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curetick

Walnut Benefits and Side Effects | How to Eat Walnuts - 0 views

curetick.com/lnut-benefits-and-side-effects

walnut_for_weight_loss walnut_health_benefits walnut_oil_during_pregnancy walnut_oil_for_skin

shared by curetick on 22 Feb 18 - No Cached
  • curetick on 22 Feb 18
     
    The walnut benefits can also be useful for weight loss purpose. The containing omega-3 inside the walnut have fatty acids with other substances into it. The 2.5 grams of 'ALA' per serving is found rich beneficial sources as the fatty acid. From studies among the women's observed that having a walnut at diet can be helpful for reducing the weight loss with greater efficiency. It also lowers the 'bad' levels of LDL cholesterol from the body. And the higher levels of 'HDL' cholesterol in a good manner as suggested by the doctors.
Nathan Goodyear

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal - 0 views

www.hindawi.com/...360438

MDA malondialdehyde peroxidation oxidative stress free radicals

shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Hydroxyl radicals cause oxidative damage to cells because they unspecifically attack biomolecules [22] located less than a few nanometres from its site of generation and are involved in cellular disorders such as neurodegeneration [23, 24], cardiovascular disease [25], and cancer [26, 27].
  • It is generally assumed that in biological systems is formed through redox cycling by Fenton reaction, where free iron (Fe2+) reacts with hydrogen peroxide (H2O2) and the Haber-Weiss reaction that results in the production of Fe2+ when superoxide reacts with ferric iron (Fe3+)
  • other transition-metal including Cu, Ni, Co, and V can be responsible for formation in living cells
  • ...20 more annotations...
  • The hydroperoxyl radical () plays an important role in the chemistry of lipid peroxidation
  • The is a much stronger oxidant than superoxide anion-radical
  • Lipid peroxidation can be described generally as a process under which oxidants such as free radicals or nonradical species attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs) that involve hydrogen abstraction from a carbon, with oxygen insertion resulting in lipid peroxyl radicals and hydroperoxides as described previously
  • under medium or high lipid peroxidation rates (toxic conditions) the extent of oxidative damage overwhelms repair capacity, and the cells induce apoptosis or necrosis programmed cell death
  • The overall process of lipid peroxidation consists of three steps: initiation, propagation, and termination
  • Once lipid peroxidation is initiated, a propagation of chain reactions will take place until termination products are produced.
  • The main primary products of lipid peroxidation are lipid hydroperoxides (LOOH)
  • Among the many different aldehydes which can be formed as secondary products during lipid peroxidation, malondialdehyde (MDA), propanal, hexanal, and 4-hydroxynonenal (4-HNE) have been extensively studied
  • MDA has been widely used for many years as a convenient biomarker for lipid peroxidation of omega-3 and omega-6 fatty acids because of its facile reaction with thiobarbituric acid (TBA)
  • MDA is one of the most popular and reliable markers that determine oxidative stress in clinical situations [53], and due to MDA’s high reactivity and toxicity underlying the fact that this molecule is very relevant to biomedical research community
  • 4-HNE is considered as “second toxic messengers of free radicals,” and also as “one of the most physiologically active lipid peroxides,” “one of major generators of oxidative stress,” “a chemotactic aldehydic end-product of lipid peroxidation,” and a “major lipid peroxidation product”
  • MDA is an end-product generated by decomposition of arachidonic acid and larger PUFAs
  • Identifying in vivo MDA production and its role in biology is important as indicated by the extensive literature on the compound (over 15 800 articles in the PubMed database using the keyword “malondialdehyde lipid peroxidation” in December 2013)
  • MDA reactivity is pH-dependent
  • When pH decreases MDA exists as beta-hydroxyacrolein and its reactivity increases
  • MAA adducts are shown to be highly immunogenic [177–181]. MDA adducts are biologically important because they can participate in secondary deleterious reactions (e.g., crosslinking) by promoting intramolecular or intermolecular protein/DNA crosslinking that may induce profound alteration in the biochemical properties of biomolecules and accumulate during aging and in chronic diseases
  • MDA is an important contributor to DNA damage and mutation
  • This MDA-induced DNA alteration may contribute significantly to cancer and other genetic diseases.
  • Dietary intake of certain antioxidants such as vitamins was associated with reduced levels of markers of DNA oxidation (M1dG and 8-oxodG) measured in peripheral white blood cells of healthy subjects, which could contribute to the protective role of vitamins on cancer risk
  • 4-HNE is an extraordinarily reactive compound
  • Nathan Goodyear on 05 Dec 17
     
    Great review of lipid peroxidation
Nathan Goodyear

EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-γ-dependent mechanism - ScienceDirect - 0 views

www.sciencedirect.com/...S0085253815505322

inflammation omega 3 omega-3 EPA DHA LPS lipopolysaccharides NF-kappaB PPAR-gamma

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Omega 3 essential fatty acids, specifically EPA and DHA, decrease LPS activation of NF-kappaB via PPAR-gamma activation.
Nathan Goodyear

Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation - 0 views

www.ncbi.nlm.nih.gov/...PMC5405524

epigenetics nutrigenomics omega 3 omega-3 diet nutrition methylation fats EPA DHA

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • Nathan Goodyear on 15 Sep 17
     
    Epigenetic and really nutrigenomics: 6 week study of 3 gram omega 3 intake induced methylation changes.  Get that?  Only 6 weeks of omega 3 intake induces a change in genetic expression.
Nathan Goodyear

Omega-3 Fatty Acids and Inflammatory Processes - 0 views

www.ncbi.nlm.nih.gov/...PMC3257651

fats nutrition diet omega 3 inflammation NF-kappaB TNF-alpha omega-3 fish oil DHA EPA docosahexaenoic acid eicosapentaenoic acid

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • marine n-3 PUFAs have also been shown to alter the production of inflammatory proteins including chemokines, cytokines, growth factors and matrix proteases
  • Two transcription factors that are likely to play a role in inflammation are nuclear factor κ B (NFκB) and PPAR-γ
  • NFκB is the principal transcription factor involved in upregulation of inflammatory cytokine, adhesion molecule and cyclooxygenase-2 genes
  • ...3 more annotations...
  • PPAR-γ, is believed to act in an anti-inflammatory manner
  • PPAR-γ directly regulates inflammatory gene expression, it also interferes with the activation of NFκB creating an intriguing interaction between these two transcription factors
  • Both NFκB and PPAR-γ may be regulated by n-3 PUFAs.
  • Nathan Goodyear on 15 Sep 17
     
    great review of the anti-inflammatory effects of omega 3 DHA and EPA.  EPA inhibits COX and 5-LOX and their downstream prostaglandin and leukotrienes.  EPA/DHA inhibited endotoxin-stimulated IL-6, IL-8,TNF-alpha, and NFkappaB.
Nathan Goodyear

https://www.researchgate.net/publication/23792166_Genome-Wide_Association_Study_of_Plasma_Polyunsaturated_Fatty_Acids_in_the_InCHIANTI_Study - 0 views

www.researchgate.net/...y_Acids_in_the_InCHIANTI_Study

epigenetics PUFA omega-3 omega 3 omega-6

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Only abstract available here. Good discussion of PUFA interactions with different genetic SNPs i.e. ELOVL2 and FADS1/2...
Nathan Goodyear

Fish Intake, Contaminants, and Human Health | Nutrition | JAMA | The JAMA Network - 0 views

jamanetwork.com/...203640

omega 3 omega-3 fish EPA DHA diet nutrition

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Study finds that higher omega 3 intake over time associated with a reduction in blood clots, heart arrhythmias, lower triglycerides, lower heart rates and lower blood pressure.
Nathan Goodyear

Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15992645

fish omega-3 omega 3 CRP IL-6 TNF-alpha amyloid WBC inflammation

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Only abstract available here but higher fish intake associated with a decrease in CRP, IL-6, TNF-alpha, amyloid A and WBC; restated, higher fish intake associated with a reduction of inflammation
Nathan Goodyear

Blood Levels of Long-Chain n-3 Fatty Acids and the Risk of Sudden Death - NEJM - 0 views

www.nejm.org/...NEJMoa012918

omega 3 omega-3 sudden cardiac dealth

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Higher omega 3 fatty acids associated with 81% lower risk of sudden cardiac death.
Nathan Goodyear

Making the Right Fish Choices: Fatty Acid Contents of 33 Different Fish Species. Plus: What Are the Implications? - SuppVersity: Nutrition and Exercise Science for Everyone - 0 views

suppversity.blogspot.com/...t-fish-choices-fatty-acid.html

omega 3 omega-3 omega-6 fish nutrition diet

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    I don't normally post blog posts, however, this post has merits for the purpose of figure 1 and figure 2.   Figure 1 highlights the different omega 3:omega 6 of different fish and figure 2 highlights the different omega3;6 in wild versus farm raised fish.
Nathan Goodyear

Survey of n-3 and n-6 polyunsaturated fatty acids in fish and fish products - 0 views

www.ncbi.nlm.nih.gov/...PMC3543232

omega 3 omega-6 omega-3 fish EPA DHA ALA diet nutrition

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Good read on the omega 3 versus omega 6 content of different fish.
Nathan Goodyear

Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid | Scientific Reports - 0 views

www.nature.com/...s41598-017-06630-0

DHA omega-3 omega 3 brain estrogen seizures fish oil

shared by Nathan Goodyear on 21 Aug 17 - No Cached
  • Nathan Goodyear on 21 Aug 17
     
    DHA supplementation increases brain estrogen in animal study. In this study, both blunted seizure induction in the animals. This has significant implications for DHA supplementation and dietary intake of fish high in DHA for the brain through estrogen.
Nathan Goodyear

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury - 0 views

www.ncbi.nlm.nih.gov/...PMC5525354

omega 3 omega-3 microglia TBI traumatic brain injury brain inflammation

shared by Nathan Goodyear on 01 Aug 17 - No Cached
  • Nathan Goodyear on 01 Aug 17
     
    Omega 3 supplementation found to blunt microglial TBI inflammation. 
Nathan Goodyear

Home: Cell Press - 0 views

www.cell.com/...S0896-6273(17)30287-8

omega-3 omega 3 DHA brain brain health

shared by Nathan Goodyear on 15 May 17 - No Cached
  • Nathan Goodyear on 15 May 17
     
    study finds that omega 3, particularly DHA, protects and preserves the blood brain barrier
Nathan Goodyear

Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21130435

preconception omega 3 omega-3 nutrition pregnancy

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    High omega 3 intake associated with improved embryo morphology i.e. likely improved conception and pregnancy rates.
Nathan Goodyear

Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation - 0 views

www.ncbi.nlm.nih.gov/...PMC4728624

obesity overweight infertility IVF nutrition pregnancy omega-6 omega-3 omega 3 omg

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    Health fat intake associated with improved fertility in overweight and obese women undergoing IVF.  Higher intake of polyunsaturated fats were associated with improved fertile rates: specifically omega 6 and Linoleum acid.  Only a trend was seen with omega 3's.
Nathan Goodyear

Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden - Johnson - 2016 - Journal of Child Psychology and Psychiatry - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

omega 3 omega-3 omega-6 brain children reading

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    Omega 3/6 supplementation in a 1:1 ration in children improved reading skills in 3 months.
Nathan Goodyear

Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes - European Journal of Sport Science | Taylor & Francis Online - 0 views

www.tandfonline.com/...17461391.2014.949310

fish oil omega 3 omega-3 n-3 cycling athletes NO endurance sports endurance athletes endurance exercise

shared by Nathan Goodyear on 06 Jul 16 - No Cached
  • Nathan Goodyear on 06 Jul 16
     
    supplementation of 2.6 grams of n-3 found to increase NO and VO2max in elite cycling athletes.  This has applications for all endurance athletes.  
Nathan Goodyear

Articles | Physiological Reports - 0 views

physreports.physiology.org/...e12438

omega 3 omega-3 n-3 fish oil

shared by Nathan Goodyear on 30 Jun 16 - No Cached
  • Nathan Goodyear on 30 Jun 16
     
    4 grams of daily n-3 decreased pulse wave velocity--decreased arteriosclerosis.  No change in blood pressure noted through the change in central pulse pressure.
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