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Nathan Goodyear

Tumor necrosis factor-α and muscle wasting: a cellular perspective - 0 views

www.ncbi.nlm.nih.gov/...PMC59514

muscle loss wasting TNF-alpha inflammation

shared by Nathan Goodyear on 12 Nov 12 - No Cached
  • Nathan Goodyear on 12 Nov 12
     
    TNF-alpha associated with muscle loss and weakness.  TNF-alpha may also decrease testosterone production/secretion resulting in muscle loss.  
Nathan Goodyear

Counteracting muscle wasting in HIV-infected individuals - 0 views

trace.tennessee.edu/...viewcontent.cgi

muscle mass low T low testosterone HGH men male

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  • Nathan Goodyear on 12 Nov 12
     
    HIV/AIDS patients are plagues with muscle loss through varying mechanism. This article discusses the various contributors to the muscle mass found in these men. However, this can be applicable to other men with chronic muscle loss, low T, HGH deficiency...
Nathan Goodyear

The Cardiovascular Risk of Adult GH Deficiency (GHD) Improved after GH Replacement and Worsened in Untreated GHD: A 12-Month Prospective Study - 0 views

jcem.endojournals.org/...1088.short

HGH IGF-1 deficiency human growth hormone CVD cardiac heart cardiovascular

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  • Nathan Goodyear on 12 Nov 12
     
    in those adults with HGH deficiency, HGH replacement found to improve lipids, IGF-1, and cardiac function.
Nathan Goodyear

ScienceDirect.com - Journal of Science and Medicine in Sport - Relationship between serum, saliva and urinary cortisol and its implication during recovery from training - 0 views

www.sciencedirect.com/...S1440244002800317

saliva salivary hormone hormones cortisol

shared by Nathan Goodyear on 14 Nov 12 - No Cached
  • Nathan Goodyear on 14 Nov 12
     
    The use of saliva found to be advantageous over that of serum and urine to assess cortisol.
Nathan Goodyear

ScienceDirect.com - Journal of Science and Medicine in Sport - Saliva as a tool for monitoring steroid, peptide and immune markers in sport and exercise science - 0 views

www.sciencedirect.com/...S144024401100048X

saliva salivary hormone hormones

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  • Nathan Goodyear on 14 Nov 12
     
    saliva shown to be valuable and reliable in assessing hormones associated with sport performance, exercise, and/or training.
Nathan Goodyear

Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression - 0 views

www.nursa.org/retrieveFile.cfm

progesterone receptor progesterone receptors A B PR-A PR-B progesterone receptor receptors

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  • Nathan Goodyear on 12 Nov 12
     
    Good discussion of PR receptors. This article focus' on the different receptors, mainly A and B, and the nuclear transcriptional signaling.
Nathan Goodyear

Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study - 0 views

www.eje.org/...687.full.pdf

low T testosterone CVD cardiovascular disease men CAD mortality

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  • Nathan Goodyear on 12 Nov 12
     
    Good article. Discusses the association between low Testosterone and cardiovascular risk in men. The conclude that no direct cause effect relationship has been provided, but a clear association is seen. Numerous studies have shown this association.
Nathan Goodyear

Maternal Obesity and Vitamin D Sufficiency Are Associated with Cord Blood Vitamin D Insufficiency - 0 views

jcem.endojournals.org/...jc.2012-2882.abstract

obesity vitamin vitamin d pregnancy deficiency

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  • Nathan Goodyear on 12 Nov 12
     
    babies born to obese mothers have lower vitamin D levels.
Nathan Goodyear

Mechanisms of Progesterone Receptor Inhibition of Inflammatory Responses in Cellular Models of Breast Cancer - 0 views

mend.endojournals.org/...2292.long

progesterone receptor receptors cancer PR inflammation

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  • Nathan Goodyear on 12 Nov 12
     
    This article describes the underlying transcription responses to the anti-inflammatory effects provided through progesterone receptors (PR) in breast cancer.
Nathan Goodyear

Testosterone and cardiovascular disease in men. [Asian J Androl. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22522504

low T testosterone CAD coronary artery disease CVD cardiovascular men

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  • Nathan Goodyear on 12 Nov 12
     
    This article, abstract only, looks at the cause of low Testosterone.  It is well known that low T increases CAD in men.  But what causes the low T?  Is the "normal" decline in testosterone actually normal or a product of accumulative dysfunction.
Nathan Goodyear

Progesterone Receptor Inhibits Aromatase and Inflammatory Response Pathways in Breast Cancer Cells via Ligand-Dependent and Ligand-Independent Mechanisms - 0 views

mend.endojournals.org/...1812.long

progesterone receptor receptors PR breast cancer anti-inflammatory

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  • Nathan Goodyear on 12 Nov 12
     
    Progesterone receptor (PR) shown to provide an important anti-inflammatory role in breast cancer in this study.  PR shown to increase NF-kappaB inhibitor IkBalpha, shown to inhibit aromatase activity, shown to inhibit COX-2 expression and shown to inhibit HER-2/neu expression.
Nathan Goodyear

EHP - Persistent Environmental Pollutants and Couple Fecundity: The LIFE Study - 0 views

ehp.niehs.nih.gov/...1205301

POP persistent environmental pollutants fertility toxins PCBs organochlorides

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  • Nathan Goodyear on 14 Nov 12
     
    Persistent Environmental pollutants reduce couple fertility rate.  The toxins they looked at included organochlorides and PCBs.  
Nathan Goodyear

EHP - Competitive Androgen Receptor Antagonism as a Factor Determining the Predictability of Cumulative Anti­androgenic Effects of Widely Used Pesticides - 0 views

ehp.niehs.nih.gov/...1205391

pesticides androgen receptor antagonists testosterone AR male men

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  • Nathan Goodyear on 14 Nov 12
     
    Many pesticides function as androgen receptor antagonists.  Others as Xenoestrogens.  Estrogen-like toxins and androgen receptor antagonists...a potent cocktail to disrupt male androgen signaling.
Nathan Goodyear

ScienceDirect.com - Frontiers in Neuroendocrinology - Progesterone receptors: Form and function in brain - 0 views

www.sciencedirect.com/...S0091302208000058

progesterone receptors receptor PR brain CNS inflammation anti-inflammatory

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  • Nathan Goodyear on 12 Nov 12
     
    progesterone through progesterone receptors, shown to have protective, anti-inflammatory effects in the CNS.
Nathan Goodyear

ScienceDirect.com - Fertility and Sterility - Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis - 0 views

www.sciencedirect.com/...S001502820400980X

progesterone PR ER-alpha ER-beta receptor receptors inflammation endometriosis Estradiol

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  • Nathan Goodyear on 12 Nov 12
     
    mice model, but progesterone deficiency results in decreased PR expression to provide counter anti-inflammatory effect in endometriosis model.  Thus pro-inflammatory transcription via E2 through ER signaling.  It would be interesting to see if that was ER-alpha or ER-beta.
Nathan Goodyear

Testosterone and Estradiol Regulate Free Insulin-Like Growth Factor I (IGF-I), IGF Binding Protein 1 (IGFBP-1), and Dimeric IGF-I/IGFBP-1 Concentrations - 0 views

jcem.endojournals.org/...2941.full

IGF-1 testosterone Estradiol growth hormone hormones HGH GH IGFBP-1

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  • Nathan Goodyear on 12 Nov 12
     
    testosterone and Estradiol effect IGF-1 levels.  This small study looked at 8 men and 8 postmenopausal women.  Findings:  low testosterone and high estradiol decrease IGF-1 availability.   Estradiol in postmenopausal women will result in a decrease in IGF-1 through an elevation of IGFBP-1.  In men, testosterone replacement stimulates increased HGH secretion and resultant IGF-1 secretion
Nathan Goodyear

Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis - 0 views

ajpendo.physiology.org/...E820.reprint

testosterone elderly men HGH IGF-1 muscle mass strength

shared by Nathan Goodyear on 13 Nov 12 - No Cached
  • Nathan Goodyear on 13 Nov 12
     
    Testosterone given to elderly men with low "serum" testosterone shown to increase IGF-1 and increased muscle growth and strength.  So, this study shows that testosterone in men, seems to increase HGH production and thus increase IGF-1 production.  This may be the mechanism by which testosterone promotes muscle growth and increase in strength in men.
Nathan Goodyear

Breast Cancer Research | Full text | The growth response to androgen receptor signaling in ERalpha negative human breast cells is dependent on p21 and mediated by MAP kinase activation - 0 views

breast-cancer-research.com/...R27

androgen receptors receptor AR breast cancer women

shared by Nathan Goodyear on 21 Nov 12 - No Cached
  • Nathan Goodyear on 21 Nov 12
     
    Androgen Receptors (AR) may play a role in some breast cancer growth and could be a target for future therapy.
Nathan Goodyear

Evidence for hypogonadism in massively obese ... [Horm Metab Res. 1981] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7198085

obesity obese overweight low T low T testosterone low testosterone aromatase SHBG estradiol men male hyogonadism

shared by Nathan Goodyear on 19 Nov 12 - No Cached
  • Nathan Goodyear on 19 Nov 12
     
    In obese men, low T is the result of increased estradiol formation from aromatase activity.  Low SHBG is no enough to offset the decrease in free T levels.
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