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Nathan Goodyear

The effects of vitamin C supplementation on ... [Arthritis Rheum. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15934094

vitamin C uric acid gout

shared by Nathan Goodyear on 17 Jan 12 - No Cached
  • Nathan Goodyear on 17 Jan 12
     
    Vitamin C therapy, at low doses, shown to reduce uric acid
Nathan Goodyear

Higher dietary fructose is associated with impaired hepatic adenosine triphosphate home... - 0 views

onlinelibrary.wiley.com/...34FD9FE5A86A5E9B8BE0490.d03t04

fructose uric acid ATP metabolic syndrome

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    uric acid used as marker for impaired ATP production in those with high fructose intake.
Nathan Goodyear

Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension - 0 views

www.ncbi.nlm.nih.gov/...PMC3677638

fructose phosphofructokinase MetS metabolic syndrome metabolic syndrome insulin resistance ATP mitochondria uric acid

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Fructose intake increases MetS and hypertension.  The high fructose intake upregulates phosphofructokinase which increases triglyceride production, bypassing central regulation.  This results in ATP depletion with reduced capacity to recover.  Thus attempts by the cells to increase ATP through AMP deaminase results in uric acid production.
Nathan Goodyear

http://atvb.ahajournals.org/content/25/5/1038.full.pdf - 0 views

atvb.ahajournals.org/...1038.full.pdf

metabolic syndrome insulin resistance uric acid carotid plaque atherosclerosis

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • Nathan Goodyear on 24 Aug 14
     
    Increasing uric acid concentrations is found to be associated with insulin resistance and metabolic syndrome in both men and women.  Equally, it is associated with carotid plaque formation.
Nathan Goodyear

Internet Scientific Publications - 0 views

ispub.com/8186

malondialdehyde glutathione GSH superoxide disumutase SOD saliva uric acid MDA stroke disease testing

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Nathan Goodyear on 21 Oct 14
     
    Study of Iraqi population at elevated risk of stroke found that both serum and salivary levels of malondialdehyde, glutathione, superoxide dismutase, and uric acid proved useful as potential biomarkers of risk assessment.
Nathan Goodyear

Higher dietary fructose is associated with impaired hepatic adenosine triphosphate home... - 1 views

onlinelibrary.wiley.com/...abstract

fructose HFCS uric acid diabetes

shared by Nathan Goodyear on 11 Jan 16 - No Cached
  • Nathan Goodyear on 11 Jan 16
     
    high fructose intake associated with elevated uric acid levels.
Nathan Goodyear

Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis - ... - 0 views

pubmed.ncbi.nlm.nih.gov/34160066

hyperuricemia vitamin C xanthine oxidase IL-6 uric acid

shared by Nathan Goodyear on 07 Jun 22 - No Cached
  • Nathan Goodyear on 07 Jun 22
     
    Vitamin C reduces xanthine oxidase and uric acid levels by at least 20%. Again, another study shows a reduction in IL-6.
Nathan Goodyear

The endurance triathlon: metabolic changes after each event and dur... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1956272

triathlon endurance training recovery lactate

shared by Nathan Goodyear on 18 Nov 14 - No Cached
  • Nathan Goodyear on 18 Nov 14
     
    Serum lactate elevates early in triathlon.  The greatest increase is associated with the swim event.  Muscle damage progressed through the 3 events (creatine phosphokinase and LDH).  Uric acid levels increased.  Recovery was seen out to 6 days post event.
Nathan Goodyear

Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidne... - 0 views

ndt.oxfordjournals.org/...608.short

fructose HFCS inflammation CRP insulin nutrition

shared by Nathan Goodyear on 10 Jan 16 - No Cached
  • Nathan Goodyear on 10 Jan 16
     
    low fructose diet decreased CRP, insulin, and uric acid levels.  
Nathan Goodyear

Gout, diet, and the insulin resistance syndrome. - 1 views

www.jrheum.org/...1350.full.pdf+html

gout insulin resistance IR inflammation uric acid metabolic metabolism

shared by Nathan Goodyear on 19 Mar 12 - No Cached
  • Nathan Goodyear on 19 Mar 12
     
    Gout is a result of Insulin resistance?  It makes perfect biologic sense.  IR causes inflammation and what is Gout?  Nothing but an inflammatory condition.  So is Gout merely a join representation of metabolic dysfunction?  I say yes.
Nathan Goodyear

A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipi... - 0 views

ajcn.nutrition.org/...ajcn.114.100461.abstract

cholesterol triglycerides HFCS fructose uric acid cardiovascular disease CVD nutrition

shared by Nathan Goodyear on 23 Jun 15 - No Cached
  • Nathan Goodyear on 23 Jun 15
     
    HFCS increase biomarkers of cardiovascular disease.
Nathan Goodyear

Systemic inflammation, metabolic syndrome and progressive renal disease - 0 views

ndt.oxfordjournals.org/...1384.full

inflammation metabolic syndrome CRP Uric Acid cardiovascular disease risk

shared by Nathan Goodyear on 15 Aug 11 - No Cached
  • Nathan Goodyear on 15 Aug 11
     
    metabolic syndrome = systemic inflammation
Nathan Goodyear

http://www.the-aps.org/mm/Publications/Journals/PIM/choi-pdf.pdf - 0 views

www.the-aps.org/...choi-pdf.pdf

gout purine xanthine oxidase uric acid

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Nathan Goodyear on 02 Feb 15
     
    review of gout and purine metabolism
Nathan Goodyear

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stag... - 0 views

www.ncbi.nlm.nih.gov/...PMC3547448

Adenosine Deaminase ADA cancer breast cancer superoxide disumutase glutathione peroxidase oxidative stress inflammation

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Reduced SOD activity might be responsible for excessive accumulation of superoxide anions leading to increased free radical mediated injury. Increased free radical production has been shown to be responsible for chromosomal damage leading to mutagenecity, cell proliferation and carcinogenesis. SOD activity showed marked improvement after mastectomy indicating the lowering of oxidative stress.
  • The increased production of reactive oxygen species causes oxidative stress leading to cell proliferation and hence increased inflammatory conditions
  • Superoxide dismutase is an important antioxidant enzyme which decomposes the harmful superoxide anions into hydrogen peroxide thus protects the body from the action of free radicals
  • ...20 more annotations...
  • Females suffering from breast cancer had significantly decreased Superoxide dismutase (SOD) and reduced glutathione (GSH) levels in comparison to normal females
  • ADA seems to be a promising marker of inflammation in breast cancer thereby suggesting that it can be used as a diagnostic tool to detect the stage of breast cancer along with cytopathological studies
  • In conclusion, our study confirmed the role of oxidative stress in the pathogenesis of breast cancer.
  • Another potent antioxidant molecule is reduced glutathione. It acts as reductant which converts hydrogen peroxide into water and reduces lipid peroxidation products into their corresponding alcohols and thus mediates protective action.
  • In the present study, significantly low SOD activity has been observed in female patients suffering from carcinoma breast both pre as well as post operative in comparison to healthy females.
  • The compromised antioxidant defence system produces the oxidative stress which in turn creates the inflammatory response shown by concomitant increased adenosine deaminase (ADA) activity in female patients.
  • Increased ADA activity in breast cancer patients has also been reported
  • We observed significantly decreased SOD activity and GSH levels in patients belonging to clinical stage 4 as compared to those having stages 1, 2 or 3 of breast cancer.
  • increased oxidative stress gives rise to inflammation which could further aggravates the disease
  • Antioxidant status was highly depressed in advanced stages of breast cancer as compared to initial stage.
  • In the present study, significantly low GSH levels were observed in female patients of carcinoma breast as compared to normal females
  • Walia et al. (1995) reported increased ADA activity in breast cancer patients as compared to age matched normal subjects.
  • These free radicals are able to cause damage to membrane, mitochondria and macromolecules including proteins, lipids and DNA and actively take part in cell proliferation. This cascade in turn generates the inflammatory response and causes the progression of the disease.
  • Experimental and epidemiological evidences implicate the involvement of oxygen derived free radical in the pathogenesis of breast cancer.
  • Breast carcinoma involves a cascade of events that are highly inflammatory.
  • Marked oxidative stress in stage 4 of breast cancer indicated advancement of the disease, hence checking oxidative stress at initial stage could be helpful for controlling the progression of the disease.
  • They concluded that ADA is a better probable parameter for detection of breast cancer
  • Adenosine deaminase enzyme (ADA) catalyzes the conversion of adenosine to inosine which finally gets converted to uric acid
  • serum ADA activity tends to increase with advancing age,
  • Prevalence of oxidative stress gives rise to inflammation.
  • Nathan Goodyear on 10 Nov 14
     
    Study finds a reduction in SuperOxide Dismutase and Glutathione Perioxidase in advancing breast cancer.  Cancer is a high oxidative stress disease that results in inflammation, mitochondrial dysfunction and proliferation.  Adenosine Deaminase (ADA) is proposed to be another biomarker to assess tumor stage.  
Nathan Goodyear

http://www.iasj.net/iasj?func=fulltext&aId=1538 - 0 views

www.iasj.net/iasj

oxidative stress glutathione GSH malondialdehyde testing superoxide disumutase SOD saliva uric acid

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Nathan Goodyear on 21 Oct 14
     
    serum and salivary oxidative stress biomarkers used to follow children with autism in Iraq.
Nathan Goodyear

Ketohexokinase-Dependent Metabolism of Fructose Induces Proinflammatory Mediators in Pr... - 0 views

jasn.asnjournals.org/...545.abstract

fructose HFCS inflammation uric acid

shared by Nathan Goodyear on 10 Jan 16 - No Cached
  • Nathan Goodyear on 10 Jan 16
     
    Fructose induces inflammation.
Nathan Goodyear

Clinical review: Specific aspects of acute renal failure in cancer patients - 0 views

www.ncbi.nlm.nih.gov/...PMC1550893

cancer renal failure

shared by Nathan Goodyear on 13 Aug 18 - No Cached
  • uric acid crystal formation in the renal tubules secondary to hyperuricaemia
  • calcium phosphate deposition related to hyperphosphataemia
  • usually develops shortly after the initiation of cytotoxic chemotherapy
  • ...18 more annotations...
  • Non-recombinant urate oxidase (Uricozyme®)
  • recombinant urate oxidase (Rasburicase®)
  • urine alkalisation may induce calcium phosphate deposition
  • renal replacement therapy should be started on an emergency basis when hydration fails to produce a prompt metabolic improvement or when ARF develops
  • Up to 50% of patients with newly diagnosed multiple myeloma have renal failure and up to 10% require dialysis
  • renal ultrasonography remains the method of choice for investigating extra-renal obstruction
  • The relief of the obstruction, either by percutaneous nephrostomy or through a ureteral stent, is the cornerstone of treatment
  • TMA may be associated with the cancer itself, with cancer chemotherapy, or with allogeneic BMT
  • thrombotic microangiopathy (TMA)
  • it may be as high as 5%
  • Most of the cases occur in patients with solid tumours, the most common type being adenocarcinoma (stomach, breast and lung)
  • The pathophysiology of the TMA-malignancy association remains controversial, although many studies suggest an insult to the vascular endothelium
  • mitomycin C. Subsequently, TMA has been reported with many anti-cancer agents, including gemcita-bine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α
  • Plasma exchanges have been shown to improve prognosis in the general population of patients with TMA
  • Causative factors should be looked for and antihypertensive treatment given. Lastly, in the absence of guidelines, we believe that plasma exchange should be proposed in patients with severe cancer treatment-associated TMA
  • The most widely used protective measure is saline infusion to induce solute diuresis
  • During methotrexate infusion and elimination, fluids should be given to maintain a high urinary output and urinary alkalisation should be performed to keep the urinary pH above 7.5. Rescue with folinic acid (50 mg four times a day) should be started 24 hours after each high-dose metho-trexate infusion and serum methotrexate concentrations should be measured every day
  • cyclophosphamide and ifosfamide
  • Nathan Goodyear on 13 Aug 18
     
    cancer and renal failure
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