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Estrogen is neuroprotective in postmenopausal women.

Postmenopausal cognitive decline is a common complaint.  Declining Estradiol and progesterone have been implicated, in part, to this cognitive decline.  This study finds that progesterone increases expression of Transthyretin, a protein that processes amyloid Beta protein.  This amyloid Beta protein is associated with damage found in Alzheimer's. 

study finds prolonged exposure to estrogen associated with increased colorectal cancer risk in postmenopausal women. So many unanswered questions. What was the ER status of these patients? What was the weight of these patients? One cannot simply compare estrogen exposure to colorectal cancer risk and say aha! What is the environment of the individual(s)?!

Premarin increases the risk of stroke in postmenopausal women.  The risk of hip fracture was reduced and no change in Coronary Heart disease was found.

study finds Testosterone improves cognitive function in postmenopausal women.  Was this due to aromatase activity and conversant to Estradiol?  Testing was limited in follow up.

Study finds that HRT is associated with a 35% reduction in relative risk of colorectal cancer in postmenopausal women.  Even use within the previous 5 years was associated with reduced risk.  This benefit is lost at 5 years..

The increased weight with tamoxifen is seen premenopausal women, but less with postmenopausal women.

increased 2 and 4-OH metabolites compared to parent compounds associated with decreased breast cancer in postmenopausal women.

Increased metabolism down the 2 hydroxylation pathway appears to reduce postmenopausal breast cancer risk.

A study to evaluate serum and urinary hormone levels following short and long term administration of two regimens of progesterone cream in postmenopausal women

Effects of progestogens on the postmenopausal breast.

Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women

medroxyprogsterone acetate (synthetic progestin) increase vascular function in postmenopausal women

antioxidants beneficial in postmenopausal women

CLA shown to reduce fat mass in postmenopausal women

Study finds non-hormonal therapy to manage hot flashes in postmenopausal women--drug them.  The authors of this study, looked to gabapentin, also known as neurontin to treat hot flashes.  Instead of looking at the causes: hormone imbalance, stress... these authors looked to a sedating drug.  The dosing of neurontin was 900 mg.   Most can't stand at this dose.  This study points to the lunacy in the research today.  Very soon, there will be the walking dead among us.  They will be the walking doped instead of dead.

study finds increases risk of breast cancer in postmenopausal women on HRT with increased 2OH-estrone metabolism.  Confusing?

Circulating progesterone increased breast cancer risk in postmenopausal women.

post menopausal estradiol in women associated with pro-inflammatory state.  SHBG was associated with a decrease in the inflammatory cytokine biomarkers.  Postmenopausal women were found to have an increased Testosterone to estradiol ratio.

elevated insulin associated with insulin resistance causes elevated male hormones in women.  Whether it is in PCOS or postmenopausal over-aggressive replacement, Testosterone also turns right around and contributes to insulin resistance.  Vicious cycle.