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Nathan Goodyear

Antiobesity effects of green tea catechins: a mechanistic review - 0 views

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    great article on the role/effects green tea catechins has on obesity.  These articles are great, because they actually show the biochemistry of the "natural" or "alternative" therapies.  
Nathan Goodyear

Brain dopamine and obesity - 0 views

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    here is the full article in pdf form
Nathan Goodyear

Central Nervous system control of food intake - 0 views

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    For you biochemistry junkies. A great review of how the Gut and CNS communicate to regulate food intake
Nathan Goodyear

Foods fail to suppress Ghrelin levels in obese humans - 0 views

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    Ghrelin is a hormone that is release to induce hunger and eating. Post meals, gherlin should decrease; but in obese individuals, a dysregulation between the GI system and the hypothalamus results in elevated gherlin resulting in overeating.
Nathan Goodyear

Ghrelin is a growth-hormone-releasing acylated peptide from stomach : Abstract : Nature - 0 views

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    ghrelin is a GH releasing peptide released from the stomach
Nathan Goodyear

Circulating Ghrelin Levels Are Decreased in Human Obesity - 0 views

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    low ghrelin levels found in obese individuals (Pima Indians).  Low ghrelin was associated with an inverse increase in fat, insulin, and leptin. It has also been shown to be associated with an inverse increase in Testosterone.
Nathan Goodyear

Effects of catechin enriched green t... [Obesity (Silver Spring). 2010] - PubMed - NCBI - 0 views

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    green tea reduces body fat in overweight chinese adults
Nathan Goodyear

Obesity - Will All Americans Become Overweight or Obese? Estimating the Progression and Cost of the US Obesity Epidemic - 0 views

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    86% of Americans projected to be obese or overweight by the year 2030.
Nathan Goodyear

Urgently needed: a framework convention for obesity control : The Lancet - 0 views

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    obesity numbers are out of control
Nathan Goodyear

Central obesity and the aging brain - 0 views

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    This study showed that abdominal obesity was associated with a smaller brain volume. Specifically, a high waist to hip ratio was associated with a 27% reduction in hippocampal volume.
Nathan Goodyear

Longer sleep duration associates with lower adiposity gain in adult short sleepers. - 0 views

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    shorter sleep associated with obesity.
Amelie warner

High Quality & Authentic, Weight Loss Green Tea - 0 views

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    We travel thousands of miles each year, to find and select definitive examples of Asia's finest teas. To help you enjoy the best possible experience... #haocha http://bit.ly/LsZ2sO
Nathan Goodyear

PCRM | Analysis of Health Problems Associated with High-Protein, High-Fat, Carbohydrate-Restricted Diets Reported via an Online Registry - 0 views

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    nice review of some of the problems associated with a high fat ,high protein diet.  These effects are seen in those utilizing long term dietary patterns of high protein and high fat intake.  
Young Leaf Wellness

How To Steep The Perfect Tea For Full Benefits - 1 views

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    Tea is enjoyed around the world, but preparing the perfect cup is more than turning the stovetop on high and throwing a tea bag in a cup. Learning to steep the perfect cup isn't as difficult as it may seem.
Nathan Goodyear

Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease - 0 views

  • The gut microbiota participates in the body’s metabolism by affecting energy balance, glucose metabolism, and low-grade inflammation associated with obesity and related metabolic disorders
  • Firmicutes and Bacteroidetes represent the two largest phyla in the human and mouse microbiota and a shift in the ratio of these phyla has been associated with many disease conditions, including obesity
  • In obese humans, there is decreased abundance of Bacteroidetes compared to lean individuals
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  • weight loss in obese individuals results in an increase in the abundance of Bacteroidetes
  • there is conflicting evidence on the composition of the obese microbiota phenotype with regards to Bacteroidetes and Firmicutes ratios
  • Bifidobacteria spp. from the phyla Actinobacteria, has been shown to be depleted in both obese mice and human subjects
  • While it is not yet clear which specific microbes are inducing or preventing obesity, evidence suggests that the microbiota is a factor.
  • targeted manipulation of the microbiota results in divergent metabolic outcomes depending on the composition of the diet
  • The microbiota has been linked to insulin resistance or type 2 diabetes (T2D) via metabolic syndrome and indeed the microbiota of individuals with T2D is also characterized by an increased Bacteroidetes/Firmicutes ratio, as well as an increase in Bacillus and Lactobacillus spp
  • It was also observed that the ratio of Bacteriodes-Prevotella to C. coccoides-E. rectale positively correlated with glucose levels but did not correlate with body mass index [80]. This suggests that the microbiota may influence T2D in conjunction with or independently of obesity
  • In humans, high-fat Western-style diets fed to individuals over one month can induce a 71% increase in plasma levels of endotoxins, suggesting that endotoxemia may develop in individuals with GI barrier dyfunction connected to dysbiosis
  • LPS increases macrophage infiltration essential for systemic inflammation preceding insulin resistance, LPS alone does not impair glucose metabolism
  • early treatment of dysbiosis may slow down or prevent the epidemic of metabolic diseases and hence the corresponding lethal cardiovascular consequences
  • increased Firmicutes and decreased Bacteroidetes, which is the microbial profile found in lean phenotypes, along with an increase in Bifidobacteria spp. and Lactobacillus spp
  • mouse and rat models of T1D have been shown to have microbiota marked by decreased diversity and decreased Lactobacillus spp., as well as a decrease in the Firmicutes/Bacteroidetes ratio
  • microbial antigens through the innate immune system are involved in T1D progression
  • The microbiota appears to be essential in maintaining the Th17/Treg cell balance in intestinal tissues, mesenteric and pancreatic lymph nodes, and in developing insulitis, although progression to overt diabetes has not been shown to be controlled by the microbiota
  • There is evidence that dietary and microbial antigens independently influence T1D
  • Lactobacillus johnsonii N6.2 protects BB-rats from T1D by mediating intestinal barrier function and inflammation [101,102] and a combination probiotic VSL#3 has been shown to attenuate insulitis and diabetes in NOD mice
  • breast fed infants have higher levels of Bifidobacteria spp. while formula fed infants have higher levels of Bacteroides spp., as well as increased Clostridium coccoides and Lactobacillus spp
  • the composition of the gut microbiota strongly correlates with diet
  • In mice fed a diet high in fat, there are many key gut population changes, such as the absence of gut barrier-protecting Bifidobacteria spp
  • diet has a dominating role in shaping gut microbiota and changing key populations may transform healthy gut microbiota into a disease-inducing entity
  • “Western” diet, which is high in sugar and fat, causes dysbiosis which affects both host GI tract metabolism and immune homeostasis
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    Nice discussion of how diet, induces gut bacterial change, that leads to metabolic endotoxemia and disease.
Nathan Goodyear

Coenzyme Q10 as a possible treatment for neurodege... [Free Radic Res. 2002] - PubMed result - 0 views

  • CoQ10 can significantly extend survival, delay motor deficits and delay weight loss and attenuate the development of striatal atrophy in a transgenic mouse model of HD
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    CoQ10 shown to shown to slow progression of the neurodegenerative disease: Huntington's disease
Nathan Goodyear

Endurance training without weight loss lowers syst... [Free Radic Biol Med. 2008] - PubMed result - 0 views

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    endurance training in obese women increases inflammation; carbohydrates reduce
Nathan Goodyear

ScienceDirect - Physiology & Behavior : The role of leptin in leptin resistance and obesity - 0 views

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    The role of leptin in leptin resistance and obesity
Nathan Goodyear

Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans - 0 views

  • Long-term supplementation with CLA-FFA or CLA-triacylglycerol reduces BFM in healthy overweight adults
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    CLA, conjugated linoleic acid, supplementation reduces body fat mass
Nathan Goodyear

Access : Central nervous system control of food intake : Nature - 0 views

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    great review on CNS regulation of food intake
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