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Nathan Goodyear

An Overview of Melatonin and Breast Cancer | Natural Medicine Journal - 0 views

  • Overall its effect on cancer cells is oncostatic at physiological levels, or cytotoxic at higher concentrations
  • direct antioxidant, antimitotic, antiestrogenic, prodifferentiating and antimetastatic effects have been well characterized
  • hypothalamic-pituitary axis (HPA) and immune system
  • ...2 more annotations...
  • On a cellular level, melatonin acts as a selective estrogen receptor modulator (SERM) through decreased expression of estrogen receptor alpha and reduction in the ability of estrogen-estrogen receptor alpha (ERα) complex to bind to the estrogen response element (ERE) on DNA
  • Melatonin also acts as a selective estrogen enzyme modulator (SEEM), reducing the activity of aromatase in cells
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    review of melatonins activity in cancer battle.
Nathan Goodyear

Estrogen Signaling Multiple Pathways to Impact Gene Transcription - 0 views

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    Good review of estrogen genomic versus non-genomic signaling.
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