Dr. Goodyear

great review of data on cardiac damage associated with extreme endurance training.  These EEEs, that they are called, are rare in those < 40 and usually involved genetic defects.  This article points to aggressive preventive testing in those > 50.

reduced glutathione, via increased oxidative stress, levels lost in HIV.  NAC and liposomal Glutathione increased innate immune function--macrophages.

Only abstract available.  Loss of glutathione leads to loss in mitochondrial DNA.

acute and chronic heart changes to endurance training/events.

white paper on protein for endurance athletes.

ibuprofen associated with increased oxidative stress in extreme exercise.

strength training improved performance of endurance athletes.  This study is a meta-analysis.

ibuprofen provided no reduction in muscle damage/soreness in 29 ultra marathoners.  However, LPS, CRP, IL-6, IL-10, IL-8, IL-1ra, GSF, MCP-1, and MIP-1beta were increased in the ibuprofen group.  TNF-alpha was unaffected.

Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes.  This post-race RVEF reduction is associated with VO2max.

Summary of 2010 report on marathons and the heart.  Less fit runners can do significant damage to the heart i.e. fibrosis compared to fit runners.  V02 max is a good way to assess aerobic endurance and differentiate between the two.  Dr Larose showed via MRI that it can take 3 months for the heart to recover.

Dandelion root has historically shown benefit as diuretic.  Study finds support for tincture, though this is a small pilot.  Dosing is critical.

men with HIV have GSH depleted macrophages.  GSH is the reduced, ready to act form of Glutathione.  In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG.  In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.

Does Tamiflu work. The evidence says no.  New cochrane review: "The influenza virus-specific mechanism of action proposed by the produces does not fit the clinical evidence".

Physical activity in colon cancer patients improves survival compared to increased mortality with increase TV viewing.  We physicians must increase the practice of exercise prescriptions.

10 year study finds that men with prostate cancer have lower mortality rates when they exercise 5+ times per week at 20+ minutes.  The type of exercise is walking and bicycling--all cardio.  

Study finds that 5+ daily servings of fruits/vegetables and 30 mins walking 6 days/week is associated with improved survival in women with breast cancer.

Study finds that acetyl-11-keto-Beta-boswellic acid (AKBA) reduced growth of pancreatic cancer and metastasis in mouse model.  AKBA also inhibits NF-kappaB and induced apoptosis.  AKBA is found in Frankinsense. 

More than 90% of drug induced autoimmune hepatitis is due to minocycline and nitrofurantoin.  No cirrhosis occurred in f/u.

minocycline induced liver hepatotoxicity

Nice review of the literature of low T and LUTS in men.