulation%20of%20AI.pdf

gut flora gut microbiome gut microbiota gut Testosterone hormone hormones autoimmune disease

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    full article to previous abstract:  fecal transplant from male mice to female mice resulted in an increase in Testosterone production in the female mice revealing a link between the gut microbial population, diversity and Testosterone production.
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