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Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorect... - 0 views

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    Vitamin D3 shown to reduce CRP, TNF, IL-6, IL-1B, IL-8 in colorectal adenoma patients. This study supports the anti-inflammatory, anti-cancer benefits of vitamin D3.
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Perspectives on sesquiterpene lactones in ... [Curr Drug Targets. 2011] - PubMed - NCBI - 0 views

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    sespquiterpenes show anti-inflammatory and anti-cancer effects.
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Comparative Studies of the Estrogen Receptors β and α and the Androgen Recept... - 0 views

  • ER-β is predominately immunolocalized in basal cells and to a lesser extent in stromal cells of the morphologically normal human prostate
  • ER-α is detected in stromal cells and rarely in basal cells of the normal gland
  • AR was predominately localized in the nuclei of differentiated secretory cells and variably in basal cells of the normal acinar/duct unit as well as in stromal cells
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  • Hall and colleagues44 have reported that ER-β functions as a transdominant inhibitor of ER-α transcription and that it acts to decrease overall cellular sensitivity to estradiol
  • The expression of ER-β was diminished in high-grade dysplasias when compared to normal glands and lower grade lesions.
  • The transition from normal to low/moderate dysplastic glands in the peripheral zone was marked by the appearance of ER-β homogeneously immunostained nuclei in secretory as well as basal cells with no changes in the localization of the other receptors.
  • proliferative signals mediated by AR in basal cells or by ER-α and AR in stromal cells may be opposed by the purported growth-inhibitory action of ER-β25, 26, 27, 28 localized in basal cells.
  • The diminution of ER-β expression in high-grade dysplasias and grade 4/5 cancers may be therefore related to the alteration of DNA methylation pattern in CpG islands of the promoter, resulting in down-regulation of the receptor at the transcriptional level
  • based on the proposed anti-proliferative function of the receptor,25, 26, 27, 28 the presence of ER-β in secretory cells of low/moderate-grade lesions may represent a transient abortive attempt to counter growth of these cells
  • the attrition of receptor-positive basal cells in the high-grade dysplasias may signify a continuing loss of growth inhibitory function mediated by ER-β in these precursor lesions
  • Our findings in prostate therefore differ from those reported for human colon cancer in which Folley and colleagues48 demonstrated that a selective loss of ER-β protein but not receptor message expression occurs in these neoplasms
  • Our findings therefore differed from those of Bonkhoff and colleagues33 who found immunostaining for the receptor in high-grade dysplasias and grade 4/5 carcinomas. Using in situ hybridization these authors also reported that a high percentage of dysplasias and carcinomas in their study contained cells that expressed ER-α message
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    Very nice study.  The authors looked at normal prostate, early disease and late stage prostate cancer.  The authors found that ER beta expression, as a general rule, was lost as progression occurred to the high-grade dysplasias and grad 4/5 carcinomas of the prostate.  Early low/moderate dysplasia was associated with an increase in ER beta--the authors propose that this was due to an attempt of the basal epithelium to counter the paracrine effect of ER alpha.   In contrast, androgen receptors appeared to be equally expressed across all.
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The anti-malarial artesunate is also active against cancer - 0 views

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    Artesunate induces apoptosis in esophageal cell lines.
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The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-nega... - 0 views

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    ART inhibited breast cancer cell proliferation via a reactive oxygen species (ROS)-dependent G2/M arrest and ROS-independent G1 arrest. ART-treated MDA-MB-468 and SK-BR-3 cells also experienced apoptotic cell death, which was both ROS- and iron-dependent. ART-induced oxidative stress caused the loss of mitochondrial outer membrane integrity and damage to the cellular DNA of MDA-MB-468 and SK-BR-3 cells. Only abstract available...I will post full article once available.
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Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Indepe... - 0 views

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    Great review of androgen dependent and androgen independent prostate cancer.
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Anti-Cancer Activity of Cannabis sativa Phytocannabinoids: Molecular Mechanisms and Pot... - 0 views

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    Review of the targeted effects of CBDA CBD and THC in cancer treatment
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Mechanisms of Progesterone Receptor Inhibition of Inflammatory Responses in Cellular Mo... - 0 views

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    This article describes the underlying transcription responses to the anti-inflammatory effects provided through progesterone receptors (PR) in breast cancer.
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An Overview of Melatonin and Breast Cancer - Natural Medicine Journal: The Official Jou... - 0 views

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    Great review on the anti-cancer properties of melatonin.  Well referenced.
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Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast c... - 0 views

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    Very interesting study.  In ER/PR + breast cancer cells, Estradiol and 5alpha-dihydroprogestorone increase the membrane expression of 5alpha-dihydroprogesterone receptors.  This has a pro-growth, pro-metastatic potential.  In contrast, the metabolites 3alpha-dihdroprogesterone and 20alpha-HP inhibit the same membrane receptor expression thus giving an antigrowth, anti-metastatic potential.
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Targeting cancer cells by an oxidant-based therapy. [Curr Mol Pharmacol. 2008] - PubMed... - 0 views

  • vitamin K3) and ascorbate (vitamin C)
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    Anti-oxidant therapy for cancer patients
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Promoting effects and mechanisms of action of androgen in bladder c... - PubMed - NCBI - 0 views

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    Another animal study finds Testosterone plays a role in bladder cancer development.  The study used anti androgen and 5 alpha reductase inhibitor therapy to see if these add on therapies provided anything to ADR whether via castration or pituitary suppression--the answer was no.  The authors concluded that Testosterone played more of a role with AR versus the more active 5alpha-DHT metabolite.
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Cancer-preventing attributes of probioti... [Int J Food Sci Nutr. 2010] - PubMed - NCBI - 0 views

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    The evidence of probiotics in cancer is limited.  The limited evidence points to an increase in anti-oxidative enzymes i.e. glutathion-S-transferase, glutathione perioxidase, catalase, SOD.
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The Use of Therapeutic Peptides to Target and to Kill Cancer Cells - 0 views

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    Great early review of peptide therapeutics in cancer. There are anti-microbial peptides (AMPs), cell penetrating peptides (CPPs), and tumor targeting peptides (TTPs)
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Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of act... - 0 views

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    Incredible review to the evidence of action of artemisinin and its metabolites in cancer: apoptotic, arrest of cell growth, anti-inflammatory, immunomodulation...
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Melatonin for the prevention and treatment of cancer - 0 views

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    Wide benefits of melatonin in the battle against cancer: HIF-1alpha inhibitor, aromatase inhibitory, anti-angiogenesis, triggers apoptosis...
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A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy f... - 0 views

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    Artesunate has anti-cancer effects.
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Metronomic Chemotherapy in Non-Small-Cell Lung Cancer | Request PDF - 0 views

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    LDMC effect in lung cancer via its Antiangiogenic and anti immunosuppressive effects.
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Vitamin C - A new player in regulation of the cancer epigenome. - PubMed - 0 views

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    Only abstract available here. I will post the full article when I find it. Vitamin C, in addition to its anti-cancer properties, found to change epigenetic expression.
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Therapeutic Effects of Curcumin against Bladder Cancer: A Review of Possible Molecular ... - 0 views

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    Curcumin has broad anti-bladder cancer properties.
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