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TNF-alpha associated with muscle loss and weakness.  TNF-alpha may also decrease testosterone production/secretion resulting in muscle loss.  

HIV/AIDS patients are plagues with muscle loss through varying mechanism. This article discusses the various contributors to the muscle mass found in these men. However, this can be applicable to other men with chronic muscle loss, low T, HGH deficiency...

in those adults with HGH deficiency, HGH replacement found to improve lipids, IGF-1, and cardiac function.

The use of saliva found to be advantageous over that of serum and urine to assess cortisol.

saliva shown to be valuable and reliable in assessing hormones associated with sport performance, exercise, and/or training.

Good discussion of PR receptors. This article focus' on the different receptors, mainly A and B, and the nuclear transcriptional signaling.

Good article. Discusses the association between low Testosterone and cardiovascular risk in men. The conclude that no direct cause effect relationship has been provided, but a clear association is seen. Numerous studies have shown this association.

babies born to obese mothers have lower vitamin D levels.

This article describes the underlying transcription responses to the anti-inflammatory effects provided through progesterone receptors (PR) in breast cancer.

This article, abstract only, looks at the cause of low Testosterone.  It is well known that low T increases CAD in men.  But what causes the low T?  Is the "normal" decline in testosterone actually normal or a product of accumulative dysfunction.

Progesterone receptor (PR) shown to provide an important anti-inflammatory role in breast cancer in this study.  PR shown to increase NF-kappaB inhibitor IkBalpha, shown to inhibit aromatase activity, shown to inhibit COX-2 expression and shown to inhibit HER-2/neu expression.

Persistent Environmental pollutants reduce couple fertility rate.  The toxins they looked at included organochlorides and PCBs.  

Many pesticides function as androgen receptor antagonists.  Others as Xenoestrogens.  Estrogen-like toxins and androgen receptor antagonists...a potent cocktail to disrupt male androgen signaling.

progesterone through progesterone receptors, shown to have protective, anti-inflammatory effects in the CNS.

mice model, but progesterone deficiency results in decreased PR expression to provide counter anti-inflammatory effect in endometriosis model.  Thus pro-inflammatory transcription via E2 through ER signaling.  It would be interesting to see if that was ER-alpha or ER-beta.

testosterone and Estradiol effect IGF-1 levels.  This small study looked at 8 men and 8 postmenopausal women.  Findings:  low testosterone and high estradiol decrease IGF-1 availability.   Estradiol in postmenopausal women will result in a decrease in IGF-1 through an elevation of IGFBP-1.  In men, testosterone replacement stimulates increased HGH secretion and resultant IGF-1 secretion

Testosterone given to elderly men with low "serum" testosterone shown to increase IGF-1 and increased muscle growth and strength.  So, this study shows that testosterone in men, seems to increase HGH production and thus increase IGF-1 production.  This may be the mechanism by which testosterone promotes muscle growth and increase in strength in men.

Androgen Receptors (AR) may play a role in some breast cancer growth and could be a target for future therapy.

In obese men, low T is the result of increased estradiol formation from aromatase activity.  Low SHBG is no enough to offset the decrease in free T levels.