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Nathan Goodyear

Investigation of the association between the fecal microbiota and breast cancer in post... - 0 views

www.ncbi.nlm.nih.gov/...26032724

breast cancer women hormones gut flora gut microbiome gut microbiota cancer

shared by Nathan Goodyear on 16 Sep 15 - No Cached
  • Nathan Goodyear on 16 Sep 15
     
    women with post menopause breast cancer have altered gut flora compared to women without.
Nathan Goodyear

Relationship of serum estrogens and estrogen metabolites to postmenopausal breast cance... - 0 views

www.ncbi.nlm.nih.gov/...PMC4053199

breast cancer cancer estrogen metabolites 2-OH-estrone 2-hydroxyestrone estrogen

shared by Nathan Goodyear on 16 Sep 15 - No Cached
  • Nathan Goodyear on 16 Sep 15
     
    Increased metabolism down the 2 hydroxylation pathway appears to reduce postmenopausal breast cancer risk.
Nathan Goodyear

Normalization of testosterone level is associated with reduced incidence of myocardial ... - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehv346

low T low Testosterone men Testosterone mortality stroke MI CVD cardiovascular disease hormones male

shared by Nathan Goodyear on 11 Aug 15 - No Cached
  • Normalized-TRT group had significantly fewer deaths than no-TRT
  • Mortality was also significantly lower in the non-normalized-TRT group compared with those in no-TRT group
  • the normalized-TRT group was associated with significantly increased all-cause mortality-free survival (log-rank, P < 0.05) compared with the non-normalized-TRT or no-TRT groups
  • ...10 more annotations...
  • normalized-TRT group showed lower risk of MI than non-normalized-TRT (HR: 0.82, CI 0.71–0.95, P = 0.008) and no-TRT
  • normalized-TRT group had significantly lower stroke events compared with non-normalized-TRT (HR: 0.70, CI 0.51–0.96, P = 0.028) and no-TRT
  • study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes
  • retrospective study
  • the first study to demonstrate that significant benefit is observed only if the dose is adequate to normalize the TT levels
  • Patients who failed to achieve the therapeutic range after TRT did not see a reduction in MI or stroke and had significantly less benefit on mortality
  • selected patients without any previous history of MI or stroke prior to initiation of TRT to reduce bias related to CV outcomes
  • currently only half of the men on TRT had been diagnosed with hypogonadism.
  • 25% of users did not have their T concentrations tested prior to initiating therapy, and 21% of those prescribed TRT did not have their levels tested at any time during treatment.
  • men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
  • Nathan Goodyear on 11 Aug 15
     
    Testosterone therapy in men with low T found to reduce all cause mortality, stroke and MI.
Nathan Goodyear

Mucosal Immunology - Molecular signatures of a disturbed nasal barrier function in the ... - 0 views

www.nature.com/...mi20119a.html

S aureus Staphylococcus aureus autoimmune disease disease autoimmune Wegener's granulomatosis WG Wegener's vasculitis

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    nasal mucos colonization of S aureus found to be associated with Wegener's vasculitis as well as relapse.
Nathan Goodyear

Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in... - 0 views

joe.endocrinology-journals.org/...217.full.pdf

CRP testosterone inflammation men male hormones cytokines

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    This study finds no difference between the sexes as it relates to testosterone and inflammatory cytokines. They only found a correlation with CRP as it relates to oxidized LDL.
Nathan Goodyear

Hormonal Regulation of Circulating C-Reactive Protein in Men - 0 views

www.clinchem.org/...911.full

estrogen inflammation CRP men male hormone cytokines

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    High dose of estrogen associated with increase CRP in men.  Definitely a dose dependent response.
Nathan Goodyear

Increased Endogenous Estrogen Synthesis Leads to the Sequential Induction of Prostatic ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2731137

male men hormones estrogen prostatitis inflammation prostate

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    male mouse model finds estrogen can induce prostatitis and dysplasia of the prostate.
Nathan Goodyear

Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostat... - 0 views

www.ncbi.nlm.nih.gov/...15215045

estrogen estradiol prostate inflammation cytokines male men hormones

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Estradiol induces prostatitis in male rat model.
Nathan Goodyear

Expression of proinflammatory genes during estrogen-induced inflammation of the rat pro... - 0 views

www.ncbi.nlm.nih.gov/...10861753

inflammation IL-1beta IL-6 MIP-2 cytokines prostate estrogen estradiol male hormones

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Estrogen increased IL-1beta, IL-6, and MIP-2 in male rat prostate model.
Nathan Goodyear

Association of sex hormones and C-reactive protein levels in men - 0 views

www.ncbi.nlm.nih.gov/...PMC2866020

male men hormones CRP inflammation cytokine Testosterone SHBG estradiol estrogen

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Low total Testosterone, low free Testosterone, and low SHBG associated with increased CRP.  Serum total estradiol and free estradiol trended to a positive association, but did not reach statistical significance.
Nathan Goodyear

Association between endogenous sex steroid hormones and inflammatory biomarkers in US men - 0 views

www.ncbi.nlm.nih.gov/...PMC3812341

low Testosterone Estrogen Estradiol low T Testosterone hormone hormones CRP inflammation SHBG WBC men male

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • modest statistically significant inverse associations for total and calculated free testosterone, and modest positive associations for total and calculated free estradiol with CRP concentration
  • Estradiol concentrations were also weakly positively associated with WBC count
  • SHBG was weakly inversely associated with WBC
  • ...21 more annotations...
  • An association between testosterone and WBC count was not observed
  • These findings are consistent with the hypothesis that in men higher androgen concentration is anti-inflammatory, and higher estrogen concentration is pro-inflammatory.
  • the probability of elevated CRP concentrations (≥ 3 mg/L) decreased with higher total and calculated free testosterone concentrations, while the probability increased with higher total and calculated free estradiol concentrations
  • there is ample evidence supporting the immunosuppressive effect of androgens
  • The incidence of autoimmune diseases is higher in androgen-deficient men
  • Studies have shown that the induction of hypogonadism in older men is followed by a significant increase in IL-6 concentrations (Khosla et al. 2002), a potent stimulator of inflammation, and that activation of the androgen receptor exerts a direct anti-inflammatory effect
  • It has been suggested that the mechanisms for the immunosuppressive effect of androgens could be either a direct effect on the expression of inflammatory genes (Bellido et al. 1995; Asirvatham et al. 2006), or an indirect effect through inhibition of nuclear factor-kB activation
  • Estradiol is the major biologically active estrogen, and about 80% is formed in adult men from the aromatization of testosterone primarily in the adipose tissue
  • estrogen can stimulate the transcription factor C/EBP-β, which is involved in CRP transcription
  • Most prior cross-sectional studies have observed inverse associations between androgen concentrations and inflammatory biomarkers
  • A recent study in Chinese men showed that lower concentrations of total and calculated free testosterone were associated with higher CRP concentration
  • Data from the Boston Area Community Health Survey also reported inverse associations between testosterone and CRP concentrations
  • Total testosterone was inversely associated with WBC count (Tang et al. 2007; Schneider et al. 2009; Brand et al. 2012), but calculated free testosterone was not associated with WBC
  • The first trial found a decrease in CRP, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNFα) but no changes in IL-6 and IL-10 concentrations between the active treatment and placebo arms
  • the majority of studies in the literature have not observed statistically significant associations between estradiol and inflammatory biomarkers in men, although several of them observed point estimates in the positive direction
  • total testosterone and estradiol compete for binding to SHBG, and seem to have opposite effects on the concentration of inflammatory biomarkers
  • A small randomized controlled trial of estrogen replacement therapy in prostate cancer patients showed an increase in CRP in the active treatment group versus the comparator group
  • Obese men are known to have lower androgen concentrations compared to their normal-weight counterparts
  • The strongest suggestion of an interaction was the inverse association between androstanediol glucuronide and CRP concentrations in obese participants, while the association was positive in the non-obese
  • A recent Chinese cross-sectional study observed stronger inverse associations between total testosterone and CRP concentrations in individuals with a BMI of 27.5 kg/m2 or greater
  • our results suggest that total and calculated free testosterone are modestly inversely associated with CRP concentrations, and that total and calculated free estradiol are modestly positively associated with CRP and WBC
  • Nathan Goodyear on 28 Apr 15
     
    Study results suggest that higher Testosterone and lower Estrogen levels provide anti-inflammatory effects in men.  The inflammatory biomarker assessed here was CRP.  Low total and calculated free Testosterone was associated with an increase in CRP.  In contrast, total and free Estrogen was associated with an increase in CRP.  Estradiol increased WBC count and SHBG was inversely related to WBC count in this study.
Nathan Goodyear

Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rhe... - 0 views

www.ncbi.nlm.nih.gov/...14677174

inflammation estradiol estrogen RF RA rheumatoid arthritis men hormones

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Estradiol positively associated with RF in men with RA.
Nathan Goodyear

Estradiol and Inflammatory Markers in Older Men - 0 views

www.ncbi.nlm.nih.gov/...PMC2646519

men hormones male hormones estradiol estrogen inflammation IL-6 cytokines CRP TNF-alpha

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    Estradiol in men is associated with increased IL-6.  No association was found with CRP or TNF-alpha.
Nathan Goodyear

Association of endogenous sex hormone with C-reactive protein levels in middle-aged and... - 0 views

www.ncbi.nlm.nih.gov/...17302874

inflammation men hormones CRP hsCRP estradiol estrogen Testosterone total Testosterone bioavailable Testosterone

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    total and bioavailable Estradiol associated with increased hsCRP in men age 40-80.  Bioavailable is calculated with serum calculated free Testosterone and albumin bound Testosterone.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2008-0940 - 0 views

press.endocrine.org/...jc.2008-0940

estradiol estrogen men male hormones hormone inflammation IL-6 cytokines

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    Estradiol found to be associated with increased IL-6 in older men. This after, the adjustments to exclude variables.  Other inflammatory markers were not associated.
Nathan Goodyear

Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insu... - 0 views

stm.sciencemag.org/...304re7

insulin resistance insulin GLUT4 diet nutrition

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    Just abstract available, but small study finds men fed high calorie typical in western diets results in GLUT4 inactivation in t think that diet needs a long interval to show effects
Nathan Goodyear

Role of Polymorphic Human Cytochrome P450 Enzymes in Estrone Oxidation - 0 views

cebp.aacrjournals.org/...551.long

estrogen metabolism estrogen metabolites cytochrome P450 estrogen estrone hormones detoxification metabolites

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • CYP1A1 and CYP1B1 are not expressed in any significant quantity in the liver. Therefore, they would not be expected to contribute to the overall systemic metabolism of estrone. However, both enzymes have been identified in breast tissue
  • CYP1A1 displayed relatively high activity for all three hydroxylations, suggesting that it may play an important role in extrahepatic tissues where it is expressed
  • CYP1A1 was more active with regard to 2-hydroxylation and 4-hydroxylation, it also displayed one of the greatest 16α-hydroxylating activities of the CYP enzymes tested.
  • ...4 more annotations...
  • CYP1B1 displayed a high affinity for estrone and preferentially catalyzed 4-hydroxylation over 2-hydroxylation
  • CYP1B1 did not seem to contribute to 16α-hydroxylation.
  • CYP1B1 was shown to preferentially catalyze 4-hydroxylation, whereas CYP1A1 was shown to preferentially catalyze 2-hydroxylation
  • Among the CYP enzymes expressed in the liver, CYP1A2 was the most active with regard to 2-hydroxylation
  • Nathan Goodyear on 11 Sep 15
     
    good discussion of estrogen metabolism and the P450 enzymes.
Nathan Goodyear

http://joe.endocrinology-journals.org/content/167/2/281.full.pdf - 0 views

joe.endocrinology-journals.org/...281.full.pdf

estrogen metabolites 4-hydroxyestrone cancer estrogen hormones 2-hydroxyestrone 2-OH-estrone 4-OH-estrone

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    good discussion of the estrogen metabolites and increased estrogenic activity; including cancer risk.  Particular attention is given to the 4-hydroxyestrone metabolite.
Nathan Goodyear

http://cancerres.aacrjournals.org/content/early/2012/01/15/0008-5472.CAN-11-2507.full.pdf - 0 views

cancerres.aacrjournals.org/...0008-5472.CAN-11-2507.full.pdf

estrogen estrogens estrogen metabolites breast cancer cancer hormones

shared by Nathan Goodyear on 12 Sep 15 - No Cached
  • Nathan Goodyear on 12 Sep 15
     
    nice article.  Good discussion on the different effects of the estrogen metabolites on the estrogen receptors and their down stream effects.
Nathan Goodyear

CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metab... - 0 views

www.ncbi.nlm.nih.gov/...16949388

estrogen metabolites estrogen metabolism menopause estrogen hormones

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    estrogen metabolites and associated risk.
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