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Nathan Goodyear

Delayed-Onset Hemolytic Anemia in Patients with Travel-Associated Severe Malaria Treate... - 0 views

wwwnc.cdc.gov/...14-1171_article

artesunate anemia

shared by Nathan Goodyear on 18 Jul 18 - No Cached
  • delayed hemolytic events occur in ≈20% of patients with severe imported malaria, and 60% of these patients require blood transfusion
  • Delayed-onset anemia (herein referred to as postartesunate delayed-onset hemolysis [PADH] pattern of anemia) has been observed to occur 2–3 weeks after initiation of IV artesunate
  • The mechanism of this anemia is hemolytic, as demonstrated by high serum lactate dehydrogenase (LDH) and low plasma haptoglobin levels
  • ...5 more annotations...
  • this side effect is associated with artesunate
  • PADH occurred in 27% of patients in this study, but it was rarely associated with severe anemia and was never fatal
  • median delayed drop in hemoglobin levels was 1.3 g/dL
  • This transfusion rate (<5%) is markedly lower than that previously reported for patients with severe imported malaria and delayed-onset anemia (≈60%)
  • Side effects of artesunate frequently include gastrointestinal disturbances, neutropenia (1.3%), reticulocytopenia (0.6%), and elevated liver enzymes (1.1%)
  • Nathan Goodyear on 18 Jul 18
     
    artesunate
Nathan Goodyear

<i>Artesunate</i> Suppresses the Growth of Prostatic Cancer Cells through Inhibiting An... - 0 views

www.jstage.jst.go.jp/...en

artesunate prostate cancer

shared by Nathan Goodyear on 03 Jun 19 - No Cached
  • Nathan Goodyear on 03 Jun 19
     
    Artesunate found to have broad range of anti-cancer activity, such as pro-apoptosis attenuation of tumor growth, metastasis, and angiogenesis. This study primarily looked at the effect in a prostate cancer mouse model. It found that the artesunate down regulated androgen receptors. Now, there is debate about how and when AR and androgens play a role in prostate cancer as studies have also pointed to estrogen and ER in carcinogenesis of the prostate.
Nathan Goodyear

How does Artesunate kill cancer? | Yaletown Naturopathic Clinic - 0 views

yaletownnaturopathic.com/ow-does-artesunate-kill-cancer

Cancer "breast cancer" Artesunate "vitamin C" "IV vitamin Iron

shared by Nathan Goodyear on 18 Oct 18 - No Cached
  • Nathan Goodyear on 18 Oct 18
     
    Blog post, but a good, though brief, description of the combined benefit of vitamin C and Artesunate in the fight against advanced breast cancer.
Nathan Goodyear

The anti-malarial artesunate is also active against cancer - 0 views

www.spandidos-publications.com/...767

Artesunate Cancer

shared by Nathan Goodyear on 18 Oct 18 - No Cached
  • Nathan Goodyear on 18 Oct 18
     
    Artesunate induces apoptosis in esophageal cell lines.
Nathan Goodyear

Artesunate inhibits the growth and induces apoptosis of human gastric | OTT - 0 views

www.dovepress.com/ric--peer-reviewed-article-OTT

Caspase-3 Caspase-9 cox-2 cancer artesunate Bcl-2 Bax

shared by Nathan Goodyear on 01 May 20 - No Cached
  • Nathan Goodyear on 01 May 20
     
    Wide spectrum of anti-cancer properties of artesunate
Nathan Goodyear

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC6489539

ovarian cancer cancer apoptosis T cells artesunate

shared by Nathan Goodyear on 23 May 19 - No Cached
  • Nathan Goodyear on 23 May 19
     
    Artesunate found to promote T cell differentiation to increase apoptosis of ovarian cancer cells in a murine model.
Nathan Goodyear

Artesunate induces apoptosis and autophagy in HCT116 colon cancer cells, and autophagy ... - 1 views

www.ncbi.nlm.nih.gov/...PMC6089754

artesunate cancer

shared by Nathan Goodyear on 05 Jun 19 - No Cached
  • Nathan Goodyear on 05 Jun 19
     
    Artesunate study to be read.
Nathan Goodyear

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines... - 0 views

www.ncbi.nlm.nih.gov/...19698702

Artesunate cancer neuroblastoma

shared by Nathan Goodyear on 18 Oct 18 - No Cached
  • Nathan Goodyear on 18 Oct 18
     
    Artesunate found to be effective agains neuroblastoma cell lines.
Nathan Goodyear

Artesunate induces oncosis-like cell death in vitro and has antitumor activity against ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2824122

Artesunate cancer "pancreatic cancer" oncosis

shared by Nathan Goodyear on 18 Oct 18 - No Cached
  • Nathan Goodyear on 18 Oct 18
     
    Study finds that Artesunate induces cell death of pancreatic cancer cells in in vitro and in vivo studies via a non-apoptosis effect-oncosis.
Nathan Goodyear

Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51 - 0 views

www.ncbi.nlm.nih.gov/...PMC5391513

artesunate cisplatin chemotherapy cancer ovarian cancer

shared by Nathan Goodyear on 19 Oct 18 - No Cached
  • Nathan Goodyear on 19 Oct 18
     
    artesunate sensitizes ovarian cancer cells to cisplatin.
Nathan Goodyear

[Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small... - 0 views

www.ncbi.nlm.nih.gov/...18241646

Artesunate cancer NSCLC "non-small cell lung cancer"

shared by Nathan Goodyear on 11 Dec 18 - No Cached
  • Nathan Goodyear on 11 Dec 18
     
    Artesunate augments cisplatin and navelbine.
Nathan Goodyear

Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibit... - 0 views

www.ncbi.nlm.nih.gov/...PMC5341871

Cancer artesunate temodar glioblastoma glioblastoma multiforme

shared by Nathan Goodyear on 19 Dec 18 - No Cached
  • Nathan Goodyear on 19 Dec 18
     
    Artesunate augments Temodar in animal model of glioblastoma.
Nathan Goodyear

A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy f... - 0 views

www.ncbi.nlm.nih.gov/...PMC4484515

artesunate cancer colorectal cancer

shared by Nathan Goodyear on 07 Aug 18 - No Cached
  • Nathan Goodyear on 07 Aug 18
     
    small human study of po artesunate found to induce apoptosis and reduce recurrent disease.
Nathan Goodyear

Contribution of Reactive Oxygen Species to Ovarian Cancer Cell Growth Arrest and Killin... - 0 views

cancer artesunate ROS

shared by Nathan Goodyear on 06 Jun 19 - No Cached
  • Nathan Goodyear on 06 Jun 19
     
    Artesunate increased ROS in ovarian cancer cells that lead to G1 cell cycle arrest and halt in proliferation.
Nathan Goodyear

Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate - 0 views

www.jstage.jst.go.jp/...en

artesunate cancer Fenton reaction Fe

shared by Nathan Goodyear on 07 Jul 19 - No Cached
  • Nathan Goodyear on 07 Jul 19
     
    Artesunate reduces Fe3+ to Fe2+ via the fenton reaction. Similar to vitamin C.
Nathan Goodyear

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function an... - 0 views

www.ncbi.nlm.nih.gov/...PMC4246098

artesunate cancer ferritin fe

shared by Nathan Goodyear on 16 Jul 19 - No Cached
  • Nathan Goodyear on 16 Jul 19
     
    Artesunate article to be read.
Nathan Goodyear

The Anti-malarial Drug Artesunate Blocks Wnt/β-catenin Pathway and Inhibits G... - 0 views

www.eurekaselect.com/...article

artesunate cancer Wnt

shared by Nathan Goodyear on 23 Aug 19 - No Cached
  • Nathan Goodyear on 23 Aug 19
     
    In vitro study finds that artesunate blocks Wnt pathway a very important signaling pathway for cancer cell proliferation and TME immunosuppression.
Nathan Goodyear

Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stre... - 0 views

www.ncbi.nlm.nih.gov/...PMC4147310

multiple myeloma artesunate

shared by Nathan Goodyear on 31 Mar 20 - No Cached
  • Nathan Goodyear on 31 Mar 20
     
    Artesunate effective at stand alone therapy and adjunctive with chemotherapy in multiple myeloma. Intracellular Ferrous is required for effect. This was a cell culture study.
Nathan Goodyear

Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli... - 0 views

www.researchgate.net/...ription_factor_NF-B_activation

inflammation artesunate LPS TLR-4 TLR4

shared by Nathan Goodyear on 17 Apr 20 - No Cached
  • Nathan Goodyear on 17 Apr 20
     
    Artesunate inhibits TLR-4 expression to block LPS induced pro-inflammatory response.
Nathan Goodyear

The combination of artesunate and carboplatin exerts a synergistic anti-tumour effect o... - 0 views

www.ncbi.nlm.nih.gov/...32072678

cancer chemotherapy artesunate lung cancer

shared by Nathan Goodyear on 12 Apr 20 - No Cached
  • Nathan Goodyear on 12 Apr 20
     
    Artesunate and carboplatin chemotherapy shows synergistic anti-cancer effects.
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