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Nathan Goodyear

Testosterone: a metabolic hormone in health and disease - 0 views

joe.endocrinology-journals.org/...JOE-12-0455.full.pdf

low T low testosterone testosterone metabolic syndrome MetS hormone hormones men male health disease

shared by Nathan Goodyear on 26 Feb 13 - No Cached
  • Nathan Goodyear on 26 Feb 13
     
    Great, great read and review on the current understanding of testosterone and metabolic dysfunction. Very well referenced.
Smile Reef

Choosing The Right Dentist for Your Child - 0 views

vegasdentist.newsvine.com/...e-right-dentist-for-your-child

special needs dentistry baby dentist childrens dentist las vegas oral sedation dentistry pediatric dentist las vegas kid dentist child dentist baby bottle tooth decay pediatric dental cavities in baby teeth dentist for kids

shared by Smile Reef on 15 May 13 - No Cached
  • Smile Reef on 15 May 13
     
    If you are looking online for a children's dentist in Las Vegas, chances are you will find several sites for dentists in the area as well as general dental practitioners who can treat children. Now the question is-how do you choose?
Day Spa Adelaide

A Soothing, Tranquil Journey - 1 views

I really love going to Day spas as their services really make me feel so relaxed. Since it has become my hobby, I usually go from one spa centre to another simply to try their services. But I can t...

started by Day Spa Adelaide on 28 May 13 no follow-up yet
Nathan Goodyear

How Medications Impact Libido - 0 views

www.pharmacytimes.com/...LossofLibido-0610

low libido libido medications prescription anti-depressants

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    This is a reference to a blog, but a well referenced blog on low libido and meds, particularly antidepressants and psychotropics.
Nathan Goodyear

Cancer as a metabolic disease - 0 views

www.biomedcentral.com/...1743-7075-7-7.pdf

cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Nathan Goodyear on 17 Jun 13
     
    Dr. Seyfried provides a different perspective on cancer as a metabolic disease and not as a "genetic" disease as is the current dogma. Dr. Seyfried is well published on this topic and presents valid points to show that a ketogenic diet with intermittent fasting is anti-cancer.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Day Spa Adelaide

Premiere Day Spa Service - 1 views

I have been working straight for a year now and yet I have not given myself the chance to relax and unwind. My friend told me about Shantai Wellness Spa, a day spa in Adelaide that is using only na...

started by Day Spa Adelaide on 18 Dec 12 no follow-up yet
Day Spa Adelaide

Gorgeous Day Spa Treatment - 1 views

Being a working mom who is also pregnant is not really easy as there are really times when you want to rest but cannot do it because you are at work. It is for this reason that I always find time t...

started by Day Spa Adelaide on 19 Dec 12 no follow-up yet
Nathan Goodyear

Dose-ranging study of indole-3-carbinol... [J Cell Biochem Suppl. 1997] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9589355

I3C indole-3-carbinol breast cancer dose dosing

shared by Nathan Goodyear on 04 Jan 13 - No Cached
  • Nathan Goodyear on 04 Jan 13
     
    Dosing information on I3C.  They found 300-400 mg to be tolerated well and an effective dose for breast cancer chemoprevention.
Nathan Goodyear

Calcium-D-glucarate - 0 views

www.thorne.com/...336.pdf

calcium-D-glucarate

shared by Nathan Goodyear on 05 Jan 13 - No Cached
  • Nathan Goodyear on 05 Jan 13
     
    great review on the benefits of calcium-D-glucarate. This article is well referenced.
Nathan Goodyear

Testosterone: a metabolic hormone in health and disease - 0 views

joe.endocrinology-journals.org/...R25.full

male hormone hormones testosterone hypogonadal-obesity-adipocytokine hypothesis

shared by Nathan Goodyear on 08 May 13 - No Cached
  • E2 and the inflammatory adipocytokines tumour necrosis factor α (TNFα) and interleukin 6 (IL6) inhibit hypothalamic production of GNRH and subsequent release of LH and FSH from the pituitary
  • Leptin, an adipose-derived hormone with a well-known role in regulation of body weight and food intake, also induces LH release under normal conditions via stimulation of hypothalamic GNRH neurons
  • In human obesity, whereby adipocytes are producing elevated amounts of leptin, the hypothalamic–pituitary axis becomes leptin resistant
  • ...39 more annotations...
  • there is evidence from animal studies that leptin resistance, inflammation and oestrogens inhibit neuronal release of kisspeptin
  • Beyond hypothalamic action, leptin also directly inhibits the stimulatory action of gonadotrophins on the Leydig cells of the testis to decrease testosterone production; therefore, elevated leptin levels in obesity may further diminish androgen status
  • increasing insulin resistance assessed by glucose tolerence test and hypoglycemic clamp was shown to be associated with a decrease in Leydig cell testosterone secretion in men
  • ADT for the treatment of prostatic carcinoma in some large epidemiological studies has been shown to be associated with an increased risk of developing MetS and T2DM
  • Non-diabetic men undergoing androgen ablation show increased occurrence of new-onset diabetes and demonstrate elevated insulin levels and worsening glycaemic control
  • Prostate cancer patients with pre-existing T2DM show a further deterioration of insulin resistance and worsening of diabetic control following ADT
  • The response to testosterone replacement of insulin sensitivity is in part dependent on the androgen receptor (AR)
  • Low levels of testosterone have been associated with an atherogenic lipoprotein profile, characterised by high LDL and triglyceride levels
  • a positive correlation between serum testosterone and HDL has been reported in both healthy and diabetic men
  • up to 70% of the body's insulin sensitivity is accounted for by muscle
  • Testosterone deficiency is associated with a decrease in lean body mass
  • relative muscle mass is inversely associated with insulin resistance and pre-diabetes
  • GLUT4 and IRS1 were up-regulated in cultured adipocytes and skeletal muscle cells following testosterone treatment at low dose and short-time incubations
  • local conversion of testosterone to DHT and activation of AR may be important for glucose uptake
  • inverse correlation between testosterone levels and adverse mitochondrial function
  • orchidectomy of male Wistar rats and associated testosterone deficiency induced increased absorption of glucose from the intestine
  • (Kelley & Mandarino 2000). Frederiksen et al. (2012a) recently demonstrated that testosterone may influence components of metabolic flexibility as 6 months of transdermal testosterone treatment in aging men with low–normal bioavailable testosterone levels increased lipid oxidation and decreased glucose oxidation during the fasting state.
  • Decreased lipid oxidation coupled with diet-induced chronic FA elevation is linked to increased accumulation of myocellular lipid, in particular diacylglycerol and/or ceramide in myocytes
  • In the Chang human adult liver cell line, insulin receptor mRNA expression was significantly increased following exposure to testosterone
  • Testosterone deprivation via castration of male rats led to decreased expression of Glut4 in liver tissue, as well as adipose and muscle
  • oestrogen was found to increase the expression of insulin receptors in insulin-resistant HepG2 human liver cell line
  • FFA decrease hepatic insulin binding and extraction, increase hepatic gluconeogenesis and increase hepatic insulin resistance.
  • Only one, albeit large-scale, population-based cross-sectional study reports an association between low serum testosterone concentrations and hepatic steatosis in men (Völzke et al. 2010)
  • This suggests that testosterone may confer some of its beneficial effects on hepatic lipid metabolism via conversion to E2 and subsequent activation of ERα.
  • hypogonadal men exhibiting a reduced lean body mass and an increased fat mass, abdominal or central obesity
  • visceral adipose tissue was inversely correlated with bioavailable testosterone
  • there was no change in visceral fat mass in aged men with low testosterone levels following 6 months of transdermal TRT, yet subcutaneous fat mass was significantly reduced in both the thigh and the abdominal areas when analysed by MRI (Frederiksen et al. 2012b)
  • ADT of prostate cancer patients increased both visceral and subcutaneous abdominal fat in a 12-month prospective observational study (Hamilton et al. 2011)
  • Catecholamines are the major lipolysis regulating hormones in man and regulate adipocyte lipolysis through activation of adenylate cyclase to produce cAMP
  • deficiency of androgen action decreases lipolysis and is primarily responsible for the induction of obesity (Yanase et al. 2008)
  • may be some regional differences in the action of testosterone on subcutaneous and visceral adipose function
  • proinflammatory adipocytokines IL1, IL6 and TNFα are increased in obesity with a downstream effect that stimulates liver production of CRP
  • observational evidence suggests that IL1β, IL6, TNFα and CRP are inversely associated with serum testosterone levels in patients
  • TRT has been reported to significantly reduce these proinflammatory mediators
  • This suggests a role for AR in the metabolic actions of testosterone on fat accumulation and adipose tissue inflammatory response
  • testosterone treatment may have beneficial effects on preventing the pathogenesis of obesity by inhibiting adipogenesis, decreasing triglyceride uptake and storage, increasing lipolysis, influencing lipoprotein content and function and may directly reduce fat mass and increase muscle mass
  • Early interventional studies suggest that TRT in hypogonadal men with T2DM and/or MetS has beneficial effects on lipids, adiposity and parameters of insulin sensitivity and glucose control
  • Evidence that whole-body insulin sensitivity is reduced in testosterone deficiency and increases with testosterone replacement supports a key role of this hormone in glucose and lipid metabolism
  • Impaired insulin sensitivity in these three tissues is characterised by defects in insulin-stimulated glucose transport activity, in particular into skeletal muscle, impaired insulin-mediated inhibition of hepatic glucose production and stimulation of glycogen synthesis in liver, and a reduced ability of insulin to inhibit lipolysis in adipose tissue
  • Nathan Goodyear on 08 May 13
     
    Great review of the Hypogonadal-obesity-adipocytokine hypothesis.
Nathan Goodyear

International Journal of Obesity - Late-life obesity is associated with smaller global and regional gray matter volumes: a voxel-based morphometric study - 1 views

www.nature.com/...ijo201213a.html

obese obesity overweight gray matter brain

shared by Nathan Goodyear on 22 Feb 13 - No Cached
  • Nathan Goodyear on 22 Feb 13
     
    obese have smaller grey matter in the brain.  Remember the old ad, "this is your brain on drugs".  Well, this is your brain when fat...smaller.
Nathan Goodyear

Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease - 0 views

www.chinaphar.com/...391.pdf

Huperzine-A memory cognition Alzheimer's Alzheimer's disease acetylcholinesterase inhibitor

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    small study, but well designed that showed that huperzine A supplementation improved executive function in Alzheimer's patients. Huperzine A is an acetylcholinesterase inhibitor.
Day Spa Adelaide

Premiere Day Spa Service - 1 views

I have been working straight for a year now and yet I have not given myself the chance to relax and unwind. My friend told me about Shantai Wellness Spa, a day spa in Adelaide that is using only na...

started by Day Spa Adelaide on 16 Oct 12 no follow-up yet
Nathan Goodyear

Inflammatory responses to trivalent influenza virus ... [Vaccine. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21945263

influenza flu pregnancy CRP IL-6 TNF-alpha women preeclampsia preterm delivery PTD vaccine

shared by Nathan Goodyear on 07 Nov 12 - No Cached
  • Nathan Goodyear on 07 Nov 12
     
    This article's conclusion fits the definition of insane. This article found that the flu vaccine in pregnant women found significant increased CRP, TNF-alpha, and IL-6 inflammatory biomarkers.  It is well recognized the impact of inflammation on health and in this case the developing baby.   For example, preeclampsia and preterm birth are inflammatory conditions.  Yet, ACOG has made recommmendations for all pregnant women to get the flu vaccine?!?! Here is their conclusion: "However, further research is needed to confirm that the mild inflammatory response elicited by vaccination is benign in pregnancy".  Take home, you are being studied to see the effects of the flu vaccine on you, if you are pregnant, and your developing child.  And who decides what "mild" is anyways.  If you develop preeclampsia and delivery early, where is the "mild" in that?
Nathan Goodyear

Therapy of Endocrine disease: Long-term effects of recombinant human GH replacement in adults with GH deficiency: a systematic review - 0 views

www.eje-online.org/...R1.full

GH human growth hormone hormone hormones HGH

shared by Nathan Goodyear on 25 Jun 13 - No Cached
  • Nathan Goodyear on 25 Jun 13
     
    This study looked at long term therapy with GH in adults with GH deficiency.  This study found the long-term therapy to be "well-tolerated".  Though there are limited studies, this study showed good patient tolerability.
Nathan Goodyear

Roundup Disrupted Male Reproductive Func... [Free Radic Biol Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23820267

roundup infertility male glyphosate glutathione

shared by Nathan Goodyear on 04 Jul 13 - No Cached
  • Nathan Goodyear on 04 Jul 13
     
    Glyphosate, component of Roundup is well known to be an endocrine disruptor.  This rat study describes the mechanism  of disruption of the Sertoli cells resulting in male infertility.  In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification.  If that is not enough, oxidative damage marker TBARS was elevated.  
Nathan Goodyear

Transdermal delivery of bioidentical proge... [J Pharm Pharm Sci. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21486536

saliva salivary progesterone 5alpha reductase transdermal progesterone hormone hormones

shared by Nathan Goodyear on 08 Jul 13 - No Cached
  • Nathan Goodyear on 08 Jul 13
     
    Transdermal progesterone levels are quickly transported to saliva.  This quick transport, while serum doesn't equally reflect progesterone, has puzzled many.  Theories have been proposed, yet no answers.   This study looked at whether 5alpha reductase expression in the skin would metabolize the progesterone  and this explain the difference in the two test mediums.  The authors of this study concluded that 5alpha reductase is the not the reason for the difference found in saliva and serum.  the same can be applied to urine as well.
Stanley Bishop

The Reliable Sleep Apnea Home Test - 1 views

Because I used to snore hard, my wife insisted that I should see a doctor to make sure that this snoring problem will not lead to a more serious health concern. However, going to a doctor is the la...

started by Stanley Bishop on 17 Oct 12 no follow-up yet
Nathan Goodyear

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence - 0 views

www.ncbi.nlm.nih.gov/...PMC3627294

TA-65 telomere Telomerase telomerase activator aging natural wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • studies have demonstrated that the shortest telomeres are causal of reduced cell viability
  • a stable and enforced expression of telomerase leads to an improved health-span, accompanied by an extension of lifespan
  • TA-65 influences the percentage of cellular short telomeres through the activation of telomerase
  • ...17 more annotations...
  • TA-65 administration during 4 months significantly improved the capacity to uptake glucose after a glucose pulse
  • liver protective action of TA-65
  • A disadvantage of mTERT potentiation could be associated to its capacity to favor proliferation of cancerous cells in murine models
  • TA-65 treated mice presented a similar incidence of malignant cancers at time of death, with a tendency to show decreased sarcomas and slightly increased lymphomas
  • We demonstrate here that TA-65 leads to a significant rescue of short telomeres through telomerase activation
  • TA-65 treatment increases proliferation and mobilization potential of mouse keratinocytes in vitro, a situation mimicking telomerase overexpression
  • TAT2, a similar molecule, have beneficial effects in the activation of CD8+ T lymphocytes from HIV-infected patients where they observe an increase of the proliferative potential and enhancement of cytokine/chemokine production
  • TA-65 resulted in a similar rescue of short telomeres in leukocytes post-treatment as observed with humans, most likely through an activation of telomerase
  • we observe that TA-65 lead to 10 fold increase of telomerase RNA levels in the liver of treated mice comparing to the non-treated same-age cohorts
  • TA-65 regulates telomerase at the transcription level, probably through the regulation of the MAPK pathway
  • TA-65 dependent telomerase activation results in a better organ fitness as demonstrated by the improved scores at the glucose tolerance test and insulin levels at fasting
  • TA-65 supplemented mice also present modest enhancement of the subcutaneous and epidermal thickness, as well as higher bone density, representative of an overall fitness status improvemen
  • TA-65 treated mice present higher levels of RBC and hemoglobin comparing to the control cohorts
  • improved health-span of TA-65 treated mice is not accompanied by increased cancer incidence, which may be related to the fact that TERT levels are very modestly increased in all tissues tested except for the liver
  • systemic telomerase overexpression from the germline leads to protection from aging associated pathologies
  • similar situation could be mimicked expressing telomerase late in life in a telomerase deficient background
  • we observed a higher proliferation rate and a partial protection from cell death in some tissues of TA65 treated mice
  • Nathan Goodyear on 16 May 16
     
    TA-65 shown to increase telomerase activity, and thus telomere length of short telomeres, in mouse study.  
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