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Nathan Goodyear

Reduced activation and increased ina... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12843166

inflammation illness thyroid hypothyroid hypothyroidism TSH free T3 rT3 T3:rT3 ratio

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness.
  • Nathan Goodyear on 02 Feb 12
     
    inflammation and critical illness associated with low TSH, low T3, elevated rT3 and low T3:rT3 ratio.
Nathan Goodyear

Combination L-T3 and L-T4... [Curr Opin Endocrinol Diabetes Obes. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23974776

hypothyroid hypothyroidism T4 T3 thyroid therapy

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    This article reviews the genetic polymorphisms that play role in low T4 to T3 conversion and thus combination T4/T3 therapy is indicated.  This study fails to recognize the environmental impacts on the deiodinase enzymes.
Nathan Goodyear

Reverse T3 as a parameter of myocardial functi... [Int J Cardiol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19428128

thyroid hormone hormones reverse T3 fT3_rT3 rT3 heart failure CHF cardiovascular disease.

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Another study regarding reverse T3 that many Endocrinologists need to read.  In this study, the authors find that significantly higher reverse T3 levels were associated with myocardial function impairment (MFI) class IV.  This MFI class IV was also found associated with a decreased fT3/rT3.
Nathan Goodyear

Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC3159779

thyroid hormone hormones reverse T3 free T3 rT3 T4 metabolism

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Here is a great review of thyroid hormone metabolism published in the very relevant journal Endocrinology.  The review describes the peripheral metabolism of the pro hormone T4 and the peripheral metabolism to free T3 and/or reverse T3 and the associated metabolic implications.  Why don't more endocrinologists read?This is an animal study.
Nathan Goodyear

The role of dietary fat in peripheral thyroid hor... [Metabolism. 1980] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7421583

diet fat carbohydrates T3 reverse T3 metabolism HF high fat

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    High fat diet in this small animal study finds an increase in reverse T3 and a decrease in T3.  Higher carbohydrate diet provided no significant change.
Nathan Goodyear

Regulation of mitochondrial biogenesis by thyroid hormone - 0 views

ep.physoc.org/...121.full.pdf+html

T3 mitochondria thyroid hormone receptors TRH thyroid hormone response elements TRE hormone thyroid

shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    Study describes the T3 effect on mitochondrial biogenesis.  T3 interacts with receptors involved with mitochondrial biogenesis in 3 ways: thyroid hormone receptors (TR), thyroid hormone receptor elements (TRE), and a combination of the two.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

jcem.endojournals.org/...3466.abstract

T3 T4 hypothyroid hypothyroidism functional armour thyroid cholesterol LDL weight-loss overweight obesity metabolic effects therapy

shared by Nathan Goodyear on 08 Dec 11 - No Cached
  • Nathan Goodyear on 08 Dec 11
     
    T3 shown increase weight loss, lower LDL, decrease apolipoprotein B, decrease T cholesterol versus T4.  This flies in the face of conventional medical dogma, that T 4 (synthroid, levothyroxine) is the only route of thyroid replacement.  In fact, this suppports the use of armour thyroid, a T4/T3 combination.
Nathan Goodyear

Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive H... - 0 views

www.ajconline.org/...abstract

CHF T3 hypothyroid hypothyroidism heart failure

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    Patients with CHF often have low T3 levels.  In this study, IV T3 was shown to be safe and well tolerated
Nathan Goodyear

Potential uses of T3 in the treatment of human dis... [Clin Cornerstone. 2005] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...16399246

T3 hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • riiodothyronine (T3), formed by the monodeiodination of T4, is the biologically active form of thyroid hormone
  • Nathan Goodyear on 01 Feb 11
     
    T3 is the active, biologically form of the thyroid hormone
Nathan Goodyear

Thyroid Hormone and Cardiac Disease: From Basic Concepts to Clinical Application - 0 views

www.ncbi.nlm.nih.gov/...PMC3134399

T3 cardiovascular death disease heart health MI myocardial infarction CHF heart failure thyroid hormone hormones hypothyroid hypothyroidism CVD

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Low T3 post MI is associated with increased CHF, morbidity and mortality.  Article discusses thyroid hormones and cardiac function/remodeling post infarct.  The article also lays the ground work for a new study of T3 in patients post MI to be followed for 6 months.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

press.endocrine.org/...jc.2011-1329

T4 T3 hypothyroid hypothyroidism thyroid lipids weight loss metabolism cholesterol hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • tissue euthyroidism is the net result of multiple steps including conversion of the prohormone T4 into its active metabolite T3, which is ultimately responsible for signaling at the end-organ target level
  • The circulating and intracellular pools of T3 of treated hypothyroid patients (i.e. devoid of endogenous TH production) depend entirely on the conversion of exogenous l-T4 into T3
  • TH is the major regulator of basal metabolic rate
  • ...8 more annotations...
  • The substitution of l-T3 for l-T4 caused a significant weight loss
  • The substitution of l-T3 for l-T4 caused a significant reduction in lipid parameters
  • TH action is increased in the liver, and the SHBG increase supports this hypothesis
  • The changes in serum lipid metabolism parameters are similar to the effects observed with drugs approved for the treatment of dyslipidemia
  • This differential response appears to be limited to the lipid metabolism and SHBG, whereas no differences in indices of insulin resistance were detected. This is remarkable because hyperthyroid states are associated with an increase in hepatic gluconeogenesis (37), and overt thyrotoxicosis is a known cause of secondary diabetes.
  • Despite the increase in serum T3, the l-T3 treatment did not cause major changes in cardiovascular or musculoskeletal function, as indicated by the echocardiographic and maximal exercise tolerance tests and DXA studies.
  • Similarly, no significant differences were observed in blood pressure, heart rate, or endothelial vascular function
  • In conclusion, the results of this pharmacology, proof-of-concept study indicate that replacement therapy of hypothyroidism with l-T3, compared with l-T4 causes weight loss and favorable changes in the lipid profile without appreciable side effects
  • Nathan Goodyear on 24 Sep 14
     
    Crossover study finds T3 versus T4 results in more weight loss, improved lipid management and increased SHBG without any adverse cardiovascular effects.   The T3 was dosed 3 x daily due to its short half life compared to T4.
Nathan Goodyear

Acute myocardial infarction and thyroid function: New pathophysiological and therapeuti... - 0 views

informahealthcare.com/...07853890.2011.573501

thyroid hormone hormones T3 heart attack heart health myocardial infarction MI

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Thyroid hormone plays significant role in cardiac remodeling after acute myocardial infarction.  Thyroid hormone, particularly T3 as the vast majority of T3 is produced in heart tissue via D1 enzymatic activity, improves cardiac contractility, reduces systemic vascular resistance, reduces cardiac work load, decreases blood pressure, improves cardiac metabolism, and thus improves outcomes post MI.
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

jcem.endojournals.org/...1351

T3 hypothyroid hypothyroidism cardiac disease

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • In DC patients, short-term synthetic L-T3 replacement therapy significantly improved neuroendocrine profile and ventricular performance
  • Nathan Goodyear on 01 Feb 11
     
    T3 provides significant improvement in cardiac function in those with dilated cardiomyopathy
Nathan Goodyear

Low-T3 Syndrome: A Strong Prognostic Predictor of Death in Patients With Heart Disease ... - 0 views

circ.ahajournals.org/...708

low t3 syndrome heart disease cardiac

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Conclusions— Low-T3 syndrome is a strong predictor of death in cardiac patients and might be directly implicated in the poor prognosis of cardiac patients.
  • Nathan Goodyear on 01 Feb 11
     
    low T3 proves to be a strong predictor of death in patients with heart disease
Nathan Goodyear

Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in... - 0 views

endo.endojournals.org/...2490

hypothyroid hypothyroidism T4 T3

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Combined replacement therapy with T4 and T3 (in proportions similar to those secreted by the normal rat thyroid) completely restored euthyroidism in thyroidectomized rats at much lower doses of T4 than those needed to normalize T3 in most tissues when T4 alone was used
  • Nathan Goodyear on 08 Mar 11
     
    combined T4/T3 therapy the best approach in hypothyroidism
Nathan Goodyear

Serum concentrations of total T4, T3, reverse T3 a... [Hum Nutr Clin Nutr. 1985] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...4055428

free T3 hypothyroidism hypothyroid obesity

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    poor nutrition leads to low free T3 in tissue which lowers cellular metabolism which leads to obesity
Nathan Goodyear

Effects of thyroid hormones on hu... [J Steroid Biochem Mol Biol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18328691

triiodothyronine T3 thyroid hormone hormones breast cancer E2 Estradiol

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    T3 may promote cancer cell proliferation says study.  Triiodothyronine was found to enhance the MCF-7 and T47-D breast cancer cell lines.  The conclusion of the abstract discusses a role of T3 in breast cancer development and progression.  This likely has more to do with progression than development through increased metabolism of the cell lines.
Nathan Goodyear

Thyroid Hormones (T3 and T4): Dual Effect on Human Cancer Cell Proliferation - 0 views

ar.iiarjournals.org/...89.long

triiodothyronine thyroid hormones hormone cancer

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    The effects of T3 on cancer cell lines varies.  All cell lines came from the same tissue. It doesn't appear that simply stating T3 promotes cellular metabolism and thus provides an increase in cancer progression risk.  Some cell lines studies actually had an inhibition of cell growth, whereas others saw an increase.  
Nathan Goodyear

Implication from thyroid function decreasing during chemotherapy in breast cancer patie... - 0 views

www.ncbi.nlm.nih.gov/...PMC3717040

triiodothyronine T3 cancer chemotherapy thyroid

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Article points to potential chemosensitizing effect of T3 in cancer treatment.  Chemotherapy with increased metabolic demand with T3 may improve cancer kill rate.
Nathan Goodyear

Arquivos Brasileiros de Endocrinologia & Metabologia - Influence of estradiol and triio... - 0 views

www.scielo.br/scielo.php

T3 triiodothyronine cancer ER ER alpha ER-alpha estrogen thyroid hormone hormones receptors Estradiol E2

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Study finds T3 effects on ER-alpha is likely a non-genomic pathway.  This study found a down regulation of ER-alpha in tumor cell lines by T3.
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